LOCUS AF118886 2565 bp mRNA linear HUM 26-OCT-1999
DEFINITION Homo sapiens VAV-3 protein beta isoform (VAV-3) mRNA, alternatively
spliced, complete cds.
ACCESSION AF118886
VERSION AF118886.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2565)
AUTHORS Movilla,N. and Bustelo,X.R.
TITLE Biological and regulatory properties of Vav-3, a new member of the
Vav family of oncoproteins
JOURNAL Mol. Cell. Biol. 19 (11), 7870-7885 (1999)
PUBMED 10523675
REFERENCE 2 (bases 1 to 2565)
AUTHORS Movilla,N. and Bustelo,X.R.
TITLE Direct Submission
JOURNAL Submitted (08-JAN-1999) Pathology, State Universtity of New York at
Stony Brook, University Hospital, Level 2, Room 718B, Stony Brook,
NY 11794-7025, USA
FEATURES Location/Qualifiers
source 1..2565
/db_xref="H-InvDB:HIT000070189"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="placenta"
gene 1..2565
/gene="VAV-3"
CDS 141..2402
/gene="VAV-3"
/function="activates Rho/Rac GTP synthase"
/note="guanosine nucleotide exchange factor; member Vav
protein family; contains acidic, zinc finger, SH2, SH3,
Dbl, and pleckstrin domains; tyrosine phosphorylated;
similar to calponin"
/codon_start=1
/product="VAV-3 protein beta isoform"
/protein_id="AAD20348.1"
/translation="MQLPDCPCRAHLPVIETLSRLSRTPIALATGIRPFPTEESINDE
DIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCC
LAEIKQTEEKYTETLESIEKHFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHD
SIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKR
ANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVNE
VKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLA
AIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKT
KDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQGYLC
FKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRN
YSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKH
IKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQR
GNRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGR
VGWFPSTYVEEDE"
BASE COUNT 847 a 499 c 577 g 642 t
ORIGIN
1 tgcccgggca ggtcagaaac caggatgcaa catctgtgcc tcgagcctct gctgctagat
61 agcaacctaa tgttgtaggg gtgtgatgcc gtggacccct tcttgaaccc ccaagttcgt
121 cttgcatttg gggctctagc atgcagctgc ctgattgccc ttgcagagcc cacctccctg
181 ttatagaaac attatcacga ctttctcgaa cacctatagc attggccaca ggaatcaggc
241 ccttcccaac agaagaaagc attaatgatg aagacatcta caaaggcctt cctgatttaa
301 tagatgaaac ccttgtggaa gatgaagaag atctctatga ctgtgtttat ggggaagatg
361 aaggtggaga agtctatgag gacttaatga aggcagagga ggcacatcag cccaaatgtc
421 cagaaaatga tatacgaagt tgttgtctag cagaaattaa gcagacagaa gaaaaatata
481 cagaaacttt ggagtcaata gaaaagcatt tcatggcacc actaaaaaga tttctgacag
541 cagcagaatt tgattcagta ttcatcaaca ttcctgaact tgtaaaactt catcggaacc
601 taatgcaaga gattcatgat tccattgtaa ataaaaatga ccagaacttg taccaagttt
661 ttattaacta caaggaaaga ttggttattt acgggcagta ctgcagtgga gtggagtcag
721 ccatctctag tttagactac atttctaaga caaaagaaga tgtcaaactg aaattagagg
781 aatgttccaa aagagcaaat aatgggaaat ttactcttcg agacttgctt gtggttccta
841 tgcaacgtgt tttaaagtac caccttctcc tccaggaact ggtcaaacat accactgatc
901 cgactgagaa ggcaaatctg aaactggctc ttgatgccat gaaggacttg gcacaatatg
961 tgaatgaagt gaaaagagat aatgagaccc ttcgtgaaat taaacagttt cagctatcta
1021 tagagaattt gaaccaacca gttttgcttt ttggacgacc tcagggagat ggtgaaattc
1081 gaataaccac tctagacaag cataccaaac aagaaaggca tatcttctta tttgatttgg
1141 cagcgatcgt atgtaagaga aaaggtgata attatgaaat gaaggaaata atagatcttc
1201 agcagtacaa gatagccaat aatcctacaa ccgataaaga aaacaaaaag tggtcttatg
1261 gcttctacct catccatacc caaggacaaa atgggttaga attttattgc aaaacaaaag
1321 atttaaagaa gaaatggcta gaacagtttg aaatggcttt gtctaacata agaccagact
1381 atgcagactc caatttccac gacttcaaga tgcatacctt cactcgagtc acatcctgca
1441 aagtctgcca gatgctcctg aggggaacat tttatcaagg ctatttatgt tttaagtgtg
1501 gagcgagagc acacaaagag tgtttgggaa gagtagacaa ttgtggcaga gttaattctg
1561 gtgaacaagg gacactcaaa ctaccagaga aacggaccaa tggactgcga agaactccta
1621 aacaggtgga tccaggttta ccaaagatgc aggtcattag gaactattct ggaacaccac
1681 ccccagctct gcatgaagga ccccctttac agctccaggc cggggatacc gttgaacttc
1741 tgaaaggaga tgcacacagt ctgttttggc agggcagaaa tttagcatct ggagaggttg
1801 gattttttcc aagtgatgca gtcaagcctt gcccatgtgt gcccaaacca gtagattatt
1861 cttgccaacc ctggtatgct ggagcaatgg aaagattgca agcagagacc gaacttatta
1921 atagggtaaa tagtacttac cttgtgaggc acaggaccaa agagtcagga gaatatgcaa
1981 ttagcattaa gtacaataat gaagcaaagc acatcaagat tttaacaaga gatggctttt
2041 ttcacattgc agaaaataga aaatttaaaa gtttaatgga acttgtggag tactacaagc
2101 atcattctct caaggaaggg ttcagaacct tagatacaac tctgcagttt ccatacaagg
2161 agccagaaca ttcagctgga cagaggggta atagagcagg caacagcttg ttaagtccaa
2221 aagtgctggg cattgccatc gctcggtatg acttctgtgc aagagatatg agagagttgt
2281 ccttgttgaa aggagatgtg gtgaagattt acacaaagat gagtgcaaat ggctggtgga
2341 gaggagaagt aaatggcagg gtgggctggt ttccatccac atatgtggaa gaggatgaat
2401 aaattcaaat cccgtgttgc accgctgcac caaaaatttc agagaaggga taaatagaag
2461 cctgcacagc atcgtgaatt aactgaagtg tttaaaaagc tgcatttctg gctgttcaac
2521 atcctccctc cttagcccct cctaagtctt aatgctgaga tttct
//