LOCUS       AF117708                2671 bp    mRNA    linear   HUM 07-JUL-1999
DEFINITION  Homo sapiens tandem pore domain potassium channel TWIK-2 (KCNK6)
            mRNA, complete cds.
ACCESSION   AF117708
VERSION     AF117708.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2671)
  AUTHORS   Gray,A.T., Kindler,C.H., Sampson,E.R. and Yost,C.S.
  TITLE     Assignment of KCNK6 encoding the human weak inward rectifier
            potassium channel TWIK-2 to chromosome band 19q13.1 by radiation
            hybrid mapping
  JOURNAL   Cytogenet. Cell Genet. 84 (3-4), 190-191 (1999)
   PUBMED   10393428
REFERENCE   2  (bases 1 to 2671)
  AUTHORS   Chavez,R.A., Gray,A.T., Zhao,B.B., Kindler,C.H., Mazurek,M.J.,
            Mehta,Y., Forsayeth,J.R. and Yost,C.S.
  TITLE     TWIK-2, a new weak inward rectifying member of the tandem pore
            domain potassium channel family
  JOURNAL   J. Biol. Chem. 274 (12), 7887-7892 (1999)
   PUBMED   10075682
REFERENCE   3  (bases 1 to 2671)
  AUTHORS   Chavez,R.A., Gray,A.T., Zhao,B.B., Kindler,C.H., Mazurek,M.J.,
            Mehta,Y., Forsayeth,J.R. and Yost,C.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-JAN-1999) Anesthesia, Room S261, UC San Francisco,
            513 Parnassus Ave., San Francisco, CA 94143-0542, USA
FEATURES             Location/Qualifiers
     source          1..2671
                     /db_xref="H-InvDB:HIT000070112"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.1"
                     /tissue_type="brain"
                     /dev_stage="adult"
     gene            1..2671
                     /gene="KCNK6"
     CDS             111..1052
                     /gene="KCNK6"
                     /note="weak inward rectifying baseline potassium channel;
                     two P domain K+ channel; intracellular pH sensitive"
                     /codon_start=1
                     /product="tandem pore domain potassium channel TWIK-2"
                     /protein_id="AAD24000.1"
                     /translation="MRRGALLAGALAAYAAYLVLGALLVARLEGPHEARLRAELETLR
                     AQLLQRSPCVAAPALDAFVERVLAAGRLGRVVLANASGSANASDPAWDFASALFFAST
                     LITTVGYGYTTPLTDAGKAFSIAFALLGVPTTMLLLTASAQRLSLLLTHVPLSWLSMR
                     WGWDPRRAACWHLVALLGVVVTVCFLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLG
                     DYVPGEAPGQPYRALYKVLVTVYLFLGLVAMVLVLQTFRHVSDLHGLTELILLPPPCP
                     ASFNADEDDRVDILGPQPESHQQLSASSHTDYASIPR"
BASE COUNT          563 a          743 c          798 g          567 t
ORIGIN      
        1 gggtgccgcg cctgtagcac tcccggaact ggaactaggt gccagacggt ccggaggcgg
       61 gggccacgtc agcggggcca cccagggctc gcggggtccc ggtgggtgcc atgcggaggg
      121 gcgcgcttct ggcgggcgcc ttggccgcgt acgccgcgta cctggtgctg ggcgcgctgt
      181 tggtggcgcg gctggagggg ccgcacgaag ccaggctccg agccgagctg gagacgctgc
      241 gggcgcagct gcttcagcgc agcccgtgtg tggctgcccc cgccctggac gccttcgtgg
      301 agcgagtgct ggcggccgga cggctggggc gggtcgtgct tgctaacgct tcggggtccg
      361 ccaacgcctc ggaccccgcc tgggacttcg cctctgctct cttcttcgcc agcacgctga
      421 tcaccaccgt gggctatggg tacacaacgc cactgactga tgcgggcaag gccttctcca
      481 tcgcctttgc gctcctgggc gtgccgacca ccatgctgct gctgaccgcc tcagcccagc
      541 gcctgtcact gctgctgact cacgtgcccc tgtcttggct gagcatgcgt tggggctggg
      601 acccccggcg ggcggcctgc tggcacttgg tggccctgtt gggggtcgta gtgaccgtct
      661 gctttctggt gccggctgtg atctttgccc acctcgagga ggcctggagc ttcttggatg
      721 ccttctactt ctgctttatc tctctgtcca ccatcggcct gggcgactac gtgcccgggg
      781 aggcccctgg ccagccctac cgggccctct acaaggtgct ggtcacagtc tacctcttcc
      841 tgggcctggt ggccatggtg ctggtgctgc agaccttccg ccacgtgtcc gacctccacg
      901 gcctcacgga gctcatcctg ctgccccctc cgtgccctgc cagtttcaat gcggatgagg
      961 acgatcgggt ggacatcctg ggcccccagc cggagtcgca ccagcaactc tctgccagct
     1021 cccacaccga ctacgcttcc atccccaggt agctggggca gcctctgcca ggcttgggtg
     1081 tgcctggcct gggactgagg ggtccaggcg accagagctg gctgtacagg aatgtccacg
     1141 agcacagcag gtgatcttga ggccttgccg tccaccgtct ctcctttgtt tcccagcatc
     1201 tggctgggat gtgaagggca gcactccctg tccccatgtc ccgggctcca ctgggcacca
     1261 acataacctt gttctctgtc ctttctctca tcctctttac actgtgtctc tctggctctc
     1321 tggcattctc gctgcctctg tctttccctc ttgctgtctc tgtttctcat tctctttcat
     1381 gttccgtctg tgtctctcaa ttaaccactc gtcaactgct gattctactg ggctgtgggc
     1441 tcagacctca tttcaggcac cagattggtc gctacaccct ggacaagtga ctgcccgtct
     1501 ctgagccttg atttcctcag ctgccaaatg ggaagaatag aagaatttgc ccctaaaccc
     1561 ctcctgtgtg ctggccctgt gctagacagt gctggagaca tagttggggg tggagaactg
     1621 cccttatgga gcttgcagtc cagtgaggtg gacagacctg tccccagaca gtgatggccc
     1681 aaaatggtca ggactttaat ggaggaggtg aggtgttgaa agcacaggca gagtggtcag
     1741 ggctgaagtc ggagaagcat agggactagg cccaatccag cctggaaagt cagggaggac
     1801 ttcctagagg aagggacatc gaactaagac ctgaactatg agaaataggc aggaagaagt
     1861 tgtacctgac tcatttttct caggtgtctc cagggagcag gacccatgga gggacccctg
     1921 gtgtaggcct gggcgataga ctcttcctca gcagcctggc aggcaggaaa cagacatagg
     1981 accccagccc agatctgaat ggcatgggag gtgctgccct taaccatgac accattgtaa
     2041 gagctgtcca catttgtatg ttgtgccctg gaatcagcct ggttgagctc aaatcccaac
     2101 ttagccacgt ctggcctgtg tccttgggca gtcacactac ctctctgatt ttgtttcctt
     2161 atctgtaaaa tggtgatcat cataatacaa cttcaaaagg atttcaggct gagtgtggtg
     2221 gctcacgcct atacacccag cactttggaa ggctgaggaa ggaggatcgc ttgaggccag
     2281 gagtttgaga ctagcctagg caacacagtg aggccttatc tcaacaacaa ccacaaaatc
     2341 taaaaattag ctgggtgtgg tggtgcatgc ctgtgatcct ggctacttca gaggctgagg
     2401 tggaaggatc acttgaggcc aggagtttga ggctgcagtg agttatgatg gcactgctgc
     2461 actccagcct gcgggacaga gtgagaccct gtctgaaaga aagagagaaa gaaagaaaga
     2521 aagagagaga aagaaagaaa gaaagaaagg gaaagatgga aggaaggaag gaaaaagaaa
     2581 gagaaagaga gagagagaga aagaaaaaga aagaaaagta agaaagaaaa aagaaaaaga
     2641 aagaaaagta agaaagaaaa aaaaaaaaaa a
//