LOCUS AF117108 4171 bp mRNA linear HUM 26-JAN-1999
DEFINITION Homo sapiens IGF-II mRNA-binding protein 3 (IMP-3) mRNA, complete
cds.
ACCESSION AF117108
VERSION AF117108.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4171)
AUTHORS Nielsen,J., Christiansen,J., Lykke-Andersen,J., Johnsen,A.H.,
Wewer,U.M. and Nielsen,F.C.
TITLE A family of insulin-like growth factor II mRNA-binding proteins
represses translation in late development
JOURNAL Mol. Cell. Biol. 19 (2), 1262-1270 (1999)
PUBMED 9891060
REFERENCE 2 (bases 1 to 4171)
AUTHORS Nielsen,J., Christiansen,J., Lykke-Andersen,J., Johnsen,A.H.,
Wewer,U.M. and Nielsen,F.C.
TITLE Direct Submission
JOURNAL Submitted (30-DEC-1998) Institute of Molecular Biology, University
of Copenhagen, Soelvgade 83H, Copenhagen DK-1307, Denmark
FEATURES Location/Qualifiers
source 1..4171
/db_xref="H-InvDB:HIT000070076"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..4171
/gene="IMP-3"
CDS 267..2006
/gene="IMP-3"
/note="binds multiple sites in IGF-II mRNA 5'UTR;
identical to KH-domain containing protein overexpressed in
cancer (koc)"
/codon_start=1
/product="IGF-II mRNA-binding protein 3"
/protein_id="AAD09828.1"
/translation="MNKLYIGNLSENAAPSDLESIFKDAKIPVSGPFLVKTGYAFVDC
PDESWALKAIEALSGKIELHGKPIEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLV
QYGVVESCEQVNTDSETAVVNVTYSSKDQARQALDKLNGFQLENFTLKVAYIPDEMAA
QQNPLQQPRGRRGLGQRGSSRQGSPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATI
RNITKQTQSKIDVHRKENAGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEE
IPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGNVE
TCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGPPSA
MTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAK
VRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGK
TVNELQNLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVKQHQQQ
KALQSGPPQSRRK"
BASE COUNT 1292 a 822 c 853 g 1199 t
ORIGIN
1 aagacttagg aagactggtg gatgcgtttg ggttgtagct aggctttttc ttttctttct
61 cttttaaaac acatctagac aaggaaaaaa caagcctcgg atctgatttt tcactcctcg
121 ttcttgtgct tggttcttac tgtgtttgtg tattttaaag gcgagaagac gaggggaaca
181 aaaccagctg gatccatcca tcaccgtggg tggttttaat ttttcgtttt ttctcgttat
241 ttttttttaa acaaccactc ttcacaatga acaaactgta tatcggaaac ctcagcgaga
301 acgccgcccc ctcggaccta gaaagtatct tcaaggacgc caagatcccg gtgtcgggac
361 ccttcctggt gaagactggc tacgcgttcg tggactgccc ggacgagagc tgggccctca
421 aggccatcga ggcgctttca ggtaaaatag aactgcacgg gaaacccata gaagttgagc
481 actcggtccc aaaaaggcaa aggattcgga aacttcagat acgaaatatc ccgcctcatt
541 tacagtggga ggtgctggat agtttactag tccagtatgg agtggtggag agctgtgagc
601 aagtgaacac tgactcggaa actgcagttg taaatgtaac ctattccagt aaggaccaag
661 ctagacaagc actagacaaa ctgaatggat ttcagttaga gaatttcacc ttgaaagtag
721 cctatatccc tgatgaaatg gccgcccagc aaaacccctt gcagcagccc cgaggtcgcc
781 gggggcttgg gcagaggggc tcctcaaggc aggggtctcc aggatccgta tccaagcaga
841 aaccatgtga tttgcctctg cgcctgctgg ttcccaccca atttgttgga gccatcatag
901 gaaaagaagg tgccaccatt cggaacatca ccaaacagac ccagtctaaa atcgatgtcc
961 accgtaaaga aaatgcgggg gctgctgaga agtcgattac tatcctctct actcctgaag
1021 gcacctctgc ggcttgtaag tctattctgg agattatgca taaggaagct caagatataa
1081 aattcacaga agagatcccc ttgaagattt tagctcataa taactttgtt ggacgtctta
1141 ttggtaaaga aggaagaaat cttaaaaaaa ttgagcaaga cacagacact aaaatcacga
1201 tatctccatt gcaggaattg acgctgtata atccagaacg cactattaca gttaaaggca
1261 atgttgagac atgtgccaaa gctgaggagg agatcatgaa gaaaatcagg gagtcttatg
1321 aaaatgatat tgcttctatg aatcttcaag cacatttaat tcctggatta aatctgaacg
1381 ccttgggtct gttcccaccc acttcaggga tgccacctcc cacctcaggg cccccttcag
1441 ccatgactcc tccctacccg cagtttgagc aatcagaaac ggagactgtt catctgttta
1501 tcccagctct atcagtcggt gccatcatcg gcaagcaggg ccagcacatc aagcagcttt
1561 ctcgctttgc tggagcttca attaagattg ctccagcaga agcaccagat gctaaagtga
1621 ggatggtgat tatcactgga ccaccagagg ctcagttcaa ggctcaggga agaatttatg
1681 gaaaaattaa agaagaaaac tttgttagtc ctaaagaaga ggtgaaactt gaagctcata
1741 tcagagtgcc atcctttgct gctggcagag ttattggaaa aggaggcaaa acggtgaatg
1801 aacttcagaa tttgtcaagt gcagaagttg ttgtccctcg tgaccagaca cctgatgaga
1861 atgaccaagt ggttgtcaaa ataactggtc acttctatgc ttgccaggtt gcccagagaa
1921 aaattcagga aattctgact caggtaaagc agcaccaaca acagaaggct ctgcaaagtg
1981 gaccacctca gtcaagacgg aagtaaaggc tcaggaaaca gcccaccaca gaggcagatg
2041 ccaaaccaaa gacagattgc ttaaccaaca gatgggcgct gaccccctat ccagaatcac
2101 atgcacaagt ttttacctag ccagttgttt ctgaggacca ggcaactttt gaactcctgt
2161 ctctgtgaga atgtatactt tatgctctct gaaatgtatg acacccagct ttaaaacaaa
2221 caaacaaaca aacaaaaaaa gggtggggga gggagggaaa gagaagagct ctgcacttcc
2281 ctttgttgta gtctcacagt ataacagata ttctaattct tcttaatatt cccccataat
2341 gccagaaatt ggcttaatga tgctttcact aaattcatca aatagattgc tcctaaatcc
2401 aattgttaaa attggatcag aataattatc acaggaactt aaatgttaag ccattagcat
2461 agaaaaactg ttctcagttt tatttttacc taacactaac atgagtaacc taagggaagt
2521 gctgaatggt gttggcaggg gtattaaacg tgcattttta ctcaactacc tcaggtattc
2581 agtaatacaa tgaaaagcaa aattgttcct tttttttgaa aattttatat actttataat
2641 gatagaagtc caaccgtttt ttaaaaaata aatttaaaat ttaacagcaa tcagctaaca
2701 ggcaaattaa gatttttact tctggctggt gacagtaaag ctggaaaatt aatttcaggg
2761 ttttttgagg cttttgacac agttattagt taaatcaaat gttcaaaaat acggagcagt
2821 gcctagtatc tggagagcag cactaccatt tattctttca tttatagttg ggaaagtttt
2881 tgacggtact aacaaagtgg tcgcaggaga ttttggaacg gctggtttaa atggcttcag
2941 gagacttcag ttttttgttt agctacatga ttgaatgcat aataaatgct ttgtgcttct
3001 gactatcaat acctaaagaa agtgcatcag tgaagagatg caagactttc aactgactgg
3061 caaaaagcaa gctttagctt gtcttatagg atgcttagtt tgccactaca cttcagacca
3121 atgggacagt catagatggt gtgacagtgt ttaaacgcaa caaaaggcta catttccatg
3181 gggccagcac tgtcatgagc ctcactaagc tattttgaag atttttaagc actgataaat
3241 taaaaaaaaa aaattagact ccaccttaag tantaaagta taacaggatt tatgtatact
3301 gtgcaatcan ttctttgaaa aaaaagtcna aagatagaga atacaagaaa agtttttggg
3361 atataatttg aatgactgtg aaaacatatg acctttgata acgaactcat ttgctcactc
3421 cttgacagca aagcccagta cgtacaattg tgttgggtgt gggtggtctc caaggccacg
3481 ctgctctctg aattgatttt ttgagttttg tttgtaagat gatcacagtc atgttacact
3541 gatctaaagg acatatatat aaccctttaa aaaaaaaatc actgcctcat tcttatttca
3601 agatgaattt ctatacagac tagatgtttt tctgaagatc aattagacat tttgaaaatg
3661 atttaaagtg ttttccttaa tgttctctga aaacaagttt cttttgtagt tttaaccaaa
3721 aaagtgccct ttttgtcact gggattctcc tagcattcat gattttngtt tcatacaatg
3781 aattaaaatt ggctaaantc atggactggc tttctgggtt ggatttcagg taagatgtgt
3841 ttaaggccag agcttttctc agtatttgat ttttttcccc aatatttgat tttttaaaaa
3901 tatacacata ggtgctgcat ttatatctgc tggtttaaat tctgtcatat ttcacttcta
3961 gccttttagt atggcaaatc atattttact tttacttaag catttgtaat ttggagtatc
4021 tggtactagc taagaaataa ttctataatt gagttttgta ctcaccatat atggatcatt
4081 cctcatgtat aatgtgcccc aaatgcagct tcattttcca gataccttga cgcagaataa
4141 attttttcat catttaggtg caaaaaaaaa a
//