LOCUS AF132607 3255 bp mRNA linear HUM 06-MAY-1999
DEFINITION Homo sapiens histone deacetylase 4 mRNA, complete cds.
ACCESSION AF132607
VERSION AF132607.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3255)
AUTHORS Grozinger,C.M., Hassig,C.A. and Schreiber,S.L.
TITLE Three proteins define a class of human histone deacetylases related
to yeast Hda1p
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (9), 4868-4873 (1999)
PUBMED 10220385
REFERENCE 2 (bases 1 to 3255)
AUTHORS Grozinger,C.M., Hassig,C.A. and Schreiber,S.L.
TITLE Direct Submission
JOURNAL Submitted (03-MAR-1999) Chemistry and Chemical Biology, Harvard
University, 12 Oxford Street, Cambridge, MA 02138, USA
FEATURES Location/Qualifiers
source 1..3255
/db_xref="H-InvDB:HIT000070900"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="leukemia"
CDS 1..3255
/note="HDAC4; similar to Saccaromyces cerevisiae Hda1p"
/codon_start=1
/product="histone deacetylase 4"
/protein_id="AAD29046.1"
/translation="MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAP
SAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSR
QHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEK
GKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQ
SGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPV
VTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLV
AREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDTERLTLPALQQRLSLFPGTH
LTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTGLGALPLHAQSLVGADRVS
PSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKII
PKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESD
EEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGH
RPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRI
QSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLG
SLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVR
PPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPS
VLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTV
VMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLAL
EGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRC
LQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL"
BASE COUNT 701 a 1070 c 988 g 496 t
ORIGIN
1 atgagctccc aaagccatcc agatggactt tctggccgag accagccagt ggagctgctg
61 aatcctgccc gcgtgaacca catgcccagc acggtggatg tggccacggc gctgcctctg
121 caagtggccc cctcggcagt gcccatggac ctgcgcctgg accaccagtt ctcactgcct
181 gtggcagagc cggccctgcg ggagcagcag ctgcagcagg agctcctggc gctcaagcag
241 aagcagcaga tccagaggca gatcctcatc gctgagttcc agaggcagca cgagcagctc
301 tcccggcagc acgaggcgca gctccacgag cacatcaagc aacaacagga gatgctggcc
361 atgaagcacc agcaggagct gctggaacac cagcggaagc tggagaggca ccgccaggag
421 caggagctgg agaagcagca ccgggagcag aagctgcagc agctcaagaa caaggagaag
481 ggcaaagaga gtgccgtggc cagcacagaa gtgaagatga agttacaaga atttgtcctc
541 aataaaaaga aggcgctggc ccaccggaat ctgaaccact gcatttccag cgaccctcgc
601 tactggtacg ggaaaacgca gcacagttcc cttgaccaga gttctccacc ccagagcgga
661 gtgtcgacct cctataacca cccggtcctg ggaatgtacg acgccaaaga tgacttccct
721 cttaggaaaa cagcttctga accgaatctg aaattacggt ccaggctaaa gcagaaagtg
781 gccgaaagac ggagcagccc cctgttacgc aggaaagacg ggccagtggt cactgctcta
841 aaaaagcgtc cgttggatgt cacagactcc gcgtgcagca gcgccccagg ctccggaccc
901 agctcaccca acaacagctc cgggagcgtc agcgcggaga acggtatcgc gcccgccgtc
961 cccagcatcc cggcggagac gagtttggcg cacagacttg tggcacgaga aggctcggcc
1021 gctccacttc ccctctacac atcgccatcc ttgcccaaca tcacgctggg cctgcctgcc
1081 accggcccct ctgcgggcac ggcgggccag caggacaccg agagactcac ccttcccgcc
1141 ctccagcaga ggctctccct tttccccggc acccacctca ctccctacct gagcacctcg
1201 cccttggagc gggacggagg ggcagcgcac agccctcttc tgcagcacat ggtcttactg
1261 gagcagccac cggcacaagc acccctcgtc acaggcctgg gagcactgcc cctccacgca
1321 cagtccttgg ttggtgcaga ccgggtgtcc ccctccatcc acaagctgcg gcagcaccgc
1381 ccactggggc ggacccagtc ggccccgctg ccccagaacg cccaggctct gcagcacctg
1441 gtcatccagc agcagcatca gcagtttctg gagaaacaca agcagcagtt ccagcagcag
1501 caactgcaga tgaacaagat catccccaag ccaagcgagc cagcccggca gccggagagc
1561 cacccggagg agacggagga ggagctccgt gagcaccagg ctctgctgga cgagccctac
1621 ctggaccggc tgccggggca gaaggaggcg cacgcacagg ccggcgtgca ggtgaagcag
1681 gagcccattg agagcgatga ggaagaggca gagcccccac gggaggtgga gccgggccag
1741 cgccagccca gtgagcagga gctgctcttc agacagcaag ccctcctgct ggagcagcag
1801 cggatccacc agctgaggaa ctaccaggcg tccatggagg ccgccggcat ccccgtgtcc
1861 ttcggcggcc acaggcctct gtcccgggcg cagtcctcac ccgcgtctgc caccttcccc
1921 gtgtctgtgc aggagccccc caccaagccg aggttcacga caggcctcgt gtatgacacg
1981 ctgatgctga agcaccagtg cacctgcggg agtagcagca gccaccccga gcacgccggg
2041 aggatccaga gcatctggtc ccgcctgcag gagacgggcc tccggggcaa atgcgagtgc
2101 atccgcggac gcaaggccac cctggaggag ctacagacgg tgcactcgga agcccacacc
2161 ctcctgtatg gcacgaaccc cctcaaccgg cagaaactgg acagtaagaa acttctaggc
2221 tcgctcgcct ccgtgttcgt ccggctccct tgcggtggtg ttggggtgga cagtgacacc
2281 atatggaacg aggtgcactc ggcgggggca gcccgcctgg ctgtgggctg cgtggtagag
2341 ctggtcttca aggtggccac aggggagctg aagaatggct ttgctgtggt ccgcccccct
2401 ggacaccatg cggaggagag cacgcccatg ggcttttgct acttcaactc cgtggccgtg
2461 gcagccaagc ttctgcagca gaggttgagc gtgagcaaga tcctcatcgt ggactgggac
2521 gtgcaccatg gaaacgggac ccagcaggct ttctacagcg accctagcgt cctgtacatg
2581 tccctccacc gctacgacga tgggaacttc ttcccaggca gcggggctcc tgatgaggtg
2641 ggcacagggc ccggcgtggg tttcaacgtc aacatggctt tcaccggcgg cctggacccc
2701 cccatgggag acgctgagta cttggcggcc ttcagaacgg tggtcatgcc gatcgccagc
2761 gagtttgccc cggatgtggt gctggtgtca tcaggcttcg atgccgtgga gggccacccc
2821 acccctcttg ggggctacaa cctctccgcc agatgcttcg ggtacctgac gaagcagctg
2881 atgggcctgg ctggcggccg gattgtcctg gccctcgagg gaggccacga cctgaccgcc
2941 atttgcgacg cctcggaagc atgtgtttct gccttgctgg gaaacgagct tgatcctctc
3001 ccagaaaagg ttttacagca aagacccaat gcaaacgctg tccgttccat ggagaaagtc
3061 atggagatcc acagcaagta ctggcgctgc ctgcagcgca caacctccac agcggggcgt
3121 tctctgatcg aggctcagac ttgcgagaac gaagaagccg agacggtcac cgccatggcc
3181 tcgctgtccg tgggcgtgaa gcccgccgaa aagagaccag atgaggagcc catggaagag
3241 gagccgcccc tgtag
//