LOCUS AF148860 4215 bp mRNA linear HUM 15-FEB-2001
DEFINITION Homo sapiens hephaestin (HEPH) mRNA, complete cds.
ACCESSION AF148860
VERSION AF148860.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4215)
AUTHORS Zhao,K.W.
TITLE Direct Submission
JOURNAL Submitted (06-MAY-1999) Biological Chemistry, UCLA, 10833 Le Conte
Ave, Los Angeles, CA 90095, USA
FEATURES Location/Qualifiers
source 1..4215
/db_xref="H-InvDB:HIT000071546"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq11-q12"
/note="similar to clone HG00360 presented in GenBank
Accession Number AB014598"
gene 1..4215
/gene="HEPH"
CDS 26..3502
/gene="HEPH"
/note="potential ferroxidase for ferrous (II) to ferric
(III) iron conversion; similar to ceruloplasmin and Mus
musculus hephaestin; contains multiple copper binding
sites"
/codon_start=1
/product="hephaestin"
/protein_id="AAK08131.1"
/translation="MESGHLLWALLFMQSLWPQLTDGATRVYYLGIRDVQWNYAPKGR
NVITNQPLDSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDEVAQPAWLGFLGPV
LQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGPLKADDSVPPGGS
HIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQ
RQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVF
GNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAE
MVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWD
YGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEED
RHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGLV
AKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALG
ADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAIN
GFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTF
VMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAE
EVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPR
PRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGE
VVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGR
SDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLY
ANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFE
VVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITKETEKAVPPRDI
EEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSI
LDDSFKLLSFKQ"
BASE COUNT 1066 a 1000 c 1077 g 1072 t
ORIGIN
1 cctgtttccc agagtaatgt gggccatgga gtcaggccac ctcctctggg ctctgctgtt
61 catgcagtcc ttgtggcctc aactgactga tggagccact cgagtctact acctgggcat
121 ccgggatgtg cagtggaact atgctcccaa gggaagaaat gtcatcacga accagcctct
181 ggacagtgac atagtggctt ccagcttctt aaagtctgac aagaaccgga tagggggaac
241 ctacaagaag accatctata aagaatacaa ggatgactca tacacagatg aagtggccca
301 gcctgcctgg ttgggcttcc tggggccagt gttgcaggct gaagtggggg atgtcattct
361 tattcacctg aagaattttg ccactcgtcc ctataccatc caccctcatg gtgtcttcta
421 cgagaaggac tctgaaggtt ccctataccc agatggctcc tctgggccac tgaaagctga
481 tgactctgtt cccccggggg gcagccatat ctacaactgg accattccag aaggccatgc
541 acccaccgat gctgacccag cgtgcctcac ctggatctac cattctcatg tagatgctcc
601 acgagacatt gcaactggcc taattgggcc tctcatcacc tgtaaaagag gagccctgga
661 tgggaactcc cctcctcaac gccaggatgt agaccatgat ttcttcctcc tcttcagtgt
721 ggtagatgag aacctcagct ggcatctcaa tgagaacatt gccacttact gctcagatcc
781 tgcttcagtg gacaaagaag atgagacatt tcaggagagc aataggatgc atgcaatcaa
841 tggctttgtt tttgggaatt tacctgagct gaacatgtgt gcacagaaac gtgtggcctg
901 gcacttgttt ggcatgggca atgaaattga tgtccacaca gcatttttcc atggacagat
961 gctgactacc cgtggacacc acactgatgt ggctaacatc tttccagcca cctttgtgac
1021 tgctgagatg gtgccctggg aacctggtac ctggttaatt agctgccaag tgaacagtca
1081 ctttcgagat ggcatgcagg cactctacaa ggtcaagtct tgctccatgg cccctcctgt
1141 ggacctgctc acaggcaaag ttcgacagta cttcattgag gcccatgaga ttcaatggga
1201 ctatggcccg atggggcatg atgggagtac tgggaagaat ttgagagagc caggcagtat
1261 ctcagataag tttttccaga agagctccag ccgaattggg ggcacttact ggaaagtgcg
1321 atatgaagcc tttcaagatg agacattcca agagaagatg catttggagg aagataggca
1381 tcttggaatc ctggggccag tgatccgggc tgaggtgggt gacaccattc aggtggtctt
1441 ctacaaccgt gcctcccagc cattcagcat gcagccccat ggggtctttt atgagaaaga
1501 ctatgaaggc actgtgtaca atgatggctc atcttaccct ggcttggttg ccaagccctt
1561 tgagaaagta acataccgct ggacagtccc ccctcatgcc ggtcccactg ctcaggatcc
1621 tgcttgtctc acttggatgt acttctctgc tgcagatccc ataagagaca caaattctgg
1681 cctggtgggc ccgctgctgg tgtgcagggc tggtgccttg ggtgcagatg gcaagcagaa
1741 aggggtggat aaagaattct ttcttctctt cactgtgttg gatgagaaca agagctggta
1801 cagcaatgcc aatcaagcag ctgctatgtt ggatttccga ctgctttcag aggatattga
1861 gggcttccaa gactccaatc ggatgcatgc cattaatggg tttctgttct ctaacctgcc
1921 caggctggac atgtgcaagg gtgacacagt ggcctggcac ctgctcggcc tgggcacaga
1981 gactgatgtg catggagtca tgttccaggg caacactgtg cagcttcagg gcatgaggaa
2041 gggtgcagct atgctctttc ctcatacctt tgtcatggcc atcatgcagc ctgacaacct
2101 tgggacattt gagatttatt gccaggcagg cagccatcga gaagcaggga tgagggcaat
2161 ctataatgtc tcccagtgtc ctggccacca agccacccct cgccaacgct accaagctgc
2221 aagaatctac tatatcatgg cagaagaagt agagtgggac tattgccctg accggagctg
2281 ggaacgggaa tggcacaacc agtctgagaa ggacagttat ggttacattt tcctgagcaa
2341 caaggatggg ctcctgggtt ccagatacaa gaaagctgta ttcagggaat acactgatgg
2401 tacattcagg atccctcggc caaggactgg accagaagaa cacttgggaa tcttgggtcc
2461 acttatcaaa ggtgaagttg gtgatatcct gactgtggta ttcaagaata atgccagccg
2521 cccctactct gtgcatgctc atggagtgct agaatctact actgtctggc cactggctgc
2581 tgagcctggt gaggtggtca cttatcagtg gaacatccca gagaggtctg gccctgggcc
2641 caatgactct gcttgtgttt cctggatcta ttattctgca gtggatccca tcaaggacat
2701 gtatagtggc ctggtggggc ccttggctat ctgccaaaag ggcatcctgg agccccatgg
2761 aggacggagt gacatggatc gggaatttgc attgttgttc ttgatttttg atgaaaataa
2821 gtcttggtat ttggaggaaa atgtggcaac ccatgggtcc caggatccag gcagtattaa
2881 cctacaggat gaaactttct tggagagcaa taaaatgcat gcaatcaatg ggaaactcta
2941 tgccaacctt aggggtctta ccatgtacca aggagaacga gtggcctggt acatgctggc
3001 catgggccaa gatgtggatc tacacaccat ccactttcat gcagagagct tcctctatcg
3061 gaatggcgag aactaccggg cagatgtggt ggatctgttc ccagggactt ttgaggttgt
3121 ggagatggtg gccagcaacc ctgggacatg gctgatgcac tgccatgtga ctgaccatgt
3181 ccatgctggc atggagaccc tcttcactgt tttttctcga acagaacact taagccctct
3241 caccgtcatc accaaagaga ctgaaaaagc agtgcccccc agagacattg aagaaggcaa
3301 tgtgaagatg ctgggcatgc agatccccat aaagaatgtt gagatgctgg cctctgtttt
3361 ggttgccatt agtgtcaccc ttctgctcgt tgttctggct cttggtggag tggtttggta
3421 ccaacatcga cagagaaagc tacgacgcaa taggaggtcc atcctggatg acagcttcaa
3481 gcttctgtct ttcaaacagt aacatctgga gcctggagat atcctcagga agcacatctg
3541 tagtgcactc ccagcaggcc atggactagt cactaacccc acactcaaag gggcatgggt
3601 ggtggagaag cagaaggagc aatcaagctt atctggatat ttctttcttt atttatttta
3661 catggaaata atatgatttc actttttctt tagtttcttt gctctacgtg ggcacctggc
3721 actaagggag taccttatta tcctacatcg caaatttcaa cagctacatt atatttcctt
3781 ctgacacttg gaaggtattg aaatttctag aaatgtatcc ttctcacaaa gtagagacca
3841 agagaaaaac tcattgattg ggtttctact tctttcaagg actcaggaaa tttcactttg
3901 aactgaggcc aagtgagctg ttaagataac ccacacttaa actaaaggct aagaatatag
3961 gcttgatggg aaattgaagg taggctgagt attgggaatc caaattgaat tttgattctc
4021 cttggcagtg aactactttg aagaagtggt caatgggttg ttgctgccat gagcatgtac
4081 aacctctgga gctagaagct cctcaggaaa gccagttctc caagttctta acctgtggca
4141 ctgaaaggaa tgttgagtta cctcttcatg ttttagacag caaaccctat ccattaaagt
4201 acttgttaga acact
//