LOCUS AF118224 3149 bp mRNA linear HUM 30-DEC-1999
DEFINITION Homo sapiens matriptase mRNA, complete cds.
ACCESSION AF118224
VERSION AF118224.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2955)
AUTHORS Lin,C.Y., Anders,J., Johnson,M., Sang,Q.A. and Dickson,R.B.
TITLE Molecular cloning of cDNA for matriptase, a matrix-degrading serine
protease with trypsin-like activity
JOURNAL J. Biol. Chem. 274 (26), 18231-18236 (1999)
PUBMED 10373424
REFERENCE 2 (bases 1 to 2955)
AUTHORS Lin,C.Y., Anders,J., Johnson,M., Sang,Q.A. and Dickson,R.B.
TITLE Direct Submission
JOURNAL Submitted (06-JAN-1999) Lombardi Cancer Center, Georgetown
University Medical Center, 3970 Reservoir Road NW, Washington, DC
20007, USA
REFERENCE 3 (bases 1 to 3149)
AUTHORS Oberst,M.D., Dickson,R.B. and Lin,C.Y.
TITLE Direct Submission
JOURNAL Submitted (30-DEC-1999) Lombardi Cancer Center, Georgetown
University Medical Center, 3970 Reservoir Road NW, Washington, DC
20007, USA
REMARK Sequence update by submitter
COMMENT On Dec 30, 1999 this sequence version replaced AF118224.1.
FEATURES Location/Qualifiers
source 1..3149
/db_xref="H-InvDB:HIT000070171"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 36..2603
/function="degrade extracellular matrix"
/note="serine protease with trypsin-like activity;
contains C1r/s and LDL receptor domains"
/codon_start=1
/product="matriptase"
/protein_id="AAD42765.2"
/translation="MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNV
KKVEKHGPGRWVVLAAVLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFV
DAYENSNSTEFVSLASKVKDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFS
IPQHLVEEAERVMAEERVVMLPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGL
HARGVELMRFTTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLV
TVYNTLSPMEPHALVQLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQL
PRMSSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGV
PAGTCPKDYVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSS
DPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVC
DSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVT
CTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQARVVGGTDADEG
EWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQS
QRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFP
AGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGV
DSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENTGV"
BASE COUNT 647 a 959 c 962 g 581 t
ORIGIN
1 gacgcctgtg agacccgcga gcggcctcgg ggaccatggg gagcgatcgg gcccgcaagg
61 gcggaggggg cccgaaggac ttcggcgcgg gactcaagta caactcccgg cacgagaaag
121 tgaatggctt ggaggaaggc gtggagttcc tgccagtcaa caacgtcaag aaggtggaaa
181 agcatggccc ggggcgctgg gtggtgctgg cagccgtgct gatcggcctc ctcttggtct
241 tgctggggat cggcttcctg gtgtggcatt tgcagtaccg ggacgtgcgt gtccagaagg
301 tcttcaatgg ctacatgagg atcacaaatg agaattttgt ggatgcctac gagaactcca
361 actccactga gtttgtaagc ctggccagca aggtgaagga cgcgctgaag ctgctgtaca
421 gcggagtccc attcctgggc ccctaccaca aggagtcggc tgtgacggcc ttcagcgagg
481 gcagcgtcat cgcctactac tggtctgagt tcagcatccc gcagcacctg gtggaggagg
541 ccgagcgcgt catggccgag gagcgcgtag tcatgctgcc cccgcgggcg cgctccctga
601 agtcctttgt ggtcacctca gtggtggctt tccccacgga ctccaaaaca gtacagagga
661 cccaggacaa cagctgcagc tttggcctgc acgcccgcgg tgtggagctg atgcgcttca
721 ccacgcccgg cttccctgac agcccctacc ccgctcatgc ccgctgccag tgggccctgc
781 ggggggacgc cgactcagtg ctgagcctca ccttccgcag ctttgacctt gcgtcctgcg
841 acgagcgcgg cagcgacctg gtgacggtgt acaacaccct gagccccatg gagccccacg
901 ccctggtgca gttgtgtggc acctaccctc cctcctacaa cctgaccttc cactcctccc
961 agaacgtcct gctcatcaca ctgataacca acactgagcg gcggcatccc ggctttgagg
1021 ccaccttctt ccagctgcct aggatgagca gctgtggagg ccgcttacgt aaagcccagg
1081 ggacattcaa cagcccctac tacccaggcc actacccacc caacattgac tgcacatgga
1141 acattgaggt gcccaacaac cagcatgtga aggtgcgctt caaattcttc tacctgctgg
1201 agcccggcgt gcctgcgggc acctgcccca aggactacgt ggagatcaat ggggagaaat
1261 actgcggaga gaggtcccag ttcgtcgtca ccagcaacag caacaagatc acagttcgct
1321 tccactcaga tcagtcctac accgacaccg gcttcttagc tgaatacctc tcctacgact
1381 ccagtgaccc atgcccgggg cagttcacgt gccgcacggg gcggtgtatc cggaaggagc
1441 tgcgctgtga tggctgggcc gactgcaccg accacagcga tgagctcaac tgcagttgcg
1501 acgccggcca ccagttcacg tgcaagaaca agttctgcaa gcccctcttc tgggtctgcg
1561 acagtgtgaa cgactgcgga gacaacagcg acgagcaggg gtgcagttgt ccggcccaga
1621 ccttcaggtg ttccaatggg aagtgcctct cgaaaagcca gcagtgcaat gggaaggacg
1681 actgtgggga cgggtccgac gaggcctcct gccccaaggt gaacgtcgtc acttgtacca
1741 aacacaccta ccgctgcctc aatgggctct gcttgagcaa gggcaaccct gagtgtgacg
1801 ggaaggagga ctgtagcgac ggctcagatg agaaggactg cgactgtggg ctgcggtcat
1861 tcacgagaca ggctcgtgtt gttgggggca cggatgcgga tgagggcgag tggccctggc
1921 aggtaagcct gcatgctctg ggccagggcc acatctgcgg tgcttccctc atctctccca
1981 actggctggt ctctgccgca cactgctaca tcgatgacag aggattcagg tactcagacc
2041 ccacgcagtg gacggccttc ctgggcttgc acgaccagag ccagcgcagc gcccctgggg
2101 tgcaggagcg caggctcaag cgcatcatct cccacccctt cttcaatgac ttcaccttcg
2161 actatgacat cgcgctgctg gagctggaga aaccggcaga gtacagctcc atggtgcggc
2221 ccatctgcct gccggacgcc tcccatgtct tccctgccgg caaggccatc tgggtcacgg
2281 gctggggaca cacccagtat ggaggcactg gcgcgctgat cctgcaaaag ggtgagatcc
2341 gcgtcatcaa ccagaccacc tgcgagaacc tcctgccgca gcagatcacg ccgcgcatga
2401 tgtgcgtggg cttcctcagc ggcggcgtgg actcctgcca gggtgattcc gggggacccc
2461 tgtccagcgt ggaggcggat gggcggatct tccaggccgg tgtggtgagc tggggagacg
2521 gctgcgctca gaggaacaag ccaggcgtgt acacaaggct ccctctgttt cgggactgga
2581 tcaaagagaa cactggggta taggggccgg ggccacccaa atgtgtacac ctgcggggcc
2641 acccatcgtc caccccagtg tgcacgcctg caggctggag actggaccgc tgactgcacc
2701 agcgccccca gaacatacac tgtgaactca atctccaggg ctccaaatct gcctagaaaa
2761 cctctcgctt cctcagcctc caaagtggag ctgggaggta gaaggggagg acactggtgg
2821 ttctactgac ccaactgggg gcaaaggttt gaagacacag cctcccccgc cagccccaag
2881 ctgggccgag gcgcgtttgt gtatatctgc ctcccctgtc tgtaaggagc agcgggaacg
2941 gagcttcgga gcctcctcag tgaaggtggt ggggctgccg gatctgggct gtggggccct
3001 tgggccacgc tcttgaggaa gcccaggctc ggaggaccct ggaaaacaga cgggtctgag
3061 actgaaaatg gtttaccagc tcccaggtga cttcagtgtg tgtattgtgt aaatgagtaa
3121 aacattttat ttctttttaa aaaaaaaaa
//