LOCUS AF147094 2891 bp mRNA linear HUM 23-AUG-2002
DEFINITION Homo sapiens heme-regulated initiation factor 2 alpha kinase (HRI)
mRNA, complete cds.
ACCESSION AF147094
VERSION AF147094.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2891)
AUTHORS Omasa,T., Chen,Y.G., Mantalaris,A., Tsai,Y.C. and Wu,J.H.
TITLE Molecular cloning and sequencing of the human heme-regulated
eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase from bone
marrow culture
JOURNAL DNA Seq. 13 (3), 133-137 (2002)
PUBMED 12391722
REFERENCE 2 (bases 1 to 2891)
AUTHORS Omasa,T., Chen,Y.G., Mantalaris,A., Tsai,Y.-C. and Wu,J.H.
TITLE Direct Submission
JOURNAL Submitted (29-APR-1999) Chemical Engineering, University of
Rochester, 206 Gavett Hall, Rochester, NY 14627-0166, USA
FEATURES Location/Qualifiers
source 1..2891
/db_xref="H-InvDB:HIT000071370"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="bone marrow"
gene 1..2891
/gene="HRI"
CDS 82..1971
/gene="HRI"
/codon_start=1
/product="heme-regulated initiation factor 2 alpha kinase"
/protein_id="AAF66736.1"
/translation="MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVP
AEIQVLKEPLQQPTFPFAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMG
LLSSFTCSDEFSSLRLHHNRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQT
SRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKPVCMKVLREVKVL
AGLQHPNIVGYHTAWIEHVHVIQPRDRAAIELPSLEVLSDQEEDREQCGVKNDESSSS
SIIFAEPTPEKEKRFGESDTENQNNKSVKYTTNLVIRESGELESTLELQENGLAGLSA
SSIVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCELSLWD
WIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLH
GPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDA
KSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRN
SSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQEKEIAELKKQLNLLSQDKGVRDDGK
DGGVG"
BASE COUNT 808 a 680 c 671 g 732 t
ORIGIN
1 ggcacgaggc tagctgcagc atcggagtgt gcagtgctgg gctggccggc gggctgggct
61 gcggcccgcg cgcggccggc gatgcagggg ggcaactccg gggtccgcaa gcgcgaagag
121 gagggcgacg gggctggggc tgtggctgcg ccgccggcca tcgactttcc cgccgagggc
181 ccggaccccg aatatgacga atctgatgtt ccagcagaaa tccaggtgtt aaaagaaccc
241 ctacaacagc caaccttccc ttttgcagtt gcaaaccaac tcttgctggt ttctttgctg
301 gagcacttga gccacgtgca tgaaccaaac ccacttcgtt caagacaggt gtttaagcta
361 ctttgccaga cgtttatcaa aatggggctg ctgtcttctt tcacttgtag tgacgagttt
421 agctcattga gactacatca caacagagct attactcact taatgaggtc tgctaaagag
481 agagttcgtc aggatccttg tgaggatatt tctcgtatcc agaaaatcag atcaagggaa
541 gtagccttgg aagcacaaac ttcacgttac ttaaatgaat ttgaagaact tgccatctta
601 ggaaaaggtg gatacggaag agtatacaag gtcaggaata aattagatgg tcagtattat
661 gcaataaaaa aaatcctgat taagggtgca actaaaccag tttgcatgaa ggtcctacgg
721 gaagtgaagg tgctggcagg tcttcagcac cccaatattg ttggctatca caccgcgtgg
781 atagaacatg ttcatgtgat tcagccacga gacagagctg ccattgagtt gccatctctg
841 gaagtgctct ccgaccagga agaggacaga gagcaatgtg gtgttaaaaa tgatgaaagt
901 agcagctcat ccattatctt tgctgagccc accccagaaa aagaaaaacg ctttggagaa
961 tctgacactg aaaatcagaa taacaagtcg gtgaagtaca ccaccaattt agtcataaga
1021 gaatctggtg aacttgagtc gaccctggag ctccaggaaa atggcttggc tggtttgtct
1081 gccagttcaa ttgtggaaca gcagctgcca ctcaggcgta attcccacct agaggagagt
1141 ttcacatcca ccgaagaatc ttccgaagaa aatgtcaact ttttgggtca gacagaggca
1201 cagtaccacc tgatgctgca catccagatg cagctgtgtg agctctcgct gtgggattgg
1261 atagtcgaga gaaacaagcg gggccgggag tatgtggacg agtctgcctg tccttatgtt
1321 atggccaatg ttgcaacaaa aatttttcaa gaattggtag aaggtgtgtt ttacatacat
1381 aacatgggaa ttgtgcaccg agatctgaag ccaagaaata tttttcttca tggccctgat
1441 cagcaagtaa aaataggaga ctttggtctg gcctgcacag acatcctaca gaagaacaca
1501 gactggacca acagaaacgg gaagagaaca ccaacacata cgtccagagt gggtacttgt
1561 ctgtacgctt cacccgaaca gttggaagga tctgagtatg atgccaagtc agatatgtac
1621 agcttgggtg tggtcctgct agagctcttt cagccgtttg gaacagaaat ggagcgagca
1681 gaagttctaa caggtttaag aactggtcag ttgccggaat ccctccgtaa aaggtgtcca
1741 gtgcaagcca agtatatcca gcacttaacg agaaggaact catcgcagag accatctgcc
1801 attcagctgc tgcagagtga acttttccaa aattctggaa atgttaacct caccctacag
1861 atgaagataa tagagcaaga aaaagaaatt gcagaactaa agaagcagct aaacctcctt
1921 tctcaagaca aaggggtgag ggatgacgga aaggatgggg gcgtgggatg aaagtggact
1981 taacttttaa ggtagttaac tggaatgtaa atttttaatc tttattaggg tatagttggt
2041 acaatgcttc gttgtattta gtaagccttt acaagacttg ttaaagatgt cagagtgccc
2101 caagctgccg ttccttccct tcctgcccca caagctcctt ttcctgaatt tcctacctaa
2161 atattaacca tatgcctagt ctctgaaact aaaaacttgg acctcatcct caattatttt
2221 ctcctttcaa ctctgttgac cctctgtctg gtcttcctct agaaggttct accgcagaaa
2281 ttgatgtgtg ctccctgccc tcgtcactgc ccaagcccgg gcctgcacat actcactgga
2341 ctgttccagt tttgacagct gccagtcttc ctgccccttt cacactgcag ctgaagttca
2401 ttacctgaag gacgcctcat catttcattc cttggctcca aaccttctgc tgcctctaag
2461 ataaaagctc aacttcttaa cagtgtacag tgtgcaactt ccaacctttt tatctgttct
2521 ctccaccttc agtttagcgt cattccaaaa ccacaccctt gcaaagcttt gtactccgca
2581 ccccagatga tctccaggca gctcagatct ctttcctgcc tttgccctgc actgttcccc
2641 ggtacttcct cctttattgt agcactcagc tccccagcca atctgtacat ccctcagagg
2701 cagcgatctg atgaattggt ttttgaatcc cagaaagggt ctgccatgga gttggcagtc
2761 atcacggtag atggcgtatg attttgctga attttaaata aaatgaaaac cataaattac
2821 atgatgcttt tattgacact tgacaactgg cctaaataaa aagactctga ctctaaaaaa
2881 aaaaaaaaaa a
//