LOCUS AF151378 1983 bp mRNA linear HUM 17-JUL-2002
DEFINITION Homo sapiens hepatocellular cancer antigen 587 (HCA587) mRNA,
complete cds.
ACCESSION AF151378
VERSION AF151378.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1983)
AUTHORS Wang,Y., Han,K.J., Pang,X.W., Vaughan,H.A., Qu,W., Dong,X.Y.,
Peng,J.R., Zhao,H.T., Rui,J.A., Leng,X.S., Cebon,J., Burgess,A.W.
and Chen,W.F.
TITLE Large scale identification of human hepatocellular
carcinoma-associated antigens by autoantibodies
JOURNAL J. Immunol. 169 (2), 1102-1109 (2002)
PUBMED 12097419
REFERENCE 2 (bases 1 to 1983)
AUTHORS Qu,W., Wang,Y., Han,K.J. and Chen,W.F.
TITLE A new MAGE family gene identified in liver cancer
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 1983)
AUTHORS Qu,W., Wang,Y., Han,K.J. and Chen,W.F.
TITLE Direct Submission
JOURNAL Submitted (13-MAY-1999) Immunology, Beijing Medical University, #38
Xueyuan Road, Beijing 100083, P. R. China
FEATURES Location/Qualifiers
source 1..1983
/db_xref="H-InvDB:HIT000071595"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/note="isolated from homologous serum of a hepatoma
patient"
gene 1..1983
/gene="HCA587"
/note="MAGE gene family"
CDS 330..1451
/gene="HCA587"
/codon_start=1
/product="hepatocellular cancer antigen 587"
/protein_id="AAF36533.1"
/translation="MPPVPGVPFRNVDNDSPTSVELEDWVDAQHPTDEEEEEASSASS
TLYLVFSPSSFSTSSSLILGGPEEEEVPSGVIPNLTESIPSSPPQGPPQGPSQSPLSS
CCSSFSWSSFSEESSSQKGEDTGTCQGLPDSESSFTYTLDEKVAELVEFLLLKYEAEE
PVTEAEMLMIVIKYKDYFPVILKRAREFMELLFGLALIEVGPDHFCVFANTVGLTDEG
SDDEGMPENSLLIIILSVIFIKGNCASEEVIWEVLNAVGVYAGREHFVYGEPRELLTK
VWVQGHYLEYREVPHSSPPYYEFLWGPRAHSESIKKKVLEFLAKLNNTVPSSFPSWYK
DALKDVEERVQATIDTADDATVMASESLSVMSSNVSFSE"
BASE COUNT 497 a 428 c 512 g 546 t
ORIGIN
1 tgggaatctg acggatcgga ggcatttgtg aggaggcgcg aatcaagtta gcggggggaa
61 gagtcttaga cctggccagt cctcagggtg agggccctga ggaagaactg agggacctcc
121 caccatagag agaagaaacc ccggcctgta ctgcgctgcc gtgagactgg tgctccagga
181 accaggtggt gacgaactgg gtgtgaggca cacagcctaa agtcagcaca gcagaggagg
241 cccaggcagt gccaggagtc aaggcctgtt ggatctcatc atccatatcc ctgttgatac
301 gtttacctgc tgctcctgaa gaagtcgtca tgcctcccgt tccaggcgtt ccattccgca
361 acgttgacaa cgactccccg acctcagttg agttagaaga ctgggtagat gcacagcatc
421 ccacagatga ggaagaggag gaagcctcct ccgcctcttc cactttgtac ttagtatttt
481 ccccctcttc tttctccaca tcctcttctc tgattcttgg tggtcctgag gaggaggagg
541 tgccctctgg tgtgatacca aatcttaccg agagcattcc cagtagtcct ccacagggtc
601 ctccacaggg tccttcccag agtcctctga gctcctgctg ctcctctttt tcatggagct
661 cattcagtga ggagtccagc agccagaaag gggaggatac aggcacctgt cagggcctgc
721 cagacagtga gtcctctttc acatatacac tagatgaaaa ggtggccgag ttagtggagt
781 tcctgctcct caaatacgaa gcagaggagc ctgtaacaga ggcagagatg ctgatgattg
841 tcatcaagta caaagattac tttcctgtga tactcaagag agcccgtgag ttcatggagc
901 ttctttttgg ccttgccctg atagaagtgg gccctgacca cttctgtgtg tttgcaaaca
961 cagtaggcct caccgatgag ggtagtgatg atgagggcat gcccgagaac agcctcctga
1021 ttattattct gagtgtgatc ttcataaagg gcaactgtgc ctctgaggag gtcatctggg
1081 aagtgctgaa tgcagtaggg gtatatgctg ggagggagca cttcgtctat ggggagccta
1141 gggagctcct cactaaagtt tgggtgcagg gacattacct ggagtatcgg gaggtgcccc
1201 acagttctcc tccatattat gaattcctgt ggggtccaag agcccattca gaaagcatca
1261 agaagaaagt actagagttt ttagccaagc tgaacaacac tgttcctagt tcctttccat
1321 cctggtacaa ggatgctttg aaagatgtgg aagagagagt ccaggccaca attgataccg
1381 cagatgatgc cactgtcatg gccagtgaaa gcctcagtgt catgtccagc aacgtctcct
1441 tttctgagtg aagtctagga tagtttcttc cccttgtgtt tgaacagggc agtttaggtt
1501 ctaggtagtg gagggccagg tggggctcga ggaacgtagt gttctttgca tttctgtccc
1561 atatgggtga tgtagagatt tacctgtttt tcagtatttt ctaaatgctt ttcctttgaa
1621 tagcaggtag ttagcttcag agtgttaatt tatgaatatt agtcgcacat gtattgctct
1681 ttatctggtt taagagtaac agtttgatat tttgttaaaa aaatggaaat accttctccc
1741 ttattttgtg atctgtaaca gggtagtgtg gtattgtaat aggcattttt tttttttttt
1801 acaatgtgca ataactcagc agttaaatag tggaacaaaa ttgaagggtg gtcagtagtt
1861 tcatttcctt gtcctgctta ttcttttgtt cttgaaaatt atatatacct ggctttgctt
1921 agcttgttga agaaagtagc agaaattaaa tcttaataaa agaaaaaaaa aaaaaaaaaa
1981 agg
//