LOCUS AF145204 3019 bp mRNA linear HUM 26-JUL-2016
DEFINITION Homo sapiens E2a-Pbx1-associated protein (EB-1) mRNA, partial cds.
ACCESSION AF145204
VERSION AF145204.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3019)
AUTHORS Fu,X., McGrath,S., Pasillas,M., Nakazawa,S. and Kamps,M.P.
TITLE EB-1, a tyrosine kinase signal transduction gene, is
transcriptionally activated in the t(1;19) subset of pre-B ALL,
which express oncoprotein E2a-Pbx1
JOURNAL Oncogene 18 (35), 4920-4929 (1999)
PUBMED 10490826
REFERENCE 2 (bases 1 to 3019)
AUTHORS Fu,X. and Kamps,M.P.
TITLE Direct Submission
JOURNAL Submitted (22-APR-1999) Pathology, University of California, San
Diego, 9500 Gilman Street, La Jolla, CA 92093, USA
FEATURES Location/Qualifiers
source 1..3019
/db_xref="H-InvDB:HIT000071305"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/note="strongly upregulated in pediatric pre-B cell acute
lymphoblastic leukemia"
gene <1..3019
/gene="EB-1"
CDS <1..2868
/gene="EB-1"
/codon_start=1
/product="E2a-Pbx1-associated protein"
/protein_id="AAD33951.1"
/translation="LEEPVQEDATQETHISSPVESPSQKTKSETVTGELSKLLDEIKL
CQEKDYSFEDLCHTISDHYLDNLSKISEEELGKNGSQSVRTSSTINLSPGEVEEEDDD
ENTCGPSGLWEALTPCNGCRNLGFPMLAQESYPKKRNYTMEIVPSASLDTFPSENENF
LCDLMDTAVTKKPCSLEIARAPSPRTDNASEVAVTTPGTSNHRNSSTGPTPDCSPPSP
DTALKNIVKVIRPQPKQRTSIVSSLDFHRMNHNQEYFEINTSTGCTSFTASPPASPPT
SSVGTTEVKNEGTNHTDDLSRQDDNDPPKEYDPGQFAGLLHGSSPACESPENPFHLYG
KREQCEKGQDEVSLANSPLPFKQSPIENNSEPLVKKIKPKVVSRTIFHKKSNQLENHT
IVGTRSTRSGSRNGDQWVMNAGGFVERACTLGRIRSLPKALIDMHLSKSVSKSDSDLI
AYPSNEKTSRVNWSESSTAEHSSKGNSERTPSFTSEWEEIDKIMSSIDVGINNELKEM
NGETTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILN
SGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLK
KIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSP
SLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQTGDWGEPSITL
RPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRAN
CQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYI
TKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFEN
KPSKPIPKPRVSIRKSVDLLHASHTGQEPSERHTEEALRKF"
misc_feature 1528..1767
/gene="EB-1"
/note="Region: SAM domain"
misc_feature 1771..1992
/gene="EB-1"
/note="Region: SAM domain"
misc_feature 2218..2700
/gene="EB-1"
/note="Region: phosphotyrosine-binding domain"
BASE COUNT 988 a 690 c 615 g 725 t
ORIGIN
1 ctcgaagagc ctgtacagga agatgcaaca caagaaacac acatttcatc tcctgttgag
61 tctccttccc aaaagaccaa aagtgaaacc gtcactggag aattatcaaa actcttggat
121 gaaataaaac tctgtcaaga aaaggattat tcgtttgaag acttgtgcca cacnatatca
181 gaccactact tagataattt gagcaagatt tcagaggaag aacttgggaa aaatggaagc
241 cagagtgtaa gaacctcatc tacaatcaat ttgtcaccag gagaagtgga agaagaggat
301 gatgatgaaa atacgtgtgg gccatcagga ctttgggaag cattaactcc gtgtaatgga
361 tgtaggaacc ttggcttccc catgcttgcc caggagtcct atccaaagaa gagaaattac
421 actatggaaa ttgtaccatc tgcttctctg gatacatttc cttcagaaaa tgagaacttt
481 ctgtgtgatc tcatggacac agctgttaca aagaaacctt gctccttaga aattgcaagg
541 gcaccttccc caagaactga taatgcctct gaggtagcag ttactactcc aggaactagt
601 aaccatagaa acagctcaac aggcccaaca cctgattgtt cacctccatc ccctgatact
661 gccctcaaaa atattgtaaa agtcattcga ccccagccta aacagcgaac atccattgtg
721 tcttctctgg attttcaccg aatgaatcac aaccaagaat attttgaaat caacacatct
781 acagggtgca caagctttac tgccagtcct cctgctagtc cacccacctc ttctgtggga
841 accacagaag tcaagaatga gggaactaac catacagatg acctctcccg acaggatgac
901 aatgatcccc caaaagaata tgatcctggg caatttgcag gcctgctcca tggatcctct
961 ccagcctgtg agtcccctga aaatccattt catctctatg ggaaaagaga acaatgtgaa
1021 aaaggacaag atgaagtcag tttggcaaac agtcctttgc ctttcaagca gtctccaata
1081 gaaaataact cagaaccttt ggtaaagaaa attaaaccca aagtggtcag tagaacaatt
1141 tttcacaaaa aaagcaacca actcgaaaac cataccattg ttggcacaag atcaaccagg
1201 agtggatctc ggaatgggga ccagtgggtt atgaacgcag ggggatttgt ggagagagcc
1261 tgtactctgg ggagaataag gtcattgcct aaagccttga tcgacatgca tttgtcaaaa
1321 agtgtctcta aatctgattc tgatctcatt gcctatcctt ccaatgagaa aacatcaaga
1381 gttaactgga gtgaatcttc cactgctgaa cacagttcta aagggaattc tgaaagaaca
1441 ccatccttca catcggaatg ggaagaaatt gacaaaataa tgagttccat agatgttgga
1501 atcaacaacg aacttaaaga gatgaatggt gagaccacaa gacccagatg ccctgtccaa
1561 acagtgggac aatggttgga aagcattggg ctacctcagt acgagaacca cctgatggct
1621 aatggatttg acaatgtgca gtttatggga agcaatgtta tggaagatca ggatttgttg
1681 gaaattggaa tccttaattc tgggcacaga caaagaattc tacaggcaat ccagctcctt
1741 ccaaagatga gacccattgg gcatgatggc taccatccca cctctgtagc tgagtggctg
1801 gattccattg aactgggcga ctacaccaaa gcctttctaa ttaatggcta cacttcgatg
1861 gacctgttga aaaaaatctg ggaggttgaa cttattaatg ttttaaaaat caatttgatt
1921 ggccacagga aacgtatttt ggcatctctg ggagacaggc tgcacgacga tcccccacag
1981 aagccccctc ggtccatcac cctcagggaa cccagtggta atcacactcc tcctcagttg
2041 tctccatcac ttagccaaag cacttacacc actggtggct ccctagacgt tcctcacatt
2101 atcatgcagg gcgatgcaag gaggagaaga aatgaaaact actttgatga tattccccga
2161 tcaaaactgg agaggcagat ggctcagaca ggagactggg gagaaccttc cattaccttg
2221 cgacctccga atgaagccac agcctctacc ccggtacagt actggcagca tcacccagaa
2281 aagcttatct tccagtcgtg tgattacaaa gctttttatt taggttctat gctgataaaa
2341 gagcttaggg ggacagaatc aacccaagat gcttgtgcaa aaatgcgggc taactgtcag
2401 aagtctacag agcaaatgaa gaaggtccct actattattc tttctgtctc atataaagga
2461 gtcaaattta ttgatgcaac aaataagaac ataattgctg agcatgaaat tcgtaatatc
2521 tcctgtgctg cccaggaccc agaagacctc tcaacatttg cctatatcac aaaagatttg
2581 aagtctaatc accactactg tcatgtgttt actgcctttg atgtgaattt agcctatgaa
2641 atcatcctaa ccctgggaca ggcattcgaa gtcgcttacc agctagcact acaagcaaga
2701 aaagggggac actcctccac acttccagaa agctttgaaa acaaaccctc caaacccatc
2761 cccaagcccc gcgttagcat tcgcaagtcc gtggatcttc ttcatgccag ccataccggg
2821 caggaaccat cagagagaca cactgaggag gcactcagaa aattttgata gaattgaatt
2881 tacatatagc tgataaagcc taaatagaaa ggttgatgta tttagcttga atccttcact
2941 ttagtggtct aatcaacaga taaatgacaa gcaaagaatg aaacaatcca aaaatgtttt
3001 tcaaaaaaaa aaaaaaaaa
//