LOCUS AF109161 1919 bp mRNA linear HUM 28-JAN-1999
DEFINITION Homo sapiens p35srj (MRG1) mRNA, complete cds.
ACCESSION AF109161
VERSION AF109161.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1919)
AUTHORS Bhattacharya,S., Michels,C.L., Leung,M.K., Arany,Z.P., Kung,A.L.
and Livingston,D.M.
TITLE Functional role of p35srj, a novel p300/CBP binding protein, during
transactivation by HIF-1
JOURNAL Genes Dev. 13 (1), 64-75 (1999)
PUBMED 9887100
REFERENCE 2 (bases 1 to 1919)
AUTHORS Bhattacharya,S., Michels,C.M., Leung,M.K., Arany,Z.P., Kung,A.L.
and Livingston,D.M.
TITLE Direct Submission
JOURNAL Submitted (24-NOV-1998) Cardiovascular Medicine, John Radcliffe
Hospital, University of Oxford, Headley Way, Oxford OX3 9DU, UK
FEATURES Location/Qualifiers
source 1..1919
/db_xref="H-InvDB:HIT000069600"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="HEK293"
gene 1..1919
/gene="MRG1"
/note="Msg1-related gene 1"
CDS 217..1029
/gene="MRG1"
/function="interferes with the binding of transcription
factors HIF-1a and STAT2 to p300/CBP"
/note="alternatively spliced isoform of MRG1, encoded by
GenBank Accession Number U65093; induced by hypoxia and
deferoxamine"
/codon_start=1
/product="p35srj"
/protein_id="AAD10055.1"
/translation="MADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQP
QHAFNALMGEHIHYGAGNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPP
VASQGGSLPASMQLQKLNNQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKH
SGGSSTPGGSGGSSTPGGSGSSSGGGAGSSNSGGGSGSGNMPASVAHVPAAMLPPNVI
DTDFIDEEVLMSLVIEMGLDRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC"
misc_feature 886..981
/gene="MRG1"
/note="Region: p300/CBP-CH1 binding site"
BASE COUNT 501 a 515 c 452 g 451 t
ORIGIN
1 gtcctgccga gctgtgaggg caacggaggg gaaataaaag ggaacggctc cgaatctgcc
61 ccagcggccg ctgcgagacc tcggcgccga catcgcgaca gcgaagcgct ttgcacgcca
121 ggaaggtccc ctctatgtgc tgctgagccg gtcctggacg cgacgagccc gccctcggtc
181 ttcggagcag aaatcgcaaa aacggaagga ctggaaatgg cagaccatat gatggccatg
241 aaccacgggc gcttccccga cggcaccaat gggctgcacc atcaccctgc ccaccgcatg
301 ggcatggggc agttcccgag cccccatcac caccagcagc agcagcccca gcacgccttc
361 aacgccctaa tgggcgagca catacactac ggcgcgggca acatgaatgc cacgagcggc
421 atcaggcatg cgatggggcc ggggactgtg aacggagggc accccccgag cgcgctggcc
481 cccgcggcca ggtttaacaa ctcccagttc atgggtcccc cggtggccag ccagggaggc
541 tccctgccgg ccagcatgca gctgcagaag ctcaacaacc agtatttcaa ccatcacccc
601 tacccccaca accactacat gccggatttg caccctgctg caggccacca gatgaacggg
661 acaaaccagc acttccgaga ttgcaacccc aagcacagcg gcggcagcag cacccccggc
721 ggctcgggcg gcagcagcac ccccggcggc tctggcagca gctcgggcgg cggcgcgggc
781 agcagcaaca gcggcggcgg cagcggcagc ggcaacatgc ccgcctccgt ggcccacgtc
841 cccgctgcaa tgctgccgcc caatgtcata gacactgatt tcatcgacga ggaagttctt
901 atgtccttgg tgatagaaat gggtttggac cgcatcaagg agctgcccga actctggctg
961 gggcaaaacg agtttgattt tatgacggac ttcgtgtgca aacagcagcc cagcagagtg
1021 agctgttgac tcgatcgaaa ccccggcgaa agaaatcaaa cccccaactt cttcggcgtg
1081 aattaaaaga aacattccct tagacacagt atctcacttt tcagatcttg aaaggtttga
1141 gaacttggaa acaaagtaaa ctataaactt gtacaaattg gttttaaaaa aaattgctgc
1201 cacttttttt tcctgttttt gtttcgtttt tgtagccttg acattcaccc acctccctta
1261 tgtagttgaa atatctagct aacttggtct ttttcgttgt ttgtttttac tcctttccct
1321 cactttctcc agtgctcaac tgttagatat taatcttggc aaactgctta atcttgtgga
1381 ttttgtagat ggtttcaaat gactgaactg cattcagatt tacgagtgaa aggaaaaatt
1441 gcattagttg gttgcatgaa ctttgaaggg cagatattac tgcacaaact gccatctcgc
1501 ttcatttttt taactatgca tttgagtaca gactaatttt taaaatatgc taaactggaa
1561 gattaaacag atgtggccca aactgttctg gatcaggaaa gtcatactgt tcactttcaa
1621 gttggctgtc ccccccgccg ccccccccca cccccatatg tacagatgat aatagggtgt
1681 ggaatgtcgt cagtggcaaa catttcacag attattttgt ttctgtcttc aacatttttg
1741 acactgtgct aatagttata ttcagtacat gaaaagatac tactgtgttg aaagcctttt
1801 aggaaatttt gacagtattt ttgtacaaaa catttttttg aaaaaatact tgttaattta
1861 ttctatttta atttgccaat gtcaataaaa agttaagaaa taaaaaaaaa aaaaaaaaa
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