LOCUS AF134395 1413 bp mRNA linear HUM 16-JUN-1999
DEFINITION Homo sapiens CARD-like apoptotic protein (CLAP) mRNA, complete cds.
ACCESSION AF134395
VERSION AF134395.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1413)
AUTHORS Srinivasula,S.M., Ahmad,M., Lin,J.H., Poyet,J.L.,
Fernandes-Alnemri,T., Tsichlis,P.N. and Alnemri,E.S.
TITLE CLAP, a novel caspase recruitment domain-containing protein in the
tumor necrosis factor receptor pathway, regulates NF-kappaB
activation and apoptosis
JOURNAL J. Biol. Chem. 274 (25), 17946-17954 (1999)
PUBMED 10364242
REFERENCE 2 (bases 1 to 1413)
AUTHORS Srinivasula,S.M., Ahmad,M. and Alnemri,E.S.
TITLE Direct Submission
JOURNAL Submitted (12-MAR-1999) Microbiology and Immunology, Thomas
Jefferson University, 233 S 10th Street, Philadelphia, PA 19107,
USA
FEATURES Location/Qualifiers
source 1..1413
/db_xref="H-InvDB:HIT000071003"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..1413
/gene="CLAP"
CDS 246..947
/gene="CLAP"
/function="activates NF-kappaB and induces apoptosis"
/codon_start=1
/product="CARD-like apoptotic protein"
/protein_id="AAD39147.1"
/translation="MEPTAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAK
KILSREDTEEISCRTSSRKRAGKLLDYLQENPKGLDTLVESIRREKTQNFLIQKITDE
VLKLRNIKLEHLKGLKCSSCEPFPDGATNNLSRSNSDESNFSEKLRASTVMYHPEGES
STTPFFSTNSSLNLPVLEVGRTENTIFSSTTLPRPGDPGAPPLPPDLQLEEEGTCANS
SEMFLPLRSRTVSRQ"
BASE COUNT 413 a 323 c 281 g 396 t
ORIGIN
1 gctgctccga gctccgcgtc gcgtcgcgta gattcgcgtc gccgtcgacc tcagaggcgg
61 ggccggaagc gctacggttt gacccccgag tccctctgtt cccgaagggg cggccgtctt
121 tctcccgacc cgctccgcct cctctccttc ttccccatta cccggaggcc gaagccccca
181 gccagggcgg ggcggcgcag cccgagctcc cggacccgga agaagcgcca tctcccgcct
241 ccaccatgga gcccaccgca ccgtccctca ccgaggagga cctcactgaa gtgaagaagg
301 acgccttaga aaatttacgt gtatacctgt gtgagaaaat catagctgag agacattttg
361 atcatctacg tgcaaaaaaa atactcagta gagaagacac tgaagaaatt tcttgtcgaa
421 catcaagtag aaaaagggct ggaaaattgt tagactactt acaggaaaac ccaaaaggtc
481 tggacaccct tgttgaatct attcggcgag aaaaaacaca gaacttcctg atacagaaga
541 ttacagatga agtgctgaaa cttagaaata taaaactaga acatctgaaa ggactaaaat
601 gtagcagttg tgaacctttt ccagatggag ccacgaacaa cctctccaga tcaaattcag
661 atgagagtaa tttctctgaa aaactgaggg catccactgt catgtaccat ccagaaggag
721 aatccagcac gacgcccttt ttttctacta attcttctct gaatttgcct gttctagaag
781 taggcagaac tgaaaatacc atcttctctt caactacact tcccagacct ggggacccag
841 gggctcctcc tttgccacca gatctacagt tagaagaaga aggaacttgt gcaaactcta
901 gtgagatgtt tcttccctta agatcacgta ctgtttcacg acaatgacac tttattgcct
961 tttaattttt aatgatgaca aaaaatgttt taaagaatat gactttttat aaaatggctg
1021 taatcatttg tttacatttg atgcatgtct tttaaaatgc aatgtaagca tactttgtaa
1081 ataggatttt tagaattaaa aaagcatact tctaggatag ctaactgtaa atcatgttga
1141 tcatgtactt tttagtaatt tctttttttc ctttttaagg tctttcagta cttttttaaa
1201 tattttctat tttaagactg attttaatag ggaatatatc tctatttgag aatagaccct
1261 tactaggaag aacgtttttt cctcagtgca tttgtgctag aaattttcaa gagtctaata
1321 gtctttgcca gtcattcagc agcaaatttt cagcattaag ctgttcctgt tcagtaataa
1381 aaccggtcac tgatgggaaa actgccaata tag
//