LOCUS AF102848 1649 bp mRNA linear HUM 01-FEB-2001
DEFINITION Homo sapiens keratin 23 (KRT23) mRNA, complete cds.
ACCESSION AF102848
VERSION AF102848.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1649)
AUTHORS Zhang,J.S., Wang,L., Huang,H., Nelson,M. and Smith,D.I.
TITLE Keratin 23 (K23), a novel acidic keratin, is highly induced by
histone deacetylase inhibitors during differentiation of pancreatic
cancer cells
JOURNAL Genes Chromosomes Cancer 30 (2), 123-135 (2001)
PUBMED 11135429
REFERENCE 2 (bases 1 to 1649)
AUTHORS Zhang,J.S. and Smith,D.I.
TITLE Direct Submission
JOURNAL Submitted (29-OCT-1998) Laboratory of Medicine and Pathology, Mayo
Clinic, 200 SW 1st Street, Rochester, MN 55905, USA
FEATURES Location/Qualifiers
source 1..1649
/db_xref="H-InvDB:HIT000068668"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21"
/cell_line="AsPC-1"
/cell_type="pancreatic cancer"
gene 1..1649
/gene="KRT23"
CDS 77..1345
/gene="KRT23"
/note="intermediate filament protein; type I cytokeratin;
hyperacetylation inducible and differentiation dependent;
hyperacetylation-inducible type I keratin"
/codon_start=1
/product="keratin 23"
/protein_id="AAK00050.1"
/translation="MNSGHSFSQTPSASFHGAGGGWGRPRSFPRAPTVHGGAGGARIS
LSFTTRSCPPPGGSWGSGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLES
RILKWHQQRDPGSKKDYSQYEENITHLQEQIVDGNMTNAQIILLIDNARMAVDDFNLK
YENEHSFKKDLEIEVEGLRRTLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHH
VPSDFNVNVKVDTGPREDLIKVLEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAAS
PATVQSRQGDIHELKRTFQALEIDLQTQYSTKSALENMLSETQSRNSCKLQDMQEIIS
HYEEELTQLRHELERQNNEYQVLLGIKTHLEKEITTYRRLLEGESEGTREESKSSMKV
SATPKIKAITQETINGRLVLCQVNEIQKHA"
BASE COUNT 494 a 411 c 412 g 332 t
ORIGIN
1 cagtctgggg cggctcagtt ctgcggtgcc agggagtgga gcagagctca gccccgtccc
61 aaacacagat gggaccatga actccggaca cagcttcagc cagaccccct cggcctcctt
121 ccatggcgcc ggaggtggct ggggccggcc caggagcttc cccagggctc ccaccgtcca
181 tggcggtgcg gggggagccc gcatctccct gtccttcacc acgcggagct gcccaccccc
241 tggagggtct tggggttctg gaagaagcag ccccctacta ggcggaaatg ggaaggccac
301 catgcagaat ctcaacgacc gcctggcctc ctacctggag aaggttcgcg ccctggagga
361 ggccaacatg aagctggaaa gccgcatcct gaaatggcac cagcagagag atcctggcag
421 taagaaagat tattcccagt atgaggaaaa catcacacac ctgcaggagc agatagtgga
481 tggtaatatg accaatgctc agattattct tctcattgac aatgccagga tggcagtgga
541 tgacttcaac ctcaagtatg aaaatgaaca ctcctttaag aaagacttgg aaattgaagt
601 cgagggcctc cgaaggacct tagacaacct gaccattgtc acaacagacc tagaacagga
661 ggtggaagga atgaggaaag agctcattct catgaagaag caccatgagc aggaaatgga
721 gaagcatcat gtgccaagtg acttcaatgt caatgtgaag gtggatacag gtcccaggga
781 agatctgatt aaggtcctgg aggatatgag acaagaatat gagcttataa taaagaagaa
841 gcatcgagac ttggacactt ggtataaaga acagtctgca gccatgtccc aggaggcagc
901 cagtccagcc actgtgcaga gcagacaagg tgacatccac gaactgaagc gcacattcca
961 ggccctggag attgacctgc agacacagta cagcacgaaa tctgctttgg aaaacatgtt
1021 atccgagacc cagtctcgta actcctgcaa gctccaggac atgcaagaga tcatctccca
1081 ctatgaggag gaactgacgc agctacgcca cgaactggag cggcagaaca atgaatacca
1141 agtgctgctg ggcatcaaaa cccacctgga gaaggaaatc accacgtacc gacggctcct
1201 ggagggagag agtgaaggga cacgggaaga atcaaagtcg agcatgaaag tgtctgcaac
1261 tccaaagatc aaggccataa cccaggagac catcaacgga agattagttc tttgtcaagt
1321 gaatgaaatc caaaagcacg catgagacca atgaaagttt ccgcctgttg taaaatctat
1381 tttcccccaa ggaaagtcct tgcacagaca ccagtgagtg agttctaaaa gatacccttg
1441 gaattatcag actcagaaac ttttattttt tttttctgta acagtctcac cagacttctc
1501 ataatgctct taatatattg cacttttcta atcaaagtgc gagtttatga gggtaaagct
1561 ctactttcct actgcagcct tcagattctc atcattttgc atctattttg tagccaataa
1621 aactccgcac tagctgaaaa aaaaaaaaa
//