LOCUS AF124491 2473 bp mRNA linear HUM 17-JUL-2000
DEFINITION Homo sapiens ARF GTPase-activating protein GIT2 (KIAA0148) mRNA,
complete cds.
ACCESSION AF124491
VERSION AF124491.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2473)
AUTHORS Premont,R.T., Claing,A., Vitale,N., Perry,S.J. and Lefkowitz,R.J.
TITLE The GIT family of ADP-ribosylation factor GTPase-activating
proteins. Functional diversity of GIT2 through alternative splicing
JOURNAL J. Biol. Chem. 275 (29), 22373-22380 (2000)
PUBMED 10896954
REFERENCE 2 (bases 1 to 2473)
AUTHORS Premont,R.T. and Lefkowitz,R.J.
TITLE Direct Submission
JOURNAL Submitted (28-JAN-1999) Cardiology, Department of Medicine, Duke
University Medical Center, Box 3821, Durham, NC 27710, USA
FEATURES Location/Qualifiers
source 1..2473
/db_xref="H-InvDB:HIT000070471"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q24.1"
gene 1..2473
/gene="KIAA0148"
CDS 1..2280
/gene="KIAA0148"
/note="GRK-interacting protein; PIX/Cool-interacting
protein; alternatively spliced compared to the sequence
presented in GenBank Accession Number D63482; includes
alternative exons A, B, C, D, and E"
/codon_start=1
/product="ARF GTPase-activating protein GIT2"
/protein_id="AAD28047.1"
/translation="MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRH
ISQVRHLKHTPWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPN
KAEFIRAKYQMLAFVHRLPCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQAN
FFHPEKGNTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAER
LVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNH
LFEELAMDVYDEVDRRETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKL
ARFNAHEFATLVIDILSDAKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDY
DSVASDEDTDLETTASKTNRQKSLDSDLSDGPVTVQEFMEVKNALVASEAKIQQLMKV
NNNLSDELRIMQKKLQTLQSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSAR
GSRPMSMYETGSGQKPYLPMGEASRPEESRMRLQPFPAHIGRSALVTSSSSLPSFPST
LSWSRDESARRASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVP
DTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTE
MAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAY
DIAKAAKQLVTITTKENNN"
BASE COUNT 737 a 626 c 586 g 524 t
ORIGIN
1 atgtcgaaac ggctccggag cagcgaggtg tgcgctgact gcagcgggcc ggatccttcc
61 tgggcatcag taaatagggg aacgttttta tgtgatgagt gctgcagtgt ccatcggagt
121 ctagggcgcc atatctccca agtgaggcat ctgaaacaca caccgtggcc tccaacactg
181 cttcagatgg ttgagacctt gtataataac ggtgctaact ctatatggga gcattctttg
241 ctggaccctg cgtctattat gagtggaaga cgtaaagcta atccacagga taaagtacat
301 cccaataaag cggaattcat cagagccaag tatcagatgt tagcgttcgt ccatcgcttg
361 ccctgccggg atgacgatag tgtgactgcc aaagatctta gcaagcaact ccattcgagc
421 gtgagaacag ggaatcttga aacctgtttg agactgttat ctttaggagc acaagccaac
481 ttctttcatc ctgaaaaagg aaacacccca ctccatgttg cctccaaagc agggcagatt
541 ttacaggctg aattattggc agtatatgga gcagacccag gcacacagga ttctagtggg
601 aaaactcccg ttgattatgc aaggcaagga gggcaccatg agctggcaga gcgcctcgtg
661 gaaatacagt atgagctaac ggacagacta gccttctatc tctgtggcag gaaaccagat
721 cacaaaaatg gacagcactt tataatacct caaatggcag acagcagcct ggatttgtct
781 gaattggcaa aagctgctaa gaagaaactt caatctctaa gtaatcattt gtttgaagaa
841 cttgccatgg atgtgtacga tgaagttgac aggcgagaga cggatgcagt ctggcttgcc
901 acgcaaaacc acagcgccct ggtaaccgag acaacggtcg tcccctttct tccggtcaat
961 cctgagtact catcaacacg aaatcagggc agacagaagt tagctcggtt caacgcccat
1021 gagtttgcca cgctggtcat tgacattctc agtgacgcca agaggagaca gcagggcagt
1081 tctctctcgg gttcaaaaga caatgtggag ctcatactga aaaccatcaa taaccagcac
1141 agcgttgaga gtcaagacaa cgatcagccc gactatgaca gcgtggcatc agacgaagac
1201 acagatttgg aaaccactgc aagcaaaaca aaccggcaga agagcctaga ttcagattta
1261 tcagatggac cagtcactgt acaggaattt atggaggtca aaaacgctct agtggcttct
1321 gaggccaaga tacagcagct aatgaaggtg aataacaact tgagtgacga gctgagaatt
1381 atgcagaaaa agcttcaaac actccagagt gaaaattcga acctcaggaa acaggccaca
1441 accaatgtat atcaggtgca aactggttct gagtacacag acacttccaa ccactcttcc
1501 ttaaagagac gtccgtctgc ccggggcagt aggcccatgt ccatgtacga gaccggatca
1561 ggtcagaaac catatctccc aatgggagaa gcgagccgcc ccgaagagag caggatgaga
1621 ctccagccct tccccgcgca catcgggagg agtgcacttg tgacctcctc ttcatctctg
1681 ccttccttcc cctccacact ttcctggtcg agggacgaaa gcgcccgaag ggcatccagg
1741 ctggagaagc agaacagcac acctgagagt gactacgaca acactcccaa cgacatggag
1801 ccagatggca tggggtcaag ccgaaaggga cggcaaagaa gtatggtgtg gccaggggat
1861 ggcttggtac cagacacagc agaaccccat gtggccccaa gccccactct ccctagcacc
1921 gaagatgtca tcaggaagac tgaacagatc accaaaaaca tacaggagct cttaagagca
1981 gcccaagaaa ataaacatga cagttatatt ccctgctcag agaggataca cgtagctgtt
2041 acagaaatgg cagcattatt ccccaaaaaa cccaagtctg atatggtgag gacttccctt
2101 cgtttactga cgtccagtgc ctaccgactg cagtcagagt gcaagaagac cctcccaggg
2161 gaccccggct cacccacaga cgttcagctg gtcacgcagc aggtcatcca gtgtgcgtac
2221 gacatcgcca aggctgccaa gcagctggtt accatcacca ccaaagagaa caacaactga
2281 caagggcagg gcaccgcctc ctctgttttc taggctttat aaagtccaat ttcaaattca
2341 gacgcagaac tcttcagatt tctacaaaaa gaaacattta atgacggttt aaaacttttt
2401 aaaagaaaac tcagtattat ttttgcatgt tttctaacca attttcaact atttaaccca
2461 cttgccttat ttt
//