LOCUS AF118395 1485 bp mRNA linear HUM 04-MAY-1999
DEFINITION Homo sapiens trans-prenyltransferase mRNA, complete cds.
ACCESSION AF118395
VERSION AF118395.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1485)
AUTHORS Rotig,A., Geromel,V., Chretien,D., Parfait,B., Kadhom,N., Edery,P.,
Lebideau,M., Rustin,P., Munnich,A., Appelkvist,E.-L., Dallner,G.
and Ernster,L.
TITLE Widespread coenzyme Q10 deficiency in familial mitochondrial
encephalomyopathy
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1485)
AUTHORS Rotig,A., Geromel,V., Chretien,D., Parfait,B., Kadhom,N., Edery,P.,
Lebideau,M., Rustin,P., Munnich,A., Appelkvist,E.-L., Dallner,G.
and Ernster,L.
TITLE Direct Submission
JOURNAL Submitted (07-JAN-1999) INSERM U393, Necker Hospital, 149 rue de
Sevres, Paris 75015, France
FEATURES Location/Qualifiers
source 1..1485
/db_xref="H-InvDB:HIT000070181"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 26..1156
/function="catalyzes the formation of all trans-polyprenyl
pyrophosphates from isopentyl diphosphate in the assembly
of polyisoprenoid side chains"
/note="TPT; polyprenyl pyrophosphate synthetase"
/codon_start=1
/product="trans-prenyltransferase"
/protein_id="AAD28559.1"
/translation="MPAQAHRQKGLDLSQIPYFNLVKHLTPACPNVYSISQFHHTTPY
SKTHSGEKYTDPFKLGWRDLKGLYEGIRKEPLISTTELKEISEYYFDVKGKAFRPIIV
VLMARACNIHHNNSRHVQASQRAIALIAEMIHTASLVHDDVIDDASSRRGKHTVNKIW
GEKKAVLAGDLILSAASIALARIGNTTVISILTQVIEDLVRGEFLQLGSKENENERFA
HYLEKTFKKTASLIANSCKAVSVLGCPDPVVHEIAYQYGKNVGIAFQLIDDVLDFTSC
SDQMGKPTSADLKLGLATGPVLFACQQFPEMNAMIMRRFSLPGDVDRARQYVLQSDGV
QQTTYLAQQYCHEAIREISKLRPSPERDALIQLSEIVLTRDK"
BASE COUNT 462 a 309 c 304 g 410 t
ORIGIN
1 gggccggggc cgcgcgccgc tgccgatgcc cgcgcaggct cataggcaga agggacttga
61 cttgtctcag ataccctatt ttaatcttgt gaagcattta acacctgcct gtccaaatgt
121 atatagtata tcacagtttc atcacacaac cccgtacagc aaaacacaca gtggtgagaa
181 atacaccgat cctttcaaac tcggttggag agacttgaaa ggtctgtatg agggtattag
241 aaaggaaccc ctcatatcaa caacagaact taaggaaatc tctgagtact actttgatgt
301 aaaaggaaaa gcctttagac cgattattgt ggtgctaatg gcccgagcat gcaatattca
361 tcataacaac tcccgacatg tgcaagccag ccagcgcgcc atagccttaa ttgcagaaat
421 gatccacact gctagtctgg ttcacgatga cgttattgac gatgcaagtt ctcgaagagg
481 aaaacacaca gttaataaga tctggggtga aaagaaggct gttcttgctg gagatttaat
541 tctttctgca gcatctatag ctctggcacg aattggaaat acaactgtta tatctatttt
601 aacccaagtt attgaagatt tggtgcgtgg tgaatttctt cagctcgggt caaaagaaaa
661 tgagaatgaa agatttgcac actaccttga gaagacattc aagaagaccg ccagcctgat
721 agccaacagt tgtaaagcag tctctgttct aggatgtccc gacccagtgg tgcatgagat
781 cgcctatcag tacggaaaaa atgtaggaat agcttttcag ctaatagatg atgtattgga
841 cttcacctcg tgttctgacc agatgggcaa accaacatca gctgatctga agctcgggtt
901 agccactggt cctgtcctgt ttgcctgtca gcagttccca gaaatgaatg ctatgatcat
961 gcgacggttc agtttgcctg gagatgtaga cagagctcga cagtatgtac tacagagtga
1021 tggtgtgcaa caaacaacct acctcgccca gcagtactgc catgaagcaa taagagagat
1081 cagtaaactt cgaccatccc cagaaagaga tgccctcatt cagctttcag aaattgtact
1141 cacaagagat aaatgacaac tctttctgtt ctttctggca gctatcttac cagactgtgc
1201 ctaaagaatt ttgtggaata cactttgttt gcttcatgtg cagataacca aaaatcattt
1261 taaaagatat caaacttatt gatgggcaat ttattttttt ttattgcaaa aggtttttca
1321 gaaaactttt taaatgtaat taataaacca cctgaatctg tcattctagt cctataaatt
1381 ataatcaagg tatcttgatg gttatatgtg gtattgttta cactgttaat atccacatgt
1441 aaggccatta cacaaataaa taaccaatgt taaaattcaa aaaaa
//