LOCUS AF139131 2098 bp mRNA linear HUM 23-JUL-1999
DEFINITION Homo sapiens beclin 1 (BECN1) mRNA, complete cds.
ACCESSION AF139131
VERSION AF139131.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2098)
AUTHORS Aita,V.M., Liang,X.H., Murty,V.V., Pincus,D.L., Yu,W., Cayanis,E.,
Kalachikov,S., Gilliam,T.C. and Levine,B.
TITLE Cloning and genomic organization of beclin 1, a candidate tumor
suppressor gene on chromosome 17q21
JOURNAL Genomics 59 (1), 59-65 (1999)
PUBMED 10395800
REFERENCE 2 (bases 1 to 2098)
AUTHORS Aita,V.M., Liang,X.H., Murty,V.V.V.S., Pincus,D.L., Yu,W.,
Cayanis,E., Kalachikov,S., Gilliam,T.C. and Levine,B.
TITLE Direct Submission
JOURNAL Submitted (29-MAR-1999) Medicine, Columbia University, 630 West
168th Street P&S 8-444, New York, NY 10032, USA
FEATURES Location/Qualifiers
source 1..2098
/db_xref="H-InvDB:HIT000071117"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21"
gene 1..2098
/gene="BECN1"
/note="candidate tumor suppressor gene"
CDS 121..1473
/gene="BECN1"
/note="Bcl-2-interacting protein"
/codon_start=1
/product="beclin 1"
/protein_id="AAD27650.1"
/translation="MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTA
PLLTTAQAKPGETQEEETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGE
VSDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQ
NYKRCLEILEQMNEDDSEQLQMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAE
AERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHI
WHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYG
NHSYLESLTDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCL
PYRMDVEKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNK
"
BASE COUNT 590 a 435 c 528 g 545 t
ORIGIN
1 cgggaagtcg ctgaagacag agcgatggta gttctggagg cctcgctccg gggccgaccc
61 gaggccacag tgcctccgcg gtagaccgga cttgggtgac gggctccggg ctcccgaggg
121 atggaagggt ctaagacgtc caacaacagc accatgcagg tgagcttcgt gtgccagcgc
181 tgcagccagc ccctgaaact ggacacgagt ttcaagatcc tggaccgtgt caccatccag
241 gaactcacag ctccattact taccacagcc caggcgaaac caggagagac ccaggaggaa
301 gagactaact caggagagga gccatttatt gaaactcctc gccaggatgg tgtctctcgc
361 agattcatcc ccccagccag gatgatgtcc acagaaagtg ccaacagctt cactctgatt
421 ggggaggtat ctgatggcgg caccatggag aacctcagcc gaagactgaa ggtcactggg
481 gacctttttg acatcatgtc gggccagaca gatgtggatc acccactctg tgaggaatgc
541 acagatactc ttttagacca gctggacact cagctcaacg tcactgaaaa tgagtgtcag
601 aactacaaac gctgtttgga gatcttagag caaatgaatg aggatgacag tgaacagtta
661 cagatggagc taaaggagct ggcactagag gaggagaggc tgatccagga gctggaagac
721 gtggaaaaga accgcaagat agtggcagaa aatctcgaga aggtccaggc tgaggctgag
781 agactggatc aggaggaagc tcagtatcag agagaataca gtgaatttaa acgacagcag
841 ctggagctgg atgatgagct gaagagtgtt gaaaaccaga tgcgttatgc ccagacgcag
901 ctggataagc tgaagaaaac caacgtcttt aatgcaacct tccacatctg gcacagtgga
961 cagtttggca caatcaataa cttcaggctg ggtcgcctgc ccagtgttcc cgtggaatgg
1021 aatgagatta atgctgcttg gggccagact gtgttgctgc tccatgctct ggccaataag
1081 atgggtctga aatttcagag ataccgactt gttccttacg gaaaccattc atatctggag
1141 tctctgacag acaaatctaa ggagctgccg ttatactgtt ctggggggtt gcggtttttc
1201 tgggacaaca agtttgacca tgcaatggtg gctttcctgg actgtgtgca gcagttcaaa
1261 gaagaggttg agaaaggcga gacacgtttt tgtcttccct acaggatgga tgtggagaaa
1321 ggcaagattg aagacacagg aggcagtggc ggctcctatt ccatcaaaac ccagtttaac
1381 tctgaggagc agtggacaaa agctctcaag ttcatgctga cgaatcttaa gtggggtctt
1441 gcttgggtgt cctcacaatt ttataacaaa tgactttttt ccttaggggg aggtttgcct
1501 taaaggcttt ttaattttgt tttgtttgca aacatgtttt aaattaaatt cgggtaatat
1561 taaacagtac atgtttacaa taccaaaaaa gaaaaaatcc acaaaagcca ctttatttta
1621 aaatatcatg tgacagatac tttccagagc tacaacatgc catctatagt tgccagccct
1681 ggtcagtttt gattcttaac cccatggact cctttccctt tcttctctga aaaaaactaa
1741 tttaaatttg cttttctttt ttttaactga gttgaattga gattgatgtg ttttcactgg
1801 atttttatct ctctcaactt cctgcactta acaatatgaa atagaaactt ttgtctttac
1861 tgagatgagg atatgtttga gatgcacagt tgggataatg tgggaaaatg acatctaagc
1921 tttacctggt caccatgtga tgtgatcaga tgcttgaaat ttaacacttt tcacttggtt
1981 cttatactga atgccgactc tgctctgtgt tagagatatg aaatggtgtt tgatactgtt
2041 tgagacatta tggagagatt taattatttg taataaaaga tttgctgcag tctgaaaa
//