LOCUS AF135028 11570 bp DNA linear HUM 27-JUN-2000
DEFINITION Homo sapiens kallikrein-like protein 2 KLK-L2 gene, complete cds.
ACCESSION AF135028
VERSION AF135028.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 11570)
AUTHORS Yousef,G.M. and Diamandis,E.P.
TITLE The new kallikrein-like gene, KLK-L2. Molecular characterization,
mapping, tissue expression, and hormonal regulation
JOURNAL J. Biol. Chem. 274 (53), 37511-37516 (1999)
PUBMED 10608802
REFERENCE 2 (bases 1 to 11570)
AUTHORS Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V.
TITLE The new human kallikrein gene family: implications in
carcinogenesis
JOURNAL Trends Endocrinol. Metab. 11 (2), 54-60 (2000)
PUBMED 10675891
REFERENCE 3 (bases 1 to 11570)
AUTHORS Yousef,G.M., Luo,L.Y. and Diamandis,E.P.
TITLE Direct Submission
JOURNAL Submitted (13-MAR-1999) Pathology and Laboratory Medicine, Mount
Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5,
Canada
FEATURES Location/Qualifiers
source 1..11570
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.3-q13.4"
mRNA join(2101..2131,2210..2293,4762..5023,5763..6019,
6105..6238,11092..11570)
/product="kallikrein-like protein 2 KLK-L2"
CDS join(2221..2293,4762..5023,5763..6019,6105..6238,
11092..11247)
/codon_start=1
/product="kallikrein-like protein 2 KLK-L2"
/protein_id="AAD26429.1"
/translation="MATARPPWMWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPS
GSNQDLGAGAGEDARSDDSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQW
LLTAAHCRKKVFRVRLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNDLMLIKLN
RRIRPTKDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCE
DAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYT
NLCKFTKWIQETIQANS"
BASE COUNT 3034 a 2562 c 3325 g 2649 t
ORIGIN
1 gggcccagag tgaaggcaag agaaggagtt gagagctccc tctgcaaagt ggcttgagtc
61 tcccctgcct aaaatgcagg gagagggagg cagaaagaca gggaagagga aggggtgggg
121 aagaaagaga gagagagaga gagacagaat aacacaacta cagaaacaca gagagaacac
181 acagagagcc tgggacacag ggacacacag agtcagagag aaaagagaag atagagaaag
241 acacaaatgg agacacagag gtgtaaagaa agagagatta acagagtccc agatacacgc
301 aaaggggcag aagcacagtt ttcagggtgg tgtctatgat catcttcttt tttttttttt
361 tttttttttt tttttgagac ggagtctcgc tctgtcgccc aggctggagt gcagtggcgg
421 gatctcggct cactgcaagc tccgcctccc gggttcacgc cattctcctg cctcagcctc
481 ccaagtagct gggactacag gcgcccgcca ctacgcccgg ctaatttttt tgtattttta
541 gtagagacgg ggtttcaccg ttttagccgg gatggcctcg atctcctgac ctcgtgatcc
601 gcccgcctcg gcctcccaaa gtgctgggat tacaggcgtg agccaccgcg cccggccatg
661 atcatcttct tgactatgct gatgtgacaa gtacctaaag ccatcagact ctacccttta
721 aatatgcagt ttgggccagg caccgtggct catgcctgta attccagcac tttgggaggc
781 agaggtgggt gaatcacttg aggccaggag tttgagacca gcctggccaa catggtgaaa
841 ctctgtcttt actaaaaaaa aaaaaaaaaa aaaaaaaatc agccgggtgt cgtggggcac
901 acctgtaatc ccagctatgc tggaggctga ggcacgagag tcacttgaac cctggaggcg
961 gaggttgcag tgggccgaga tcacatcacc gccctccagc ctgggcgaca gagcaagact
1021 ctgtctcaaa taaataaata aacaaacgaa caagcagttt gttgtacctt agttatatct
1081 aaaaaaaaaa tgctgtcaac aaatagagca gaagtgaaat aaaggaaaat aaatgggcca
1141 agaactctaa ggtatatttg acaaatcatt cagaaccttt aaaaaagaaa gaatcacaga
1201 ggcatagaaa gacagggagg aacagggaga cagaaacacc tgtggcccaa ggagaacaaa
1261 acaaggctcc taagacagac aggaggagag agagagagag tgagtgagag acagacagag
1321 aaaaagacag agagagagag acagagacag agagacagag aggcgagagg gatagaaaga
1381 gagagagggg tggagagaga cacgagatat tgagagagac tcagaaagat agccgaggga
1441 gaaccacaga gagatggaag aagactctga gaaaaaacca gagacaaaga tggaaagagg
1501 agtatcgagg gtgaacagac agtggtggaa tgagcaaaat gcagagaaga aagcaagcaa
1561 tccaggcgcc aagaatagtg acccagagtt ggtgagaagc cagatcctta aggctggggg
1621 aggcagggaa ggggctggcc tggcttccgg agacccctcc ccattctccg ggccagggag
1681 gtagggagtg acattccgga ctgggtgggg ggtgctctgg gggtggagat agggggagca
1741 ggaggagcta ttgctaaggc ccgataggca cctcattgcc cgggaatgtg ccccagggag
1801 cagtgggtgg ttataactca ggcccggtgc ccagagccca ggaggaggca gtggccagga
1861 aggcacaggc ctgagaagtc tgcggctgag ctgggagcaa atcccccacc ccctacctgg
1921 gggacagggc aagtgagacc tggtgagggt ggctcagcag gcagggaagg agaggtgtct
1981 gtgcgtcctg cacccacatc tttctctgtc ccctccttgc cctgtctgga ggctgctaga
2041 ctcctatctt ctgaattcta tagtgcctgg gtctcagcgc agtgccgatg gtggcccgtc
2101 cttgtggttc ctctctacct ggggaaataa ggtaggggag ggaggggaag tgggttaagg
2161 gctccccgga tcgcctgggc ctcccaaccc tctgacattc cccatccagg tgcagcggcc
2221 atggctacag caagaccccc ctggatgtgg gtgctctgtg ctctgatcac agccttgctt
2281 ctgggggtca caggtaacca gaactctggg gtgggagggt tgtgggattg ggaggactgt
2341 ctctgcggca ctagagcgcc tgtcccctgg ggaactgtgt gagcctgggc atgactccgg
2401 gaccgggtga atgtgagtct ctgtctgtac ttgtggttgt gcgatcgtat gtggccctgt
2461 gactgccacg gtgtgtgtcg gggaggggga tgccttttcc catatcaggt gactgtgcgg
2521 caggtggcac tgaccctttg aggctgtgtg tgtggttttg tgattgtgtg tgcatttaag
2581 attgtgtgtg gctccacagc tgtgtgggtg aatgcatgta gcactggggg tgttcactgt
2641 gtgtttggct gtgtgtggtg acttggcatt gtatatgact gcaggtatct gcagttcctg
2701 tccctgaggt cccgggattg cgtgcaacaa aagtggtcat caccatggaa agctgtgact
2761 gtgtgctgct tgcaggcgat tatgtgattg tggctgagtg tgacgttatg gatgcccgta
2821 tttgtgaccg tgtgactacc tgaagctctg tgtaggggtg actgtatgtg actgtgtgtg
2881 tctgtgtgag gccgtgtaaa tgctactgta tgtgtgatgg tgcagctgtg tgtctggagt
2941 ttctgtctct gcctggaggg atagagggtg caggggtagc tatctctggg agatgggtgc
3001 caggtgactg acttgcagtg tgtgcctgtg tgcagaagag tatgtggcag tctgaacatc
3061 tgtgcacaca cggcatctgt gcgtggcact gagacactgt ggatgagggt gtgcgatccc
3121 gctaggctgc ccgggagcgt gtgtacctgg agacagagct gtatgttagc tgcacctgtg
3181 gaggcaacat gggcgtgtct gcagaactgc gtgcgtgctt ggctgttact gctgttgtgc
3241 gcgtggttct tggggtgagt tcgtgaatga tggtggtgcc agggccatca gcaagggtaa
3301 gaaccaggcc gggcgcggtg gctcacgcct gtaatcccag ccctttggga ggccgaggca
3361 ggcggatcac ctgaggtcgg gagatcgagg ccagcctgac caacatggag aaccccgtct
3421 ctactaaaaa tacaaaaaat tagctggtgt ggtggcgcgt gcctgtaatc ccagctactc
3481 gggagactgg ggcagaaaaa tcgcttgaac ccgggaggtg gaggttgcgg tgagccgaga
3541 tcgcgccatt gcactccagc ctgggcaaca agagcgaaac tccgtctcga aagaaaaaaa
3601 gaaaaaaaaa agggtaagaa ccagtgaatg ggcacgggag gactgatgat ggagtggggc
3661 atgcatgtag tctgtaggtc tgtgtgtgag aggaggagat tgacaggatt gagaaggcat
3721 gttttcatct gagaattcag aaacctaggc ctgctcttcc cctccatgtg gccccctaag
3781 ctgagccctt ctttcctggt cctgctttcg gaaccctagc tccgcccatg agctctgacc
3841 ccacctcctt tcctcaacca cgcccctagg ccagactcta gtggaccccg cctaaggcca
3901 cacccctttg ggccaggctc caccccctat tctgtgggta ccttctagaa cccccttcaa
3961 agtcagagct tttttttttt tttttttgga gacagtcttg ctctctctcc caggctggag
4021 tgcagtggcg tgatctcggc tcactgcaac ctctgcctcc caggttcaag tgattctcgt
4081 gcctccacct cctgagtagc tgggattaca ggtgcgcgcc accacgcctg gctaattttt
4141 gtgtctttag tagagacagg gtttcacctt gttggccagg ctggtctcaa actcccaacc
4201 tcaggtgatc cgcccacctc ggcctcccag agtgctgggg ttacaggcgt gagccaccgc
4261 ccccagccca aagtcagagc tctttatagg agactctaac atgtaaccct gaccctggcc
4321 ctaactaagt caattccaaa ccccttcctg cctccagccc tgaccccact cactgaggcc
4381 tgaccccact tcttgagacc agttccatcc ctaaagccct ggtctccctc ccatccccag
4441 gctccagccc ccacagcttt ggcactaccc ctgagcttgt ccaggaatcc tgtacccaat
4501 tttaccctca catgtagttc tagccaattc caggaatctg tgaggtccag ttagagtcca
4561 gtaaccctac ctgagcctgg gctctgtcct tgagcttgag cctgggcttg agaggtgcca
4621 ctcttattct ccaggccctg cccctgcccc ctcagcatgt cagacaccca ccctctagct
4681 ggtctggcct cttgagtctg aaacccaccc ccagcccaag ccccgcctct gagccccgcc
4741 caacccattt tccgttccca gagcatgttc tcgccaacaa tgatgtttcc tgtgaccacc
4801 cctctaacac cgtgccctct gggagcaacc aggacctggg agctggggcc ggggaagacg
4861 cccggtcgga tgacagcagc agccgcatca tcaatggatc cgactgcgat atgcacaccc
4921 agccgtggca ggccgcgctg ttgctaaggc ccaaccagct ctactgcggg gcggtgttgg
4981 tgcatccaca gtggctgctc acggccgccc actgcaggaa gaagtgagtg ggagttccaa
5041 gaggagggtt ggtggggacg gggaagtggg ggtgggggtg gggaagtggg ggtgggggtg
5101 tcatggaggt gagggctggt ggggacgggg aagtggggtt gggggtgtca tggaaggtga
5161 gggttggtgg ggatgggttg gggatgtggg agcaggagga ggtcgagttg gggataggac
5221 taaggatgga gttttgcggg ggagcaaggt gggaggatga ggttggagag gggagagtgt
5281 tgtggtaggg aatgggaagg agccaaggat gggttggatt tggggttagg agcatatatt
5341 tgttgaatgg tttgggatgg aggtggaatt gggattggct ttagaattgg gggtgggtga
5401 aaatcgggct ggggtggaaa tgaagatagc atggagatag ggttgagatt gggagcagat
5461 atagaatgaa ggatggggat tggagttttg ggtggggttg gagatggttg gatttgggct
5521 tgagaatgca tatggtgatg gcttctgggt agggaaagaa ttagggttgg gaatgggatg
5581 ggtttggaat tgtgactggg atggggacag gcatgggatt ggagaccaag agggagttga
5641 ggatggtttg gggaccgggg gtggggatgg gggtggggct ggggctgggt gtggggttgg
5701 gattggcgtt ggacgtggag atagagatca gggttggtgg tgacctgccc catcttcctc
5761 agagttttca gagtccgtct cggccactac tccctgtcac cagtttatga atctgggcag
5821 cagatgttcc agggggtcaa atccatcccc caccctggct actcccaccc tggccactct
5881 aacgacctca tgctcatcaa actgaacaga agaattcgtc ccactaaaga tgtcagaccc
5941 atcaacgtct cctctcattg tccctctgct gggacaaagt gcttggtgtc tggctggggg
6001 acaaccaaga gcccccaagg tgagtgtcca ggttcttctt gataccgacc catctctgcc
6061 gccttccatc tttctccact tctcattgtg ttcctgtttg acagtgcact tccctaaggt
6121 cctccagtgc ttgaatatca gcgtgctaag tcagaaaagg tgcgaggatg cttacccgag
6181 acagatagat gacaccatgt tctgcgccgg tgacaaagca ggtagagact cctgccaggt
6241 gaggacacct ctctttattc agcagataca cactgagtgc caactcggta acatggagcg
6301 ttgccaaatt ctgagaatcc agcaattgcc aagacagtca ggacccctgt tctcacagag
6361 ctcataccct agagtagtgg tgtttagtag aaataatgct gagctgctta tgtcatttcc
6421 agttttttag tagccacatt aaaacaggta aaaaaggctg ggcgcagtgg ctcacacctg
6481 taatcccagc actttgggag gctgaggcag gcagatcacc tttggtcagg agtttgagac
6541 tagcctggcc aacatggcga aactctgtct ctaaaaaaaa atacaaaaat tagcctggca
6601 tggtggcggg cgcctgtaat ctcagctgct caggaggccg agacacaaga atcacttaaa
6661 cccaggaggt ggaggttgca gtgagctgag atcgtgccac tcactccaac ctgggagaca
6721 gagtgacact tttgtctcaa aaagaaaaaa aaaaacaagt aaaaaagaaa caggtgaagt
6781 taactttaat aacccaatgt atcccaaata caatcatttc aaagtgtaat taatataaaa
6841 caattatgaa tgagatactt tacattcttt tcttgttttc atattaagtc tttgaaagtg
6901 agtatatatg ttatgctgac agcacatctc aatttggact agctacattt caggtgctca
6961 gtagccacat gtggctagca gttactgtat tggatggcac ggatctagag ggaaagatca
7021 gggctgtttt gtatggttgg gcaggttgtg cactgcataa agataccata tctaataggg
7081 gcactccgtg ttacagatgt cagttttggc agttttcagg cgtgtggtag ttaagtgtct
7141 tgtttcaaca aaatctgtaa tatgacagtt ttctagcaag tgctggtaaa atatcttgag
7201 gaaggaaaag agaaatctgg taggtatttt tacaagagaa tatttaatac aggggattaa
7261 ttgcaaagct gctggaaggg ctggaggaac aaagttaaaa aataaaaaac tctgtggtca
7321 agaatctgca taaatagggc aatttcagag agtggtaaag gttaacccca aaataaaaca
7381 tggttttagg atagtaaaca ataagggcca atattcaaaa aggtggtcag gggagcctcc
7441 ttggagaggt ggcatttgag cagagaatgg atgacacaaa gaagctaaac tcgtgaagtt
7501 taaggggaaa gaaaaggcac gtgcaaaggc cctgaggcag taaggaattt ggctgattca
7561 aagaagaaga ggaaaccaat gcaactggag aacaaaagtg ggggcaacag tagaaagtga
7621 cgctggaggt gtaggcaggg gcgaatgctc tgcaagtatt tcttggtcac caacacagag
7681 cttccctatg ttctaatgga agctgtatct gttgaggaag acagaattta aaatcaaact
7741 gttacatcaa ccagcaccct tctctgtatt caggctccca agggatctag aaggacgtaa
7801 gttaacaagc tctcattagc agggtgtgtg tttcaacagt agttaggaag ctggggattc
7861 aggagtactc cagtcccatg gctatgaaaa gctcccccca aattgtacaa acctgacaaa
7921 tgcaacacct ccccagctct ccccatttct tctctgtgcc ctgggtgtgg gggggtgggt
7981 tgcgaggggg aaaactttta acagaagaaa gcacatctcg gccgggcgtg gtggctcaca
8041 cctgtaatcc caacactttg ggaggccgag gcgggtggat cactaggtca ggagatggag
8101 accatcctgg ctgacacggt gaaaccctgt ctctactaaa aacacaaaaa attagccggg
8161 cgtggtggca ggcgcctgta gtcccagcta ctcgggaggc tgaggcagga gaatggcctg
8221 aacccgggag gcggaacttg cagtgagccg aggttgcacc actgcactcc agcctgggca
8281 acacagtgag actccgtctc aaaaaaaaaa aaagaaaaga aaagaaatca catctcattc
8341 aagtggtggc atttaaaact atttagcctt tctgtaggca aggttagtat cttgtttttc
8401 cagacctcaa ggtgtttttt tgtttgtttt ttcataccgg tgtgtggtct gggtgtggcc
8461 actaaaagct acaagcaaga aataataaca actacaacaa tactaatacc aatagtataa
8521 aaataatagc atctggctaa ttgctggaca ctgttttaag tggtttgcat gcctcagctc
8581 attaactcat ttacctgtta ttattggccc tattttacaa acaaggagcc aaggctcaga
8641 gcagttaact aacagcctct caaaagaaac tctgcagaga tattaaattt aaaaaataat
8701 gagagaaatt aaaccacaag aaagttgaaa tttagaggta caggcagcta agcttgtttg
8761 ctttgaaaca gtgtctgcta ctgggaaaaa ggcaagtctt ggctttccta ataattgata
8821 ccaggactct gtaattcata ttttgcatgc atgtaagtaa gaaatgaagc cgggtgcaat
8881 ggcacatgcc agtaatccca gcactctggg agactgaagt gggaagatca cttgagctca
8941 ggagttcaag accagcctgg gcaactaaaa attaaaaaaa taaaaatact aattgttttt
9001 attttagtag attttattca taccacttac atcattattg tagtatgtac atatttattt
9061 cttttctttt cttttctttt cttttttgag acggagtctc gctctgtcac ccaggctgga
9121 gtgcaatggc accatatcag ctcactgcag catgcgcctc ctgggttcaa gcatttcttc
9181 cacctcagcc tcccaagtag ctgggataac aggcacccac caccatgcct ggctattttt
9241 ttttttccgt agagatgggg ttccaccatg ttggccaggc tggtcttgaa ctcctgacct
9301 ccagtgatct gcctgcctcg gcctcccaaa ttgctggtat tacaggtgtg agccaccgtg
9361 cccaggtggg agatagacat ttctctctac ctcaaacaga ggtccactca agctactttt
9421 cattttcttc ataaatatta gccgagtggc tattttgcac caggaatggt tccaggtgct
9481 gtggatatgg catcaggcaa aacagaccaa aaacttcctg ccgcgtggac ctcatgttcc
9541 ccaagtggaa gacaggcaat aaagagatag ataaatatgt agtaaattaa aaaaaaaaaa
9601 aattagccgg gtgtggtggc ttgcacctgt agttccagct acttgggagg ctgaggtggg
9661 agaattgctt gagcccaaac gtttgaggct gcggtaagcc atgactgcac tgctgcactc
9721 cagacagcag cctgggtgac aaagcaagac gtttttgtca gaaagaaaaa aaaaagagac
9781 gaagggagga aggagagaga aaggaaggaa ggaaggagaa agaaaggaag gaaggagaaa
9841 gaaaggaagg aaggaaggag aaagaaagga agaaagagaa agaaagaaaa agaaagaaag
9901 aaagaagaaa gaaaagagag aggaaggaag gaaagaagga aaagagggaa aaaaatgact
9961 gttgaagagc agtgagtatt attataggag ggtaattata gggaggtatg gggaattgaa
10021 gacaggaaac acaaattagt ccaagcgaat ggatttctat tgggagtgat tctgccccta
10081 gaagacactg gcaataccag gagacatttt tggttgtcac aactatatgg aggggcatta
10141 ctggcaacta atggatagat gccaagtgtg ctgttcaaca tgctatgatg cacacggcag
10201 gcctccacaa caaaccatta tccagcttca gatgcccaca gtgcccagat cgaggaaccc
10261 tcatccaggg gctgagaacc gtatttttgc agaagggagg tataaggatg ggttggtgga
10321 gaatggggaa ggaaggtgtg tgtccagtaa gagaaataag gcctgcacag gctggagggg
10381 agagtgagag agaaagggag gcggagagat acacgatgag ggagacaggc tggaacagaa
10441 agtagagacg aagattcgag atgtggagag gaagggtcac agaccccccc gaaatgatgt
10501 gtggacaaca ggaatctgga agaggaagat ggagtggaga gtgacaaatg gggtctaaag
10561 gttgaacttg gaggccaggc atggtggctc acgcctgtaa tcccaacact ttggaggctg
10621 aggtgggcga atcacttgag gccaggagtt cgagaccagc ctggccaaca tggtgaaacc
10681 ccgtctctac aaaaaaaata caaaaaatta gccgggtgtg gtgatggaca cctgtagtca
10741 cagctacttg ggaggctgag gcaggagaat tgcttgaacc cgggagatgg aggctgcagt
10801 gagctgaggt caggccactg cgctccaacc tgggcaacag agtaagactc catctcaaaa
10861 aaaaaaaagc tggatttgga gtgaaatatt aataacattc tccctctctc tccttttgcc
10921 tgtgtctcca tctctgtctt tttctgcatt tcttcatctc tgtactttcc atctctgtgt
10981 gtctgttccc atctgcttct ccatctatgg gcatctctgg gtctctcatg tctccttctg
11041 cccactttgc cacatctctg cctctctcat gccccccttt ctctcctgca gggtgattct
11101 ggggggcctg tggtctgcaa tggctccctg cagggactcg tgtcctgggg agattaccct
11161 tgtgcccggc ccaacagacc gggtgtctac acgaacctct gcaagttcac caagtggatc
11221 caggaaacca tccaggccaa ctcctgagtc atcccaggac tcagcacacc ggcatcccca
11281 cctgctgcag ggacagccct gacactcctt tcagaccctc attccttccc agagatgttg
11341 agaatgttca tctctccagc ccctgacccc atgtctcctg gactcagggt ctgcttcccc
11401 cacattgggc tgaccgtgtc tctctagttg aaccctggga acaatttcca aaactgtcca
11461 gggcgggggt tgcgtctcaa tctccctggg gcactttcat cctcaagctc agggcccatc
11521 ccttctctgc agctctgacc caaatttagt cccagaaata aactgagaag
//