LOCUS       AF104419                1114 bp    mRNA    linear   HUM 06-JAN-1999
DEFINITION  Homo sapiens decoy receptor 3 (DcR3) mRNA, complete cds.
ACCESSION   AF104419
VERSION     AF104419.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1114)
  AUTHORS   Pitti,R.M., Marsters,S.A., Lawrence,D.A., Roy,M., Kischkel,F.C.,
            Dowd,P., Huang,A., Donahue,C.J., Sherwood,S.W., Baldwin,D.T.,
            Godowski,P.J., Wood,W.I., Gurney,A.L., Hillan,K.J., Cohen,R.L.,
            Goddard,A.D., Botstein,D. and Ashkenazi,A.
  TITLE     Genomic amplification of a decoy receptor for Fas ligand in lung
            and colon cancer
  JOURNAL   Nature 396 (6712), 699-703 (1998)
   PUBMED   9872321
REFERENCE   2  (bases 1 to 1114)
  AUTHORS   Pitti,R.M., Marsters,S.A., Lawrence,D.A., Roy,M., Kischkel,F.C.,
            Dowd,P., Huang,A., Donahue,C.J., Sherwood,S.W., Baldwin,D.T.,
            Godowski,P.J., Wood,W.I., Gurney,A.L., Hillan,K.J., Cohen,R.L.,
            Goddard,A.D., Botstein,D. and Ashkenazi,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-NOV-1998) Molecular Oncology, Genentech, 1 DNA Way,
            San Francisco, CA 94080, USA
FEATURES             Location/Qualifiers
     source          1..1114
                     /db_xref="H-InvDB:HIT000069423"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13"
                     /note="linked by radiation-hybrid analysis to chromosome
                     20 marker AFM218xe7"
     gene            1..1114
                     /gene="DcR3"
     CDS             101..1003
                     /gene="DcR3"
                     /function="binds to Fas/Apo1/CD95 ligand and blocks its
                     activity"
                     /note="secreted soluble member of the tumor necrosis
                     factor receptor family; amplified in lung and colon
                     cancer"
                     /codon_start=1
                     /product="decoy receptor 3"
                     /protein_id="AAD03056.1"
                     /translation="MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDAETG
                     ERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEA
                     RACHATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSA
                     SSSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDF
                     VAFQDISIKRLQRLLQALEAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRL
                     LQALRVARMPGLERSVRERFLPVH"
BASE COUNT          188 a          379 c          356 g          191 t
ORIGIN      
        1 tccgcaggcg gaccgggggc aaaggaggtg gcatgtcggt caggcacagc agggtcctgt
       61 gtccgcgctg agccgcgctc tccctgctcc agcaaggacc atgagggcgc tggaggggcc
      121 aggcctgtcg ctgctgtgcc tggtgttggc gctgcctgcc ctgctgccgg tgccggctgt
      181 acgcggagtg gcagaaacac ccacctaccc ctggcgggac gcagagacag gggagcggct
      241 ggtgtgcgcc cagtgccccc caggcacctt tgtgcagcgg ccgtgccgcc gagacagccc
      301 cacgacgtgt ggcccgtgtc caccgcgcca ctacacgcag ttctggaact acctggagcg
      361 ctgccgctac tgcaacgtcc tctgcgggga gcgtgaggag gaggcacggg cttgccacgc
      421 cacccacaac cgtgcctgcc gctgccgcac cggcttcttc gcgcacgctg gtttctgctt
      481 ggagcacgca tcgtgtccac ctggtgccgg cgtgattgcc ccgggcaccc ccagccagaa
      541 cacgcagtgc cagccgtgcc ccccaggcac cttctcagcc agcagctcca gctcagagca
      601 gtgccagccc caccgcaact gcacggccct gggcctggcc ctcaatgtgc caggctcttc
      661 ctcccatgac accctgtgca ccagctgcac tggcttcccc ctcagcacca gggtaccagg
      721 agctgaggag tgtgagcgtg ccgtcatcga ctttgtggct ttccaggaca tctccatcaa
      781 gaggctgcag cggctgctgc aggccctcga ggccccggag ggctggggtc cgacaccaag
      841 ggcgggccgc gcggccttgc agctgaagct gcgtcggcgg ctcacggagc tcctgggggc
      901 gcaggacggg gcgctgctgg tgcggctgct gcaggcgctg cgcgtggcca ggatgcccgg
      961 gctggagcgg agcgtccgtg agcgcttcct ccctgtgcac tgatcctggc cccctcttat
     1021 ttattctaca tccttggcac cccacttgca ctgaaagagg ctttttttta aatagaagaa
     1081 atgaggtttc ttaaaaaaaa aaaaaaaaaa aaaa
//