LOCUS AF132609 3648 bp mRNA linear HUM 06-MAY-1999
DEFINITION Homo sapiens histone deacetylase 6 mRNA, complete cds.
ACCESSION AF132609
VERSION AF132609.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3648)
AUTHORS Grozinger,C.M., Hassig,C.A. and Schreiber,S.L.
TITLE Three proteins define a class of human histone deacetylases related
to yeast Hda1p
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (9), 4868-4873 (1999)
PUBMED 10220385
REFERENCE 2 (bases 1 to 3648)
AUTHORS Grozinger,C.M., Hassig,C.A. and Schreiber,S.L.
TITLE Direct Submission
JOURNAL Submitted (03-MAR-1999) Chemistry and Chemical Biology, Harvard
University, 12 Oxford Street, Cambridge, MA 02138, USA
FEATURES Location/Qualifiers
source 1..3648
/db_xref="H-InvDB:HIT000070902"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone_lib="U957"
CDS 1..3648
/note="HDAC6; similar to Saccaromyces cerevisiae Hda1p"
/codon_start=1
/product="histone deacetylase 6"
/protein_id="AAD29048.1"
/translation="MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSI
PNLAEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWD
DSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMN
EGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQ
HSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIH
RYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEF
QPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALA
EGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNM
EEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRIL
RIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNF
DSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFN
SVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPM
GDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAG
FDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSL
LGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAP
QPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSETAVVALTQDQPSEAA
TGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGAILDQTTSEDAVG
GATLGQTTSEEAVGGATLAQTISEAAMEGATLDQTTSEEAPGGTELIQTPLASSTDHQ
TPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEAAGGQDMAD
SMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCL
SCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQ
NKFGEDMPHPH"
BASE COUNT 798 a 1080 c 1036 g 734 t
ORIGIN
1 atgacctcaa ccggccagga ttccaccaca accaggcagc gaagaagtag gcagaacccc
61 cagtcgcccc ctcaggactc cagtgtcact tcgaagcgaa atattaaaaa gggagccgtt
121 ccccgctcta tccccaatct agcggaggta aagaagaaag gcaaaatgaa gaagctcggc
181 caagcaatgg aagaagacct aatcgtggga ctgcaaggga tggatctgaa ccttgaggct
241 gaagcactgg ctggcactgg cttggtgttg gatgagcagt taaatgaatt ccattgcctc
301 tgggatgaca gcttcccgga aggccctgag cggctccatg ccatcaagga gcaactgatc
361 caggagggcc tcctagatcg ctgcgtgtcc tttcaggccc ggtttgctga aaaggaagag
421 ctgatgttgg ttcacagcct agaatatatt gatctgatgg aaacaaccca gtacatgaat
481 gagggagaac tccgtgtcct agcagacacc tacgactcag tttatctgca tccgaactca
541 tactcctgtg cctgcctggc ctcaggctct gtcctcaggc tggtggatgc ggtcctgggg
601 gctgagatcc ggaatggcat ggccatcatt aggcctcctg gacatcacgc ccagcacagt
661 cttatggatg gctattgcat gttcaaccac gtggctgtgg cagcccgcta tgctcaacag
721 aaacaccgca tccggagggt ccttatcgta gattgggatg tgcaccacgg tcaaggaaca
781 cagttcacct tcgaccagga ccccagtgtc ctctatttct ccatccaccg ctacgagcag
841 ggtaggttct ggccccacct gaaggcctct aactggtcca ccacaggttt cggccaaggc
901 caaggatata ccatcaatgt gccttggaac caggtgggga tgcgggatgc tgactacatt
961 gctgctttcc tgcacgtcct gctgccagtc gccctcgagt tccagcctca gctggtcctg
1021 gtggctgctg gatttgatgc cctgcaaggg gaccccaagg gtgagatggc cgccactccg
1081 gcagggttcg cccagctaac ccacctgctc atgggtctgg caggaggcaa gctgatcctg
1141 tctctggagg gtggctacaa cctccgcgcc ctggctgaag gcgtcagtgc ttcgctccac
1201 acccttctgg gagacccttg ccccatgctg gagtcacctg gtgccccctg ccggagtgcc
1261 caggcttcag tttcctgtgc tctggaagcc cttgagccct tctgggaggt tcttgtgaga
1321 tcaactgaga ccgtggagag ggacaacatg gaggaggaca atgtagagga gagcgaggag
1381 gaaggaccct gggagccccc tgtgctccca atcctgacat ggccagtgct acagtctcgc
1441 acagggctgg tctatgacca aaatatgatg aatcactgca acttgtggga cagccaccac
1501 cctgaggtac cccagcgcat cttgcggatc atgtgccgtc tggaggagct gggccttgcc
1561 gggcgctgcc tcaccctgac accgcgccct gccacagagg ctgagctgct cacctgtcac
1621 agtgctgagt acgtgggtca tctccgggcc acagagaaaa tgaaaacccg ggagctgcac
1681 cgtgagagtt ccaactttga ctccatctat atctgcccca gtaccttcgc ctgtgcacag
1741 cttgccactg gcgctgcctg ccgcctggtg gaggctgtgc tctcaggaga ggttctgaat
1801 ggtgctgctg tggtgcgtcc cccaggacac cacgcagagc aggatgcagc ttgcggtttt
1861 tgctttttca actctgtggc tgtggctgct cgccatgccc agactatcag tgggcatgcc
1921 ctacggatcc tgattgtgga ttgggatgtc caccacggta atggaactca gcacatgttt
1981 gaggatgacc ccagtgtgct atatgtgtcc ctgcaccgct atgatcatgg caccttcttc
2041 cccatggggg atgagggtgc cagcagccag atcggccggg ctgcgggcac aggcttcacc
2101 gtcaacgtgg catggaacgg gccccgcatg ggtgatgctg actacctagc tgcctggcat
2161 cgcctggtgc ttcccattgc ctacgagttt aacccagaac tggtgctggt ctcagctggc
2221 tttgatgctg cacgggggga tccgctgggg ggctgccagg tgtcacctga gggttatgcc
2281 cacctcaccc acctgctgat gggccttgcc agtggccgca ttatccttat cctagagggt
2341 ggctataacc tgacatccat ctcagagtcc atggctgcct gcactcgctc cctccttgga
2401 gacccaccac ccctgctgac cctgccacgg cccccactat caggggccct ggcctcaatc
2461 actgagacca tccaagtcca tcgcagatac tggcgcagct tacgggtcat gaaggtagaa
2521 gacagagaag gaccctccag ttctaagttg gtcaccaaga aggcacccca accagccaaa
2581 cctaggttag ctgagcggat gaccacacga gaaaagaagg ttctggaagc aggcatgggg
2641 aaagtcacct cggcatcatt tggggaagag tccactccag gccagactaa ctcagagaca
2701 gctgtggtgg ccctcactca ggaccagccc tcagaggcag ccacaggggg agccactctg
2761 gcccagacca tttctgaggc agccattggg ggagccatgc tgggccagac cacctcagag
2821 gaggctgtcg ggggagccac tccggaccag accacctcag aggagactgt gggaggagcc
2881 attctggacc agaccacctc agaggatgct gttgggggag ccacgctggg ccagactacc
2941 tcagaggagg ctgtaggagg agctacactg gcccagacca tctcggaggc agccatggag
3001 ggagccacac tggaccagac tacgtcagag gaggctccag ggggcaccga gctgatccaa
3061 actcctctag cctcgagcac agaccaccag acccccccaa cctcacctgt gcagggaact
3121 acaccccaga tatctcccag tacactgatt gggagtctca ggaccttgga gctaggcagc
3181 gaatctcagg gggcctcaga atctcaggcc ccaggagagg agaacctact aggagaggca
3241 gctggaggtc aggacatggc tgattcgatg ctgatgcagg gatctagggg cctcactgat
3301 caggccatat tttatgctgt gacaccactg ccctggtgtc cccatttggt ggcagtatgc
3361 cccatacctg cagcaggcct agacgtgacc caaccttgtg gggactgtgg aacaatccaa
3421 gagaattggg tgtgtctctc ttgctatcag gtctactgtg gtcgttacat caatggccac
3481 atgctccaac accatggaaa ttctggacac ccgctggtcc tcagctacat cgacctgtca
3541 gcctggtgtt actactgtca ggcctatgtc caccaccagg ctctcctaga tgtgaagaac
3601 atcgcccacc agaacaagtt tggggaggat atgccccacc cacactaa
//