LOCUS AF131284 2118 bp mRNA linear HUM 07-JUL-1999
DEFINITION Homo sapiens membrane type 5 matrix metalloproteinase (MMP24) mRNA,
complete cds.
ACCESSION AF131284
VERSION AF131284.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2118)
AUTHORS Llano,E., Pendas,A.M., Freije,J.P., Nakano,A., Knauper,V.,
Murphy,G. and Lopez-Otin,C.
TITLE Identification and characterization of human MT5-MMP, a new
membrane-bound activator of progelatinase a overexpressed in brain
tumors
JOURNAL Cancer Res. 59 (11), 2570-2576 (1999)
PUBMED 10363975
REFERENCE 2 (bases 1 to 2118)
AUTHORS Llano,E., Pendas,A.M. and Lopez-Otin,C.
TITLE Direct Submission
JOURNAL Submitted (26-FEB-1999) Bioquimica, Fac de Medicina, Universidad de
Oviedo, Julian Claveria 6, Oviedo, Asturias 33006, Spain
FEATURES Location/Qualifiers
source 1..2118
/db_xref="H-InvDB:HIT000070740"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="20"
/map="20q11.2"
gene 1..2118
/gene="MMP24"
CDS 1..1938
/gene="MMP24"
/function="an activator of the progelatinase A"
/note="MT5-MMP"
/codon_start=1
/product="membrane type 5 matrix metalloproteinase"
/protein_id="AAD42962.1"
/translation="MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALC
CLPGAARAAAAAAGAGNRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALH
SAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTG
QKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEA
DIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDL
FLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLE
PTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNICDGNFNTVALFRG
EMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWV
FKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDP
GYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDW
MGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNAVAVVIPCILSLCILVLVYTIFQ
FKNKTGPQPVTYYKRPVQEWV"
BASE COUNT 430 a 647 c 668 g 373 t
ORIGIN
1 atgccgagga gccggggcgg ccgcgccgcg ccggggccgc cgccgccgcc gccgccgccg
61 ggccaggccc cgcgctggag ccgctggcgg gtccctgggc ggctgctgct gctgctgctg
121 cccgcgctct gctgcctccc gggcgccgcg cgggcggcgg cggcggcggc gggggcaggg
181 aaccgggcag cggtggcggt ggcggtggcg cgggcggacg aggcggaggc gcccttcgcc
241 gggcagaact ggttaaagtc ctatggctat ctgcttccct atgactcacg ggcatctgcg
301 ctgcactcag cgaaggcctt gcagtcggca gtctccacta tgcagcagtt ttacgggatc
361 ccggtcaccg gtgtgttgga tcagacaacg atcgagtgga tgaagaaacc ccgatgtggt
421 gtccctgatc acccccactt aagccgtagg cggagaaaca agcgctatgc cctgactgga
481 cagaagtgga ggcaaaaaca catcacctac agcattcaca actatacccc aaaagtgggt
541 gagctagaca cgcggaaagc tattcgccag gctttcgatg tgtggcagaa ggtgacccca
601 ctgacctttg aagaggtgcc ataccatgag atcaaaagtg accggaagga ggcagacatc
661 atgatctttt ttgcttctgg tttccatggc gacagctccc catttgatgg agaaggggga
721 ttcctggccc atgcctactt ccctggccca gggattggag gagacaccca ctttgactcc
781 gatgagccat ggacgctagg aaatgccaac catgacggga acgacctctt cctggtggct
841 gtgcatgagc tgggccacgc gctgggactg gagcactcca gcgaccccag cgccatcatg
901 gcgcccttct accagtacat ggagacgcac aacttcaagc tgccccagga cgatctccag
961 ggcatccaga agatctatgg acccccagcc gagcctctgg agcccacaag gccactccct
1021 acactccccg tccgcaggat ccactcacca tcggagagga aacacgagcg ccagcccagg
1081 ccccctcggc cgcccctcgg ggaccggcca tccacaccag gcaccaaacc caacatctgt
1141 gacggcaact tcaacacagt ggccctcttc cggggcgaga tgtttgtctt taaggatcgc
1201 tggttctggc gtctgcgcaa taaccgagtg caggagggct accccatgca gatcgagcag
1261 ttctggaagg gcctgcctgc ccgcatcgac gcagcctatg aaagggccga tgggagattt
1321 gtcttcttca aaggtgacaa gtattgggtg tttaaggagg tgacggtgga gcctgggtac
1381 ccccacagcc tgggggagct gggcagctgt ttgccccgtg aaggcattga cacagctctg
1441 cgctgggaac ctgtgggcaa gacctacttt ttcaaaggcg agcggtactg gcgctacagc
1501 gaggagcggc gggccacgga ccctggctac cctaagccca tcaccgtgtg gaagggcatt
1561 ccacaggctc cccaaggagc cttcatcagc aaggaaggat attacaccta tttctacaag
1621 ggccgggact actggaagtt tgacaaccag aaactgagcg tggagccagg ctacccgcgc
1681 aacatcctgc gtgactggat gggctgcaac cagaaggagg tggagcggcg gaaggagcgg
1741 cggctgcccc aggacgacgt ggacatcatg gtgaccatca acgatgtgcc gggctccgtg
1801 aacgccgtgg ccgtggtcat cccctgcatc ctgtccctct gcatcctggt gctggtctac
1861 accatcttcc agttcaagaa caagacaggc cctcagcctg tcacctacta taagcggcca
1921 gtccaggaat gggtgtgagc agcccagagc cctctctatc cacttggtct ggccagccag
1981 gcccttcctc accagggtct gaggggcagc tctggccagt gctcaccagg gccagcaggg
2041 ctaggctggg gtcgtacagc tgaagtggtg ggtgcattgg cctaggctga gcgtggggca
2101 gggaattatg ggggctgt
//