LOCUS AF126372 5666 bp mRNA linear HUM 25-NOV-1999
DEFINITION Homo sapiens thyrotropin-releasing hormone degrading ectoenzyme
(TRHDE) mRNA, complete cds.
ACCESSION AF126372
VERSION AF126372.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5666)
AUTHORS Schomburg,L., Turwitt,S., Prescher,G., Lohmann,D., Horsthemke,B.
and Bauer,K.
TITLE Human TRH-degrading ectoenzyme cDNA cloning, functional expression,
genomic structure and chromosomal assignment
JOURNAL Eur. J. Biochem. 265 (1), 415-422 (1999)
PUBMED 10491199
REFERENCE 2 (bases 1 to 5666)
AUTHORS Schomburg,L., Turwitt,S. and Bauer,K.
TITLE Direct Submission
JOURNAL Submitted (05-FEB-1999) Max Planck Institut, Feodor-Lynen-Str. 7,
Hannover 30625, Germany
FEATURES Location/Qualifiers
source 1..5666
/db_xref="H-InvDB:HIT000070538"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q15-q21"
gene 1..5666
/gene="TRHDE"
CDS 97..3171
/gene="TRHDE"
/EC_number="3.4.19.6"
/note="Zn-metallopeptidase; pyroglutamyl aminopeptidase
II; PAP II; TRH-specific aminopeptidase"
/codon_start=1
/product="thyrotropin-releasing hormone degrading
ectoenzyme"
/protein_id="AAF13141.1"
/translation="MGEDDAALRAGSRGLSDPWADSVGVRPRTTERHIAVHKRLVLAF
AVSLVALLAVTMLAVLLSLRFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHA
GGDSWQPEAGGVASPGTTSAQPPSEEEREPWEPWTQLRLSGHLKPLHYNLMLTAFMEN
FTFSGEVNVEIACRNATRYVVLHASRVAVEKVQLAEDRAFGAVPVAGFFLYPQTQVLV
VVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYVLHGERRFLGVTQFSPTHARKAF
PCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAW
AICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPK
LDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDL
VTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPV
SQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARND
LWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDIS
AKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGN
INQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLE
IIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNN
FNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIV
YCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVV
LDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTE
GELKELKNFMKNYDGVAAASFSRAVETVEANVRWKMLYQDELFQWLGKALRH"
BASE COUNT 1699 a 1080 c 1193 g 1694 t
ORIGIN
1 aagaaaaaga agaagaaaaa gaggaagaag aagaaggagg aggaggagga ggaggaggag
61 ggggccgaga agagcagctc acccttcgca gccgcgatgg gggaagacga cgccgcgctt
121 cgggctggca gcagggggct ctccgacccg tgggcagact cagtgggagt gcgaccccgc
181 accacggagc gccacatcgc cgtacacaag cggcttgtgc tggccttcgc tgtgtccctc
241 gtggcattgc tcgcggtcac aatgctcgct gtgctgctca gcctgcgctt cgacgagtgc
301 ggggcgagtg ccacgccagg cgccgacggt ggcccctcag gctttccgga gcgcggcggc
361 aacgggagcc tccctggatc ggcccggcgc aaccaccacg caggcgggga ctcctggcag
421 cccgaggcgg gtggggtggc cagtccgggg accacgtcgg cccagccgcc gtcggaggag
481 gagcgggagc cgtgggagcc gtggacgcag ctgcgcctgt cgggccacct gaagccgctg
541 cactacaatc tgatgctcac cgccttcatg gagaacttca ccttctccgg ggaggtcaac
601 gtggagatcg cgtgccggaa cgccacccgc tacgtagtgc tgcacgcttc ccgagtggcg
661 gtggagaaag tgcagctggc cgaggaccgg gcgttcgggg ctgtccctgt agccggtttt
721 ttcctctacc cgcaaaccca ggtcttagtg gtggtgctga ataggacact ggacgcgcag
781 aggaattaca atctgaagat tatctacaac gcgctcatcg agaatgagct cctgggcttc
841 ttccgcagct cctatgtgct ccacggggag agaagattcc ttggtgttac tcagttttcg
901 cctacacatg ccagaaaggc atttccttgt tttgatgagc caatctacaa ggctactttc
961 aaaatcagca tcaagcatca agcaacctat ttatctttat ctaatatgcc agtggaaact
1021 tccgtgtttg aggaagatgg atgggttacg gatcactttt cacagacccc tctcatgtcc
1081 acatattatt tagcctgggc aatttgcaac ttcacataca gagaaactac caccaagagt
1141 ggggttgtag tacgattata tgcaagacct gatgctatca gaagaggatc cggggactat
1201 gctctccata taacaaagag attaatagaa ttttatgaag actactttaa agtgccctat
1261 tccttgccaa aactagatct tttagctgtg cctaagcatc cgtatgctgc tatggagaac
1321 tggggactaa gtatttttgt ggaacaaaga atactgctgg atcccagtgt ttcatctatt
1381 tcttatttgc tggatgtcac catggtcatt gttcatgaga tatgtcacca gtggtttggt
1441 gaccttgtga cgcctgtgtg gtgggaagac gtgtggctga aggaagggtt tgctcactac
1501 tttgaatttg ttggtacaga ctacctctat cctggctgga acatggaaaa gcagaggttt
1561 ctgaccgatg ttctgcatga agtgatgctg ctggacggtt tggccagttc ccatccagta
1621 tcacaggaag tgctgcaggc aacagatatt gacagggtgt ttgactggat cgcatataaa
1681 aagggtgctg ctttaataag aatgctggct aattttatgg gccattcagt tttccagagg
1741 ggtttgcaag attatttaac cattcataag tatggtaatg cagccagaaa tgatctctgg
1801 aatacattat cggaggcttt aaaaagaaat gggaaatatg taaatataca agaagtaatg
1861 gatcagtgga cactccagat gggttatcct gttatcacca tcttgggaaa cacaacagca
1921 gaaaatagaa taataattac ccaacagcat tttatctatg atatcagtgc taaaactaaa
1981 gcacttaaac ttcagaataa cagttacctg tggcagattc cattaactat tgtggtagga
2041 aatagaagcc atgtgtcttc agaagcaatt atttgggtgt ctaacaaatc agagcaccac
2101 agaataactt atttggacaa aggaagctgg ctgctgggga acatcaatca aactggctat
2161 tttagagtca actatgacct aaggaactgg agattattaa ttgatcaatt aatccggaat
2221 catgaggttc tttctgtcag taaccgagcg ggcttgatcg atgatgcctt cagcctagcc
2281 agggctggct atttgcctca gaatattcct ctggagatta tcagatacct gtctgaggag
2341 aaggattttc ttccttggca tgctgccagc cgagctcttt atcctctaga taaattactg
2401 gaccgcatgg aaaactacaa cattttcaat gaatatattt taaagcaagt tgcaacaaca
2461 tatatcaagc ttgggtggcc gaaaaataat tttaatggat ctcttgttca agcatcctac
2521 caacatgaag aactacgtag agaagttata atgctggcct gcagttttgg caacaagcac
2581 tgtcaccaac aggcatcaac acttatttca gattggattt ccagcaacag gaacagaata
2641 ccactaaatg ttagagacat cgtatactgt acaggagtgt cactactgga tgaggatgtc
2701 tgggaattca tatggatgaa attccattcc accacagcag tttctgagaa gaaaatatta
2761 ttggaagcct taacttgcag tgatgacagg aatttattaa acaggcttct aaatctgtca
2821 ctgaattctg aggtggtgct ggatcaagat gcaattgatg tcataatcca tgtagctcga
2881 aatccacatg gtcgagacct tgcctggaag tttttcaggg ataaatggaa gatattaaat
2941 accaggtatg gagaagcatt gtttatgaat tccaaactca tcagtggtgt cacagaattt
3001 cttaatactg aaggtgaact caaagagctc aagaacttca tgaaaaacta tgatggggta
3061 gctgctgctt ctttctcacg agctgtggaa actgtcgaag ccaatgtgcg ctggaaaatg
3121 ctttaccaag acgagctttt ccaatggtta ggaaaagctc taagacacta atatatgtat
3181 cttataaaca aacaattcaa ctcagaagtt tatgagaaga cacgcttttt gtggaatgag
3241 gaaaatgtac tacctagaaa atggccagat tttcagtgtt aacatgtggg aggaattttt
3301 tttttagttt ttattttttg gttttggggg atatttttta tttgtttcat tcattctgtt
3361 ctgtttctct actgggtgtt cctctctaaa gaaactcttg caagtgaaac tagccatgat
3421 tgcttcagct gtacattcct tgctgtacag gaccaaatat gatagtgatg catgttgatg
3481 ttacagtcaa tttggaaaaa catattcaga atatctgtgc atggatatat tgtcctgcct
3541 gtgttccagc atgcttattt caaacgtcca gtgttgtgtg tgaatatgtg ttacacctag
3601 gatgggcatt atgcaaaagc acaaagatta tatatgacaa tcagtattgc aatgaaagaa
3661 aaactaaaaa cagaaatgat attctcaatt ttgggcaatg tgagaggtaa aatagccctt
3721 gacatgatga acatcactta tttcagcact tggattgtct ggcaatgatt actgtgttgc
3781 taactcattt tctttgagtt aaagctgtgt atacatttta aaaggcatat agatagtgta
3841 tgcatatgta tatgtacata gggaagcccc atatgtatat agtatgttgt acactgcaca
3901 tgtacaaaga atgtcttcag atcaaagaaa atttatctct ttttataaac ttaaggacag
3961 ttgcaaaagg cttcaaggaa tttatctcaa cattattctt tctatgtcct aactaaattt
4021 ctcaactgtt atgaattttt catctacttc ttgaacagtg gtctattctg ctacatgaag
4081 atgaatacaa acaaaatttt tgtataaact actattccag ttctcctgtg tcagtcttgc
4141 ctatagattt tgccatcgtt ttctgtcaaa gttccttttg catgaaacaa ttatgcaaac
4201 ttataattat tagtgctgaa aaagagttta ttttccatct tgtttgtttt cctaccttat
4261 gctgagtagt ccagagagtt aaaaaaattc tctgcatgtt ggtcttttaa gtctgttttg
4321 ctctaatcct ccattaagcg agcatacctc aagtgggtct attagcattt aatgaccttt
4381 tatgccagtt gtgccatccc ttaagatgaa aagttccttt tcttgtgtta atgtacaaag
4441 cttttctttt ggcactgaca actgtgttct acctgggaat tttgaatagc cattttcatg
4501 gctgtgtgtt gtgtaacaca aatgttttta aatggtattc tcacccagta ggccagctct
4561 ccaaacgttg cttagatgct tcaaaattag catattttaa gtttaccagt ataaaatacc
4621 aatgcaacta ctctacatag ccaaatgttt gtaaatcacg tcttattttc ctgaggtttt
4681 tcactccacc aaatcttaca aatcattgaa agaaatatat tctaacagta cgcactgaat
4741 agtgaaaata attagacatt ttaagaacca gagccataga attattttaa attagtagaa
4801 aagaggagct atttccgaat ctatagaata aagtaccacc taaaactgaa ttttatcata
4861 taagcaagta atacctatta gtcataccta aatttttcag cacttcattc aattaaaata
4921 catgaatttt aaatatttta catgatgtga ataggcatga taatactttt agtataaaat
4981 ctaaactttt tccatttatc agaaatgata aaatccagtt accacatatt cacgtttata
5041 aaatccttaa ttaaatgagt aacttctaaa atataacaat actaaatatc acactgtgat
5101 ggaggtccca aatatgtggt ctatcaccac tgaattcatg taatagataa gaaaaaaatt
5161 agaggtggat gtcttgtttt gtgtcatgaa ttactaaaat ctcttagtag ttgtggtata
5221 tttttgagta aaattaccat ttccagattt gagtttgaag ggcttttata gttgtatttt
5281 cctcctcact gttaataatc ataatccttt ttcagtattt tagtggcctt gaacaactgg
5341 tttatctaca atctcaaatc ctaagtgtat aattatgtgc aatgttcaat acctcatata
5401 atacttgctc aacagtatag tggtaccaat ggcattaaga tggtgttttt gttctacata
5461 tttttcaata atttattctt tctaatgttg aaattatatc aggctttacc ggttttttta
5521 gttgtttaaa taagtaatat tttcaaaaga ataaaataac caatgatatc tcttggaata
5581 atctgtaaaa cgtagttata aaattctatt ttctacttaa aaaaaaaaaa aaaaaaaaaa
5641 aaaaaaaaaa aaaaaaaaaa aaaaaa
//