LOCUS AF145782 2308 bp mRNA linear HUM 13-JUL-1999
DEFINITION Homo sapiens 2B4 type I transmembrane protein mRNA, complete cds.
ACCESSION AF145782
VERSION AF145782.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2308)
AUTHORS Tangye,S.G., Lazetic,S., Woollatt,E., Sutherland,G.R., Lanier,L.L.
and Phillips,J.H.
TITLE Human 2B4, an activating natural killer cell receptor, recruits the
protein tyrosine phosphatase SHP-2 and the adaptor signalig protein
SAP
JOURNAL J. Immunol. 162 (1999) In press
REFERENCE 2 (bases 1 to 2308)
AUTHORS Tangye,S.G., Lazetic,S., Woollatt,E., Sutherland,G.R., Lanier,L.L.
and Phillips,J.H.
TITLE Direct Submission
JOURNAL Submitted (26-APR-1999) Immunobiology, DNAX Research Institute, 901
California Ave., Palo Alto, CA 94304, USA
FEATURES Location/Qualifiers
source 1..2308
/db_xref="H-InvDB:HIT000071321"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q22"
gene 1..2308
/gene="2B4 variant"
CDS 1..1098
/gene="2B4 variant"
/function="receptor for the CD48 adhesion molecule"
/codon_start=1
/product="2B4 type I transmembrane protein"
/protein_id="AAD38951.1"
/translation="MLGQVVTLILLLLLKVYQGKGCQGSADHVVSISGVPLQLQPNSI
QTKVDSIAWKKLLPSQNGFHHILKWENGSLPSNTSNDRFSFIVKNLSLLIKAAQQQDS
GLYCLEVTSISGKVQTATFQVFVFDKVEKPRLQGQGKILDRGRCQVALSCLVSRDGNV
SYAWYRGSKLIQTAGNLTYLDEEVDINGTHTYTCNVSNPVSWESHTLNLTQDCQNAHQ
EFRFWPFLVIIVILSALFLGTLACFCVWRRKRKEKQSETSPKEFLTIYEDVKDLKTRR
NHEQEQTFPGGGSTIYSMIQSQSSAPTSQEPAYTLYSLIQPSRKSGSRKRNHSPSFNS
TIYEVIGKSQPKAQNPARLSRKELENFDVYS"
BASE COUNT 623 a 520 c 580 g 585 t
ORIGIN
1 atgctggggc aagtggtcac cctcatactc ctcctgctcc tcaaggtgta tcagggcaaa
61 ggatgccagg gatcagctga ccatgtggtt agcatctcgg gagtgcctct tcagttacaa
121 ccaaacagca tacagacgaa ggttgacagc attgcatgga agaagttgct gccctcacaa
181 aatggatttc atcacatatt gaagtgggag aatggctctt tgccttccaa tacttccaat
241 gatagattca gttttatagt caagaacttg agtcttctca tcaaggcagc tcagcagcag
301 gacagtggcc tctactgcct ggaggtcacc agtatatctg gaaaagttca gacagccacg
361 ttccaggttt ttgtatttga taaagttgag aaaccccgcc tacaggggca ggggaagatc
421 ctggacagag ggagatgcca agtggctctg tcttgcttgg tctccaggga tggcaatgtg
481 tcctatgctt ggtacagagg gagcaagctg atccagacag cagggaacct cacctacctg
541 gacgaggagg ttgacattaa tggcactcac acatatacct gcaatgtcag caatcctgtt
601 agctgggaaa gccacaccct gaatctcact caggactgtc agaatgccca tcaggaattc
661 agattttggc cgtttttggt gatcatcgtg attctaagcg cactgttcct tggcaccctt
721 gcctgcttct gtgtgtggag gagaaagagg aaggagaagc agtcagagac cagtcccaag
781 gaatttttga caatttacga agatgtcaag gatctgaaaa ccaggagaaa tcacgagcag
841 gagcagactt ttcctggagg ggggagcacc atctactcta tgatccagtc ccagtcttct
901 gctcccacgt cacaagaacc tgcatataca ttatattcat taattcagcc ttccaggaag
961 tctggatcca ggaagaggaa ccacagccct tccttcaata gcactatcta tgaagtgatt
1021 ggaaagagtc aacctaaagc ccagaaccct gctcgattga gccgcaaaga gctggagaac
1081 tttgatgttt attcctagtt gctgcagcaa ttctcacctt tcttgcacat cagcatctgc
1141 tttgggaatt ggcacagtgg atgacggcac aggagtctct atagaacagt tcctagtctg
1201 gagaggatat ggaaatttgt tcttgttcta tattttgttt tgaaaatgat gtctaacaac
1261 catgataaga gcaaggctgt taaataatat cttccaattt acagatcaga catgaatggg
1321 tggaggggtt aggttgttca caaaaggcca cattccaagt atttgtaatc tagaaagtgt
1381 tatgtaagtg atgttattag catcgagatt ccctccacct gattttcaag ctgtcacttg
1441 tttccttttc tcccctctct gggttgactg catttctaga ctctcgccgg cccaggccca
1501 tcttccaaag caagaggaag gaatgataat ggtgactcag gggaagaaga aacagccctc
1561 ctctgaaagc ctggactgtc cggctgtgaa ctggctggca ggttctgcac gtgggtgggg
1621 gccagggcct gggctttact caattgcaga gaaaaaactt tctccctgca tctcacacct
1681 ttacctctgc ccagttggcc accaggggga gtgggctgaa gggagagtag atggtgcaaa
1741 gcaagcccat ctctgagtag aaaaatcacc cagagcacat gctgacctga taactggggt
1801 gttgagacca gctttgtcca tggtatgatg tttgatttat gaagacgcat tgttagaaat
1861 ccatttggct tcttcataga agtggcttcc cagaggaaga ggcctctcag aaaccatgtt
1921 ctatttaagt tctgagtcct gatgagtgtt ccccaggatg cacattgaag ggagggctca
1981 ggcagctgag ggctgagaat gaggcagttg gaatctagac actatgctgg gttccctgag
2041 tcgtcaggcc agacatttca acaaggctgt ggggagcagg gctgtgactc tggctgagcc
2101 caggaaagcg acaagggtga actgggagag gacttactca gagaccccaa caggtgatac
2161 tgcacaaagc ctggttcttc aattttccta ccctgtatct aacataggag tttcatataa
2221 aacggtgata tcatgcagat gcagtctgaa ttccttgcct gaattaaatt tatgatcctc
2281 tccaaaaaaa aaaaaaaagg gcggccgc
//