LOCUS AF136939 4594 bp DNA linear HUM 10-MAY-2000
DEFINITION Homo sapiens sine oculis homeobox homolog 2 (SIX2) gene, complete
cds.
ACCESSION AF136939
VERSION AF136939.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4594)
AUTHORS Boucher,C.A., Winchester,C.L., Hamilton,G.M., Winter,A.D.,
Johnson,K.J. and Bailey,M.E.
TITLE Structure, mapping and expression of the human gene encoding the
homeodomain protein, SIX2
JOURNAL Gene 247 (1-2), 145-151 (2000)
PUBMED 10773454
REFERENCE 2 (bases 1 to 4594)
AUTHORS Boucher,C.A., Hamilton,G.M., Johnson,K.J. and Bailey,M.E.S.
TITLE Direct Submission
JOURNAL Submitted (24-MAR-1999) Division of Molecular Genetics, Institute
of Biomedical and Life Sciences, University of Glasgow, Anderson
College, 56 Dumbarton Rd., Glasgow G11 6NU, United Kingdom
FEATURES Location/Qualifiers
source 1..4594
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p15-p24"
gene <1103..>4594
/gene="SIX2"
mRNA join(<1103..1714,3782..>4594)
/gene="SIX2"
/product="sine oculis homeobox homolog 2"
CDS join(1155..1714,3782..4097)
/gene="SIX2"
/note="similar to Drosophila melanogaster sine oculus"
/codon_start=1
/product="sine oculis homeobox homolog 2"
/protein_id="AAF69031.1"
/translation="MSMLPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLH
KNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRP
LGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEA
TGLTTTQVSNWFKNRRQRDRAAEAKERENNENSNSNSHNPLNGSGKSVLGSSEDEKTP
SGTPDHSSSSPALLLSPPPPGLPSLHSLGHPPGPSAVPVPVPGGGGADPLQHHHGLQD
SILNPMSANLVDLGS"
regulatory 4341..4346
/regulatory_class="polyA_signal_sequence"
/gene="SIX2"
BASE COUNT 898 a 1421 c 1354 g 920 t
ORIGIN
1 ggatcctccg ggaagtcgat tctccggcgt ccgcctgcgg ccactgccaa atcttcccca
61 tttctttcgt ctactccctc cccttttccc tcgaggaccg ctgagtccag agtttctagg
121 atgggggtgg ggcgctgtca gcagaaaaag ccaagtcttt gggcggcacc cgagcacgtc
181 caaactctcc catcccactg gcctgcgccg gggtagaatg tgcccggtga acagacagcc
241 tgggagggac gcggtgacct ggggagaagg ggaaccctgt agggtctggg cgaggctgca
301 taaccctctc ctagccaaag ctgcccaaac tttcttcccc tggagtctcc ttccacccct
361 ctccctcccc ttcctcctgg acaccccctt aaacggtctc cgccttccct tctctcctct
421 tctctcccca cctcgatcca ccccttttcg tcttcgcccg ctccccccgc tctcctgtcc
481 tcctcctccc tccctctttg ggcatccgcc ccgtcaatct ccgccgccgc cggccccaac
541 ccggcccctc tccgcctccc aggctctcag agcgccccag gctccagtag agccgccctc
601 agttctgcgc ggagcggggc gatctgtcag cggagccggc cggggggagc cgcccggccc
661 gccgaggctc gggttaccag tgactgacag cgtctccatg gcgaataatt tgactccgac
721 tattgtctgg cgctggcagg ccccgggtca gataaccgga ccaatcaggg cgcgggccgc
781 cgcgcctcat gcccgcttag aataatatta ttaagaaagc tgagagccag ctagacggga
841 gggagaacga gtgagaagcg agcgagggaa cggcgggcgg gcgcggagca tgcggagcgg
901 cgccccgggc ggcccccggg cttgggcgag ggcttgggcc aggcgcgcgg gccgttgggg
961 ttcggagctt cgtgggaccc gcggccggcg cggggacgta cggcagtgac tcggggctca
1021 ccgggggcca gtgccgggcc agggggccag ccccgcccgc gtctcggccc ggacggcccg
1081 gcgaggaagc tcccatgcgg gaccgcgcgg cccggtgagg gcgcgcgcgg gcgggcgggg
1141 acgcagccgg caccatgtcc atgctgccca ccttcggctt cacgcaggag caagtggcgt
1201 gcgtgtgcga ggtgctgcag cagggcggca acatcgagcg gctgggccgc ttcctgtggt
1261 cgctgcccgc ctgcgagcac cttcacaaga atgaaagcgt gctcaaggcc aaggccgtgg
1321 tggccttcca ccgcggcaac ttccgcgagc tctacaagat cctggagagc caccagttct
1381 cgccgcacaa ccacgccaag ctgcagcagc tgtggctcaa ggcacactac atcgaggcgg
1441 agaagctgcg cggccgaccc ctgggcgccg tgggcaaata ccgcgtgcgc cgcaaattcc
1501 cgctgccgcg ctccatctgg gacggcgagg agaccagcta ctgcttcaag gaaaagagtc
1561 gcagcgtgct gcgcgagtgg tacgcgcaca acccctaccc ttcaccccgc gagaagcgtg
1621 agctggcgga ggccacgggc ctcaccacca cacaggtcag caactggttc aagaaccggc
1681 ggcagcgcga ccgggcggcc gaggccaagg aaaggtacga gtaagtagac cttcttcggc
1741 gccagctccc cggggcccaa gggaggggtt cgcagggctt ctgccggtcc cccggagagg
1801 cctaaactgg gcccccaggc ccggccacag cccagcggca gcccggcctg acttggacga
1861 tgcttaggcc tttctatgcc ggagacccgg cgagcaggga tttgtctaaa gcgggcagag
1921 caattcagga agttgtcaac taactactcg gtcgctagag gaaaagggtg gagaagcaga
1981 gagcttcggg gcagcgcaga actgtgggcc tgtatcccct gtgaggcagg cacagtaggt
2041 ctggtcatcc tcaggacaga ggggtttgag cccagatgaa aggggatttg cagatttctt
2101 gctggtggtg cttcccggca tttcccccca gccttagctc caggccaaag tgtgatgggg
2161 tcgggactgg ggctggaact tccctagaat gacctggatg gggaaaagcc aggccatgaa
2221 ttttcgttgt cacatggagt tgagagcggg tcctttatct ccttagaaag gatccagagg
2281 tgaaagggag gaagtgtcag ttctgggaga gaagagacgc atgccctgtt ttctgccttg
2341 ctagagatag ccgcccttcc ctggcactcc aggcccttga tgcctctctc cttgggccct
2401 acctctgatg ggtaggtcgg aatgtctgcg gtgagctgag aggcacagag gggctgggag
2461 ttggatgtcc tcaggtaaac caggacttcc tgaaccagcc taaaggttga tcattaggcc
2521 cttgccactg cctgccctat aacccctcag gacctcaaac ctggagagaa acttattatg
2581 ggaacagaat ccagcccggg gtaagagcaa aacaggacac ctggggttgg tgatatgggg
2641 tgtgttccac cctgagtttg aatgatcagg gtcagaggtg agggtgctga accacnaaac
2701 atcttagggg gagtgctgca ggctcagata cttccaggta tctgagaccc tgaggttgga
2761 gtttccacag tggtgaggtc tcagctgcca gccctgtggg aagctccctc ccaggaaagc
2821 agaaagaaaa accctcccga agctggtgac aagagatcct acccaggatt ttaaatatcc
2881 aaatctgggg aggagctgtc agtcaaaggc atagaaggag gtgggttctc tctgctgggt
2941 ccccctccac ccaaaccggc atgtgatcag actcctgaaa acctgggttc tcagaccagg
3001 ccccagatga gagctgcaga ttcccggagt ggctggttac aatggaaaag cctcggcctt
3061 ctcccagggg ctgcccttta tcccccaagc ttctggtctc cgagctgacg ttttcaatgt
3121 accaccacgg aaagggagtc ctccatcctt ggacccttgt ctttaggccc agcaaggaga
3181 gccctcacag ggctgcccag tttggagcta cagggaaagg acgcttagcc ccaggagcct
3241 gtctcccagc caggggtctc cctcgggcag aaaaagcaaa gggaaatgaa gtcttgtgag
3301 aggccctaaa tcccttgacc tgggatccag ggttccttaa cctgctagcc ccacatttac
3361 ccagcaaacc tggcttgtgg agcctagagt gatctgaaaa tccaggcatc gtctcttcct
3421 cccggctcac cccacaactt cagggaaccc tgttctcctg cacctctgtt cctgaaaaga
3481 aatattgggg aaggggggaa agaggaaata tagaaaagat attgatgaga ttgacagcat
3541 gagaggtggg gacgataagg gcagaggggc aagagaaatt gggtgttgag agatggagag
3601 aacgggcaga aaggagaacc cagaccaggt cgaggaaatg gtagaaaccg aaaacacccg
3661 caggccacaa gcccgggatc tgtctcccga ggctggtggc tggctctgac tgtgactgag
3721 atggcgctgg gtggtctcga tgtcccctgc tgaccccgct gctttgctcc cgcacttgca
3781 gggagaacaa cgagaactcc aattctaaca gccacaaccc gctgaatggc agcggcaagt
3841 cggtgttagg cagctcggag gatgagaaga ctccatcggg gacgccagac cactcatcat
3901 ccagccccgc actgctcctc agcccgccgc cccctgggct gccgtccctg cacagcctgg
3961 gccaccctcc gggccccagc gcagtgccag tgccggtgcc aggcggaggt ggagcggacc
4021 cactgcaaca ccaccatggc ctgcaggact ccatcctcaa ccccatgtca gccaacctcg
4081 tggacctggg ctcctagaac ccatttgcct tgatgagctt gccttttgtg acttgacact
4141 ggggacgtgg agtggcggtg tccaggggcg ccccgcccct gcggccccac caggtactga
4201 aagacccgca ggctgagcgg gtagaacagc cgggtagggc agatagctgt ctatgttggt
4261 tcttgtttgg gatttatttt caacaagtta cttttaggat ccttttgggg ctggagactg
4321 agtcttgaac cacagaaggg aataaattat acaccactgt cattctctct ctccctctgt
4381 ctcttccttt taccctctct tgtcttgcct tttccccctt tcctcttcct ttcccttcct
4441 tctcttttct tttttctgct ttctgtcttt ctccctctcc ttgtattgct ttccttctag
4501 atttctagct tgccaccgtt cattctctcc ttctgtctct ccctttctct ctccttctct
4561 gtttctcctc tcttctctcc tgccagtctc ttgc
//