LOCUS AF104419 1114 bp mRNA linear HUM 06-JAN-1999 DEFINITION Homo sapiens decoy receptor 3 (DcR3) mRNA, complete cds. ACCESSION AF104419 VERSION AF104419.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1114) AUTHORS Pitti,R.M., Marsters,S.A., Lawrence,D.A., Roy,M., Kischkel,F.C., Dowd,P., Huang,A., Donahue,C.J., Sherwood,S.W., Baldwin,D.T., Godowski,P.J., Wood,W.I., Gurney,A.L., Hillan,K.J., Cohen,R.L., Goddard,A.D., Botstein,D. and Ashkenazi,A. TITLE Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer JOURNAL Nature 396 (6712), 699-703 (1998) PUBMED 9872321 REFERENCE 2 (bases 1 to 1114) AUTHORS Pitti,R.M., Marsters,S.A., Lawrence,D.A., Roy,M., Kischkel,F.C., Dowd,P., Huang,A., Donahue,C.J., Sherwood,S.W., Baldwin,D.T., Godowski,P.J., Wood,W.I., Gurney,A.L., Hillan,K.J., Cohen,R.L., Goddard,A.D., Botstein,D. and Ashkenazi,A. TITLE Direct Submission JOURNAL Submitted (04-NOV-1998) Molecular Oncology, Genentech, 1 DNA Way, San Francisco, CA 94080, USA FEATURES Location/Qualifiers source 1..1114 /db_xref="H-InvDB:HIT000069423" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="20" /map="20q13" /note="linked by radiation-hybrid analysis to chromosome 20 marker AFM218xe7" gene 1..1114 /gene="DcR3" CDS 101..1003 /gene="DcR3" /function="binds to Fas/Apo1/CD95 ligand and blocks its activity" /note="secreted soluble member of the tumor necrosis factor receptor family; amplified in lung and colon cancer" /codon_start=1 /product="decoy receptor 3" /protein_id="AAD03056.1" /translation="MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDAETG ERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEA RACHATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSA SSSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDF VAFQDISIKRLQRLLQALEAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRL LQALRVARMPGLERSVRERFLPVH" BASE COUNT 188 a 379 c 356 g 191 t ORIGIN 1 tccgcaggcg gaccgggggc aaaggaggtg gcatgtcggt caggcacagc agggtcctgt 61 gtccgcgctg agccgcgctc tccctgctcc agcaaggacc atgagggcgc tggaggggcc 121 aggcctgtcg ctgctgtgcc tggtgttggc gctgcctgcc ctgctgccgg tgccggctgt 181 acgcggagtg gcagaaacac ccacctaccc ctggcgggac gcagagacag gggagcggct 241 ggtgtgcgcc cagtgccccc caggcacctt tgtgcagcgg ccgtgccgcc gagacagccc 301 cacgacgtgt ggcccgtgtc caccgcgcca ctacacgcag ttctggaact acctggagcg 361 ctgccgctac tgcaacgtcc tctgcgggga gcgtgaggag gaggcacggg cttgccacgc 421 cacccacaac cgtgcctgcc gctgccgcac cggcttcttc gcgcacgctg gtttctgctt 481 ggagcacgca tcgtgtccac ctggtgccgg cgtgattgcc ccgggcaccc ccagccagaa 541 cacgcagtgc cagccgtgcc ccccaggcac cttctcagcc agcagctcca gctcagagca 601 gtgccagccc caccgcaact gcacggccct gggcctggcc ctcaatgtgc caggctcttc 661 ctcccatgac accctgtgca ccagctgcac tggcttcccc ctcagcacca gggtaccagg 721 agctgaggag tgtgagcgtg ccgtcatcga ctttgtggct ttccaggaca tctccatcaa 781 gaggctgcag cggctgctgc aggccctcga ggccccggag ggctggggtc cgacaccaag 841 ggcgggccgc gcggccttgc agctgaagct gcgtcggcgg ctcacggagc tcctgggggc 901 gcaggacggg gcgctgctgg tgcggctgct gcaggcgctg cgcgtggcca ggatgcccgg 961 gctggagcgg agcgtccgtg agcgcttcct ccctgtgcac tgatcctggc cccctcttat 1021 ttattctaca tccttggcac cccacttgca ctgaaagagg ctttttttta aatagaagaa 1081 atgaggtttc ttaaaaaaaa aaaaaaaaaa aaaa //