LOCUS AF124490 3532 bp mRNA linear HUM 17-JUL-2000
DEFINITION Homo sapiens ARF GTPase-activating protein GIT1 mRNA, complete cds.
ACCESSION AF124490
VERSION AF124490.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3532)
AUTHORS Premont,R.T., Claing,A., Vitale,N., Perry,S.J. and Lefkowitz,R.J.
TITLE The GIT family of ADP-ribosylation factor GTPase-activating
proteins. Functional diversity of GIT2 through alternative splicing
JOURNAL J. Biol. Chem. 275 (29), 22373-22380 (2000)
PUBMED 10896954
REFERENCE 2 (bases 1 to 3532)
AUTHORS Premont,R.T. and Lefkowitz,R.J.
TITLE Direct Submission
JOURNAL Submitted (28-JAN-1999) Cardiology, Department of Medicine, Duke
University Medical Center, Box 3821, Durham, NC 27710, USA
FEATURES Location/Qualifiers
source 1..3532
/db_xref="H-InvDB:HIT000070470"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17p11.2"
CDS 15..2300
/note="GRK-interacting protein; PIX/Cool-interacting
protein"
/codon_start=1
/product="ARF GTPase-activating protein GIT1"
/protein_id="AAD28046.1"
/translation="MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRH
ISIVKHLRHSAWPPTLLQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPI
KSEFIRAKYQMLAFVHKLSCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQAN
FFHPEKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAER
LVECQYELTDRLAFYLCGRKPDHKNGHYIIPQMADSLDLSELAKAAKKKLQALSNRLF
EELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLAR
FNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDT
DQEPLRSTGATRSNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSL
SDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFS
MYEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVP
FTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYENTQSGDPLLGLEGKRFLELGKEEDF
HPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAV
TEMASLFPKRPALEPVRSSLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQC
AYDIAKAAKQLVTITTREKKQ"
BASE COUNT 728 a 1142 c 1017 g 645 t
ORIGIN
1 gttcgccgtg gaggatgtcc cgaaaggggc cgcgagcgga ggtgtgtgcg gactgcagcg
61 ccccggaccc tggctgggca tccatcagca ggggtgtgct ggtgtgtgac gagtgctgca
121 gcgtgcaccg gagcctggga cgccacatct ccattgtcaa gcaccttcgc cacagcgcct
181 ggcctcccac gctgctgcag atggtgcaca cgcttgccag caacggggcc aactccatct
241 gggagcactc cctgctggac cccgcacaag tgcagagcgg ccggcgtaaa gcaaaccccc
301 aagacaaagt ccaccccatc aagtcagagt tcatcagggc caagtaccag atgctggcat
361 ttgtgcacaa gctttcctgc cgggacgatg atggagtcac cgccaaagac ctcagcaagc
421 aactacactc gagcgtgcgg acaggcaacc tggagacatg tctgcgcctg ctctccctgg
481 gtgcccaggc caacttcttc cacccagaga agggcaccac acctctgcac gtggctgcca
541 aggcaggaca gacactgcag gccgagctgc ttgtagtgta tggggctgac cctggctccc
601 ctgatgttaa tggccgcaca cccattgact atgccaggca ggcggggcac catgagctgg
661 cggaaaggct ggttgagtgc caatatgagc tcactgaccg gctggccttc tacctctgtg
721 gacgcaagcc ggatcacaag aatgggcatt acatcatccc acagatggct gacagccttg
781 acttatccga attggccaaa gctgctaaga agaagctgca ggcgctcagc aaccggcttt
841 ttgaggaact cgccatggac gtgtatgacg aggtggatcg aagagaaaat gatgcagtgt
901 ggctggctac ccaaaaccac agcactctgg tgacagagcg cagtgctgtg cccttcctgc
961 ctgttaaccc ggaatactca gccacgcgga atcaggggcg acaaaagctg gcccgcttta
1021 atgcccgaga gtttgccacc ttgatcatcg acattctcag tgaggccaag cggagacagc
1081 agggcaagag cctgagcagc cccacagaca acctcgagct gtctctgcgg agccagagtg
1141 acctcgacga ccaacacgac tacgacagcg tggcctctga cgaggacaca gaccaggagc
1201 ccctgcgcag caccggcgcc actcggagca accgggcccg gagcatggac tcctcggact
1261 tgtctgacgg ggctgtgacg ctgcaggagt acctggagct gaagaaggcc ctggctacat
1321 cggaggcaaa ggtgcagcag ctcatgaagg tcaacagtag cctgagcgac gagctccgga
1381 ggctgcagcg agagatccac aagctgcagg cggagaacct gcagctccgg cagcctccag
1441 ggccggtgcc cacacctcca ctccccagtg aacgggcgga acacacaccc atggcgccag
1501 gcgggagcac acaccgcagg gatcgccagg ccttttccat gtatgaacct ggctctgccc
1561 tgaagccctt tgggggcccc cctggggacg agctcactac gcggctgcag cctttccaca
1621 gcactgagct agaggacgac gccatctatt cagtgcacgt ccctgctggc ctttaccgga
1681 tccggaaagg ggtgtctgcc tcagctgtgc ccttcactcc ctcctccccg ctgctgtcct
1741 gctcccagga gggaagccgc cacacgagca agctttcccg ccacggcagt ggagccgaca
1801 gtgactatga gaacacgcaa agtggggacc cactgctggg gctggaaggg aagaggtttc
1861 tagagctggg caaagaggaa gacttccacc cagagctgga aagcctggat ggagacctag
1921 atcctgggct tcccagcaca gaggatgtca tcttgaagac agagcaggtc accaagaaca
1981 ttcaggaact gttgcgggca gcccaggagt tcaagcatga cagcttcgtg ccctgctcag
2041 agaagatcca tttggctgtg accgagatgg cctccctctt cccaaagagg ccagccctgg
2101 agccagtgcg gagctcactg cggctgctca acgccagcgc ctaccggctg cagagtgagt
2161 gccggaagac agtgccccca gagcccggcg ccccagtgga cttccagctg ctgactcagc
2221 aggtgatcca gtgcgcctat gacatcgcca aggctgccaa gcagctggtc accatcacca
2281 cccgagagaa gaagcagtga cctctctccc cacaccctca cctgcaccct aggacctcac
2341 tggccatagg agctgggcca ctccagacat taatccccac cccaacagag ccactggcac
2401 aagtgccctt agtgctgcca cactccctgg gcagccaggt gccctggtgc ccacccctgt
2461 cgagccccta aggatgggga ggttgggggg gcaggagctt ctgtccccca cattccatgc
2521 acctcccctc tgtatatagc atctcccccc tcctagtgag caggggcctg caaggattca
2581 ctcccagccc ctcgccttct agggcaccct cagcaaaggg gcaggtgggg acactccaag
2641 tggggcagct ctccgtacat gcgccccacc cccatgagcc agttcagccc tactgggggc
2701 tgagcggggg catcccctcc tttgtacata gtctccatgg atgtccctgc cctgtagcca
2761 ccagcccctt gctgctctcc ctttaatgcc atatggcccc tgcctagggc acaggcccca
2821 acctgtgtgc tggggtcccc agcaggcaaa cactggaaag tctgtttttt ttttttcttt
2881 cttcttcccc accccttaat tttaactttg tggtaactga gtgcccccgc gtgcctgcgt
2941 gttgagtgtg tgggcggcag tgctttccgg aggcctggtc catctggagt tttgaggggt
3001 gaggggacca gagcagtggg accagcatgg ggatcagctt cccttcccca cctgggagcc
3061 agggactgtc cgggtagcca gttttggtcc tgccagctgc ctccctgatc cctccccact
3121 ctcgcccctt ctctatgaac ttaaaatcaa aaaaccactt ccctcccatc tcctccctgc
3181 tcctgcgtgg agggggaatg tgtgctggcc agggtggagg actgagcacc tgagcctggg
3241 gctggctccc cggggtcccc gactcagctg gtggctgtgg agctgagtcc cctccccgta
3301 acctctgcaa ggccagcacc caccatcact acctgcacct gctgtggtcc caccctctgg
3361 aggcctggga acctggctgc agcctgggaa ggctggagag gcagacggtg ggacccacca
3421 gctctctccc catcccgctt cttccctggg gccaggccct acctgtgtgg tggtgggtgg
3481 gctgtcaaga cgtgtcatgt acatttgtat caaaaataaa gaagtgacca tg
//