LOCUS AF110146 4325 bp mRNA linear HUM 12-MAR-1999
DEFINITION Homo sapiens eukaryotic translation initiation factor 2 alpha
kinase PEK mRNA, complete cds.
ACCESSION AF110146
VERSION AF110146.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4325)
AUTHORS Shi,Y., An,J., Liang,J., Hayes,S.E., Sandusky,G.E., Stramm,L.E. and
Yang,N.N.
TITLE Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and
co-localization with somatostatin in islet delta cells
JOURNAL J. Biol. Chem. 274 (9), 5723-5730 (1999)
PUBMED 10026192
REFERENCE 2 (bases 1 to 4325)
AUTHORS Shi,Y.
TITLE Direct Submission
JOURNAL Submitted (01-DEC-1998) Diabetes Research, Endocrine Divison, DC
0545, Lilly Research Laboratories, Eli Lilly and Company,
Indianapolis, IN 46285, USA
FEATURES Location/Qualifiers
source 1..4325
/db_xref="H-InvDB:HIT000069623"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="pancreas"
CDS 73..3420
/note="pancreatic eIF-2 alpha kinase"
/codon_start=1
/product="eukaryotic translation initiation factor 2 alpha
kinase PEK"
/protein_id="AAD19961.1"
/translation="MERAISPGLLVRALLLLLLLGLAARTVAAGRARGLPAPTAEAAF
GLGAAAAPTSATRVPAAGAVAAAEVTVEDAEALPAAAGEQEPRGPEPDDETELRPRGR
SLVIISTLDGRIAALDPENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGAL
FQWDRDRESMETVPFTVESLLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSAL
GCRQWDSDEMEQEEDILLLQRTQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAG
FIESTFKPNENTEESKIISDVEEQEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQF
CTPIASAWLLKDGKVIPISLFDDTSYTSNDDVLEDEEDIVEAARGATENSVYLGMYRG
QLYLQSSVRISEKFPSSPKALESVTNENAIIPLPTIKWKPLIHSPSRTPVLVGSDEFD
KCLSNDKFSHEEYSNGALSILQYPYDNGYYLPYYKRERNKRSTQITVRFLDNPHYNKN
IRKKDPVLLLHWWKEIVATILFCIIATTFIVRRLFHPHPHRQRKESETQCQTENKYDS
VSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIR
LPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWP
LSSPSPMDAPSVKIRRMDPFSTKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPL
EFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSR
ERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISP
PRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCL
HIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLT
PMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTL
TDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLR
QRSRSLSSSGTKHSRQSNNSHSPLPSN"
BASE COUNT 1257 a 877 c 1015 g 1176 t
ORIGIN
1 ggagctccaa gcggcgggag aggcaggcgt cagtggctgc gcctccatgc ctgcgcgcgg
61 ggcgggacgc tgatggagcg cgccatcagc ccggggctgc tggtacgggc gctgctgctg
121 ctgctgctgc tggggctcgc ggcaaggacg gtggccgcgg ggcgcgcccg tggcctccca
181 gcgccgacgg cggaggcggc gttcggcctc ggggcggccg ctgctcccac ctcagcgacg
241 cgagtaccgg cggcgggcgc cgtggctgcg gccgaggtga ctgtggagga cgctgaggcg
301 ctgccggcag ccgcgggaga gcaggagcct cggggtccgg aaccagacga tgagacagag
361 ttgcgaccgc gcggcaggtc attagtaatt atcagcactt tagatgggag aattgctgcc
421 ttggatcctg aaaatcatgg taaaaagcag tgggatttgg atgtgggatc cggttccttg
481 gtgtcatcca gccttagcaa accagaggta tttgggaata agatgatcat tccttccctg
541 gatggagccc tcttccagtg ggaccgagac cgtgaaagca tggaaacagt tcctttcaca
601 gttgaatcac ttcttgaatc ttcttataaa tttggagatg atgttgtttt ggttggagga
661 aaatctctga ctacatatgg actcagtgca tatagtggaa aggtgaggta tatctgttca
721 gctctgggtt gtcgccaatg ggatagtgac gaaatggaac aagaggaaga catcctgctt
781 ctacagcgta cccaaaaaac tgttagagct gtcggacctc gcagtggcaa tgagaagtgg
841 aatttcagtg ttggccactt tgaacttcgg tatattccag acatggaaac gagagccgga
901 tttattgaaa gcacctttaa gcccaatgag aacacagaag agtctaaaat tatttcagat
961 gtggaagaac aggaagctgc cataatggac atagtgataa aggtttcggt tgctgactgg
1021 aaagttatgg cattcagtaa gaagggagga catctggaat gggagtacca gttttgtact
1081 ccaattgcat ctgcctggtt acttaaggat gggaaagtca ttcccatcag tctttttgat
1141 gatacaagtt atacatctaa tgatgatgtt ttagaagatg aagaagacat tgtagaagct
1201 gccagaggag ccacagaaaa cagtgtttac ttgggaatgt atagaggcca gctgtatctg
1261 cagtcatcag tcagaatttc agaaaagttt ccttcaagtc ccaaggcttt ggaatctgtc
1321 actaatgaaa acgcaattat tcctttacca acaatcaaat ggaaaccctt aattcattct
1381 ccttccagaa ctcctgtctt ggtaggatct gatgaatttg acaaatgtct cagtaatgat
1441 aagttttctc atgaagaata tagtaatggt gcactttcaa tcttgcagta tccatatgat
1501 aatggttatt atctaccata ctacaagagg gagaggaaca aacgaagcac acagattaca
1561 gtcagattcc tcgacaaccc acattacaac aagaatatcc gcaaaaagga tcctgttctt
1621 cttttacact ggtggaaaga aatagttgca acgattttgt tttgtatcat agcaacaacg
1681 tttattgtgc gcaggctttt ccatcctcat cctcacaggc aaaggaagga gtctgaaact
1741 cagtgtcaaa ctgaaaataa atatgattct gtaagtggtg aagccaatga cagtagctgg
1801 aatgacataa aaaactctgg atatatatca cgatatctaa ctgattttga gccaattcag
1861 tgcctgggac gtggtggctt tggagttgtt tttgaagcta aaaacaaagt agatgactgc
1921 aattatgcta tcaagaggat ccgtctcccc aatagggaat tggctcggga aaaggtaatg
1981 cgagaagtta aagccttagc caagcttgaa cacccgggca ttgttagata tttcaatgcc
2041 tggctcgaag caccaccaga gaagtggcaa gaaaagatgg atgaaatttg gctgaaagat
2101 gaaagcacag actggccact cagctctcct agcccaatgg atgcaccatc agttaaaata
2161 cgcagaatgg atcctttctc tacaaaagaa catattgaaa tcatagctcc ttcaccacaa
2221 agaagcaggt ctttttcagt agggatttcc tgtgaccaga caagttcatc tgagagccag
2281 ttctcaccac tggaattctc aggaatggac catgaggaca tcagtgagtc agtggatgca
2341 gcatacaacc tccaggacag ttgccttaca gactgtgatg tggaagatgg gactatggat
2401 ggcaatgatg aggggcactc ctttgaactt tgtccttctg aagcttctcc ttatgtaagg
2461 tcaagggaga gaacctcctc ttcaatagta tttgaagatt ctggctgtga taatgcttcc
2521 agtaaagaag agccgaaaac taatcgattg catattggca accattgtgc taataaacta
2581 actgctttca agcccaccag tagcaaatct tcttctgaag ctacattgtc tatttctcct
2641 ccaagaccaa ccactttaag tttagatctc actaaaaaca ccacagaaaa actccagccc
2701 agttcaccaa aggtgtatct ttacattcaa atgcagctgt gcagaaaaga aaacctcaaa
2761 gactggatga atggacgatg taccatagag gagagagaga ggagcgtgtg tctgcacatc
2821 ttcctgcaga tcgcagaggc agtggagttt cttcacagta aaggactgat gcacagggac
2881 ctcaagccat ccaacatatt ctttacaatg gatgatgtgg tcaaggttgg agactttggg
2941 ttagtgactg caatggacca ggatgaggaa gagcagacgg ttctgacccc aatgccagct
3001 tatgccagac acacaggaca agtagggacc aaactgtata tgagcccaga gcagattcat
3061 ggaaacagct attctcataa agtggacatc ttttctttag gcctgattct atttgaattg
3121 ctgtatccat tcagcactca gatggagaga gtcaggacct taactgatgt aagaaatctc
3181 aaatttccac cattatttac tcagaaatat ccttgtgagt acgtgatggt tcaagacatg
3241 ctctctccat cccccatgga acgacctgaa gctataaaca tcattgaaaa tgctgtattt
3301 gaggacttgg actttccagg aaaaacagtg ctcagacaga ggtctcgctc cttgagttca
3361 tcgggaacaa aacattcaag acagtccaac aactcccata gccctttgcc aagcaattag
3421 ccttaagttg tgctagcaac cctaataggt gatgcagata atagcctact tcttagaata
3481 tgcctgtcca aaattgcaga cttgaaaagt ttgttcttcg ctcaattttt ttgtggacta
3541 ctttttttat atcaaattta agctggattt gggggcataa cctaatttga gccaactcct
3601 gagttttgct atacttaagg aaagggctat ctttgttctt tgttagtctc ttgaaactgg
3661 ctgctggcca agctttatag ccctcaccat ttgcctaagg aggtagcagc aatccctaat
3721 atatatatat agtgagaact aaaatggata tatttttata atgcagaaga aggaaagtcc
3781 ccctgtgtgg taactgtatt gttctagaaa tatgctttct agagatatga tgattttgaa
3841 actgatttct agaaaaagct gactccattt ttgtccctgg cgggtaaatt aggaatctgc
3901 actattttgg aggacaagta gcacaaactg tataacggtt tatgtccgta gttttatagt
3961 cctatttgta gcattcaata gctttattcc ttagatggtt ctagggtggg tttacagctt
4021 tttgtacttt tacctccaat aaagggaaaa tgaagctttt tatgtaaatt ggttgaaagg
4081 tctagttttg ggaggaaaaa agccgtagta agaaatggat catatatatt acaactaact
4141 tcttcaacta tggacttttt aagcctaatg aaatcttaag tgtcttatat gtaatcctgt
4201 aggttggtac ttcccccaaa ctgattatag gtaacagttt aatcatctca cttgctaaca
4261 tgtttttatt tttcactgta aatatgttta tgttttattt ataaaaattc tgaaatcaat
4321 ccatg
//