LOCUS AF126484 3561 bp mRNA linear HUM 05-FEB-2018
DEFINITION Homo sapiens CARD4 mRNA, complete cds.
ACCESSION AF126484
VERSION AF126484.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3561)
AUTHORS Bertin,J., Nir,W.J., Fischer,C.M., Tayber,O.V., Errada,P.R.,
Grant,J.R., Keilty,J.J., Gosselin,M.L., Robison,K.E., Wong,G.H.,
Glucksmann,M.A. and DiStefano,P.S.
TITLE Human CARD4 protein is a novel CED-4/Apaf-1 cell death family
member that activates NF-kappaB
JOURNAL J. Biol. Chem. 274 (19), 12955-12958 (1999)
PUBMED 10224040
REFERENCE 2 (bases 1 to 3561)
AUTHORS Bertin,J.
TITLE Direct Submission
JOURNAL Submitted (08-FEB-1999) Neurobiology, Millennium Pharmaceuticals,
Inc., 640 Memorial Drive, Cambridge, MA 02139, USA
REFERENCE 3 (bases 1 to 3561)
AUTHORS Bertin,J.
TITLE Direct Submission
JOURNAL Submitted (05-FEB-2018) Neurobiology, Millennium Pharmaceuticals,
Inc., 640 Memorial Drive, Cambridge, MA 02139, USA
REMARK Sequence update by database staff to remove vector contamination
COMMENT On Feb 5, 2018 this sequence version replaced AF126484.1.
FEATURES Location/Qualifiers
source 1..3561
/db_xref="H-InvDB:HIT000070544"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 424..3285
/note="CED-4/APAF-1 cell death family member; activates
NF-kB and caspase-9"
/codon_start=1
/product="CARD4"
/protein_id="AAD29125.1"
/translation="MEEQGHSEMEIIPSESHPHIQLLKSNRELLVTHIRNTQCLVDNL
LKNDYFSAEDAEIVCACPTQPDKVRKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRP
WLLEIGFSPSLLTQSKVVVNTDPVSRYTQQLRHHLGRDSKFVLCYAQKEELLLEEIYM
DTIMELVGFSNESLGSLNSLACLLDHTTGILNEQGETIFILGDAGVGKSMLLQRLQSL
WATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLFKHYCYPERDPEEVFAFLLRFP
HVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPLVLLANLLSGKLLKGASKLLTART
GIEVPRQFLRKKVLLRGFSPSHLRAYARRMFPERALQDRLLSQLEANPNLCSLCSVPL
FCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFLLVTEVHLNRMQPSSLVQRNTRSPV
ETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERDMQLGFLRALPELGPGG
DQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEWMPPAGAATTSCYPPFLPFQ
CLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRHLVPAAALRRKRKALWAHL
FSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIYETQSQKVGQLAARGICANYLKL
TYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSRLTVLRLSVNQI
TDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITS
EGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEG
GKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTA
QLADALQSNTGITEICLNGNLIKPEEAKVYEDEKRIICF"
BASE COUNT 815 a 1017 c 990 g 739 t
ORIGIN
1 cccggaccat ggcgctctcc gggctcttct ctagctctca gcggctgcga agtctgtaaa
61 cctggtggcc aagtgattgt aagtcaggag actttccttc ggtttctgcc tttgatggca
121 agaggtggag attgtggcgg cgattacaga aaacgtctgg gaagacaagt tgctgttttt
181 atgggaatcg caggcttgga agagacagaa gcaattccag aaataaattg gaaattgaag
241 atttaaccaa tgttgtttta aaatattcta acttcaaaga atgatgccag aaacttaaaa
301 aggggctgcg cagagtagca ggggccctgg agggcgcggc ctgaatcctg attgcccttc
361 tgctgagagg acacacgcag ctgaagatga atttgggaaa agtagccgct tgctacttta
421 actatggaag agcagggcca cagtgagatg gaaataatcc catcagagtc tcacccccac
481 attcaattac tgaaaagcaa tcgggaactt ctggtcactc acatccgcaa tactcagtgt
541 ctggtggaca acttgctgaa gaatgactac ttctcggccg aagatgcgga gattgtgtgt
601 gcctgcccca cccagcctga caaggtccgc aaaattctgg acctggtaca gagcaagggc
661 gaggaggtgt ccgagttctt cctctacttg ctccagcaac tcgcagatgc ctacgtggac
721 ctcaggcctt ggctgctgga gatcggcttc tccccttccc tgctcactca gagcaaagtc
781 gtggtcaaca ctgacccagt gagcaggtat acccagcagc tgcgacacca tctgggccgt
841 gactccaagt tcgtgctgtg ctatgcccag aaggaggagc tgctgctgga ggagatctac
901 atggacacca tcatggagct ggttggcttc agcaatgaga gcctgggcag cctgaacagc
961 ctggcctgcc tcctggacca caccaccggc atcctcaatg agcagggtga gaccatcttc
1021 atcctgggtg atgctggggt gggcaagtcc atgctgctac agcggctgca gagcctctgg
1081 gccacgggcc ggctagacgc aggggtcaaa ttcttcttcc actttcgctg ccgcatgttc
1141 agctgcttca aggaaagtga caggctgtgt ctgcaggacc tgctcttcaa gcactactgc
1201 tacccagagc gggaccccga ggaggtgttt gccttcctgc tgcgcttccc ccacgtggcc
1261 ctcttcacct tcgatggcct ggacgagctg cactcggact tggacctgag ccgcgtgcct
1321 gacagctcct gcccctggga gcctgcccac cccctggtct tgctggccaa cctgctcagt
1381 gggaagctgc tcaagggggc tagcaagctg ctcacagccc gcacaggcat cgaggtcccg
1441 cgccagttcc tgcggaagaa ggtgcttctc cggggcttct cccccagcca cctgcgcgcc
1501 tatgccagga ggatgttccc cgagcgggcc ctgcaggacc gcctgctgag ccagctggag
1561 gccaacccca acctctgcag cctgtgctct gtgcccctct tctgctggat catcttccgg
1621 tgcttccagc acttccgtgc tgcctttgaa ggctcaccac agctgcccga ctgcacgatg
1681 accctgacag atgtcttcct cctggtcact gaggtccatc tgaacaggat gcagcccagc
1741 agcctggtgc agcggaacac acgcagccca gtggagaccc tccacgccgg ccgggacact
1801 ctgtgctcgc tggggcaggt ggcccaccgg ggcatggaga agagcctctt tgtcttcacc
1861 caggaggagg tgcaggcctc cgggctgcag gagagagaca tgcagctggg cttcctgcgg
1921 gctttgccgg agctgggccc cgggggtgac cagcagtcct atgagttttt ccacctcacc
1981 ctccaggcct tctttacagc cttcttcctc gtgctggacg acagggtggg cactcaggag
2041 ctgctcaggt tcttccagga gtggatgccc cctgcggggg cagcgaccac gtcctgctat
2101 cctcccttcc tcccgttcca gtgcctgcag ggcagtggtc cggcgcggga agacctcttc
2161 aagaacaagg atcacttcca gttcaccaac ctcttcctgt gcgggctgtt gtccaaagcc
2221 aaacagaaac tccttcggca tctggtgccc gcggcagccc tgaggagaaa gcgcaaggcc
2281 ctgtgggcac acctgttttc cagcctgcgg ggctacctga agagcctgcc ccgcgttcag
2341 gtcgaaagct tcaaccaggt gcaggccatg cccacgttca tctggatgct gcgctgcatc
2401 tacgagacac agagccagaa ggtggggcag ctggcggcca ggggcatctg cgccaactac
2461 ctcaagctga cctactgcaa cgcctgctcg gccgactgca gcgccctctc cttcgtcctg
2521 catcacttcc ccaagcggct ggccctagac ctagacaaca acaatctcaa cgactacggc
2581 gtgcgggagc tgcagccctg cttcagccgc ctcactgttc tcagactcag cgtaaaccag
2641 atcactgacg gtggggtaaa ggtgctaagc gaagagctga ccaaatacaa aattgtgacc
2701 tatttgggtt tatacaacaa ccagatcacc gatgtcggag ccaggtacgt caccaaaatc
2761 ctggatgaat gcaaaggcct cacgcatctt aaactgggaa aaaacaaaat aacaagtgaa
2821 ggagggaagt atctcgccct ggctgtgaag aacagcaaat caatctctga ggttgggatg
2881 tggggcaatc aagttgggga tgaaggagca aaagccttcg cagaggctct gcggaaccac
2941 cccagcttga ccaccctgag tcttgcgtcc aacggcatct ccacagaagg aggaaagagc
3001 cttgcgaggg ccctgcagca gaacacgtct ctagaaatac tgtggctgac ccaaaatgaa
3061 ctcaacgatg aagtggcaga gagtttggca gaaatgttga aagtcaacca gacgttaaag
3121 catttatggc ttatccagaa tcagatcaca gctaagggga ctgcccagct ggcagatgcg
3181 ttacagagca acactggcat aacagagatt tgcctaaatg gaaacctgat aaaaccagag
3241 gaggccaaag tctatgaaga tgagaagcgg attatctgtt tctgagagga tgctttcctg
3301 ttcatggggt ttttgccctg gagcctcagc agcaaatgcc actctgggca gtcttttgtg
3361 tcagtgtctt aaaggggcct gcgcaggcgg gactatcagg agtccactgc ctccatgatg
3421 caagccagct tcctgtgcag aaggtctggt cggcaaactc cctaagtacc cgctacaatt
3481 ctgcagaaaa agaatgtgtc ttgcgagctg ttgtagttac agtaaataca ctgtgaagag
3541 aaaaaaaaaa cggacgcgtg g
//