LOCUS AF104413 4307 bp mRNA linear HUM 18-MAR-1999
DEFINITION Homo sapiens large tumor suppressor 1 (LATS1) mRNA, complete cds.
ACCESSION AF104413
VERSION AF104413.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4307)
AUTHORS Xu,T., Wang,W., Zhang,S., Stewart,R.A. and Yu,W.
TITLE Identifying tumor suppressors in genetic mosaics: the Drosophila
lats gene encodes a putative protein kinase
JOURNAL Development 121 (4), 1053-1063 (1995)
PUBMED 7743921
REFERENCE 2 (bases 1 to 4307)
AUTHORS Tao,W., Zhang,S., Turenchalk,G.S., Stewart,R.A., St John,M.A.,
Chen,W. and Xu,T.
TITLE Human homologue of the Drosophila melanogaster lats tumour
suppressor modulates CDC2 activity
JOURNAL Nat. Genet. 21 (2), 177-181 (1999)
PUBMED 9988268
REFERENCE 3 (bases 1 to 4307)
AUTHORS St John,M.A., Tao,W., Fei,X., Fukumoto,R., Carcangiu,M.L.,
Brownstein,D.G., Parlow,A.F., McGrath,J. and Xu,T.
TITLE Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian
tumours and pituitary dysfunction
JOURNAL Nat. Genet. 21 (2), 182-186 (1999)
PUBMED 9988269
REFERENCE 4 (bases 1 to 4307)
AUTHORS Tao,W. and Xu,T.
TITLE Direct Submission
JOURNAL Submitted (04-NOV-1998) Genetics, HHMI, Yale University, 295
Congress Ave BCMM 254D, New Haven, CT 06536, USA
FEATURES Location/Qualifiers
source 1..4307
/db_xref="H-InvDB:HIT000069422"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="brain"
/dev_stage="fetus"
gene 1..4307
/gene="LATS1"
CDS 549..3941
/gene="LATS1"
/note="putative serine threonine kinase"
/codon_start=1
/product="large tumor suppressor 1"
/protein_id="AAD16882.1"
/translation="MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKP
SDAAKAEHNMSKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVN
PQMLQDLQAAGFDEDMVIQALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPIN
ASMKPGNVQQSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGS
GISAFVQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKR
YSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQS
SSKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAANGQSPSALQTG
GSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHE
IPTWQPNIPVRSNSFNNPLGNRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPEL
QTALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQ
NPSVPPYESISKPSKEDQPSLPKEDESEKSYENVDSGDKEKKQITTSPITVRKNKKDE
ERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMR
KMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKD
VLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMG
IFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWT
HDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTP
NYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIP
PQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKI
THPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNG
YPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV"
BASE COUNT 1337 a 963 c 916 g 1091 t
ORIGIN
1 gcgacgctca cgaacgatca gagctgcggg cgacgcaacg aagcccggag gccgcaggct
61 gcgcgctccc tcgcagcagc cgggcgggca aaagccccca gtcctcggcc cccgcgcaag
121 cgacgccggg aaatgcccac atccgggaaa cctgcagcgg agtgcggcgg cggcgacact
181 gagtggaagg caaaatggcg gcggcggcgg cggtggcctg gtgttaaggg gagagccagg
241 tccttacgac ccctgggacg ggccgcgctg gcccgcggca gcccccccgt tcgtctcccc
301 gctctgcccc accagggata cttggggttg ctgggacgga ctctggccgc ctcagcgtcc
361 gccctcaggc ccgtggccgc tgtccaggag ctctgctctc ccctccagag ttaattattt
421 atattgtaaa gaattttaac agtcctgggg acttccttga aggatcattt tcacttttgc
481 tcagaagaaa gctctggatc tatcaaataa agaagtcctt cgtgtgggct acatatatag
541 atgttttcat gaagaggagt gaaaagccag aaggatatag acaaatgagg cctaagacct
601 ttcctgccag taactatact gtcagtagcc ggcaaatgtt acaagaaatt cgggaatccc
661 ttaggaattt atctaaacca tctgatgctg ctaaggctga gcataacatg agtaaaatgt
721 caaccgaaga tcctcgacaa gtcagaaatc cacccaaatt tgggacgcat cataaagcct
781 tgcaggaaat tcgaaactct ctgcttccat ttgcaaatga aacaaattct tctcggagta
841 cttcagaagt taatccacaa atgcttcaag acttgcaagc tgctggattt gatgaggata
901 tggttataca agctcttcag aaaactaaca acagaagtat agaagcagca attgaattca
961 ttagtaaaat gagttaccaa gatcctcgac gagagcagat ggctgcagca gctgccagac
1021 ctattaatgc cagcatgaaa ccagggaatg tgcagcaatc agttaaccgc aaacagagct
1081 ggaaaggttc taaagaatcc ttagttcctc agaggcatgg cccgccacta ggagaaagtg
1141 tggcctatca ttctgagagt cccaactcac agacagatgt aggaagacct ttgtctggat
1201 ctggtatatc agcatttgtt caagctcacc ctagcaacgg acagagagtg aaccccccac
1261 caccacctca agtaaggagt gttactcctc caccacctcc aagaggccag actccccctc
1321 caagaggtac aactccacct cccccttcat gggaaccaaa ctctcaaaca aagcgctatt
1381 ctggaaacat ggaatacgta atctcccgaa tctctcctgt cccacctggg gcatggcaag
1441 agggctatcc tccaccacct ctcaacactt cccccatgaa tcctcctaat caaggacaga
1501 gaggcattag ttctgttcct gttggcagac aaccaatcat catgcagagt tctagcaaat
1561 ttaactttcc atcagggaga cctggaatgc agaatggtac tggacaaact gatttcatga
1621 tacaccaaaa tgttgtccct gctggcactg tgaatcggca gccaccacct ccatatcctc
1681 tgacagcagc taatggacaa agcccttctg ctttacaaac agggggatct gctgctcctt
1741 cgtcatatac aaatggaagt attcctcagt ctatgatggt gccaaacaga aatagtcata
1801 acatggaact atataacatt agtgtacctg gactgcaaac aaattggcct cagtcatctt
1861 ctgctccagc ccagtcatcc ccgagcagtg ggcatgaaat ccctacatgg caacctaaca
1921 taccagtgag gtcaaattct tttaataacc cattaggaaa tagagcaagt cactctgcta
1981 attctcagcc ttctgctaca acagtcactg caattacacc agctcctatt caacagcctg
2041 tgaaaagtat gcgtgtatta aaaccagagc tacagactgc tttagcacct acacaccctt
2101 cttggatacc acagccaatt caaactgttc aacccagtcc ttttcctgag ggaaccgctt
2161 caaatgtgac tgtgatgcca cctgttgctg aagctccaaa ctatcaagga ccaccaccac
2221 cctacccaaa acatctgctg caccaaaacc catctgttcc tccatacgag tcaatcagta
2281 agcctagcaa agaggatcag ccaagcttgc ccaaggaaga tgagagtgaa aagagttatg
2341 aaaatgttga tagtggggat aaagaaaaga aacagattac aacttcacct attactgtta
2401 ggaaaaacaa gaaagatgaa gagcgaaggg aatctcgtat tcaaagttat tctcctcaag
2461 catttaaatt ctttatggag caacatgtag aaaatgtact caaatctcat cagcagcgtc
2521 tacatcgtaa aaaacaatta gagaatgaaa tgatgcgggt tggattatct caagatgccc
2581 aggatcaaat gagaaagatg ctttgccaaa aagaatctaa ttacatccgt cttaaaaggg
2641 ctaaaatgga caagtctatg tttgtgaaga taaagacact aggaatagga gcatttggtg
2701 aagtctgtct agcaagaaaa gtagatacta aggctttgta tgcaacaaaa actcttcgaa
2761 agaaagatgt tcttcttcga aatcaagtcg ctcatgttaa ggctgagaga gatatcctgg
2821 ctgaagctga caatgaatgg gtagttcgtc tatattattc attccaagat aaggacaatt
2881 tatactttgt aatggactac attcctgggg gtgatatgat gagcctatta attagaatgg
2941 gcatctttcc agaaagtctg gcacgattct acatagcaga acttacctgt gcagttgaaa
3001 gtgttcataa aatgggtttt attcatagag atattaaacc tgataatatt ttgattgatc
3061 gtgatggtca tattaaattg actgactttg gcctctgcac tggcttcaga tggacacacg
3121 attctaagta ctatcagagt ggtgaccatc cacggcaaga tagcatggat ttcagtaatg
3181 aatgggggga tccctcaagc tgtcgatgtg gagacagact gaagccatta gagcggagag
3241 ctgcacgcca gcaccagcga tgtctagcac attctttggt tgggactccc aattatattg
3301 cacctgaagt gttgctacga acaggataca cacagttgtg tgattggtgg agtgttggtg
3361 ttattctttt tgaaatgttg gtgggacaac ctcctttctt ggcacaaaca ccattagaaa
3421 cacaaatgaa ggttatcaac tggcaaacat ctcttcacat tccaccacaa gctaaactca
3481 gtcctgaagc ttctgatctt attattaaac tttgccgagg acccgaagat cgcttaggca
3541 agaatggtgc tgatgaaata aaagctcatc cattttttaa aacaattgac ttctccagtg
3601 acctgagaca gcagtctgct tcatacattc ctaaaatcac acacccaaca gatacatcaa
3661 attttgatcc tgttgatcct gataaattat ggagtgatga taacgaggaa gaaaatgtaa
3721 atgacactct caatggatgg tataaaaatg gaaagcatcc tgaacatgca ttctatgaat
3781 ttaccttccg aaggtttttt gatgacaatg gctacccata taattatccg aagcctattg
3841 aatatgaata cattaattca caaggctcag agcagcagtc ggatgaagat gatcaaaaca
3901 caggctcaga gattaaaaat cgcgatctag tatatgttta acacactagt aaataaatgt
3961 aatgaggatt tgtaaaaggg cctgaaatgc gaggtgtttt gaggttctga gagtaaaatt
4021 atgcaaatat gacagagcta tatatgtgtg ctctgtgtac aatattttat tttcctaaat
4081 tatgggaaat ccttttaaaa tgttaattta ttccagccgt ttaaatcagt atttagaaaa
4141 aaattgttat aaggaaagta aattatgaac tgaatattat agtcagttct tggtacttaa
4201 agtacttaaa ataagtagtg ctttgtttaa aaggagaaac ctggtatcta tttgtatata
4261 tgctaaataa ttttaaaata caagagtttt tgaaattttt ttctaga
//