LOCUS AF103798 1750 bp mRNA linear HUM 16-OCT-1999
DEFINITION Homo sapiens clone C40 unknown mRNA.
ACCESSION AF103798
VERSION AF103798.1
KEYWORDS FLI_CDNA.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1750)
AUTHORS Oh,J.J., Grosshans,D.R., Wong,S.G. and Slamon,D.J.
TITLE Identification of differentially expressed genes associated with
HER-2/neu overexpression in human breast cancer cells
JOURNAL Nucleic Acids Res. 27 (20), 4008-4017 (1999)
PUBMED 10497265
REFERENCE 2 (bases 1 to 1750)
AUTHORS Oh,J.J., Wong,S.G. and Slamon,D.J.
TITLE Direct Submission
JOURNAL Submitted (02-NOV-1998) Hematology/Oncology, UCLA School of
Medicine, 5-535 MRL, 675 Circle Drive South, Los Angeles, CA 90095,
USA
FEATURES Location/Qualifiers
source 1..1750
/db_xref="H-InvDB:HIT000069390"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="C40"
/cell_line="MCF-7/HER2"
/cell_type="breast adenocarcinoma"
/note="MCF-7 cells retrovirally transformed with human
HER-2/neu full-length cDNA"
CDS 74..1606
/note="expression decreases in HER-2/neu overexpressing
cells; differentially expressed"
/codon_start=1
/product="unknown"
/protein_id="AAF02418.1"
/translation="MPGGGASAASGRLLTAAEQRGSREAAGSASRSGFGGSGGGRGGA
SGPGSGSGGPGGPAGRMSLTPKELSSLLSIISEEAGGGSTFEGLSTAFHHYFSKADHF
RLGSVLVMLLQQPDLLPSAAQRLTALYLLWEMYRTEPLAANPFAASFAHLLNPAPPAR
GGQEPDRPPLSGFLPPITPPEKFFLSQLMLAPPRELFKKTPRQIALMDVGNMGQSVDI
SGLQLALAERQSELPTQSKASFPSILSDPDPDSSNSGFDSSVASQITEALVSGPKPPI
ESHFRPEFIRPPPPLHICEDELAWLNPTEPDHAIQWDKSMCVKNSTGVEIKRIMAKAF
KSPLSSPQQTQLLGELEKDPKLVYHIGLTPAKLPDLVENNPLVAIEMLLKLMQSSQIT
EYFSVLVNMDMSLHSMEVVNRLTTAVDLPPEFIHLYISNCISTCEQIKDKYMQNRLVR
LVCVFLQSLIRNKIINVQDLFIEVQAFCIEFSRIREAAGLFRLLKTLDTGETPSETKM
SK"
BASE COUNT 423 a 488 c 445 g 394 t
ORIGIN
1 ggcacgagcg gggacggagc gagccggcgc cagggcccct cgggccggga agaggggaag
61 gggagcgagg ttgatgcccg gcggaggggc gagcgcggcg tctggccggc ttctcaccgc
121 cgcggagcaa agagggtccc gggaagcggc agggtcggcg tccaggagcg gcttcggggg
181 ctccggcggc ggcagaggcg gagcaagcgg ccccgggtcc gggagcggag gccctggggg
241 ccccgcgggc aggatgagct tgaccccgaa ggagctctcg agcctgctga gcatcatatc
301 ggaggaggcg ggcggcggca gcaccttcga gggcctgtcc accgccttcc accactactt
361 cagcaaggcc gaccacttcc gcctgggctc ggtgctcgtc atgctgctcc agcagcccga
421 cctgctgcct agcgcggcgc agcgcctcac ggcgctctac ctgctctggg agatgtaccg
481 caccgagccg ctggccgcca accccttcgc cgccagcttc gcgcacctgc tcaaccccgc
541 gccgcccgcc cgcggcggcc aggaacccga ccgccctccg ctctcaggat ttttacctcc
601 tataactcca ccagaaaagt tttttctttc ccagctgatg ctggcacccc cacgggaact
661 cttcaaaaag acgcctcgcc agattgcact gatggacgtt ggaaacatgg gccagtctgt
721 ggacattagt gggcttcagt tagccttggc cgaacgccaa tctgaattgc caacgcaaag
781 caaagcgagc ttccccagta ttctcagtga cccagacccg gattcttcta attctggatt
841 tgacagctca gttgcctctc agatcacaga agctttagtc agcggaccaa agccacctat
901 tgaaagccat tttcgaccag agtttattcg tccaccgcct ccactccaca tttgtgagga
961 tgaacttgct tggctaaacc ccacggagcc tgaccacgcg atccagtggg ataaatcgat
1021 gtgtgttaag aatagcactg gtgtggagat caaacgaata atggccaaag ccttcaaaag
1081 ccccttatcc tctccccaac aaacacagct acttggtgag ttggaaaaag accccaaact
1141 tgtctaccat attggcctca ccccagccaa acttcctgac cttgtggaaa acaacccttt
1201 agtcgctata gaaatgttgc tgaaattaat gcagtcaagc cagatcactg agtatttctc
1261 tgtcctggtc aatatggaca tgtctttaca ttcaatggaa gttgtaaatc gactaactac
1321 agctgttgat ctacctcctg aatttattca cctttatata tcaaattgca tctctacttg
1381 tgaacagatt aaggataaat atatgcagaa tcggttggtg cgtcttgtgt gtgtgtttct
1441 ccaatccttg atccgtaaca aaattattaa tgtacaggat ttgtttatag aagtgcaggc
1501 attctgtatt gaattcagta ggatacgaga agctgctggt cttttccggt tgttgaagac
1561 attggatact ggggaaacac cttctgagac caaaatgtca aaataatacc tcatcagaac
1621 catcccatcc attcactgtt cagctgtact gtgatttagt ttttacaccg ttaaaaccct
1681 gagtggattg cttggtttaa tgcatataaa cagtacttta tctacttaaa gcaaaaaaaa
1741 aaaaaaaaaa
//