LOCUS AF116458 7660 bp mRNA linear HUM 04-MAR-1999
DEFINITION Homo sapiens polycystic kidney disease and receptor for egg jelly
related protein (PKDREJ) mRNA, complete cds.
ACCESSION AF116458
VERSION AF116458.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7660)
AUTHORS Hughes,J., Ward,C.J., Aspinwall,R., Butler,R. and Harris,P.C.
TITLE Identification of a human homologue of the sea urchin receptor for
egg jelly: a polycystic kidney disease-like protein
JOURNAL Hum. Mol. Genet. 8 (3), 543-549 (1999)
PUBMED 9949214
REFERENCE 2 (bases 1 to 7660)
AUTHORS Hughes,J., Ward,C.J., Aspinwall,R., Butler,R. and Harris,P.C.
TITLE Direct Submission
JOURNAL Submitted (23-DEC-1998) MRC Molecular Haematology Unit, Institute
of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford,
Oxon OX3 9DS, UK
FEATURES Location/Qualifiers
source 1..7660
/db_xref="H-InvDB:HIT000069927"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="22"
/map="22q13"
/tissue_type="testis"
gene 1..7660
/gene="PKDREJ"
CDS 1..6762
/gene="PKDREJ"
/note="similar to sea urchin receptor for egg jelly (REJ)
protein; similar to Homo sapiens cosmid B5E3 sequence
presented in GenBank Accession Number Z79998 and Homo
sapiens cosmid N5H6 cosmid sequence presented in GenBank
Accession Number Z93024"
/codon_start=1
/product="polycystic kidney disease and receptor for egg
jelly related protein"
/protein_id="AAD18021.1"
/translation="MRPGPALLLLGVGLSLSVGRLPLPPVPRGAQAAVSGAPGGLLRG
APGLGVRGGRALLSLRPSAVRAGGAVLSGRGSLCFPHGGTGRRWYCLDLRVLLSAQRL
PWPAAPALALVDLQLSARGGRLSLTWSVRLPRSPGRLAWAFRLRLLGPGAARPASPAA
RVSPRSAAPGPRPQQGFVARTECPTDGPARVMLQAVNSSSHRAVESSVSCQINACVIQ
RVRINTDQKGAPVRLSMQAEATINASVQLDCPAARAIAQYWQVFSVPAVGQAPDWTQP
LDLPQLEIRNSPLFIHIPNNSLQWGVYVFNFTVSITTGNPKMPEVKDSDAVYVWIVRS
SLQAVMLGDANITANFTEQLILDGSTSSDPDADSPLQGLQFFWYCTTDPRNYGGDRII
LGSKEVCHPEQANLKWPWASGPVLTLLPETLKGDHVYFFRMVIRKDSRTAFSDKRVHV
LQGPKAIAHITCIENCERNFIVSDRFSLFLNCTNCASRDFYKWSILSSSGGEMLFDWM
GETVTGRNGAYLSIKAFAFRHFLEAEFSISLYLACWSGVTSVFRHSFIINHGPQIGEC
KINPAKGIALITKFVVQCSNFRDKHVPLTYKIIVSDLHSVGEISSVKENTLGTILYLG
PQSTVPPSFLPVGMLASQYGLKIYAQVYDSLGAFSQVTLHATAQAPTDKNSSKTVLNQ
LLSFTVGPSSLLSTLIQKKDFLPAGYLLYIVASVLNNMKTELPLRDDRVNLRKHLIDQ
SFLLPVSTLVEIGQVVMTITKLTQKPSEFTWDAQKRATMRVWQANQALQEYQQKDKRF
RSEQIEIVSTGILMSLSNILKMTSPHQVVKDPFYVIESLSDTILANKVPGNKTTSMRT
PNFNMYVKKVEKWGINQLFRNEKHCRNCFYPTLNVSSVPGLSANGPISTMFCDFTNDL
FPWLNDQENTSVEVSGFRMTGVADNGSVLEITPDVAEVYLVRKNLTFAAFNLTVGPNS
EVDGSLKKTTGGFSFQVDSTVLREVLVHIVTEVMVLFTVLVYTGSQITPTALVATFLV
PHDIPPFASQSALFDPACTVKKARVVCLPVSLLQLIAQHSHSPHCTVSIVLQAPRFVM
KLNDKLVRISIFSVQCLDMYGIQSEWREGYCILGEKTSWYEVHCICKNVVRARRQLGT
IGLTGIHLHTHYVMAKVIVIPNPVDLRLNIIKSLHQNPVTLFTVLFIILLYVGLAFWA
LYRDEMDQHLRGHVIVLPDNDPYDNLCYLVTIFTGSRWGSGTRANVFVQLRGTVSTSD
VHCLSHPHFTTLYRGSINTFLLTTKSDLGDIHSIRVWHNNEGRSPSWYLSRIKVENLF
SRHIWLFICQKWLSVDTTLDRTFHVTHPDERLTRKDFFFIDVSSNLRKNHMWFSIFAS
VVAKTFNRLQRLSCCLAMLLSSLLCNIMFFNLNRQEQTESRERKYMRSMMIGIESVLI
TIPVQLLITFLFTCSQRKPQADLKEVSPQKHPLMSEASEHWEEYLRKWHAYETAKVHP
REVAKPASKGKPRLPKASPKATSKPKHRHRKAQIKTPETLGPNTNSNNNIEDDQDVHS
EQHPSQKDLQQLKKKPRIVLPWWCVYVAWFLVFATSSISSFFIVFYGLTYGYDKSIEW
LFASFCSFCQSVLLVQPSKIILLSGFRTNKPKYCKNLSWSTKYKYTEIRLDGMRMHPE
EMQRIHDQIVRIRGTRMYQPLTEDEIRIFKRKKRIKRRALLFLSYILTHFIFLALLLI
LIVLLRHTDCFYYNQFIRDRFSMDLATVTKLEDIYRWLNSVLLPLLHNDLNPTFLPES
SSKILGLPLMRQVRAKSSEKMCLPAEKFVQNSIRREIHCHPKYGIDPEDTKNYSGFWN
EVDKQAIDESTNGFTYKPQGTQWLYYSYGLLHTYGSGGYALYFFPEQQRFNSTLRLKE
LQESNWLDEKTWAVVLELTTFNPDINLFCSISVIFEVSQLGVVNTSISLHSFSLADFD
RKASAEIYLYVAILIFFLAYVVDEGCIIMQERASYVRSVYNLLNFALKCIFTVLIVLF
LRKHFLATGIIRFYLSNPEDFIPFHAVSQVDHIMRIILGFLLFLTILKTLRYSRFFYD
VRLAQRAIQAALPGICHMAFVVSVYFFVYMAFGYLVFGQHEWNYSNLIHSTQTVFSYC
VSAFQNTEFSNNRILGVLFLSSFMLVMICVLINLFQAVILSAYEEMKQPVYEEPSDEV
EAMTYLCRKLRTMFSFLTSQSKAKDEPEFFIDMLYGQPEKNSHRYLGLKTRNINGKKM
VYLVV"
regulatory 7636..7641
/regulatory_class="polyA_signal_sequence"
/gene="PKDREJ"
BASE COUNT 1926 a 1827 c 1809 g 2098 t
ORIGIN
1 atgaggcctg ggcccgctct cctccttctg ggcgtgggcc tgagcctgag cgtcggccgc
61 ctcccgctgc cgccggttcc tcgcggggca caagccgccg tctccggggc gcccggtggc
121 ctcctcaggg gcgccccggg cctcggggtg cgcggcggcc gcgccctcct cagtctgcgg
181 cccagcgcgg tgcgggcggg cggcgctgtc ctgagcggcc gcggcagcct ctgcttcccc
241 catggcggga ccgggcggcg ctggtactgc ctcgacttgc gcgtcctgct cagcgcccaa
301 cgcctgccct ggccggccgc gcccgcgctc gcgctcgtcg acctgcagct ctccgcgcgc
361 ggcggccgcc tctccctgac gtggtccgtg cggctgccgc gctcgcccgg gcgcctggcc
421 tgggccttcc gcctgcggct gctcggaccc ggcgccgccc gcccggcctc ccccgcggcc
481 cgcgtctccc cgcgctccgc cgcgccaggc ccgcggcccc agcagggctt cgtggcccgc
541 accgagtgcc ccacagacgg ccccgcgcgc gtgatgttgc aggccgtcaa ctcgtccagc
601 cacagagccg tcgagtcgtc cgtgtcctgt cagataaacg cctgcgtcat ccagcgcgtg
661 aggatcaaca cggaccagaa gggcgccccc gtgcgcctga gcatgcaggc ggaggccacc
721 atcaacgcct cggtgcagct ggactgcccg gccgcgcgcg ccatcgccca gtactggcag
781 gtgttctccg tgcccgccgt gggtcaggcg cccgactgga cgcagccctt ggatctgccc
841 cagctcgaga tcaggaacag ccccttgttc attcacatcc ccaataattc gttacagtgg
901 ggagtgtatg tgtttaattt cacggtgtcc atcaccacag ggaaccccaa gatgcccgag
961 gtgaaagact cggacgccgt ctatgtctgg atcgtcagga gttccctgca ggcggtgatg
1021 cttggcgatg ccaacataac agctaatttc acagagcagc tgattctgga cgggtccacg
1081 tcctcggacc cagatgcgga cagcccgtta cagggactcc agttcttttg gtactgtacc
1141 acagatccca gaaactacgg tggggatcga ataatcctgg ggagcaagga agtctgtcac
1201 cccgagcagg ccaatctgaa atggccctgg gcctcgggcc ctgtactgac acttttgcca
1261 gaaacactta aaggcgacca cgtgtatttc ttcagaatgg tgattcggaa ggactctagg
1321 acagcgtttt ctgataagag ggtccacgtg ctccaaggac caaaagccat agcacacatc
1381 acatgtatcg aaaattgtga gagaaacttc attgtctctg atagattttc tttgttccta
1441 aattgcacaa attgtgcaag ccgtgatttc tataaatggt caattttgtc ttcttcaggt
1501 ggtgagatgc tatttgattg gatgggggaa actgtaacag gaaggaatgg tgcttatctg
1561 tctataaaag cttttgcttt tcggcatttt ttggaagctg agttttcgat ttctctgtat
1621 ctagcatgtt ggagtggagt gacctcggtc ttcaggcatt cttttattat taaccatggc
1681 cctcagatcg gagaatgcaa aattaatcca gctaaaggaa ttgcacttat tactaaattt
1741 gttgtccagt gtagtaattt tagggataag cacgtccctc ttacatataa aataattgtt
1801 tctgatttgc acagtgttgg tgaaatcagt tcagtaaaag agaacaccct ggggaccatc
1861 ctgtacttgg ggcctcagtc cacagtaccc ccttcctttc tccctgttgg tatgttggct
1921 agtcaatatg gcttgaagat atatgcccag gtctatgatt ctctaggagc tttttctcag
1981 gtgactttgc atgccaccgc acaggctccc actgacaaaa attcatcaaa gacagtgttg
2041 aatcagttac tcagtttcac cgtgggacca agttcattgc tgtctacttt gattcaaaag
2101 aaggattttt tacctgcagg ttacttactg tatatagtag cttccgtttt gaataacatg
2161 aaaactgaat tacctctccg agatgacaga gtcaatctcc gaaaacacct catcgatcag
2221 tctttccttc ttcctgtaag cactttggta gaaattggcc aggtagtcat gactattacc
2281 aaattaaccc agaaaccctc tgaattcact tgggatgctc agaaacgtgc caccatgagg
2341 gtatggcaag caaatcaagc cctacaagag tatcagcaaa aagataaacg ctttcgatct
2401 gaacaaatag aaatcgtgag tactggaata ctaatgagtt tgtctaatat tcttaaaatg
2461 acttctcctc accaagtagt taaagatcct ttctatgtaa tagaatctct atcagacaca
2521 atactggcta ataaagtgcc agggaacaaa accacctcaa tgagaacccc caatttcaac
2581 atgtatgtca agaaagttga aaagtggggt atcaaccagc tcttcagaaa tgagaaacac
2641 tgcagaaatt gtttttatcc aacactcaat gtgagcagtg ttcctggtct gtctgcaaat
2701 ggtcccattt ctacaatgtt ttgtgatttc acaaatgacc tctttccttg gttaaatgat
2761 caggaaaaca cttcggtgga ggtgtctgga ttcagaatga caggagttgc agataacggt
2821 agtgtgctag agatcacacc tgatgtagcg gaagtgtacc ttgtcaggaa aaacttgacc
2881 tttgcagctt ttaatctcac agtgggaccc aacagcgagg ttgatgggtc cttgaagaag
2941 acgacaggtg ggtttagctt tcaagtggac agcacagtgc ttagggaggt tctggtccac
3001 atagtaacag aagtgatggt gctgttcaca gtgttggtgt acacaggcag tcagatcact
3061 cccacagcgc tggtcgccac cttcctggtg cctcatgaca tccctccatt tgccagccag
3121 agtgccctgt ttgacccagc ctgcacagtg aagaaggccc gtgtagtctg cctccctgtg
3181 tccctgctgc aactcatagc tcagcacagc cactctcccc actgtactgt atccatagtt
3241 ctgcaggcac ctcgttttgt catgaagctc aatgacaagc tagtgagaat ttctattttc
3301 agcgtccagt gcttggacat gtatgggatc cagagtgaat ggagagaggg ttattgcatt
3361 cttggtgaga agaccagctg gtatgaggtg cactgcatct gcaagaatgt agtaagggct
3421 aggcggcagc tgggcacaat cggactcacg ggcattcacc tgcataccca ctatgtgatg
3481 gccaaggtga ttgtgatccc taatcctgtg gatctacggt taaacatcat caagagcctt
3541 caccaaaacc ccgtgaccct cttcactgtg cttttcatta ttctcttata cgtgggccta
3601 gctttttggg ctttatacag ggatgaaatg gaccagcatc ttcgggggca tgtgatagtt
3661 ctaccagata atgatcctta tgataattta tgctacttgg tgactatttt tacaggaagt
3721 cgttgggggt ctgggaccag ggccaatgtc tttgtgcaac ttagaggaac tgtgagtacc
3781 agcgacgtgc attgtttaag ccatccacat ttcacaactc tctaccgagg tagcatcaac
3841 actttcctcc taacgacaaa aagtgacttg ggggacatcc attccatccg tgtgtggcac
3901 aacaacgagg gtcgatcgcc tagctggtat ttaagtagaa tcaaagtgga aaatctgttt
3961 agcaggcaca tttggctgtt catatgccag aaatggcttt ctgttgatac cactttggac
4021 agaacatttc acgttaccca tccagatgag cgtctgacta gaaaagactt tttctttata
4081 gatgtgagta gtaatctccg gaaaaaccac atgtggttct ctatttttgc tagtgttgtt
4141 gctaaaacat tcaataggct ccagagattg tcctgttgtt tagcaatgtt gcttagctct
4201 cttctttgta acattatgtt ctttaatcta aatagacaag aacaaactga gtcaagagag
4261 aggaaataca tgagatcaat gatgatagga attgaaagtg tcttaattac aatccctgtg
4321 caattattaa taactttttt gttcacctgt tcccagagga aacctcaagc ggatctaaag
4381 gaggtatctc ctcaaaagca tcctctaatg tcagaagcaa gtgagcactg ggaagaatac
4441 ttgagaaagt ggcatgctta cgaaactgct aaggtgcacc ccagggaggt tgcaaaacct
4501 gcatctaaag gaaagcccag gcttccaaag gcttctccta aggcaacctc caaacccaag
4561 cacaggcata ggaaagcaca aatcaagacc ccggagaccc tcgggccaaa tacaaattcc
4621 aataacaaca tagaagatga tcaggatgtc cattccgaac agcacccttc ccaaaaggat
4681 ctccagcagc ttaagaaaaa gccccggatc gtcctacctt ggtggtgtgt ttatgttgca
4741 tggtttttgg tttttgctac ttctagcata tcctcattct tcattgtatt ttatggactg
4801 acttacggct atgacaagtc aatagaatgg ctctttgcat ctttttgttc attctgtcag
4861 tcagttcttc tggtgcagcc atctaaaatt atactcctgt caggcttcag aacgaataaa
4921 cccaagtatt gcaaaaacct ttcatggtca accaagtata aatatactga gatcaggttg
4981 gatggaatgc gtatgcatcc agaagaaatg cagaggatac atgaccagat cgtccgaatc
5041 cgaggcacga ggatgtacca accccttaca gaagatgaaa tcagaatatt caaaagaaag
5101 aagaggatca agagaagagc actcctgttt ctgagttaca ttctaactca ctttatcttt
5161 ctagcccttc tgttgatcct tatcgtctta ctacgtcaca ctgactgctt ttactataac
5221 cagtttattc gtgatcggtt ctctatggat cttgctactg tgactaagct ggaagacatc
5281 tatagatggc taaacagcgt gctgttgcct ttgttacaca atgacctgaa tccaacattt
5341 cttcctgaaa gctcgtctaa aatccttggc cttccattga tgaggcaagt gagagcaaaa
5401 tctagtgaaa aaatgtgtct acctgccgaa aagtttgtgc aaaacagcat cagaagagaa
5461 attcattgtc accccaaata tggcattgac ccagaagaca caaaaaacta ttctggcttt
5521 tggaatgaag ttgataagca ggctatagat gagagtacca atggatttac ttataagcct
5581 caaggaacgc aatggctata ttattcctat ggactactac acacctatgg atctggagga
5641 tatgcactct atttttttcc agaacagcag cggtttaatt ccacactgag gctcaaagaa
5701 cttcaagaaa gcaattggct ggatgagaag acatgggctg tggttttgga attaacaact
5761 tttaatccag atataaatct gttctgtagc atttcggtca tatttgaagt ctctcagtta
5821 ggagttgtca acacaagcat atctctgcac tctttttcac ttgctgattt tgacagaaaa
5881 gcttcagcag aaatctactt gtatgtggcc attctcattt ttttcttagc ctacgttgtt
5941 gatgagggtt gtatcattat gcaagaaaga gcctcctatg tgagaagtgt gtataatttg
6001 ctcaactttg ctttaaagtg catatttact gtgttgattg tgctctttct caggaaacat
6061 ttcctggcca ctggcataat tcggttttac ttgtcgaacc cagaagactt cattcccttt
6121 catgcagttt ctcaggtaga tcacattatg aggataattt tgggtttcct gttatttctg
6181 acaattttga agaccctcag gtattccaga ttcttctacg atgtgcgcct ggctcagagg
6241 gccatccagg ctgccctccc tggcatctgc cacatggcat ttgttgtgtc cgtgtatttc
6301 ttcgtataca tggcttttgg ttacctggtg tttggtcagc atgaatggaa ctacagtaac
6361 ttgattcatt ccactcagac agtattttcc tattgtgtct cagctttcca gaacactgaa
6421 ttttccaata acaggattct gggggtcctg ttcctctcat ctttcatgct ggtgatgatc
6481 tgcgtcttga tcaacttatt tcaggctgta attctgtctg catatgagga aatgaagcag
6541 cccgtgtatg aggagccatc ggatgaagtg gaagcaatga cctatttgtg ccgtaagctg
6601 agaaccatgt tcagctttct gacctcgcaa tctaaggcca aagatgagcc tgagttcttt
6661 attgacatgc tgtatgggca gccagagaag aacagccacc gttatctggg gctgaagacc
6721 agaaacatca acgggaagaa aatggtttac cttgttgttt gatgaatgat ggtttcatga
6781 gtcacaagca agcgttcccc caactgctga gtctgtggga ttaaggggat tagggagtgt
6841 cagtggccta gtcatgcttt ctactcatgt ccttcacaag gcacatcccc tacatttgga
6901 agaatcccca atcttgtcct ctgctcttgg gagtgtaaaa gttgggagtg tagtgtagca
6961 tctggggaga cagcaggatc acagtgtggg attcctggac tgatttccct ttagagggga
7021 gttatgtgac tccccgtaca agggcaaccc tgtttctttg gtgcctgcag tttagagaag
7081 gcagagccac tggttttgag aaccagattt gagagaggga cctggccagg gtggagcatt
7141 gtctgggtgt ttctgcgctt gacccatgct ggaagctaat ggcctgttgc tcctgacaga
7201 gccccaaact cctcggcctc actgggaggc ccctttgtag accagggctc ccctcctctt
7261 gttccccctg ggcttagggc ctcgtgggga gttccaggac ttgcttcatg cttgagaatg
7321 cagatgtggt gcttctcatt tattcttaaa gctactggta gttaaagtaa aattcagtaa
7381 cattttctga ccaagagaca tgttttgtta aacaacaaaa aggtacatat gggttcacat
7441 tgaaatatgt ctatatgctg aatatagcaa catatgcatc taagatttgg gcatttggtt
7501 attaatagcg tgctggacta ttcaggaata aggaaaatgt ggtttatcac ttaagagaaa
7561 caagggctgg tagctgtact attttcactc agaagcatgt tcatttatgt agatgccact
7621 ttaagcttta tcagaattaa atgtgagatt tcttctttga
//