LOCUS AF104304 4839 bp mRNA linear HUM 03-JAN-1999
DEFINITION Homo sapiens Smad anchor for receptor activation (SARA) mRNA,
complete cds.
ACCESSION AF104304
VERSION AF104304.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4839)
AUTHORS Tsukazaki,T., Chiang,T.A., Davison,A.F., Attisano,L. and Wrana,J.L.
TITLE SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta
receptor
JOURNAL Cell 95 (6), 779-791 (1998)
PUBMED 9865696
REFERENCE 2 (bases 1 to 4839)
AUTHORS Wrana,J.L.
TITLE Direct Submission
JOURNAL Submitted (04-NOV-1998) Program in Developmental Biology, Hospital
for Sick Children, 555 University Avenue, Toronto, Ontario M6G 1X8,
Canada
FEATURES Location/Qualifiers
source 1..4839
/db_xref="H-InvDB:HIT000069418"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="HepG2"
gene 1..4839
/gene="SARA"
CDS 439..4410
/gene="SARA"
/codon_start=1
/product="Smad anchor for receptor activation"
/protein_id="AAC99462.1"
/translation="MWIDENAVAEDQLIKRNYSWDDQCSAVEVGEKKCGNLACLPDEK
NVLVVAVMHNCDKRTLQNDLQDCNNYNSQSLMDAFSCSLDNENRQTDQFSFSINESTE
KDMNSEKQMDPLNRPKTEGRSVNHLCPTSSDSLASVCSPSQLKDDGSIGRDPSMSAIT
SLTVDSVISSQGTDGCPAVKKQENYIPDEDLTGKISSPRTDLGSPNSFSHMSEGILMK
KEPAEESTTEESLRSGLPLLLKPDMPNGSGRNNDCERCSDCLVPNEVRADENEGYEHE
ETLGTTEFLNMTEHFSESQDMTNWKLTKLNEMNDSQVNEEKEKFLQISQPEDTNGDSG
GQCVGLADAGLDLKGTCISESEECDFSTVIDTPAANYLSNGCDSYGMQDPGVSFVPKT
LPSKEDSVTEEKEIEESKSECYSNIYEQRGNEATEGSGLLLNSTGDLMKKNYLHNFCS
QVPSVLGQSSPKVVASLPSISVPFGGARPKQPSNLKLQIPKPLSDHLQNDFPANSGNN
TKNKNDILGKAKLGENSATNVCSPSLGNISNVDTNGEHLESYEAEISTRPCLALAPDS
PDNDLRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGK
VFCASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMMSASSQSPNPNNPAEYCS
TIPPLQQAQASGALSSPPPTVMVPVGVLKHPGAEVAQPREQRRVWFADGILPNGEVAD
AAKLTMNGTSSAGTLAVSHDPVKPVTTSPLPAETDICLFSGSITQVGSPVGSAMNLIP
EDGLPPILISTGVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNYV
NRKCWCFTTKGMHAVGQSEIVILLQCLPDEKCLPKDIFNHFVQLYRDALAGNVVSNLG
HSFFSQSFLGSKEHGGFLYVTSTYQSLQDLVLPTPPYLFGILIQKWETPWAKVFPIRL
MLRLGAEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLVVDMEV
RKTSIKIPSNRYNEMMKAMNKSNEHVLAGGACFNEKADSHLVCVQNDDGNYQTQAISI
HNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDF
TITCGKADAEEPQEHIHIQWVDDDKNVSKGVVSPIDGKSMETITNVKIFHGSEYKANG
KVIRWTEVFFLENDDQHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGL
RVTLDSDQVGYQAGSNGQPLPSQYMNDLDSALVPVIHGGACQLSEGPVVMELIFYILE
NIV"
BASE COUNT 1460 a 965 c 1140 g 1274 t
ORIGIN
1 gcatactgaa tcagcaggac tggctggtgg tgcagcagac atcatgagta agcaccgaga
61 agtctgttcc ttatcacgtg tgtaagggga aaaaggttta aacaagtctc ttaagtggtg
121 tttcctcacc gatggagaat tacttccaag cagaagctta caacctggga caaggtgtta
181 gatgaatttg aacaaaacga agatgaaaca gtttcttcta ctttattgga tacaaagtgg
241 aataagattc tagatccccc ttctcaccgg ctgtcattta accctacttt ggccagtgtg
301 aatgaatctg cagtttctaa tgagtcacaa ccacaactga aagtcttctc cctggctcat
361 tcagctcccc tgaccacaga ggaagaggat cactgtgcta atggacagga ctgtaatcta
421 aatccagaga ttgccacaat gtggattgat gaaaatgctg ttgcagaaga ccagttaatt
481 aagagaaact atagttggga tgatcaatgc agtgctgttg aagtgggaga gaagaaatgt
541 ggaaacctgg cttgtctgcc agatgagaag aatgttcttg ttgtagccgt catgcataac
601 tgtgataaaa ggacattaca aaacgattta caggattgta ataattataa tagtcaatcc
661 cttatggatg cttttagctg ttcactggat aatgaaaaca gacaaactga tcaatttagt
721 tttagtataa atgagtccac tgaaaaagat atgaattcag agaaacaaat ggatccattg
781 aatagaccga aaacagaggg gagatctgtt aaccatctgt gtcctacttc atctgatagt
841 ctagccagtg tctgttcccc ttcacaatta aaggatgacg gaagtatagg tagagacccc
901 tccatgtctg cgattacaag tttaacggtt gattcagtaa tctcatccca gggaacagat
961 ggatgtcctg ctgttaaaaa gcaagagaac tatataccag atgaggacct cactggcaaa
1021 atcagctctc ctaggacaga tctagggagt ccaaattcct tttcccacat gagtgagggg
1081 attttgatga aaaaagagcc agcagaggag agcaccactg aagaatccct ccggtctggt
1141 ttacctttgc ttctcaaacc agacatgcct aatgggtctg gaaggaataa tgactgtgaa
1201 cggtgttcag attgccttgt gcctaatgaa gttagggctg atgaaaatga aggttatgaa
1261 catgaagaaa ctcttggcac tacagaattc cttaatatga cagagcattt ctctgaatct
1321 caggacatga ctaattggaa gttgactaaa ctaaatgaga tgaatgatag ccaagtaaac
1381 gaagaaaagg aaaagtttct acagattagt cagcctgagg acactaatgg tgatagtgga
1441 ggacagtgtg ttggattggc agatgcaggt ctagatttaa aaggaacttg cattagtgaa
1501 agtgaagaat gtgatttctc cactgttata gacacaccag cagcaaatta tctatctaat
1561 ggttgtgatt cctatggaat gcaagaccca ggtgtttctt ttgttccaaa gactttaccc
1621 tccaaagaag attcagtaac agaagaaaaa gaaatagagg aaagcaagtc agaatgctac
1681 tcaaatattt atgaacagag aggaaatgag gccacagaag ggagtggact acttttaaac
1741 agcactggtg acctaatgaa gaaaaattat ttacataatt tctgtagtca agttccatca
1801 gtgcttgggc aatcttcccc caaggtagta gcaagcctgc catctatcag tgttcctttt
1861 ggtggtgcaa gacccaagca accttctaat cttaaacttc aaattccaaa gccattatca
1921 gaccatttac aaaatgactt tcctgcaaac agtggaaata atactaaaaa taaaaatgat
1981 attcttggga aagcaaaatt aggggaaaac tcagcaacca atgtatgcag tccatctttg
2041 ggaaacatct ctaatgtcga tacaaatggg gaacatttag aaagttatga ggctgagatc
2101 tccactagac catgccttgc attagctcca gatagcccag ataatgatct cagagctggt
2161 cagtttggaa tttctgccag aaagccattc accacgctgg gtgaggtggc tccagtatgg
2221 gtaccggatt ctcaggctcc aaattgcatg aaatgtgaag ccaggtttac attcaccaaa
2281 aggaggcatc actgcagagc atgtgggaag gttttctgtg cttcctgctg tagcctgaaa
2341 tgtaaactgt tatacatgga cagaaaggaa gctagagtgt gtgtaatctg ccattcagtg
2401 ctaatgaatg ctcaagcctg ggagaacatg atgagtgcct caagccagag ccctaaccct
2461 aacaatcctg ctgaatactg ttctactatc cctcccttgc agcaagctca ggcctcagga
2521 gctctgagct ctccacctcc cactgtgatg gtacctgtgg gagttttaaa gcaccctgga
2581 gcagaagtgg ctcagcccag agagcagagg cgagtttggt ttgctgatgg gatcttgccc
2641 aatggagaag ttgctgatgc agccaaatta acaatgaatg gaacttcctc tgcaggaacc
2701 ctggctgtgt cacacgaccc agtcaagcca gtaactacca gtcctctacc agcagagacg
2761 gatatttgtc tattctctgg gagtataact caggttggaa gtcctgttgg aagtgcaatg
2821 aatcttattc ctgaagatgg ccttcctccc attctcatct ccactggtgt aaaaggagac
2881 tatgctgtgg aagagaaacc atcacagatt tcagtaatgc agcagttgga ggatggtggc
2941 cctgacccac ttgtatttgt tttaaatgca aatttgttgt caatggttaa aattgtaaat
3001 tatgtgaaca ggaagtgctg gtgtttcaca accaagggaa tgcatgcagt gggtcagtct
3061 gagatagtca ttcttctaca gtgtttaccg gatgaaaagt gtttgccaaa ggatatcttt
3121 aatcactttg tgcagcttta tcgggatgct ctggcaggga atgtggtgag caacttggga
3181 cattccttct tcagtcaaag tttccttggc agtaaagaac atggtggatt cttatatgtg
3241 acatctacct accagtcact gcaagaccta gtactcccaa ccccacctta cttgtttggg
3301 attcttatcc agaaatggga aactccttgg gctaaagtat ttcctatccg tctgatgttg
3361 agacttggag ctgaatatcg actttatcca tgcccactat tcagtgtcag atttcggaag
3421 ccattgtttg gagagacggg gcataccatc atgaatcttc ttgcagactt cagaaattac
3481 cagtatacct tgccagtagt tcaaggtttg gtggttgata tggaagttcg gaaaactagc
3541 atcaaaattc ccagcaacag atacaatgag atgatgaaag ccatgaacaa gtccaatgag
3601 catgtcctgg caggaggtgc ctgcttcaat gaaaaggcag actctcatct tgtgtgtgta
3661 cagaatgatg atggaaacta tcagacccag gctatcagta ttcacaatca gcccagaaaa
3721 gtgactggtg ccagtttctt tgtgttcagt ggcgctctga aatcctcttc tggatacctt
3781 gccaagtcca gtattgtgga agatggtgtt atggtccaga ttactgcaga gaacatggat
3841 tccttgaggc aggcactgcg agagatgaag gacttcacca tcacctgtgg gaaggcggac
3901 gcggaggaac cccaggagca catccacatc cagtgggtgg atgatgacaa gaacgttagc
3961 aagggtgtcg taagtcctat agatgggaag tccatggaga ctataacaaa tgtgaagata
4021 ttccatggat cagaatataa agcaaatgga aaagtaatca gatggacaga ggtgtttttc
4081 ctagaaaacg atgaccagca caattgcctc agtgatcctg cagatcacag tagattgact
4141 gagcatgttg ccaaagcttt ttgccttgct ctctgtcctc acctgaaact tctgaaggaa
4201 gatggaatga ccaaactggg actacgtgtg acacttgact cagatcaggt tggctatcaa
4261 gcagggagca atggccagcc ccttccctcg cagtacatga atgatctgga tagcgccttg
4321 gtgccggtga tccatggagg ggcctgccag cttagtgagg gccccgttgt catggaactc
4381 atcttttata ttctggaaaa catcgtataa acagagaaga cttcattttt ttctgttcag
4441 acttgttgca acagcagtca tacccaaatc atttgcactt taaaactgga agattaagct
4501 tttgttaaca ctattaatgg ggtggggaat agggtgggag tgggggtttg ggagacgggt
4561 gggaaagggt ggttgggggg accgatgttc cataattcta agtcttctat gcattgtcca
4621 ccaagaagat ctgggcagct tctgttcctg cacaacagtt atgctatcct tgcagctaat
4681 ccccttctgt tactgtttag acaagaattc cgctcctctc tcaagattta cttatggtca
4741 tgtgctcaga aatgctcaaa tgggtacaac catcaccaag ggtgggatgg gagggcagag
4801 gggaaataaa atataaagca tcaaaaaaaa aaaaaaaaa
//