LOCUS AF139374 1799 bp DNA linear HUM 05-MAY-2000
DEFINITION Homo sapiens DIR1 protein (DIR1) gene, complete cds.
ACCESSION AF139374
VERSION AF139374.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1799)
AUTHORS Robson,T.A., Lohrer,H., Bailie,J.R., Hirst,D.G., Joiner,M.C. and
Arrand,J.E.
TITLE Gene regulation by low-dose ionizing radiation in a normal human
lung epithelial cell line
JOURNAL Biochem. Soc. Trans. 25 (1), 335-342 (1997)
PUBMED 9056895
REFERENCE 2 (bases 1 to 1799)
AUTHORS Robson,T., Joiner,M.C., Wilson,G.D., McCullough,W., Price,M.E.,
Logan,I., Jones,H., McKeown,S.R. and Hirst,D.G.
TITLE A novel human stress response-related gene with a potential role in
induced radioresistance
JOURNAL Radiat. Res. 152 (5), 451-461 (1999)
PUBMED 10521921
REFERENCE 3 (bases 1 to 1799)
AUTHORS Robson,T., Joiner,M.C., McCullough,W., Hirst,D.G., Moore,L.M. and
Moore,S.D.
TITLE Direct Submission
JOURNAL Submitted (29-MAR-1999) Biomedical Science, University of Ulster at
Jordanstown, Newtonabbey, Co. Antrim BT37 OQB, Northern Ireland
FEATURES Location/Qualifiers
source 1..1799
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="6"
/cell_line="L132"
/cell_type="epithelial"
/tissue_type="lung"
gene <718..>1767
/gene="DIR1"
mRNA <718..>1767
/gene="DIR1"
/product="DIR1 protein"
CDS 718..1767
/gene="DIR1"
/note="immunophilin-like; repressed by radiation;
cyclophilin; contains tetratrico repeats"
/codon_start=1
/product="DIR1 protein"
/protein_id="AAF67785.1"
/translation="METPPVNTIGEKDTSQPQQEWEKNLRENLDSVIQIRQQPRDPPT
ETLELEVSPDPASQILEHTQGAEKLVAELEGDSHKSHGSTSQMPEALQASDLWYCPDG
SFVKKIVIRGHGLDKPKLGSCCRVLALGFPFGSGPPEGWTELTMGVGPWREETWGELI
EKCLESMCQGEEAELQLPGHSGPPVRLTLASFTQGRDSWELETSEKEALAREERARGT
ELFRAGNPEGAARCYGRALRLLLTLPPPGPPERTVLHANLAACQLLLGQPQLAAQSCD
RVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQGK
NQDAGLAQGLRKMFG"
BASE COUNT 426 a 459 c 522 g 392 t
ORIGIN
1 cttgagcagc ctggccagcc cgaccgcgcc aaattctgtt cgattctgcc tagttcggtt
61 gctctggcct agttcagttg ctaaggcctg gagcttcatg gttgcggagg aaatgatgtc
121 acgttcaata ggcgggctaa ccagattcct cccttctccc gattggctgc caggaatttg
181 actagattcg gagtctcgcg ggctccaggg ttagttgtca gtatctttcc cagttgttcc
241 gccccctacc cccgcctccc gcaccgcgcc cctctccggc tgccctctcc gcgtggggca
301 aggctccgag ggcagcattc agtagccatt tagctttgga aggagaggtg attcgaatgg
361 cccggctcct cctgtcacca tgccaggcac tttggccgcg caggtactta ttgacccgac
421 cgggtgtccg tagttggcgc ggctacctta accgcaggga attgtggaat ttatagttct
481 aaattatatg tgggtggaac ggggaagctg gagcagattt ttggaggaaa gcaaaactgg
541 ggactttcag gactaggggc ctgggtctca gaagaatggg aaaggacgag aaaggagtct
601 aaataagaac cctgctatta gcattgtttg gttttctttt caggtgctga cctgaacctg
661 gttcatccct ttctgaccaa aactgttcac tcaccgtgga agggactaag catccatatg
721 gagacgccac cagtcaatac aattggagaa aaggacacct ctcagccgca acaagagtgg
781 gaaaagaacc ttcgggagaa ccttgattca gttattcaga ttaggcagca gccccgagac
841 cctcctaccg aaacgcttga gctggaagta agcccagatc cagccagcca aattctagag
901 catactcaag gagctgaaaa actggttgct gaacttgaag gagactctca taagtctcat
961 ggatcaacca gtcagatgcc agaggccctt caagcttctg atctctggta ctgccccgat
1021 gggagctttg tcaagaagat cgtaatccgt ggccatggct tggacaaacc caaactaggc
1081 tcctgctgcc gggtactggc tttggggttt cctttcggat cagggccgcc agagggctgg
1141 acagagctaa ctatgggcgt agggccatgg agggaggaaa cttgggggga gctcatagag
1201 aaatgcttgg agtccatgtg tcaaggtgag gaagcagagc ttcagctgcc tgggcactct
1261 ggacctcctg tcaggctcac actggcatcc ttcactcaag gccgagactc ctgggagctg
1321 gagactagcg agaaggaagc cctggccagg gaagaacgtg caaggggcac agaactattt
1381 cgagctggga accctgaagg agctgcccga tgctatggac gggctcttcg gctgctcctg
1441 actttacccc cacctggccc tccagaacga actgtccttc atgccaatct ggctgcctgt
1501 cagttgttgc tagggcagcc tcagttggca gcccagagct gtgaccgggt gttggagcgg
1561 gagcctggcc atttaaaggc cttataccga aggggggttg cccaggctgc ccttgggaac
1621 ctggaaaaag caactgctga cctcaagaag gtgctggcga tagatcccaa aaaccgggca
1681 gcccaggagg aactggggaa ggtggtcatt caggggaaga accaggatgc agggctggct
1741 cagggtctgc gcaagatgtt tggctgatta aaagttaaac cttaaaagag aaaaaaaaa
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