LOCUS AF153679 2136 bp mRNA linear HUM 02-JUN-1999
DEFINITION Homo sapiens malonyl-CoA decarboxylase mRNA, complete cds.
ACCESSION AF153679
VERSION AF153679.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2136)
AUTHORS Sacksteder,K.A., Morrell,J.C., Wanders,R.J., Matalon,R. and
Gould,S.J.
TITLE MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA
decarboxylase and is mutated in malonyl-CoA decarboxylase
deficiency
JOURNAL J. Biol. Chem. 274 (35), 24461-24468 (1999)
PUBMED 10455107
REFERENCE 2 (bases 1 to 2136)
AUTHORS Sacksteder,K.A.
TITLE Direct Submission
JOURNAL Submitted (24-MAY-1999) Biological Chemistry, Johns Hopkins
University School of Medicine, 725 North Wolfe Street, Baltimore,
MD 21205, USA
FEATURES Location/Qualifiers
source 1..2136
/db_xref="H-InvDB:HIT000071864"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="between D16S422 and D16S402"
CDS 96..1460
/EC_number="4.1.1.9"
/function="catalyzes the conversion of malonyl-CoA to
acetyl-CoA"
/note="MCD; cytoplasmic and peroxisomal localization"
/codon_start=1
/product="malonyl-CoA decarboxylase"
/protein_id="AAD34631.1"
/translation="MDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQ
RAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLF
HHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSPGFLNLER
VTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVAL
TGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKEL
QREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINE
TLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLW
RINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQK
NSKL"
BASE COUNT 447 a 590 c 659 g 440 t
ORIGIN
1 tgacggccag gcgtctcctc ccgctgcggt tgcccccgcg gccgcccggg ccccggctgg
61 cgagcgggca ggcggccggc gccctggagc gggccatgga cgagctgctg cgccgcgcgg
121 tgccgccgac gccggcctac gagctgcgcg agaagacacc ggcgcccgcc gagggtcagt
181 gcgcggactt cgtgagcttc tacggtgggc tggccgagac ggcccagcgg gccgaactgc
241 tgggccgcct ggcgcggggc ttcggcgtgg accacggcca ggtggcggag cagagcgccg
301 gcgtgctcca tctgcgccag cagcagcggg aggcggcggt gctgctgcag gccgaggacc
361 ggctgcgcta cgcgctggtg ccgcgctatc gcggcctctt ccaccacatc agcaagctgg
421 acggcggcgt gcgcttcctg gtgcagctgc gggccgacct gctggaggcg caggccctca
481 agctggtgga ggggccggac gtccgggaaa tgaatggggt gctgaaagga atgctctcag
541 aatggttttc ccccgggttc ctgaacctag aacgggttac ctggcattca ccgtgtgaag
601 tgcttcagaa aatcagtgag gctgaggctg tgcatcctgt aaaaaactgg atggacatga
661 agcgccgcgt tgggccctac agaaggtgtt acttcttttc tcactgttcg acccctgggg
721 agcccctggt cgttttgcac gtggcactga ctggtgacat ctccagcaac atccaggcaa
781 tcgtgaagga acatcctcca tcagaaacag aagagaagaa caaaatcact gctgcgatct
841 tttattccat cagcttgacc cagcagggac tccaaggggt ggagctggga acattcctca
901 taaagcgagt cgtcaaggag ttgcagagag agtttcctca ccttggggtg ttttcaagtc
961 tgtcacctat acctggtttc accaaatggc ttctggggct tctgaactcg caaacgaagg
1021 agcatgggag gaatgaactc tttacagatt cggaatgtaa ggaaatctcg gagatcacag
1081 gtggccccat taacgagacc ctcaagctcc tcctcagcag cagcgagtgg gtgcagtcgg
1141 agaagctggt gcgggcgctg cagactccgc tgatgaggct gtgcgcctgg tacctgtatg
1201 gagagaagca ccgcggctac gcgctgaacc ccgtggccaa cttccacctg cagaacgggg
1261 cggtgctgtg gcgcatcaac tggatggcgg atgtgagcct cagaggcatc accggctcct
1321 gcggcctgat ggccaactac cgctacttcc tggaggagac gggccccaac agcacctcct
1381 acctcggctc caagatcatc aaagcctctg agcaggtcct cagcctagtg gcccagtttc
1441 aaaagaacag caagctctga cagtaaacct ctcctaaagc acagggcccc ggctaagaaa
1501 acgatcattt tcaggagggg ccggagttat gtatctgaag cagctttcca gcaaagccaa
1561 agttgactgt gttcttgtcc cgcagccggt ccacactgtg aggccaggcc tcaacttcct
1621 acctggcgtg acatgcaccc agtgcaagac ggttgtgggt gcgggtgcac acaaatgagt
1681 gggttgctgt gctgtctccg gaagattctg tcgttgccct tggcctggct ccctgcccgg
1741 ggctggtgct gtggtaccta catcttcagg aagctgtgca gcctctgcca ttgccatccc
1801 agggggatct ggcatcctcc taaggaccgg ggcgcgtggc ccagataaga ataggtgttc
1861 ctttgtgctc ataaaacaga atgcggcgat ggttgcttta gccgtttctc accatgcaat
1921 gcagagggac aaagggctgt gctacacttc ccagttacat tctgaagctc ataaatgtat
1981 gagaaggttt gtgattttgc acaaggtgtg tgtagtaagt taaattgttg aacacaaaaa
2041 tgttgctgct tgaggcataa gttggataat aggctttaaa tgatcaggga ttcaggttca
2101 taatgaactt cacagtaaag aacacgtttg ttctgt
//