LOCUS AF126008 4290 bp mRNA linear HUM 23-MAR-1999
DEFINITION Homo sapiens breast cancer nuclear receptor-binding auxiliary
protein (BRX) mRNA, complete cds.
ACCESSION AF126008
VERSION AF126008.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4290)
AUTHORS Rubino,D., Driggers,P., Arbit,D., Kemp,L., Miller,B., Coso,O.,
Pagliai,K., Gray,K., Gutkind,S. and Segars,J.
TITLE Characterization of Brx, a novel Dbl family member that modulates
estrogen receptor action
JOURNAL Oncogene 16 (19), 2513-2526 (1998)
PUBMED 9627117
REFERENCE 2 (bases 1 to 4290)
AUTHORS Rubino,D.M., Driggers,P.H., Miller,B. and Segars,J.H.
TITLE Direct Submission
JOURNAL Submitted (04-FEB-1999) Obstetrics and Gynecology, Uniformed
Services of the Health Sciences, 4301 Jones Bridge Rd., Bethesda,
MD 20814, USA
FEATURES Location/Qualifiers
source 1..4290
/db_xref="H-InvDB:HIT000070527"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q25"
/clone="pDR2"
/tissue_type="testis"
/clone_lib="Clontech cat# K1450-1; Clontech lambda gt-aa
(ZR-75-1) cat# HL1059b"
gene 1..4290
/gene="BRX"
CDS 1..4290
/gene="BRX"
/note="Brx/Proto-Lbc; guanine nucleotide exchange factor;
similar to lbc; similar to the C-terminal region of ht31,
a type II cAMP-dependent protein kinase A-anchoring
protein (AKAP)"
/codon_start=1
/product="breast cancer nuclear receptor-binding auxiliary
protein"
/protein_id="AAD21311.1"
/translation="MLYINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTS
KQGVLKRESGSDSDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSS
HGSDVSLSQILKPNRSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEV
PANCSVLRSSMRSLSPFRRHSWGPGKNAASDAEMNHRSSMRVLGDVVRRPPIHRRSFS
LEGLTGGAGVGNKPSSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRM
FDQQICHRSKQQGFNYCTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTE
SITEENYNFLPHSPSKKDSEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKE
KDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRES
LASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFAN
RRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTESLTDEG
VGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFH
HVRTLKIMSGVYSQGMMADLLFEQQMDEKLFPCLDELISIHSQFFQRILERKKESLVD
KSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAF
VKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVK
DVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFL
KNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEEKGL
FLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLDT
RARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEA
LKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVSPVSLPRRAETFGGFD
SHQMNASKGGEKEEGGDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYE
LLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQ
KQQAQYLEEKRRREREWEARERELRDGRPSWPSARRRCSRGSRTWKRSGRSSSRRRAH
SQYDLERLRAAQKQLEREQEHVRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSP
EEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQ
APASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC"
BASE COUNT 1315 a 944 c 1137 g 894 t
ORIGIN
1 atgttgtata taaaccgaga aaactggtgt acaatagagc catgccctga tgcagcatct
61 cttctggctt ccaagcagag cccagaatgt gagaacttcc tggatgttgg actgggcaga
121 gagtgtacct caaaacaagg tgtacttaaa agagaatctg ggagtgattc tgacctcttt
181 cactcaccca gtgatgacat ggacagcatc atcttcccaa agccagagga agagcatttg
241 gcctgtgata tcaccggatc cagttcatcc accgatgaca cggcttcact ggaccgacat
301 tcttctcatg gcagtgatgt gtctctctcc cagattttaa agccaaacag gtcaagagat
361 cggcaaagcc ttgatggatt ctacagccat gggatgggag ctgagggtcg agaaagtgag
421 agtgagcctg ctgacccagg cgacgtggag gaggaggaga tggacagtat cactgaagtg
481 cctgcaaact gctctgtcct aaggagctcc atgcgctctc tttctccctt ccggaggcac
541 agctgggggc ctgggaaaaa tgcagccagc gatgcagaaa tgaaccaccg gagttcaatg
601 cgagttcttg gggatgttgt caggagacct cccattcata ggagaagttt cagtctagaa
661 ggcttgacag gaggagctgg tgtcggaaac aagccatcct catctctaga agtaagctct
721 gcaaatgccg aagagctcag acacccattc agtggtgagg aacgggttga ctctttggtg
781 tcactttcag aagaggatct ggagtcagac cagagagaac ataggatgtt tgatcagcag
841 atatgtcaca gatctaagca gcagggattt aattactgta catcagccat ttcctctcca
901 ttgacaaaat ccatctcatt aatgacaatc agccatcctg gattggacaa ttcacggccc
961 ttccacagta ccttccacaa taccagtgct aatctgactg agagtataac agaagagaac
1021 tataatttcc tgccacatag cccctccaag aaagattctg aatggaagag tggaacaaaa
1081 gtcagtcgta cattcagcta catcaagaat aaaatgtcta gcagcaagaa gagcaaagaa
1141 aaggaaaaag aaaaagataa gattaaggag aaggagaaag attctaaaga caaggagaaa
1201 gataagaaga ctgtcaacgg gcacactttc agttccattc ctgttgtggg tcccatcagc
1261 tgtagccagt gtatgaagcc cttcaccaac aaagatgcct atacttgtgc aaattgcagt
1321 gcttttgtcc acaaaggctg ccgagaaagt ctagcctcct gtgcaaaggt caaaatgaag
1381 cagcccaaag ggagccttca ggcacatgac acatcatcac tgcccacggt cattatgaga
1441 aacaagccct cacagcccaa ggagcgtcct cggtccgcag tcctcctggt ggatgaaacc
1501 gctaccaccc caatatttgc caatagacga tcccagcaga gtgtctcgct ctccaaaagt
1561 gtctccatac agaacattac tggagttggc aatgatgaga acatgtcaaa cacctggaaa
1621 ttcctgtctc attcaacaga ctcactaaat aaaatcagca aggtcaatga gtcaacagaa
1681 tcacttactg atgagggagt aggtacagac atgaatgaag gacaactact gggagacttt
1741 gagattgagt ccaaacagct ggaagcagag tcttggagtc ggataataga cagcaagttt
1801 ctaaaacagc aaaagaaaga tgtggtcaaa cggcaagaag taatatatga gttgatgcag
1861 acagagtttc atcatgtccg cactctcaag atcatgagtg gtgtgtacag ccaggggatg
1921 atggcggatc tgctttttga gcagcagatg gatgaaaagc tgttcccctg tttggatgag
1981 ctgatcagta tccatagcca attcttccag aggattctgg agcggaagaa ggagtctctg
2041 gtggataaaa gtgaaaagaa ctttctcatc aagaggatag gggatgtgct tgtaaatcag
2101 ttttcaggtg agaatgcaga acgtttaaag aagacatatg gcaagttttg tgggcaacat
2161 aaccagtctg taaactactt caaagacctt tatgccaagg ataagcgttt tcaagccttt
2221 gtaaagaaga agatgagcag ttcagttgtt agaaggcttg gaattccaga gtgcatattg
2281 cttgtaactc agcggattac caagtaccca gttttattcc aaagaatatt gcagtgtacc
2341 aaagacaatg aagtggagca ggaagatcta gcacagtcct tgagcctggt gaaggatgtg
2401 attggagctg tagacagcaa agtggcaagt tatgaaaaga aagtgcgtct caatgagatt
2461 tatacaaaga cagatagcaa gtcaatcatg aggatgaaga gtggtcagat gtttgccaag
2521 gaagatttga aacggaagaa gcttgtacgt gatgggagtg tgtttctgaa gaatgcagca
2581 ggaaggttga aagaggttca agcagttctt ctcactgaca ttttagtttt ccttcaagaa
2641 aaagaccaga agtacatctt tgcatcattg gaccagaagt caacagtgat ctctttaaag
2701 aagctgattg tgagagaagt ggcacatgag gagaaaggtt tattcctgat cagcatgggg
2761 atgacagatc cagagatggt agaagtccat gccagctcca aagaggaacg aaacagctgg
2821 attcagatca ttcaggacac aatcaacacc ctgaacagag atgaagatga aggaattcct
2881 agtgagaatg aggaagaaaa gaaaatgttg gacaccagag cccgagaatt aaaagaacaa
2941 cttcaccaga aggaccaaaa aatcctactc ttgttggaag agaaggagat gattttccgg
3001 gacatggctg agtgcagcac ccctctccca gaggattgct ccccaacaca tagccctaga
3061 gttctcttcc gctccaacac agaagaggct ctcaaaggag gacctttaat gaaaagtgca
3121 ataaatgagg tggagatcct tcagggtttg gtgagtggaa atctgggagg cacacttggg
3181 ccgactgtca gcagccccat tgagcaagat gtggtcagtc ccgtttccct gccccggaga
3241 gcagagacct ttggaggatt tgacagccat cagatgaatg cttcaaaagg aggcgagaag
3301 gaagagggag gtgatggcca agatcttagg agaacggaat cagatagtgg cctaaaaaag
3361 ggtggaaatg ctaacctggt atttatgctt aaaagaaaca gtgagcaggt tgtccagagc
3421 gttgttcatc tctacgagct cctcagcgct ctgcagggtg tggtgctgca gcaggacagc
3481 tacattgagg accagaaact ggtgctgagc gagagggcgc tcactcgcag cttgtcccgc
3541 ccgagctccc tcattgagca ggagaagcag cgcagcctgg agaagcagcg ccaggacctg
3601 gccaacctgc agaagcagca ggcccagtac ctcgaggaga agcgcaggcg cgagcgtgag
3661 tgggaagctc gtgagaggga gctgcgggac gggaggccct cctggcccag cgcgaggagg
3721 aggtgcagca ggggcagcag gacctggaaa aggagcggga ggagctccag cagaagaagg
3781 gcacatagcc agtatgacct ggagcgactg cgtgctgccc agaaacagct tgagagggaa
3841 caggagcacg tgcgccggga ggcagagcgg ctcagccagc ggcagacaga acgggacctg
3901 tgtcaggttt cccatccaca taccaagctg atgaggatcc catcgttctt ccccagtcct
3961 gaggagcccc cctcgccatc tgcaccttcc atagccaaat cagggtcatt ggactcagaa
4021 ctttcagtgt ccccaaaaag gaacagcatc tctcggacac acaaagataa ggggcctttt
4081 cacatactga gttcaaccag ccagacaaac aaaggaccag aagggcagag ccaggcccct
4141 gcgtccacct ctgcctctac ccgcctgttt gggttaacaa agccaaagga aaagaaggag
4201 aaaaaaaaga agaacaaaac cagccgctct cagcccggtg atggtcccgc gtcagaagta
4261 tcagcagagg gtgaagagat cttctgctga
//