LOCUS AF105369 1641 bp mRNA linear HUM 17-JUN-1999
DEFINITION Homo sapiens actin-associated protein 2E4/kaptin (2E4) mRNA, 2E4-1
allele, complete cds.
ACCESSION AF105369
VERSION AF105369.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1641)
AUTHORS Bearer,E.L.
TITLE An actin-associated protein present in the microtubule organizing
center and the growth cones of PC-12 cells
JOURNAL J. Neurosci. 12 (3), 750-761 (1992)
PUBMED 1372044
REFERENCE 2 (bases 1 to 1641)
AUTHORS Bearer,E.L. and Abraham,M.T.
TITLE 2E4 (kaptin): a novel actin-associated protein from human blood
platelets found in lamellipodia and the tips of the stereocilia of
the inner ear
JOURNAL Eur. J. Cell Biol. 78 (2), 117-126 (1999)
PUBMED 10099934
REFERENCE 3 (bases 1 to 1641)
AUTHORS Bearer,E. and Abraham,M.
TITLE Direct Submission
JOURNAL Submitted (10-NOV-1998) Pathology, Brown University, BioMed Center,
Providence, RI 02912, USA
FEATURES Location/Qualifiers
source 1..1641
/db_xref="H-InvDB:HIT000069481"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="HEL"
/note="isolated by monoclonal antibody 2E4 screen of
phorbol-esther treated HEL cells"
gene 1..1641
/gene="2E4"
/allele="2E4-1"
CDS 40..1530
/gene="2E4"
/allele="2E4-1"
/note="found at barbed ends of actin filament in
platelets, fibroblasts, neuronal growth cones, intestinal
microvilli and stereocilia of the inner ear"
/codon_start=1
/product="actin-associated protein 2E4/kaptin"
/protein_id="AAD39358.1"
/translation="MMGEAAVPRGLSLREDSFTRFSSQNNVYGLAGGAGGRGELLAAT
LKGKVLGFRYQDLRQKIRPVAKELQFNYIPVDAEIVSIDTFNKSPPKRGLVVGITFIK
DSGDKGSPFLNIYCDYETGSVYNLVSIAQSCLNLELQFTPFQLCHAEVQVGDQLETVF
LLSGNDPAIHLYKENEGLHQFEEQPVENLFPELTNLTSSVLWLDVHNFPGTSRRLSAL
GCQSGYVRVAHVDQRSREVLQMWSVLQDGPISRVIVFSLSAAKETKDRPLQDEYSVLV
ASMLEPAVVYRDLLNRGLEDQLLLPGSDQFDSVLCSLVTDVDLDGRPEVLVATYGQEL
LCYKYRGPESGLPEAQHGFHLLWQRSFSSPLLAMAHVDLTGDGLQELAVVSLKGVHIL
QHSLIQASELVLTRLRTSSGAEETSAYRGWRTGQVQGLLRMQPLKHPCTHSSQTWGDS
WRAHLQPLVGGVLKDRMLSPDLPRVVKLCPGAPANPLLSLYVNVPI"
BASE COUNT 325 a 479 c 503 g 334 t
ORIGIN
1 gaattcgggg gctgcggaga gggtgcttaa ctgaggggca tgatggggga ggcggccgtg
61 ccgcggggct tgtcgttgcg cgaggacagc ttcacgcgct tctcgtcgca gaacaatgtg
121 tacgggctgg caggcggcgc cggcgggcgc ggggagctgc tggccgccac ccttaaaggc
181 aaggtgctcg gcttccgtta ccaagacctc cgacagaaaa tccggccagt ggccaaggag
241 ctgcagttca actacattcc cgtggatgcg gagattgtct ccatcgacac tttcaacaag
301 tcacccccca agcggggtct ggttgtgggg atcacgttca tcaaggattc aggggacaag
361 ggcagcccct tcctgaacat ttactgcgac tacgagaccg gctctgtgta caaccttgtc
421 tctattgccc agagctgcct gaacctggag ctccagttca ctccgttcca gctgtgccat
481 gcggaggtcc aggtcgggga tcaacttgag actgtgtttc tcttgagtgg gaacgacccg
541 gccattcatc tctacaagga gaacgagggc ctgcatcagt ttgaggaaca gcccgtggaa
601 aacctcttcc cagagctgac gaacctgacc agtagcgtcc tctggctgga cgtccacaac
661 ttccccggca cgtcccggcg cctctcagct ctgggctgtc agagtggtta tgtccgtgtc
721 gcccacgtgg accagcggag tcgagaggtt ctgcagatgt ggtcggtcct gcaggacggt
781 cccatctccc gagtgattgt gttcagcctc tcggccgcca aggagaccaa ggacaggcca
841 ctacaagatg agtacagcgt gctcgtggcc agcatgttgg agccagcagt ggtgtatcgg
901 gacctgctga accggggtct tgaagaccag cttctcctgc ccggcagtga ccagtttgac
961 agcgtcctct gcagcctggt caccgatgtg gatttggatg ggcggccaga agtcctggtg
1021 gccacctatg gacaggaact gctgtgttat aagtaccggg gcccagagtc ggggcttcct
1081 gaggcccagc acgggttcca tctgctgtgg cagcggagct tctccagtcc cctgctggcc
1141 atggctcacg tggacctgac cggggatggg ctgcaggagc ttgccgtggt ctccctgaag
1201 ggcgtgcaca tcctgcagca cagcctgatt caggcctcag agctggtctt gacccggctt
1261 cgaacatcaa gtggagcaga ggagacgtcg gcctacaggg gttggaggac ggggcaggtg
1321 cagggcctgc tgagaatgca gcctcttaag cacccatgca cccactcttc ccagacctgg
1381 ggcgactcat ggcgtgctca cctccagccg ctggtggggg gtgtcctgaa ggacaggatg
1441 ctctccccag acctccccag ggtggtgaag ctgtgccctg gggccccagc taacccactc
1501 ctctctctgt acgtcaatgt ccctatttga aagcagggat gatcccattc caccctgtcc
1561 actctggatg agaattggcc acctgatggt tatttatacg tccagaagaa catccccaaa
1621 aaaaaaaaaa aaaccgaatt c
//