LOCUS AF154005 1612 bp mRNA linear HUM 14-JUL-1999
DEFINITION Homo sapiens junction adhesion molecule mRNA, complete cds.
ACCESSION AF154005
VERSION AF154005.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1612)
AUTHORS Liu,Y., Nusrat,A., Schnell,F.J., Walsh,S., Reaves,T.A., Pochet,M.,
Foley,C. and Parkos,C.A.
TITLE Human junctional adhesion molecule is expressed by polarized
columnar epithelia and regulates tight junction resealing
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1612)
AUTHORS Schnell,F.J. and Liu,Y.
TITLE Direct Submission
JOURNAL Submitted (25-MAY-1999) Pathology, Emory University, 1639 Pierce
Drive: WMRB 2333, Atlanta, GA 30322, USA
FEATURES Location/Qualifiers
source 1..1612
/db_xref="H-InvDB:HIT000071887"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="T84 colonic adenocarcinoma"
CDS 63..842
/function="involved in integrity of epithelial barrier"
/note="immunoglobulin superfamily; location at tight
junction and lateral surface of epithelium; expression
also found in peripheral neutrophils, lymphocytes and
monocytes"
/codon_start=1
/product="junction adhesion molecule"
/protein_id="AAD43794.1"
/translation="MGTKAQVERKLLCLFILAILPENNPVKLSCAYSGFSSPRAASYE
DRVTFLPTGITFKSVTREDTGTYTCMVFEEGGNSYGEVKVKLIVLVPPSKPTVNIPSS
ATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFD
PLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVGVIVAAVLVTLILLGILVFGIW
FAYSRGHFDRTKKGTSSKKVIYSQPSARSEGEFKQTSSFLV"
BASE COUNT 351 a 411 c 427 g 423 t
ORIGIN
1 cgcggagctg tgtctgttcc caggagtcct tcggcggctg ttgtgtcggg agcctgatcg
61 cgatggggac aaaggcgcaa gtcgagagga aactgttgtg cctcttcata ttggcgatcc
121 ttcctgagaa taatcctgtg aagttgtcct gtgcctactc gggcttttct tctccccgtg
181 cagcttccta tgaggaccgg gtgaccttct tgccaactgg tatcaccttc aagtccgtga
241 cacgggaaga cactgggaca tacacttgta tggtctttga ggaaggcggc aacagctatg
301 gggaggtcaa ggtcaagctc atcgtgcttg tgcctccatc caagcctaca gttaacatcc
361 cctcctctgc caccattggg aaccgggcag tgctgacatg ctcagaacaa gatggttccc
421 caccttctga atacacctgg ttcaaagatg ggatagtgat gcctacgaat cccaaaagca
481 cccgtgcctt cagcaactct tcctatgtcc tgaatcccac aacaggagag ctggtctttg
541 atcccctgtc agcctctgat actggagaat acagctgtga ggcacggaat gggtatggga
601 cacccatgac ttcaaatgct gtgcgcatgg aagctgtgga gcggaatgtg ggggtcatcg
661 tggcagccgt ccttgtaacc ctgattctcc tgggaatctt ggtttttggc atctggtttg
721 cctatagccg aggccacttt gacagaacaa agaaagggac ttcgagtaag aaggtgattt
781 acagccagcc tagtgcccga agtgaaggag aattcaaaca gacctcgtca ttcctggtgt
841 gagcctggtc ggctcaccgc ctatcatctg catttgcctt actcaggtgc tactggactc
901 tggcccctga tgtctgtagt ttcacaggat gccttatttg tcttctacac cccacagggc
961 cccctacttc ttcggatgtg tttttaataa tgtcagctat gtgccccatc ctccttcatg
1021 ccctccctcc ctttcctacc actgctgagt ggcctggaac ttgtttaaag tgtttattcc
1081 ccatttcttt gagggatcag gaaggaatcc tgggtatgcc attgacttcc cttctaagta
1141 gacagcaaaa atggcggggg tcgcaggaat ctgcactcaa ctgcccacct ggctggcagg
1201 gatctttgaa taggtatctt gagcttggtt ctgggctctt tccttgtgta ctgacgacca
1261 gggccagctg ttctagagtg ggaattagag gctagagcgg ctgaaatggt tgtttggtga
1321 tgacactggg gtccttccat ctctggggcc cactctcttc tgtcttccca tgggaagtgc
1381 cactgggatc cctctgccct gtcctcctga atacaagctg actgacattg actgtgtctg
1441 tggaaaatgg gagctcttgt tgtggagagc atagtaaatt ttcagagaac ttgaagcgaa
1501 aaggatttaa aaccgctgct ctaaagaaaa gaaaactgga ggctgggcgc agtggctcac
1561 gcctataatc ccagaggctg aggcaggcgg atcacctgag gtcaggagtt ca
//