LOCUS AF107297 3670 bp mRNA linear HUM 10-AUG-1999
DEFINITION Homo sapiens mitotic checkpoint protein kinase BUB1B (BUB1B) mRNA,
complete cds.
ACCESSION AF107297
VERSION AF107297.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3670)
AUTHORS Davenport,J.W., Fernandes,E.R., Harris,L.D., Neale,G.A. and
Goorha,R.
TITLE The mouse mitotic checkpoint gene bub1b, a novel bub1 family
member, is expressed in a cell cycle-dependent manner
JOURNAL Genomics 55 (1), 113-117 (1999)
PUBMED 9889005
REFERENCE 2 (bases 1 to 3670)
AUTHORS Davenport,J.W., Fernandes,E.R., Harris,L.D., Neale,G.A.M. and
Goorha,R.
TITLE Direct Submission
JOURNAL Submitted (17-NOV-1998) Virology and Molecular Biology, St. Jude
Children's Research Hospital, 332 N. Lauderdale, Memphis, TN
38105-2794, USA
FEATURES Location/Qualifiers
source 1..3670
/db_xref="H-InvDB:HIT000069546"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q15"
/dev_stage="8 week-old embryo"
/note="sequence derived from TIGR EST AA332513"
gene 1..3670
/gene="BUB1B"
CDS 138..3290
/gene="BUB1B"
/function="probable component of the mitotic checkpoint
that delays anaphase until all chromosomes are properly
attached to the mitotic spindle"
/codon_start=1
/product="mitotic checkpoint protein kinase BUB1B"
/protein_id="AAD11941.1"
/translation="MAAVKKEGGALSEAMSLEGDEWELSKENVQPLRQGRIMSTLQGA
LAQESACNNTLQQQKRAFEYEIRFYTGNDPLDVWDRYISWTEQNYPQGGKESNMSTLL
ERAVEALQGEKRYYSDPRFLNLWLKLGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAE
EYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARVSRQTLLALEKEEEEEVFE
SSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFD
ENADEASTAELSKPTVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVP
AVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQRVQSHQQASEEK
KEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEME
KKLKEIQTTQQERTGDQQEETMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARET
SLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAVLKTSES
ITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHE
IMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTLSIKKLSPIIEDSREATHS
SGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSAS
AELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSS
QPVPWDFYINLKLKERLNEDFDHFCSCYQYQDGCIVWHQYINCFTLQDLLQHSEYITH
EITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSY
SVDLRVQLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVF
WDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFDTTFQSH
LNKALWKVGKLTSPGALLFQ"
misc_feature 186..737
/gene="BUB1B"
/note="homology region A; similar to mammalian Bub1a and
yeast Bub1 and Mad3; other site"
misc_feature 1281..1505
/gene="BUB1B"
/note="homology region B; similar to mammalian Bub1a;
other site"
misc_feature 1842..2054
/gene="BUB1B"
/note="homology region C; similar to mammalian Bub1a;
other site"
misc_feature 2388..3287
/gene="BUB1B"
/note="homology region D; Region: kinase domain"
BASE COUNT 1144 a 741 c 830 g 955 t
ORIGIN
1 ccggtttgtt agggagtcgt gtacgtgcct tggtcgcttc tgtagctccg agggcaggtt
61 gcggaagaaa gcccaggcgg tctgtggccc agaggaaagg cctgcagcag gacgaggacc
121 tgagccagga atgcaggatg gcggcggtga agaaggaagg gggtgctctg agtgaagcca
181 tgtccctgga gggagatgaa tgggaactga gtaaagaaaa tgtacaacct ttaaggcaag
241 ggcggatcat gtccacgctt cagggagcac tggcacaaga atctgcctgt aacaatactc
301 ttcagcagca gaaacgggca tttgaatatg aaattcgatt ttacactgga aatgaccctc
361 tggatgtttg ggataggtat atcagctgga cagagcagaa ctatcctcaa ggtgggaagg
421 agagtaatat gtcaacgtta ttagaaagag ctgtagaagc actacaagga gaaaaacgat
481 attatagtga tcctcgattt ctcaatctct ggcttaaatt agggcgttta tgcaatgagc
541 ctttggatat gtacagttac ttgcacaacc aagggattgg tgtttcactt gctcagttct
601 atatctcatg ggcagaagaa tatgaagcta gagaaaactt taggaaagca gatgcgatat
661 ttcaggaagg gattcaacag aaggctgaac cactagaaag actacagtcc cagcaccgac
721 aattccaagc tcgagtgtct cggcaaactc tgttggcact tgagaaagaa gaagaggagg
781 aagtttttga gtcttctgta ccacaacgaa gcacactagc tgaactaaag agcaaaggga
841 aaaagacagc aagagctcca atcatccgtg taggaggtgc tctcaaggct ccaagccaga
901 acagaggact ccaaaatcca tttcctcaac agatgcaaaa taatagtaga attactgttt
961 ttgatgaaaa tgctgatgag gcttctacag cagagttgtc taagcctaca gtccagccat
1021 ggatagcacc ccccatgccc agggccaaag agaatgagct gcaagcaggc ccttggaaca
1081 caggcaggtc cttggaacac aggcctcgtg gcaatacagc ttcactgata gctgtacccg
1141 ctgtgcttcc cagtttcact ccatatgtgg aagagactgc acgacagcca gttatgacac
1201 catgtaaaat tgaacctagt ataaaccaca tcctaagcac cagaaagcct ggaaaggaag
1261 aaggagatcc tctacaaagg gttcagagcc atcagcaagc gtctgaggag aagaaagaga
1321 agatgatgta ttgtaaggag aagatttatg caggagtagg ggaattctcc tttgaagaaa
1381 ttcgggctga agttttccgg aagaaattaa aagagcaaag ggaagccgag ctattgacca
1441 gtgcagagaa gagagcagaa atgcagaaac agattgaaga gatggagaag aagctaaaag
1501 aaatccaaac tactcagcaa gaaagaacag gtgatcagca agaagagacg atgcctacaa
1561 aggagacaac taaactgcaa attgcttccg agtctcagaa aataccagga atgactctat
1621 ccagttctgt ttgtcaagta aactgttgtg ccagagaaac ttcacttgcg gagaacattt
1681 ggcaggaaca acctcattct aaaggtccca gtgtaccttt ctccattttt gatgagtttc
1741 ttctttcaga aaagaagaat aaaagtcctc ctgcagatcc cccacgagtt ttagctcaac
1801 gaagacccct tgcagttctc aaaacctcag aaagcatcac ctcaaatgaa gatgtgtctc
1861 cagatgtttg tgatgaattt acaggaattg aacccttgag cgaggatgcc attatcacag
1921 gcttcagaaa tgtaacaatt tgtcctaacc cagaagacac ttgtgacttt gccagagcag
1981 ctcgttttgt atccactcct tttcatgaga taatgtcctt gaaggatctc ccttctgatc
2041 ctgagagact gttaccggaa gaagatctag atgtaaagac ctctgaggac cagcagacag
2101 cttgtggcac tatctacagt cagactctca gcatcaagaa gctgagccca attattgaag
2161 acagtcgtga agccacacac tcctctggct tctctggttc ttctgcctcg gttgcaagca
2221 cctcctccat caaatgtctt caaattcctg agaaactaga acttactaat gagacttcag
2281 aaaaccctac tcagtcacca tggtgttcac agtatcgcag acagctactg aagtccctac
2341 cagagttaag tgcctctgca gagttgtgta tagaagacag accaatgcct aagttggaaa
2401 ttgagaagga aattgaatta ggtaatgagg attactgcat taaacgagaa tacctaatat
2461 gtgaagatta caagttattc tgggtggcgc caagaaactc tgcagaatta acagtaataa
2521 aggtatcttc tcaacctgtc ccatgggact tttatatcaa cctcaagtta aaggaacgtt
2581 taaatgaaga ttttgatcat ttttgcagct gttatcaata tcaagatggc tgtattgttt
2641 ggcaccaata tataaactgc ttcacccttc aggatcttct ccaacacagt gaatatatta
2701 cccatgaaat aacagtgttg attatttata accttttgac aatagtggag atgctacaca
2761 aagcagaaat agtccatggt gacttgagtc caaggtgtct gattctcaga aacagaatcc
2821 acgatcccta tgattgtaac aagaacaatc aagctttgaa gatagtggac ttttcctaca
2881 gtgttgacct tagggtgcag ctggatgttt ttaccctcag cggctttcgg actgtacaga
2941 tcctggaagg acaaaagatc ctggctaact gttcttctcc ctaccaggta gacctgtttg
3001 gtatagcaga tttagcacat ttactattgt tcaaggaaca cctacaggtc ttctgggatg
3061 ggtccttctg gaaacttagc caaaatattt ctgagctaaa agatggtgaa ttgtggaata
3121 aattctttgt gcggattctg aatgccaatg atgaggccac agtgtctgtt cttggggagc
3181 ttgcagcaga aatgaatggg gtttttgaca ctacattcca aagtcacctg aacaaagcct
3241 tatggaaggt agggaagtta actagtcctg gggctttgct ctttcagtga gctaggcaat
3301 caagtctcac agattgctgc ctcagagcaa tggttgtatt gtggaacact gaaactgtat
3361 gtgctgtaat ttaatttagg acacatttag atgcactacc attgctgttc tactttttgg
3421 tacaggtata ttttgacgtc actgatattt tttatacagt gatatactta ctcatggcct
3481 tgtctaactt ttgtgaagaa ctattttatt ctaaacagac tcattacaaa tggttacctt
3541 gttatttaac ccatttgtct ctacttttcc ctgtactttt cccatttgta atttgtaaaa
3601 tgttctctta tgatcaccat gtattttgta aataataaaa tagtatctgt taaaaaaaaa
3661 aaaaaaaaaa
//