LOCUS AF117708 2671 bp mRNA linear HUM 07-JUL-1999 DEFINITION Homo sapiens tandem pore domain potassium channel TWIK-2 (KCNK6) mRNA, complete cds. ACCESSION AF117708 VERSION AF117708.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2671) AUTHORS Gray,A.T., Kindler,C.H., Sampson,E.R. and Yost,C.S. TITLE Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping JOURNAL Cytogenet. Cell Genet. 84 (3-4), 190-191 (1999) PUBMED 10393428 REFERENCE 2 (bases 1 to 2671) AUTHORS Chavez,R.A., Gray,A.T., Zhao,B.B., Kindler,C.H., Mazurek,M.J., Mehta,Y., Forsayeth,J.R. and Yost,C.S. TITLE TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family JOURNAL J. Biol. Chem. 274 (12), 7887-7892 (1999) PUBMED 10075682 REFERENCE 3 (bases 1 to 2671) AUTHORS Chavez,R.A., Gray,A.T., Zhao,B.B., Kindler,C.H., Mazurek,M.J., Mehta,Y., Forsayeth,J.R. and Yost,C.S. TITLE Direct Submission JOURNAL Submitted (04-JAN-1999) Anesthesia, Room S261, UC San Francisco, 513 Parnassus Ave., San Francisco, CA 94143-0542, USA FEATURES Location/Qualifiers source 1..2671 /db_xref="H-InvDB:HIT000070112" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="19" /map="19q13.1" /tissue_type="brain" /dev_stage="adult" gene 1..2671 /gene="KCNK6" CDS 111..1052 /gene="KCNK6" /note="weak inward rectifying baseline potassium channel; two P domain K+ channel; intracellular pH sensitive" /codon_start=1 /product="tandem pore domain potassium channel TWIK-2" /protein_id="AAD24000.1" /translation="MRRGALLAGALAAYAAYLVLGALLVARLEGPHEARLRAELETLR AQLLQRSPCVAAPALDAFVERVLAAGRLGRVVLANASGSANASDPAWDFASALFFAST LITTVGYGYTTPLTDAGKAFSIAFALLGVPTTMLLLTASAQRLSLLLTHVPLSWLSMR WGWDPRRAACWHLVALLGVVVTVCFLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLG DYVPGEAPGQPYRALYKVLVTVYLFLGLVAMVLVLQTFRHVSDLHGLTELILLPPPCP ASFNADEDDRVDILGPQPESHQQLSASSHTDYASIPR" BASE COUNT 563 a 743 c 798 g 567 t ORIGIN 1 gggtgccgcg cctgtagcac tcccggaact ggaactaggt gccagacggt ccggaggcgg 61 gggccacgtc agcggggcca cccagggctc gcggggtccc ggtgggtgcc atgcggaggg 121 gcgcgcttct ggcgggcgcc ttggccgcgt acgccgcgta cctggtgctg ggcgcgctgt 181 tggtggcgcg gctggagggg ccgcacgaag ccaggctccg agccgagctg gagacgctgc 241 gggcgcagct gcttcagcgc agcccgtgtg tggctgcccc cgccctggac gccttcgtgg 301 agcgagtgct ggcggccgga cggctggggc gggtcgtgct tgctaacgct tcggggtccg 361 ccaacgcctc ggaccccgcc tgggacttcg cctctgctct cttcttcgcc agcacgctga 421 tcaccaccgt gggctatggg tacacaacgc cactgactga tgcgggcaag gccttctcca 481 tcgcctttgc gctcctgggc gtgccgacca ccatgctgct gctgaccgcc tcagcccagc 541 gcctgtcact gctgctgact cacgtgcccc tgtcttggct gagcatgcgt tggggctggg 601 acccccggcg ggcggcctgc tggcacttgg tggccctgtt gggggtcgta gtgaccgtct 661 gctttctggt gccggctgtg atctttgccc acctcgagga ggcctggagc ttcttggatg 721 ccttctactt ctgctttatc tctctgtcca ccatcggcct gggcgactac gtgcccgggg 781 aggcccctgg ccagccctac cgggccctct acaaggtgct ggtcacagtc tacctcttcc 841 tgggcctggt ggccatggtg ctggtgctgc agaccttccg ccacgtgtcc gacctccacg 901 gcctcacgga gctcatcctg ctgccccctc cgtgccctgc cagtttcaat gcggatgagg 961 acgatcgggt ggacatcctg ggcccccagc cggagtcgca ccagcaactc tctgccagct 1021 cccacaccga ctacgcttcc atccccaggt agctggggca gcctctgcca ggcttgggtg 1081 tgcctggcct gggactgagg ggtccaggcg accagagctg gctgtacagg aatgtccacg 1141 agcacagcag gtgatcttga ggccttgccg tccaccgtct ctcctttgtt tcccagcatc 1201 tggctgggat gtgaagggca gcactccctg tccccatgtc ccgggctcca ctgggcacca 1261 acataacctt gttctctgtc ctttctctca tcctctttac actgtgtctc tctggctctc 1321 tggcattctc gctgcctctg tctttccctc ttgctgtctc tgtttctcat tctctttcat 1381 gttccgtctg tgtctctcaa ttaaccactc gtcaactgct gattctactg ggctgtgggc 1441 tcagacctca tttcaggcac cagattggtc gctacaccct ggacaagtga ctgcccgtct 1501 ctgagccttg atttcctcag ctgccaaatg ggaagaatag aagaatttgc ccctaaaccc 1561 ctcctgtgtg ctggccctgt gctagacagt gctggagaca tagttggggg tggagaactg 1621 cccttatgga gcttgcagtc cagtgaggtg gacagacctg tccccagaca gtgatggccc 1681 aaaatggtca ggactttaat ggaggaggtg aggtgttgaa agcacaggca gagtggtcag 1741 ggctgaagtc ggagaagcat agggactagg cccaatccag cctggaaagt cagggaggac 1801 ttcctagagg aagggacatc gaactaagac ctgaactatg agaaataggc aggaagaagt 1861 tgtacctgac tcatttttct caggtgtctc cagggagcag gacccatgga gggacccctg 1921 gtgtaggcct gggcgataga ctcttcctca gcagcctggc aggcaggaaa cagacatagg 1981 accccagccc agatctgaat ggcatgggag gtgctgccct taaccatgac accattgtaa 2041 gagctgtcca catttgtatg ttgtgccctg gaatcagcct ggttgagctc aaatcccaac 2101 ttagccacgt ctggcctgtg tccttgggca gtcacactac ctctctgatt ttgtttcctt 2161 atctgtaaaa tggtgatcat cataatacaa cttcaaaagg atttcaggct gagtgtggtg 2221 gctcacgcct atacacccag cactttggaa ggctgaggaa ggaggatcgc ttgaggccag 2281 gagtttgaga ctagcctagg caacacagtg aggccttatc tcaacaacaa ccacaaaatc 2341 taaaaattag ctgggtgtgg tggtgcatgc ctgtgatcct ggctacttca gaggctgagg 2401 tggaaggatc acttgaggcc aggagtttga ggctgcagtg agttatgatg gcactgctgc 2461 actccagcct gcgggacaga gtgagaccct gtctgaaaga aagagagaaa gaaagaaaga 2521 aagagagaga aagaaagaaa gaaagaaagg gaaagatgga aggaaggaag gaaaaagaaa 2581 gagaaagaga gagagagaga aagaaaaaga aagaaaagta agaaagaaaa aagaaaaaga 2641 aagaaaagta agaaagaaaa aaaaaaaaaa a //