LOCUS AF110798 8292 bp DNA linear HUM 03-MAR-1999
DEFINITION Homo sapiens interleukin-18 binding protein precursor (IL18BP)
gene, alternative splice products, complete cds.
ACCESSION AF110798
VERSION AF110798.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8292)
AUTHORS Novick,D., Kim,S.H., Fantuzzi,G., Reznikov,L.L., Dinarello,C.A. and
Rubinstein,M.
TITLE Interleukin-18 binding protein: a novel modulator of the Th1
cytokine response
JOURNAL Immunity 10 (1), 127-136 (1999)
PUBMED 10023777
REFERENCE 2 (bases 1 to 8292)
AUTHORS Novick,D., Kim,S.-H., Fantuzzi,G., Reznikov,L.L., Dinarello,C.A.
and Rubinstein,M.
TITLE Direct Submission
JOURNAL Submitted (04-DEC-1998) Molecular Genetics, Weizmann Institute of
Science, P.O. Box 26, Rehovot 76100, Israel
FEATURES Location/Qualifiers
source 1..8292
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q13"
gene 235..4925
/gene="IL18BP"
mRNA join(235..1184,1523..1729,2373..2496,2577..4925)
/gene="IL18BP"
/product="interleukin-18 binding protein c precursor"
mRNA join(1098..1184,1523..1729,2373..2496,2577..2724,
2956..3699)
/gene="IL18BP"
/product="interleukin-18 binding protein a precursor"
mRNA join(1098..1184,1523..1729,2956..3699)
/gene="IL18BP"
/product="interleukin-18 binding protein b precursor"
CDS join(1163..1184,1523..1729,2956..3068)
/gene="IL18BP"
/note="IL-18BPb"
/codon_start=1
/product="interleukin-18 binding protein b precursor"
/protein_id="AAD17188.1"
/translation="MRHNWTPDLSPLWVLLLCAHVVTLLVRATPVSQTTTAATASVRS
TKDPCPSQPPVFPAAKQCPALEVTWPEVEVPLSWAEGNLAPHPRSPALQPQQSTAAGL
RLSTGPAAAQP"
mat_peptide join(1585..1729,2956..3065)
/gene="IL18BP"
/product="interleukin-18 binding protein b"
CDS join(1163..1184,1523..1729,2373..2496,2577..2724,
2956..3033)
/gene="IL18BP"
/note="IL-18BPa"
/codon_start=1
/product="interleukin-18 binding protein a precursor"
/protein_id="AAD17187.1"
/translation="MRHNWTPDLSPLWVLLLCAHVVTLLVRATPVSQTTTAATASVRS
TKDPCPSQPPVFPAAKQCPALEVTWPEVEVPLNGTLSLSCVACSRFPNFSILYWLGNG
SFIEHLPGRLWEGSTSRERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQRH
VVLAQLWAGLRATLPPTQEALPSSHSSPQQQG"
sig_peptide join(1163..1184,1523..1584)
/gene="IL18BP"
mat_peptide join(1585..1729,2373..2496,2577..2724,2956..3030)
/gene="IL18BP"
/product="interleukin-18 binding protein a"
CDS join(1163..1184,1523..1729,2373..2496,2577..2817)
/gene="IL18BP"
/note="IL-18BPc"
/codon_start=1
/product="interleukin-18 binding protein c precursor"
/protein_id="AAD17189.1"
/translation="MRHNWTPDLSPLWVLLLCAHVVTLLVRATPVSQTTTAATASVRS
TKDPCPSQPPVFPAAKQCPALEVTWPEVEVPLNGTLSLSCVACSRFPNFSILYWLGNG
SFIEHLPGRLWEGSTSRERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQRH
VVLAQLWVRSPRRGLQEQEELCFHMWGGKGGLCQSSL"
mat_peptide join(1585..1729,2373..2496,2577..2814)
/gene="IL18BP"
/product="interleukin-18 binding protein c"
BASE COUNT 1791 a 2367 c 2350 g 1784 t
ORIGIN
1 tagggttggc tctcgagctt gtgtgccagt tcctgggttg gccgtgagag ttctacagac
61 aaggaggaag tgctctcggt gtatttcctg tggtgggttc acacgcagct agacacagct
121 aacttgagtc ttggagctcc tagagggaag cttctggaaa ggaaggctct tcaggacctc
181 ttaggagcca ggtaggagtc tgggactact agtgaaccta gacctgtggc tctggccaga
241 ggggctagga tgagagacag agggtgtgat ggtgggtgct gggagatgta gccgaccttg
301 gggctggtgg ctgggggagt gggtagcctg ggaaaggcca ggatgtggac ggactggtat
361 ggcattgagc ctgaagtggt ccaacttggg gttccccagt gcctaggaaa gttgtcccct
421 tgaatgtcag tgtgaaggtg aaggaggaag cagatgcctg ttcatatgga aacaaagacc
481 tggctgtgaa gaggggaggc ggacaccaaa gtcctgacac ttgggcggga cagaattgat
541 ctgtgagaga ctcatctagt tcatacccta ggtgaccctg ggggtggcat gggggtagat
601 tagagatccc agtctggtat cctctggaga gtaggagtcc caggagctga aggtttctgg
661 ccactgaact ttggctaaag cagaggtgtc acagctgctc aagattccct ggttaaaaag
721 tgaaagtgaa atagagggtc ggggcagtgc tttcccagaa ggattgctcg gcatcctgcc
781 cttcccagaa gcagctctgg tgctgaagag agcactgcct ccctgtgtga ctgggtgagt
841 ccatattctc tctttgggtc tcaattttgc cttccctaat gaaggggtaa gattggacta
901 ggtaagcatc ttacaaccat ttgtggtcat gagagctggg gtggggaagg attgtcactt
961 gaccccccca gctctgtttc taagtgctga aagagctcca ggctatgcta cgggaggaga
1021 agccagctac tgaggaaaag ccagctactg agaaaaagcg ggagtggttt accattctcc
1081 tcccccacct ttcaccagag aagaggacgt tgtcacagat aaagagccag gctcaccagc
1141 tcctgacgca tgcatcatga ccatgagaca caactggaca ccaggtaggc cttggggcta
1201 cgcatgggca ggcggggtag ggtgaggtct atgaacagaa tggagcaatg ggctaacccg
1261 gagccttcac tccaaggcaa accacccagc gcacctggtg ctgttgcttt aagaacctgg
1321 gcagatattg tagctctggc tccagtctaa agcttctctg tactctgttc aataaagggc
1381 taaggggtgg gtgctgaggg gtccctcttc ccgctctgat tccctggcta gaacccagac
1441 atctctgggc tggagttaca tccttacccg ggcagcccac tctgtctcca gagccgctga
1501 cctgtaactg tcctttcctc agacctcagc cctttgtggg tcctgctcct gtgtgcccac
1561 gtcgtcactc tcctggtcag agccacacct gtctcgcaga ccaccacagc tgccactgcc
1621 tcagttagaa gcacaaagga cccctgcccc tcccagcccc cagtgttccc agcagctaag
1681 cagtgtccag cattggaagt gacctggcca gaggtggaag tgccactgag taagaagcac
1741 agtggtggag ggtgggctat gggcacagag gttcccaggg tcgggttgac tcctgagcgc
1801 cagtcccctt ctgcccatgt accaccagct gagccagctg ggctgagcac gcaccattct
1861 ccctccccaa cccagtgtca tgggtgcagg cttggcgcag ctcccaagat gctccctatc
1921 aaataggaca gagaactcaa gacataagta atggtcacag gacctcccag agccttggtt
1981 gcagtggacc ccaaggccag cccctccacc cagagcctgc tggcctctgg ccatctcaga
2041 ggagcagcag ccatccagca ctgcctctgt cacctgggct cccaagtcac cgaggctggg
2101 cactagaaaa ggtcatcctg aggagacagg ttcagaagag gattcatcac gtgaaccaag
2161 gaccattcct cacattcccc gtgtttaggg ctagggcctc tcggagacaa ctgcacttct
2221 gtaacggacg ttcccaccta ggtggtgtgc agagcagttc tctaggttcc agatgcatgg
2281 ggactggggg gagctggcag agagggcaca gcagagcagg gtaggggaag ggcctgctct
2341 tctgaagagc taactgctgc ctgtgtccct agatggaacg ctgagcttat cctgtgtggc
2401 ctgcagccgc ttccccaact tcagcatcct ctactggctg ggcaatggtt ccttcattga
2461 gcacctccca ggccgactgt gggaggggag caccaggtga gggtcgcagc agccaggtgg
2521 gtgggaagga agccttctgc ggccttctca tgacctttcc ttcccttccg ctccagccgg
2581 gaacgtggga gcacaggtac gcagctgtgc aaggccttgg tgctggagca gctgacccct
2641 gccctgcaca gcaccaactt ctcctgtgtg ctcgtggacc ctgaacaggt tgtccagcgt
2701 cacgtcgtcc tggcccagct ctgggtgagg agcccaagga gaggcctcca ggaacaggag
2761 gagctctgct tccatatgtg gggaggaaag ggtgggctct gccagagcag cctgtgaact
2821 aatgcccagc attcctcaag gtcagccaga caaaaaggaa cttaggtctt gggcagagga
2881 ggtgtagcct ggggcaaagt gatgagatgt ccctcctttc cttggcctga tccttgtctg
2941 ccttcacttc cctaggctgg gctgagggca accttgcccc ccacccaaga agccctgccc
3001 tccagccaca gcagtccaca gcagcagggt taagactcag cacagggcca gcagcagcac
3061 aaccttgacc agagcttggg tcctacctgt ctacctggag tgaacagtcc ctgactgcct
3121 gtaggctgcg tggatgcgca acacaccccc tccttctctg ctttgggtcc cttctctcac
3181 caaattcaaa ctccattccc acctacctag aaaatcacag cctccttata atgcctcctc
3241 ctcctgccat tctctctcca cctatccatt agccttccta acgtcctact cctcacactg
3301 ctctactgct cagaaaccac caagactgtt gatgccttag ccttgcactc cagggcccta
3361 cctgcatttc ccacatgact ttctggaagc ctcccaacta ttcttgcttt tcccagacag
3421 ctcccactcc catgtctctg ctcatttagt cccgtcttcc tcaccgcccc agcaggggaa
3481 cgctcaagcc tggtcgaaat gctgcctctt cagtgaagtc atcctctttc agctctggcc
3541 gcattctgca gacttcctat cttcgtgctg tatgtttttt ttttccccct tcactctaat
3601 ggactgttcc agggaaggga tgggggcagc agctgcttcg gatccacact gtatctgtgt
3661 catccccaca tgggtcctca taaaggatta ttcaatggag gcatcctgac atctgttcat
3721 ttaggcttca gttccactcc caggaacttt gcctgtccca cgagggagta tgggagagag
3781 ggactgccac acagaagctg aagacaacac ctgcttcagg ggaacacagg cgcttgaaaa
3841 agaaaagaga gaacagccca taatgctccc cgggagcaga ggccactaat ggagagtggg
3901 aagagcctgg aaagatgtgg cctcaggaaa agggatgaga gaaaggaggt ggtatggaag
3961 actcagcagg aacaaggtag gcttcaaaga gcctatattc ctctttttcc cacaccgatc
4021 aagtcaactc agtactcacg ggagaaaaat agactttatt tacaagtaat aacatttaga
4081 aaagatccat ccccggccct taaaaacctt cccatcactc caaatcccac cccagtgcaa
4141 gtctggggaa ggtagggtgt gagctgctgc tgaaggctgt cccccaaccc cactcctgag
4201 acacagggcc catccgtcct gggaaagagc atcctctggc aggtgctccc accaggtcag
4261 acccagtcct ggacttcaag agtgagggcc cctgctgggc ccagccacca ggacagcagg
4321 aaccagggcc tactcctctt atggtccctt ctagatccag aggctaagag gaagactggc
4381 caggcccaag gacccagcca tcaaaaccag cctcaaatct ggttgtgatg gagaagtgac
4441 tttgctttaa gaaaaaagga ggcaaggtag ggagagcgcc cacactgtcc atgctccagg
4501 ccccctgggc cagctccgag aaggcgccag tgaaggacca gggaccaggc cagggtgcgg
4561 gcaggcatca ctgtctctag gggtttggct actgttggcc tgggagctga gagaaggcac
4621 tgagagggac agtaggcgga ggaccaggtg acggcagcat cggggacaca ggtggggcca
4681 ctcactggta ctggcccttt agtgctttgc ctgaaagaga cacagtcaca tggccagatg
4741 agaacttgcg atactagcct gcacccactg gctgggaaga tctcttcctg ctcccacgcc
4801 cctgtctgga tcccctccct tgtgagcccc agggttatca gttgctggct gtgcctgagc
4861 agctctgggt gctctccatg agaatggggc catctgtctt ctctccttgg agaggagcta
4921 ccaggacagg gacacctctt accccacacc ctccagcagc ctggcgtggc cccatcttgg
4981 atgctacttg gtggggcggt ctggggggtg cccatgctct catcgggttt ccctccccca
5041 tcctgccagt gcctctacct tgcccttggc tcgaggggtg gcaccaatgg cggcagcagt
5101 ggcggcgctg gctgtggtgg tggcaatgcg cggagaacgg cgggttccac tgcgagtgtt
5161 gggggaagcc ttggacaggg ccttctttga ggctccccgc cgcagaaggc tgttccctag
5221 cttcttgggt gtgttgagga tgctgaaggc catcgactgg cgccggtcag cctgcaagga
5281 agggctgtca gaccgggaga cccaatgctg ccttcccagg ccagcgtgct gtgccacgct
5341 gtaccagcaa ggtcccgcca gggcgtcgct tcatccccct tcagccccag cctcacctgt
5401 ttagtagaag ctggagctgc tttcttctgg gcctcagtag tgctctgttt gcgcccttca
5461 tgtcggtctc ggggagtcat ggggcgtggg aaacagctgg tggccttctt agactatgga
5521 gaagaggaca gttaggcaga cagtagcaag aggagtcaca tctgaagcca ggtgtcttgt
5581 cctctcagag ctgagtggac cttgtaagtc aacgtgcaac ctgctcccct tcccaactct
5641 gggccagatc cttcccttcc caacagttcc catccatggg tcaggccctt ggagagaggg
5701 aaagagaggg ggaagtgagg gaaggagaga gaaggctccc tttagtcctt ggtgagctgg
5761 gcctgacctg agcacagtgc tggagtaaca cccaggagcc accgcgccta cctcaggagt
5821 tccagggccc tggtggggct ctagggagac ccgtttgcgc tgctgccggg tggtgatgcc
5881 agtgccctcg gctatctgga ttggctgcat gctggctcgg cgcagggtct cttgggggtc
5941 tccagttttc atctcctcat ctgtgatggt gcccaggctc agggaaggct gcatgggtgg
6001 aagaggtggt cagtggacca tagctgtatg gagatggagg aggacctggg gctgttccag
6061 aactctacac tcgcccgaca cttatggtcg ggacccttcc tgcctacgag gtagaaagac
6121 acaagcctcc tttcctgttc tgctttctac ctaagccctg ggcaaatggc acaagcagtg
6181 cagtcctgac cagattcctc tctgagctcc tgcctacccc cagggacttc acccctgagt
6241 gccctccagc tgtctgttcc acctggaaca tgagaaggtc accccttccc ctcttcggcc
6301 agtcagtgat ccagggccct agtgctcagg ctagatcagc aggtgggatt ccaaggaagg
6361 gcagggatgg gaggccctgc acagtgaccc caggcctcac cctggactcc agggatagca
6421 ggtcttcaga tgtggggggc acactcgatt gcgctgctgc agctctgcaa tgcggttcca
6481 gtcatccagc tgctcaggct catcctggca agtgcccatg tagaagctgt tccttcctgt
6541 ggaaggcagg gaagtgggaa caaatgagcc tggagtcggc aggtcacctc ctggccctgg
6601 catcttgcca gcctttgctg ccacctaccc cataaacttg aagcccggca caccagtctg
6661 attcagtgcc gcaggtgcag gagtacggca cacagactat ttctatccta ggggcttgct
6721 caccaccttc tccctggaga gggcagaaga ggtcacacgc agagactgct actacatctt
6781 attcacctgc caaggcttgg tggccaacac ccagaggaac aaattaagga ccgggaatta
6841 attcccaggg gctccctggt gcccaaagga caagagcttc caagaagagt ctggccagcc
6901 tggcctttcc agcagcccat caccgcctga gaagggcatg gaggactccc cacagctaag
6961 tgtcacaatt gtgctgggaa tcccgggccc ttaactctgg ctaagagtgc ccccaacaca
7021 gccagcccct agatgggcag gtaaggaagg ccctgaggct gcaggaagga ggggcaggtg
7081 gagctggatg gtagcaagga ggccagcctt ggatttttaa aaagctttcc tcttttccct
7141 gtgccacgat ccaccttcca gtctaatttt ggggtatagt aagtccctgt agtcccctca
7201 cctggagggg ccccactgga caccccggcc tgggaacgac gagcagaact gcgagtggtg
7261 gggcggtagc caggcaagct gagcagggct gagttgccat aatcgggaga acccaggcga
7321 gctagagact gagtagagga ggtggctcgc aggctagcct gggaagcagg agcagaccgc
7381 gtgctgtaga acgatgagtt ggcgctgtct ggctcttcca catctagctt ctggaagaca
7441 gagtgaatct gttgcagtgt acagtccctg gcactgtaca gaagcttccc attcccttcc
7501 gaagccctca gatcccacgg cacatccatg tattcccaac tgctttgcaa aggtccttaa
7561 agtgtgtgtc tgcaagaaat gggccttgtc gacagaagcc ctcacaaggt ggtgctgatg
7621 ttgtcaagac tcttctacgc atttttttca tggagtctat tcataatgct ttgaggtagg
7681 gaatgcagag tgtttatcgg cccattttgg agatgaagtg caaagaaata aagtgactag
7741 ccccaaatca cactgctagg aagtatcaga gctggggcta ggccccatgt ctcctgacta
7801 gtcaggctca tcccacagcc tctgctgtcc ctcagtccaa acttccaggg cccttaccat
7861 gttccagaac ttcccccaac ttcttggtag cagggggcac cctaaacaca caggtccccc
7921 ctgctgtacc aggggccccc tctcccctcc tcccaaacct ccccttcaag atgtggaaac
7981 aaaggcaagg gcctgcagcc tgtcaggcag tccactgggc agcaacaatg cctctcagct
8041 gcatggggca tgctgggagg cacaggatgg gctgcagctt cgccacgttc tctcccttca
8101 ccctgcacag gctcagtgct acgcatggag agaatgctag ccttagtcag gaggcaggga
8161 tctaatccta gccctgcctt tttcttcaga agtgccctta accaagtcac tgcccttttt
8221 aagacctctc agctttccca ctgtaacatg gactggctgc tcatccctcc ctgctcctga
8281 ctgagtgccc ag
//