LOCUS AF104260 3362 bp mRNA linear HUM 30-APR-2003
DEFINITION Homo sapiens HIWI mRNA, complete cds.
ACCESSION AF104260
VERSION AF104260.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3362)
AUTHORS Cox,D.N., Chao,A., Baker,J., Chang,L., Qiao,D. and Lin,H.
TITLE A novel class of evolutionarily conserved genes defined by piwi are
essential for stem cell self-renewal
JOURNAL Genes Dev. 12 (23), 3715-3727 (1998)
PUBMED 9851978
REFERENCE 2 (bases 1 to 3362)
AUTHORS Qiao,D., Zeeman,A.M., Deng,W., Looijenga,L.H. and Lin,H.
TITLE Molecular characterization of hiwi, a human member of the piwi gene
family whose overexpression is correlated to seminomas
JOURNAL Oncogene 21 (25), 3988-3999 (2002)
PUBMED 12037681
REFERENCE 3 (bases 1 to 3362)
AUTHORS Lin,H.
TITLE Direct Submission
JOURNAL Submitted (04-NOV-1998) Cell Biology, Duke University Medical
Center, 412 Nanaline Duke Bldg., Research Dr., Durham, NC 27710,
USA
REFERENCE 4 (bases 1 to 3362)
AUTHORS Qiao,D., Zeeman,A.-M., Deng,W., Looijenga,L.H.J. and Lin,H.
TITLE Direct Submission
JOURNAL Submitted (09-JAN-2002) Cell Biology, Duke University, 412 Nanaline
Duke Building, DUMC, Durham, NC 27710, USA
REMARK Nucleotide sequence updated by submitter
COMMENT On Jan 9, 2002 this sequence version replaced AF104260.1.
FEATURES Location/Qualifiers
source 1..3362
/db_xref="H-InvDB:HIT000069416"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q24.33"
/tissue_type="testis"
CDS 57..2642
/note="member of the PIWI family"
/codon_start=1
/product="HIWI"
/protein_id="AAC97371.2"
/translation="MTGRARARARGRARGQETAQLVGSTASQQPGYIQPRPQPPPAEG
ELFGRGRQRGTAGGTAKSQGLQISAGFQELSLAERGGRRRDFHDLGVNTRQNLDHVKE
SKTGSSGIIVRLSTNHFRLTSRPQWALYQYHIDYNPLMEARRLRSALLFQHEDLIGKC
HAFDGTILFLPKRLQQKVTEVFSKTRNGEDVRITITLTNELPPTSPTCLQFYNIIFRR
LLKIMNLQQIGRNYYNPNDPIDIPSHRLVIWPGFTTSILQYENSIMLCTDVSHKVLRS
ETVLDFMFNFYHQTEEHKFQEQVSKELIGLVVLTKYNIKTYRVDDIDWDQNPKSTFKK
ADGSGVSFLEYYRKQYNQEITDLKQPVLVSQPKRRRGPGGTLPGPAMLIPELCYLTGL
TDKMRNDFNVMKDLAVHTRLTPEQRQREVGRLIDYIHKNDNVQRELRDWGLSFDSNLL
SFSGRILQTEKIHQGGKTFDYNPQFADWSKETRGAPLISVKPLDNWLLIYTRRNYEAA
NSLIQNLFKVTPAMGMQMRKAIMIEVDDRTEAYLRVLQQKVTADTQIVVCLLSSNRKD
KYDAIKKYLCTDCPTPSQCVVARTLGKQQTVMAIATKIALQMNCKMGGELWRVDIPLK
LVMIVGIDCYHDMTAGRRSIAGFVASINEGMTRWFSRCIFQDRGQELVDGLKVCLQAA
LRAWNSCNEYMPSRIIVYRDGVGDGQLKTLVNYEVPQFLDCLKSIGRGYNPRLTVIVV
KKRVNTRFFAQSGGRLQNPLPGTVIDVEVTRPEWYDFFIVSQAVRSGSVSPTHYNVIY
DNSGLKPDHIQRLTYKLCHIYYNWPGVIRVPAPCQYAHKLAFLVGQSIHREPNLSLSN
RLYYL"
BASE COUNT 1026 a 659 c 759 g 918 t
ORIGIN
1 ctgaggtgca aggaccagga ctagggcgag ggcagcggtc caagaaatag aaaacaatga
61 ctgggagagc ccgagccaga gccagaggaa gggcccgcgg tcaggagaca gcgcagctgg
121 tgggctccac tgccagtcag caacctggtt atattcagcc taggcctcag ccgccaccag
181 cagaggggga attatttggc cgtggacggc agagaggaac agcaggagga acagccaagt
241 cacaaggact ccagatatct gctggatttc aggagttatc gttagcagag agaggaggtc
301 gtcgtagaga ttttcatgat cttggtgtga atacaaggca gaacctagac catgttaaag
361 aatcaaaaac aggttcttca ggcattatag taaggttaag cactaaccat ttccggctga
421 catcccgtcc ccagtgggcc ttatatcagt atcacattga ctataaccca ctgatggaag
481 ccagaagact ccgttcagct cttctttttc aacacgaaga tctaattgga aagtgtcatg
541 cttttgatgg aacgatatta tttttaccta aaagactaca gcaaaaggtt actgaagttt
601 ttagtaagac ccggaatgga gaggatgtga ggataacgat cactttaaca aatgaacttc
661 cacctacatc accaacttgt ttgcagttct ataatattat tttcaggagg cttttgaaaa
721 tcatgaattt gcaacaaatt ggacgaaatt attataaccc aaatgaccca attgatattc
781 caagtcacag gttggtgatt tggcctggct tcactacttc catccttcag tatgaaaaca
841 gcatcatgct ctgcactgac gttagccata aagtccttcg aagtgagact gttttggatt
901 tcatgttcaa cttttatcat cagacagaag aacataaatt tcaagaacaa gtttccaaag
961 aactaatagg tttagttgtt cttaccaagt ataacattaa gacatacaga gtggatgata
1021 ttgactggga ccagaatccc aagagcacct ttaagaaagc cgacggctct ggggtcagct
1081 tcttagaata ctacaggaag caatacaacc aagagatcac cgacttgaag cagcctgtct
1141 tggtcagcca gcccaagaga aggcggggcc ctggggggac actgccaggg cctgccatgc
1201 tcattcctga gctctgctat cttacaggtc taactgataa aatgcgtaat gattttaacg
1261 tgatgaaaga cttagccgtt catacaagac taactccaga gcaaaggcag cgtgaagtgg
1321 gacgactcat tgattacatt cataaaaacg ataatgttca aagggagctt cgagactggg
1381 gtttgagctt tgattccaac ttactgtcct tctcaggaag aattttgcaa acagaaaaga
1441 ttcaccaagg tggaaaaaca tttgattaca atccacaatt tgcagattgg tccaaagaaa
1501 caagaggtgc accattaatt agtgttaagc cactagataa ctggctgttg atctatacgc
1561 gaagaaatta tgaagcagcc aattcattga tacaaaatct atttaaagtt acaccagcca
1621 tgggcatgca aatgagaaaa gcaataatga ttgaagtgga tgacagaact gaagcctact
1681 taagagtctt acagcaaaag gtcacagcag acacccagat agttgtctgt ctgttgtcaa
1741 gtaatcggaa ggacaaatac gatgctatta aaaaatacct gtgtacagat tgccctaccc
1801 caagtcagtg tgtggtggcc cgaaccttag gcaaacagca aactgtcatg gccattgcta
1861 caaagattgc cctacagatg aactgcaaga tgggaggaga gctctggagg gtggacatcc
1921 ccctgaagct cgtgatgatc gttggcatcg attgttacca tgacatgaca gctgggcgga
1981 ggtcaatcgc aggatttgtt gccagcatca atgaagggat gacccgctgg ttctcacgct
2041 gcatatttca ggatagagga caggagctgg tagatgggct caaagtctgc ctgcaagcgg
2101 ctctgagggc ttggaatagc tgcaatgagt acatgcccag ccggatcatc gtgtaccgcg
2161 atggcgtagg agacggccag ctgaaaacac tggtgaacta cgaagtgcca cagtttttgg
2221 attgtctaaa atccattggt agaggttaca accctagact aacggtaatt gtggtgaaga
2281 aaagagtgaa caccagattt tttgctcagt ctggaggaag acttcagaat ccacttcctg
2341 gaacagttat tgatgtagag gttaccagac cagaatggta tgactttttt atcgtgagcc
2401 aggctgtgag aagtggtagt gtttctccca cacattacaa tgtcatctat gacaacagcg
2461 gcctgaagcc agaccacata cagcgcttga cctacaagct gtgccacatc tattacaact
2521 ggccaggtgt cattcgtgtt cctgctcctt gccagtacgc ccacaagctg gcttttcttg
2581 ttggccagag tattcacaga gagccaaatc tgtcactgtc aaaccgcctt tactacctct
2641 aacctgcaga agacgatgca gccgcttttc tttttgaaat gactttggga tttttttaag
2701 cttttattta cttttttttt aactgttatc tttctggatg aaacttggga aggggattag
2761 gagatctagc attttatttc tagcattgct attcaccggc ttccttattt tatatgtaaa
2821 aattaagatt ttatatttta tcttcttgtt tctcatagat attttgtgag catttttttg
2881 tttattttga agaaatgtgg ataagatact tggtagtata aaacagactc tctgagagta
2941 tttgaaatgt gtttggagat ttacttaaac gtactttcag gagtgagcaa gtcctactta
3001 taaacctata ttaactttat ttttgagata cctgttttga atttaaagga gataagaggc
3061 gtaaagtagg atgctcacta caaccatagg tggggtttca gctcatatct taaagataaa
3121 aggtactatt atataaccta tacacaagat acaggagaaa atatgcttga tttttatttg
3181 gcaggggggc taggttgtat gggagtaaaa aaaacattga aaatttttaa attgtccaaa
3241 gaaacatttt aagactcttt aacaaaaaag gccatgagta aatctctata ttaacatcac
3301 tatttatttt gttttggaac tgggacatga ttctatttgt tataaaataa aattgatgtc
3361 cc
//