LOCUS       AF144325                1758 bp    mRNA    linear   HUM 29-JUN-1999
DEFINITION  Homo sapiens heparanase (HPA) mRNA, complete cds.
ACCESSION   AF144325
VERSION     AF144325.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1758)
  AUTHORS   Vlodavsky,I., Friedman,Y., Elkin,M., Aingorn,H., Atzmon,R.,
            Ishai-Michaeli,R., Bitan,M., Pappo,O., Peretz,T., Michal,I.,
            Spector,L. and Pecker,I.
  TITLE     Mammalian heparanase: a novel gene involved in tumor progression
            and metastasis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1758)
  AUTHORS   Pecker,I. and Vlodavsky,I.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-1999) Insight Ltd., Hamada 12, Rabin Science
            Park, Rehovot 76100, Israel
FEATURES             Location/Qualifiers
     source          1..1758
                     /db_xref="H-InvDB:HIT000071289"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
     gene            1..1758
                     /gene="HPA"
     CDS             100..1731
                     /gene="HPA"
                     /codon_start=1
                     /product="heparanase"
                     /protein_id="AAD41342.1"
                     /translation="MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFF
                     TQEPLHLVSPSFLSVTIDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFL
                     IFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKF
                     KNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNI
                     SWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTA
                     KMLKSFLKAGGEVIDSVTWHHYYLNGRTATREDFLNPDVLDIFISSVQKVFQVVESTR
                     PGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYH
                     LVDENFDPLPDYWLSLLFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDL
                     TLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTL
                     PPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI"
BASE COUNT          459 a          419 c          430 g          450 t
ORIGIN      
        1 aggagaaaag ggcgctgggg ctcggcggga ggaagtgcta gagctctcga ctctccgctg
       61 cgcggcagct ggcgggggga gcagccaggt gagcccaaga tgctgctgcg ctcgaagcct
      121 gcgctgccgc cgccgctgat gctgctgctc ctggggccgc tgggtcccct ctcccctggc
      181 gccctgcccc gacctgcgca agcacaggac gtcgtggacc tggacttctt cacccaggag
      241 ccgctgcacc tggtgagccc ctcgttcctg tccgtcacca ttgacgccaa cctggccacg
      301 gacccgcggt tcctcatcct cctgggttct ccaaagcttc gtaccttggc cagaggcttg
      361 tctcctgcgt acctgaggtt tggtggcacc aagacagact tcctaatttt cgatcccaag
      421 aaggaatcaa cctttgaaga gagaagttac tggcaatctc aagtcaacca ggatatttgc
      481 aaatatggat ccatccctcc tgatgtggag gagaagttac ggttggaatg gccctaccag
      541 gagcaattgc tactccgaga acactaccag aaaaagttca agaacagcac ctactcaaga
      601 agctctgtag atgtgctata cacttttgca aactgctcag gactggactt gatctttggc
      661 ctaaatgcgt tattaagaac agcagatttg cagtggaaca gttctaatgc tcagttgctc
      721 ctggactact gctcttccaa ggggtataac atttcttggg aactaggcaa tgaacctaac
      781 agtttcctta agaaggctga tattttcatc aatgggtcgc agttaggaga agattttatt
      841 caattgcata aacttctaag aaagtccacc ttcaaaaatg caaaactcta tggtcctgat
      901 gttggtcagc ctcgaagaaa gacggctaag atgctgaaga gcttcctgaa ggctggtgga
      961 gaagtgattg attcagttac atggcatcac tactatttga atggacggac tgctaccagg
     1021 gaagattttc taaaccctga tgtattggac atttttattt catctgtgca aaaagttttc
     1081 caggtggttg agagcaccag gcctggcaag aaggtctggt taggagaaac aagctctgca
     1141 tatggaggcg gagcgccctt gctatccgac acctttgcag ctggctttat gtggctggat
     1201 aaattgggcc tgtcagcccg aatgggaata gaagtggtga tgaggcaagt attctttgga
     1261 gcaggaaact accatttagt ggatgaaaac ttcgatcctt tacctgatta ttggctatct
     1321 cttctgttca agaaattggt gggcaccaag gtgttaatgg caagcgtgca aggttcaaag
     1381 agaaggaagc ttcgagtata ccttcattgc acaaacactg acaatccaag gtataaagaa
     1441 ggagatttaa ctctgtatgc cataaacctc cataacgtca ccaagtactt gcggttaccc
     1501 tatccttttt ctaacaagca agtggataaa taccttctaa gacctttggg acctcatgga
     1561 ttactttcca aatctgtcca actcaatggt ctaactctaa agatggtgga tgatcaaacc
     1621 ttgccacctt taatggaaaa acctctccgg ccaggaagtt cactgggctt gccagctttc
     1681 tcatatagtt tttttgtgat aagaaatgcc aaagttgctg cttgcatctg aaaataaaat
     1741 atactagtcc tgacactg
//