LOCUS AF111105 2133 bp mRNA linear HUM 04-MAY-1999
DEFINITION Homo sapiens mitogen-activated protein kinase kinase kinase MEKK2
mRNA, complete cds.
ACCESSION AF111105
VERSION AF111105.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2133)
AUTHORS Su,B., Yang,J.H., Xia,Y. and Karin,M.
TITLE MEKK2 is involved in transducing T-cell co-stimulatory signals to
the JNK cascade
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 2133)
AUTHORS Su,B. and Karin,M.
TITLE Direct Submission
JOURNAL Submitted (04-DEC-1998) Immunology, The University of Texas M.D.
Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA
FEATURES Location/Qualifiers
source 1..2133
/db_xref="H-InvDB:HIT000069683"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 102..1958
/codon_start=1
/product="mitogen-activated protein kinase kinase kinase
MEKK2"
/protein_id="AAD28547.1"
/translation="MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDV
RVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKA
LELLDRSIHMKSLKILLVINGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSR
DRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESMEQMLDPLSLSSPENSGSGSCP
SLDSPLGGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHKD
NDGRKTFPRARRTQGNQLTSPVSFSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDN
PTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDS
PETSKEVNALECEIQLLKNFLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKA
YGALTENGTRKYTRQILEGVHYLHSNMILHRDIKGANILRDSTGNVKLGDFGASKRLQ
TICLSGTGMKSVTGTPYWMSPEVISGQGYGRKADIWSVACTVVEMLTEKPPWAEFEAM
AAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSADELLRHMFVHYH"
BASE COUNT 674 a 439 c 451 g 568 t
ORIGIN
1 ttttattaat atgctgatct gttttatctt ctcacggcca taaagaatgc tgattggaga
61 accattttcc taattttcaa attgttnagc tgtttgccat aatggatgat cagcaagctt
121 tgaactcaat catgcaagat ttggctgtcc ttcataaggc cagtcgacca gcattatcct
181 tgcaggaaac cagaaaagca aaatcttcat caccaaaaaa acagaatgat gtccgagtca
241 aatttgaaca tagaggagaa aaaagaatcc ttcagttccc cagaccagtt aaactggaag
301 atctgagatc taaagctaaa attgcctttg gacagtctat ggatctacat tataccaata
361 acgagttggt aattccatta actactcaag atgacttgga caaagctctg gaactgctgg
421 atcgtagtat tcatatgaag agcctcaaga tattacttgt aataaatgga agtacacagg
481 ctactaattt agaaccattg ccatcactag aagatttgga taatacagta tttggagcag
541 agaggaaaaa acggctatct ataataggtc ctactagtag agatagaagt tctcctcccc
601 cgggttacat tccagatgaa ttacaccagg ttgcccggaa tgggtcattc actagtatca
661 acagtgaagg agagttcatt ccagagagca tggaacaaat gctggatcca ttatctttaa
721 gcagccctga aaattctggc tcaggaagtt gtccatcact tgatagtcct ttgggtggag
781 agagctatcc aaaatcacga atgcctaggg ctcagagcta cccagataat catcaggaat
841 tttcagacta tgataaccct atctttgaga aatttggaaa aggaggaaca tatccaagaa
901 ggtatcatgt ttcatatcat cataaggata atgatggtcg taaaactttt ccaagagcta
961 gaaggaccca ggggaaccag cttacgtctc ctgtgagttt cagtcctact gatcattcct
1021 taagcactag tagtggaagc agtatcttta ccccagagta tgatgatagt cgaataagaa
1081 gaaggggaag tgacatagac aatcctactt tgacagtaat ggacatcagc ccacccagcc
1141 gttcacctcg agctccgacc aactggagat tgggcaaact gcttggccaa ggagcctttg
1201 gaagggtcta cctctgttat gatgttgata caggaagaga attggctgtt aagcaagttc
1261 aatttgaccc cgatagtcct gagaccagca aggaagtaaa tgcacttgag tgtgaaattc
1321 agttgctgaa aaactttcta catgagcgaa ttgttcagta ttatggctgt ttgagggatc
1381 cccaggaaaa aacactttcc atatttatgg aatatatgcc agggggttca attaaggacc
1441 aattaaaagc atatggcgct cttactgaga atggtactag gaaatacacc cgtcagattc
1501 tggagggtgt ccattatttg cacagtaata tgattctcca ccgcgacatc aaaggcgcaa
1561 atatccttcg agattcaaca ggcaacgtca aactaggaga ttttggggcc agcaaacggc
1621 ttcagaccat ctgtctctca gggacaggaa tgaagtctgt cacgggcaca ccatactgga
1681 tgagccctga agtcatcagt ggacaaggct atggaagaaa agcagacatc tggagtgttg
1741 catgtaccgt ggtagaaatg ctaactgaaa agccgccttg ggctgaattt gaagcaatgg
1801 ctgccatctt taaaatcgcc actcagccaa caaacccaaa gctgccacct catgtctcag
1861 actatactcg agatttcctc aaacggattt ttgtagaggc caaactgaga ccttcagctg
1921 atgaactctt aaggcacatg tttgtgcatt atcactagca gccagtaacc tctcctgtgc
1981 ctctacctag ctcccatcta ttcattcacc ttctctctga ctgcactttt cttttttata
2041 aaaaaagaga gagggggaga aaaaagacaa gagggaaagt atttctcttg attcttggtt
2101 aaattgttaa taataataat atcctaattt ata
//