LOCUS AF102177 3480 bp mRNA linear HUM 03-MAR-2000
DEFINITION Homo sapiens tumor antigen SLP-8p (HCC8) mRNA, complete cds.
ACCESSION AF102177
VERSION AF102177.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3480)
AUTHORS Stenner-Liewen,F., Luo,G., Tureci,O., Sahin,U., Liewen,H.,
Koslowski,M. and Pfreundschuh M.
TITLE HOM-HCC-8, a novel tumor antigen associated with hepatocellular
carcinoma
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 3480)
AUTHORS Stenner-Liewen,F., Luo,G., Tureci,O., Sahin,U., Liewen,H.,
Koslowski,M. and Pfreundschuh M.
TITLE Direct Submission
JOURNAL Submitted (27-OCT-1998) Innere Medizin I, University of the
Saarland, Homburg, Saar 66421, Germany
FEATURES Location/Qualifiers
source 1..3480
/db_xref="H-InvDB:HIT000068652"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p13-p14"
/tissue_type="hepatocellular carcinoma; liver"
gene 1..3480
/gene="HCC8"
misc_feature 18..24
/gene="HCC8"
/note="Kozak region"
CDS 21..2921
/gene="HCC8"
/note="HOM-HCC-8; hepatocellular carcinoma associated
antigen"
/codon_start=1
/product="tumor antigen SLP-8p"
/protein_id="AAF37319.1"
/translation="MASSHSSSPVPQGSSSDVFFKIEVDPSKHIRPVPSLPDVCPKEP
TGDSHSLYVAPSLVTDQHRWTVYHSKVNLPAALNDPRLAKRESDFFTKTWGLDFVDTE
VIPSFYLPQISKEHFTVYQQEISQREKVHERCKNICPPKDTFERTLLHTHDKSRTDLE
QVPKIFMKPDFALDDSLTFNSVLPWSHFNTAGGKGNRDAASSKLLQEKLSHYLDIVEV
NIAHQISLRSEAFFHAMTSQHELQDYLRKTSQAVKMLRDKIAQIDKVMCEGSLHILRL
ALTRNNCVKVYNKLKLMATVHQTQPTVQVLLSTSEFVGALDLIATTQEVLQQELQGIH
SFRHLGSQLCELEKLIDKMMIAEFSTYSHSDLNRPLEDDCQVLEEERLISLVFGLLKQ
RKLNFLEIYGEKMVITAKNIIKQCVINKVSQTEEIDTDVVVKLADQMRMLNFPQWFDL
LKDIFSKFTIFLQRVKATLNIIHSVVLSVLDKNQRTRELEEISQQKNAAKDNSLDTEV
AYLIHEGMFISDAFGEGKLTPIAVDTTSQRNASPNSEPCSSDSVSEPECTTDSSSSKE
HTSSSAIPGGVDIMVSEDMKLTDSELGKLANNIQGLLYSASDICHDRAVKFLMSRAKD
GFLEKLNSMEFITLSRLMGTFILDTAQICGRKSTSLLGALQSQAIKFVNRFHVGGKTK
LSLLLDNERWKQADVPAEFQDLVDSLSDGKIALPEKKSGATEERKPAEVLIVEGQQYA
VVGTVLLLIRIILEYCQCVDNIPSVTTDMLTRLSDLLKYFNSRSCQLVLGAGALQVVG
LKTITTKNLALSSRCLQLIVHYIPVIRAHFEARLPPKQYSMLRHFDHITKDYHDHIAE
ISAKLVAIMDSLFDKLLSKYEVKAPVPSACFRNICKQMTKMHEAIFDLLPEEQTQMLF
LRINASYKLHLKKQLSHLNVINDGGPQNGLVTADVAFYTGNLQALKGLKIWT"
misc_feature 2232..2285
/gene="HCC8"
/note="putative transmembrane region"
regulatory 3457..3462
/regulatory_class="polyA_signal_sequence"
/gene="HCC8"
BASE COUNT 1124 a 624 c 706 g 1026 t
ORIGIN
1 ttgagtggtg attttatgca atggcttcaa gccacagttc ttcaccagtg cctcaaggaa
61 gcagcagtga tgttttcttt aaaatagagg tagatccgtc aaaacacatt cgacctgtgc
121 catcactgcc agatgtgtgt cccaaggaac ccacaggtga ttcacatagt ttatatgttg
181 ccccatctct agttacagat caacataggt ggactgtata tcattccaaa gtaaatctcc
241 cagcagcatt aaacgatcct agattagcaa aaagagaatc tgacttcttc acaaaaacat
301 ggggattgga ctttgtggac actgaagtca taccttcatt ctacctccca cagatcagca
361 aggaacattt tacagtatat caacaggaaa tctctcagag agagaaggtt catgagagat
421 gcaagaatat ttgtcctcct aaagatacct tcgaaaggac tcttttacat actcatgata
481 aatccaggac agatctggag caagtaccta agatttttat gaaaccagat tttgccttgg
541 atgattcctt aacttttaat tcagttttac catggtctca ttttaatact gctggtggaa
601 aaggaaatcg tgatgcagct tcctcaaagt tgcttcaaga aaagctgagc cattatctgg
661 atattgtgga agtaaacatt gctcaccaga tctctctacg ttcagaagca ttttttcatg
721 caatgacctc tcaacacgag ttgcaggact acctcaggaa aacttcccag gctgtaaaaa
781 tgcttcgaga taaaattgca cagattgata aagtaatgtg tgaaggatca ctccacattt
841 taagactggc acttaccaga aataattgtg ttaaagtata caataagctg aagttaatgg
901 ccactgtaca ccagactcag cctacagtac aggtgttatt atctacttct gaatttgttg
961 gagcattgga cttaatagca acaacacaag aggttctaca gcaggaactt cagggcattc
1021 acagtttccg gcatttggga tcacagcttt gtgaattaga aaaactgata gataaaatga
1081 tgattgcaga attttctact tattctcaca gtgacttaaa tagaccactg gaggatgact
1141 gtcaagtttt agaagaggaa agactaatat cccttgtatt tggactttta aaacaaagaa
1201 agcttaattt tttagaaatc tatggtgaaa aaatggttat tacagcaaag aatatcatta
1261 aacagtgtgt gattaataaa gtttcacaaa cagaagaaat agacacagat gttgttgtga
1321 agcttgcaga tcagatgaga atgttgaatt ttccccagtg gtttgatctg ctcaaggata
1381 ttttctctaa gtttacaatt ttcctacaga gagtgaaggc aacattaaat atcattcaca
1441 gtgttgttct ctcagttctt gacaaaaacc aaaggactag agaattggaa gagatttcac
1501 aacagaagaa tgctgcaaaa gataattcac tggacacaga ggtggcttat ttaatccatg
1561 aaggcatgtt tataagtgat gcattcggtg agggtaagct aacacctata gcagttgaca
1621 ctacctctca aagaaatgca tctccaaata gtgagccctg cagcagtgat tctgtatccg
1681 agccagaatg tactactgat tcttcatcca gcaaagagca cacatcatca tctgctattc
1741 caggaggtgt ggatattatg gtcagtgaag atatgaaatt aactgactca gagctaggaa
1801 agctggcaaa taatatccag ggattattat atagtgcctc agatatatgc catgatcgag
1861 ctgtcaaatt tctcatgtca agagcaaagg atggttttct tgagaagcta aattccatgg
1921 aattcataac actttctaga ttaatgggaa cattcatttt agacaccgca cagatctgtg
1981 gaagaaaaag cacgtcatta cttggggcac ttcagagcca agctattaag tttgtaaata
2041 ggtttcatgt tgggggaaaa accaagctca gcctcctctt agacaatgag cgctggaagc
2101 aagcagatgt tcctgcagaa tttcaggatc ttgttgattc tctgtcagat gggaagattg
2161 ctttacctga aaaaaaatca ggagccacag aagaaaggaa accagctgaa gttcttattg
2221 tcgagggaca acagtatgca gttgttggaa ccgtattgct gttaataaga attatccttg
2281 aatattgcca gtgtgtggat aacatcccat ctgttactac tgacatgctt actcgtctgt
2341 cagatttatt gaagtacttc aattcaagaa gttgccagtt agttcttgga gctggtgcac
2401 tgcaagttgt tggactaaaa acgataacta caaaaaattt ggctctttct tcacgatgtt
2461 tgcagttaat tgtgcactac attcctgtga tccgggctca ttttgaagct cgactaccac
2521 ctaagcaata tagcatgctt aggcattttg atcatatcac taaggactac catgatcaca
2581 tagctgaaat atcagctaag cttgtagcga taatggatag cttatttgac aagctgttat
2641 ctaagtatga agtgaaggct cctgttcctt ctgcctgttt caggaatatt tgtaagcaaa
2701 tgacaaaaat gcacgaagct atatttgatc tccttccaga agaacaaaca cagatgttat
2761 ttttaagaat taatgcaagt tataaactcc acttgaaaaa gcagttatct cacttaaatg
2821 tgataaatga tggaggacct caaaatgggt tggtcacagc agatgtagct ttttacactg
2881 gaaatcttca agccttaaaa ggcttaaaga tttggaccta aatatggcga aatttgggag
2941 cagaagaggt gatgtcatcc tgggaaactg ggtagttcat ctgaccatgg gatgtgtttg
3001 ttatgaagaa aatctggatg cctgtgattc gagaattgaa cctgaaaccc aaagtgaact
3061 ggggtggggg aagggaaaaa ggaaagtatc aagtgttggg aaactggatt cagtgggatc
3121 tacaaggaat gtcatttttg tgcatcctac agtgaggggt aactgatcag gtgtctataa
3181 catttttcat tctctctgga aacagactca ggtttctttg gaccaaatcc aaaagaacac
3241 atagctgtaa cacagctgta gttgactaga atgctctgta tactttatat taaaaaatgc
3301 tttgcatttc ttccagtgca atgaaattca tatggtgtcc caccttattt aatgatggta
3361 caatttaaaa tcttagtcaa cttctgtaga aagttttctc tatgaaagta aagctgtttg
3421 aaaaattatt atttttttac agatctttct ataaaaaata aacatctttt gattgcttgg
//