LOCUS AF117907 5874 bp mRNA linear HUM 18-MAY-1999 DEFINITION Homo sapiens tetrodotoxin-resistant voltage-gated sodium channel (SCN10A) mRNA, complete cds. ACCESSION AF117907 VERSION AF117907.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5874) AUTHORS Rabert,D.K., Koch,B.D., Ilnicka,M., Obernolte,R.A., Naylor,S.L., Herman,R.C., Eglen,R.M., Hunter,J.C. and Sangameswaran,L. TITLE A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A JOURNAL Pain 78 (2), 107-114 (1998) PUBMED 9839820 REFERENCE 2 (bases 1 to 5874) AUTHORS Rabert,D.K., Koch,B.D., Ilnicka,M., Obernolte,R.A., Naylor,S.L., Herman,R.C., Eglen,R.M., Hunter,J.C. and Sangameswaran,L. TITLE Direct Submission JOURNAL Submitted (05-JAN-1999) Target Identification, Roche Bioscience, 3401 Hillview, Palo Alto, CA 94304, USA FEATURES Location/Qualifiers source 1..5874 /db_xref="H-InvDB:HIT000070126" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3p24.2-p22" /tissue_type="dorsal root ganglia" gene 1..5874 /gene="SCN10A" CDS 1..5871 /gene="SCN10A" /note="SCN10A/PN3" /codon_start=1 /product="tetrodotoxin-resistant voltage-gated sodium channel" /protein_id="AAD30863.1" /translation="MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQ KDQEEKPRPQLDLKACNQLPKFYGELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTIS RFSATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEYVF TVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFR VLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKC VKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDF NYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLI LAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPL TSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFR SPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSPLPQPSNPDSRHGE DEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVLEEL EESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFM AMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVS LLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIV FVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWA CMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVAL ARIQVFGHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLSSSKAENHIAANTARGSSG GLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQ EQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQAPAEGVDDTSSSEGST VDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCY RIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLK WVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALS RFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSL VPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVD SREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMT EEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMM VETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIA SLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNI GLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLS PILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIVVNMYIAVILENFN VATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNI LIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPI ATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRAEEEAASLPDEGFVAFTAN ENCVLPDKSETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEATSMELIAPGP" BASE COUNT 1434 a 1552 c 1428 g 1460 t ORIGIN 1 atggaattcc ccattggatc cctcgaaact aacaacttcc gtcgctttac tccggagtca 61 ctggtggaga tagagaagca aattgctgcc aagcagggaa caaagaaagc cagagagaag 121 catagggagc agaaggacca agaagagaag cctcggcccc agctggactt gaaagcctgc 181 aaccagctgc ccaagttcta tggtgagctc ccagcagaac tgatcgggga gcccctggag 241 gatctagatc cgttctacag cacacaccgg acatttatgg tgctgaacaa agggaggacc 301 atttcccggt ttagtgccac tcgggccctg tggctattca gtcctttcaa cctgatcaga 361 agaacggcca tcaaagtgtc tgtccactcg tggttcagtt tatttattac ggtcactatt 421 ttggttaatt gtgtgtgcat gacccgaact gaccttccag agaaaattga atatgtcttc 481 actgtcattt acacctttga agccttgata aagatactgg caagaggatt ttgtctaaat 541 gagttcacgt acctgagaga tccttggaac tggctggatt ttagcgtcat taccctggca 601 tatgttggca cagcaataga tctccgtggg atctcaggcc tgcggacatt cagagttctt 661 agagcattaa aaacagtttc tgtgatccca ggcctgaagg tcattgtggg ggccctgatt 721 cactcagtga agaaactggc tgatgtgacc atcctcacca tcttctgcct aagtgttttt 781 gccttggtgg ggctgcaact cttcaagggc aacctcaaaa ataaatgtgt caagaatgac 841 atggctgtca atgagacaac caactactca tctcacagaa aaccagatat ctacataaat 901 aagcgaggca cttctgaccc cttactgtgt ggcaatggat ctgactcagg ccactgccct 961 gatggttata tctgccttaa aacttctgac aacccggatt ttaactacac cagctttgat 1021 tcctttgctt gggctttcct ctcactgttc cgcctcatga cacaggattc ctgggaacgc 1081 ctctaccagc agaccctgag gacttctggg aaaatctata tgatcttttt tgtgctcgta 1141 atcttcctgg gatctttcta cctggtcaac ttgatcttgg ctgtagtcac catggcgtat 1201 gaggagcaga accaggcaac cactgatgaa attgaagcaa aggagaagaa gttccaggag 1261 gccctcgaga tgctccggaa ggagcaggag gtgctagcag cactagggat tgacacaacc 1321 tctctccact cccacaatgg atcaccttta acctccaaaa atgccagtga gagaaggcat 1381 agaataaagc caagagtgtc agagggctcc acagaagaca acaaatcacc ccgctctgat 1441 ccttacaacc agcgcaggat gtcttttcta ggcctcgcct ctggaaaacg ccgggctagt 1501 catggcagtg tgttccattt ccggtcccct ggccgagata tctcactccc tgagggagtc 1561 acagatgatg gagtctttcc tggagaccac gaaagccatc ggggctctct gctgctgggt 1621 gggggtgctg gccagcaagg ccccctccct agaagccctc ttcctcaacc cagcaaccct 1681 gactccaggc atggagaaga tgaacaccaa ccgccgccca ctagtgagct tgcccctgga 1741 gctgtcgatg tctcggcatt cgatgcagga caaaagaaga ctttcttgtc agcagaatac 1801 ttagatgaac ctttccgggc ccaaagggca atgagtgttg tcagtatcat aacctccgtc 1861 cttgaggaac tcgaggagtc tgaacagaag tgcccaccct gcttgaccag cttgtctcag 1921 aagtatctga tctgggattg ctgccccatg tgggtgaagc tcaagacaat tctctttggg 1981 cttgtgacgg atccctttgc agagctcacc atcaccttgt gcatcgtggt gaacaccatc 2041 ttcatggcca tggagcacca tggcatgagc cctaccttcg aagccatgct ccagataggc 2101 aacatcgtct ttaccatatt ttttactgct gaaatggtct tcaaaatcat tgccttcgac 2161 ccatactatt atttccagaa gaagtggaat atctttgact gcatcatcgt cactgtgagt 2221 ctgctagagc tgggcgtggc caagaaggga agcctgtctg tgctgcggag cttccgcttg 2281 ctgcgcgtat tcaagctggc caaatcctgg cccaccttaa acacactcat caagatcatc 2341 ggaaactcag tgggggcact ggggaacctc accatcatcc tggccatcat tgtctttgtc 2401 tttgctctgg ttggcaagca gctcctaggg gaaaactacc gtaacaaccg aaaaaatatc 2461 tccgcgcccc atgaagactg gccccgctgg cacatgcacg acttcttcca ctctttcctc 2521 attgtcttcc gtatcctctg tggagagtgg attgagaaca tgtgggcctg catggaagtt 2581 ggccaaaaat ccatatgcct catccttttc ttgacggtga tggtgctagg gaacctggtg 2641 gtgcttaacc tgttcatcgc cctgctattg aactctttca gtgctgacaa cctcacagcc 2701 ccggaggacg atggggaggt gaacaacctg caggtggccc tggcacggat ccaggtcttt 2761 ggccatcgta ccaaacaggc tctttgcagc ttcttcagca ggtcctgccc attcccccag 2821 cccaaggcag agcctgagct ggtggtgaaa ctcccactct ccagctccaa ggctgagaac 2881 cacattgctg ccaacactgc cagggggagc tctggagggc tccaagctcc cagaggcccc 2941 agggatgagc acagtgactt catcgctaat ccgactgtgt gggtctctgt gcccattgct 3001 gagggtgaat ctgatcttga tgacttggag gatgatggtg gggaagatgc tcagagcttc 3061 cagcaggaag tgatccccaa aggacagcag gagcagctgc agcaagtcga gaggtgtggg 3121 gaccacctga cacccaggag cccaggcact ggaacatctt ctgaggacct ggctccatcc 3181 ctgggtgaga cgtggaaaga tgagtctgtt cctcaggccc ctgctgaggg agtggacgac 3241 acaagctcct ctgagggcag cacggtggac tgcctagatc ctgaggaaat cctgaggaag 3301 atccctgagc tggcagatga cctggaagaa ccagatgact gcttcacaga aggatgcatt 3361 cgccactgtc cctgctgcaa actggatacc accaagagtc catgggatgt gggctggcag 3421 gtgcgcaaga cttgctaccg tatcgtggag cacagctggt ttgagagctt catcatcttc 3481 atgatcctgc tcagcagtgg atctctggcc tttgaagact attacctgga ccagaagccc 3541 acggtgaaag ctttgctgga gtacactgac agggtcttca cctttatctt tgtgttcgag 3601 atgctgctta agtgggtggc ctatggcttc aaaaagtact tcaccaatgc ctggtgctgg 3661 ctggacttcc tcattgtgaa tatctcactg ataagtctca cagcgaagat tctggaatat 3721 tctgaagtgg ctcccatcaa agcccttcga acccttcgcg ctctgcggcc actgcgggct 3781 ctttctcgat ttgaaggcat gcgggtggtg gtggatgccc tggtgggcgc catcccatcc 3841 atcatgaatg tcctcctcgt ctgcctcatc ttctggctca tcttcagcat catgggtgtg 3901 aacctcttcg cagggaagtt ttggaggtgc atcaactata ccgatggaga gttttccctt 3961 gtacctttgt cgattgtgaa taacaagtct gactgcaaga ttcaaaactc cactggcagc 4021 ttcttctggg tcaatgtgaa agtcaacttt gataatgttg caatgggtta ccttgcactt 4081 ctgcaggtgg caacctttaa aggctggatg gacattatgt atgcagctgt tgattcccgg 4141 gaggtcaaca tgcaacccaa gtgggaggac aacgtgtaca tgtatttgta ctttgtcatc 4201 ttcatcattt ttggaggctt cttcacactg aatctctttg ttggggtcat aattgacaac 4261 ttcaatcaac agaaaaaaaa gttagggggc caggacatct tcatgacaga ggagcagaag 4321 aaatactaca atgccatgaa gaagttgggc tccaagaagc cccagaagcc catcccacgg 4381 cccctgaaca agttccaggg ttttgtcttt gacatcgtga ccagacaagc ttttgacatc 4441 accatcatgg tcctcatctg cctcaacatg atcaccatga tggtggagac tgatgaccaa 4501 agtgaagaaa agacgaaaat tctgggcaaa atcaaccagt tctttgtggc cgtcttcaca 4561 ggcgaatgtg tcatgaagat gttcgctttg aggcagtact acttcacaaa tggctggaat 4621 gtgtttgact tcattgtggt ggttctctcc attgcgagcc tgattttttc tgcaattctt 4681 aagtcacttc aaagttactt ctccccaacg ctcttcagag tcatccgcct ggcccgaatt 4741 ggccgcatcc tcagactgat ccgagcggcc aaggggatcc gcacactgct ctttgccctc 4801 atgatgtccc tgcctgccct cttcaacatc gggctgttgc tattccttgt catgttcatc 4861 tactccatct tcggtatgtc cagctttccc catgtgaggt gggaggctgg catcgacgac 4921 atgttcaact tccagacctt cgccaacagc atgctgtgcc tcttccagat taccacgtcg 4981 gccggctggg atggcctcct cagccccatc ctcaacacag ggccccccta ctgtgacccc 5041 aatctgccca acagcaatgg caccagaggg gactgtggga gcccagccgt aggcatcatc 5101 ttcttcacca cctacatcat catctccttc ctcatcgtgg tcaacatgta cattgcagtg 5161 attctggaga acttcaatgt ggccacggag gagagcactg agcctctgag tgaggacgac 5221 tttgacatgt tctatgagac ctgggagaag tttgacccag aggccactca gtttattacc 5281 ttttctgctc tctcggactt tgcagacact ctctctggtc ccctgagaat cccaaaaccc 5341 aatcgaaata tactgatcca gatggacctg cctttggtcc ctggagataa gatccactgc 5401 ttggacatcc tttttgcttt caccaagaat gtcctaggag aatccgggga gttggattct 5461 ctgaaggcaa atatggagga gaagtttatg gcaactaatc tttcaaaatc atcctatgaa 5521 ccaatagcaa ccactctccg atggaagcaa gaagacattt cagccactgt cattcaaaag 5581 gcctatcgga gctatgtgct gcaccgctcc atggcactct ctaacacccc atgtgtgccc 5641 agagctgagg aggaggctgc atcactccca gatgaaggtt ttgttgcatt cacagcaaat 5701 gaaaattgtg tactcccaga caaatctgaa actgcttctg ccacatcatt cccaccgtcc 5761 tatgagagtg tcactagagg ccttagtgat agagtcaaca tgaggacatc tagctcaata 5821 caaaatgaag atgaagccac cagtatggag ctgattgccc ctgggcccta gtga //