LOCUS AF100928 1906 bp mRNA linear HUM 03-MAR-1999
DEFINITION Homo sapiens apoptosis-inducing factor AIF mRNA, nuclear gene
encoding mitochondrial protein, complete cds.
ACCESSION AF100928
VERSION AF100928.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1906)
AUTHORS Susin,S.A., Lorenzo,H.K., Zamzami,N., Marzo,I., Snow,B.E.,
Brothers,G.M., Mangion,J., Jacotot,E., Costantini,P., Loeffler,M.,
Larochette,N., Goodlett,D.R., Aebersold,R., Siderovski,D.P.,
Penninger,J.M. and Kroemer,G.
TITLE Molecular characterization of mitochondrial apoptosis-inducing
factor
JOURNAL Nature 397 (6718), 441-446 (1999)
PUBMED 9989411
REFERENCE 2 (bases 1 to 1906)
AUTHORS Snow,B.E., Siderovski,D.P., Penninger,J.M., Susin,S.A., Zamzami,N.
and Kroemer,G.
TITLE Direct Submission
JOURNAL Submitted (23-OCT-1998) Quantitative Biology Laboratory, Amgen
Institute, 620 University Avenue, Toronto, ON M5G 2C1, Canada
FEATURES Location/Qualifiers
source 1..1906
/db_xref="H-InvDB:HIT000068633"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq25"
CDS 43..1884
/function="potential oxidoreductase"
/note="similar to bacterial oxidoreductases; released from
mitochondria and translocated to the nucleus upon
pro-apoptotic stimulus"
/codon_start=1
/product="apoptosis-inducing factor AIF"
/protein_id="AAD16436.1"
/translation="MFRCGGLAAGALKQKLVPLVRTVCVRSPRQRNRLPGNLFQRWHV
PLELQMTRQMASSGASGGKIDNSVLVLIVGLSTVGAGAYAYKTMKEDEKRYNERISGL
GLTPEQKQKKAALSASEGEEVPQDKAPSHVPFLLIGGGTAAFAAARSIRARDPGARVL
IVSEDPELPYMRPPLSKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLP
HIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAE
VKSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALGTEVIQLF
PEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETD
HIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRR
RVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVF
AKATAQDNPKSATEQSGTGIRSESETESEASEITIPPSTPAVPQAPVQGEDYGKGVIF
YLRDKVVVGIVLWNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED"
BASE COUNT 532 a 403 c 546 g 425 t
ORIGIN
1 agaggaaagg gaaggaggag gtcccgaata gcggtcgccg aaatgttccg gtgtggaggc
61 ctggcggcgg gtgctttgaa gcagaagctg gtgcccttgg tgcggaccgt gtgcgtccga
121 agcccgaggc agaggaaccg gctcccaggc aacttgttcc agcgatggca tgttcctcta
181 gaactccaga tgacaagaca aatggctagc tctggtgcat cagggggcaa aatcgataat
241 tctgtgttag tccttattgt gggcttatca acagtaggag ctggtgccta tgcctacaag
301 actatgaaag aggacgaaaa aagatacaat gaaagaattt cagggttagg gctgacacca
361 gaacagaaac agaaaaaggc cgcgttatct gcttcagaag gagaggaagt tcctcaagac
421 aaggcgccaa gtcatgttcc tttcctgcta attggtggag gcacagctgc ttttgctgca
481 gccagatcca tccgggctcg ggatcctggg gccagggtac tgattgtatc tgaagatcct
541 gagctgccgt acatgcgacc tcctctttca aaagaactgt ggttttcaga tgacccaaat
601 gtcacaaaga cactgcgatt caaacagtgg aatggaaaag agagaagcat atatttccag
661 ccaccttctt tctatgtctc tgctcaggac ctgcctcata ttgagaatgg tggtgtggct
721 gtcctcactg ggaagaaggt agtacagctg gatgtgagag acaacatggt gaaacttaat
781 gatggctctc aaataaccta tgaaaagtgc ttgattgcaa caggaggtac tccaagaagt
841 ctgtctgcca ttgatagggc tggagcagag gtgaagagta gaacaacgct tttcagaaag
901 attggagact ttagaagctt ggagaagatt tcacgggaag tcaaatcaat tacgattatc
961 ggtgggggct tccttggtag cgaactggcc tgtgctcttg gcagaaaggc tcgagccttg
1021 ggcacagaag tgattcaact cttccccgag aaaggaaata tgggaaagat cctccccgaa
1081 tacctcagca actggaccat ggaaaaagtc agacgagagg gggttaaggt gatgcccaat
1141 gctattgtgc aatccgttgg agtcagcagt ggcaagttac ttatcaagct gaaagacggc
1201 aggaaggtag aaactgacca catagtggca gctgtgggcc tggagcccaa tgttgagttg
1261 gccaagactg gtggcctgga aatagactca gattttggtg gcttccgggt aaatgcagag
1321 ctacaagcac gctctaacat ctgggtggca ggagatgctg catgcttcta cgatataaag
1381 ttgggaagga ggcgggtaga gcaccatgat cacgctgttg tgagtggaag attggctgga
1441 gaaaatatga ctggagctgc taagccgtac tggcatcagt caatgttctg gagtgatttg
1501 ggccccgatg ttggctatga agctattggt cttgtggaca gtagtttgcc cacagttggt
1561 gtttttgcaa aagcaactgc acaagacaac cccaaatctg ccacagagca gtcaggaact
1621 ggtatccgat cagagagtga gacagagtcc gaggcctcag aaattactat tcctcccagc
1681 accccggcag ttccacaggc tcccgtccag ggggaggact acggcaaagg tgtcatcttc
1741 tacctcaggg acaaagtggt cgtggggatt gtgctatgga acatctttaa ccgaatgcca
1801 atagcaagga agatcattaa ggacggtgag cagcatgaag atctcaatga agtagccaaa
1861 ctattcaaca ttcatgaaga ctgaagcccc acagtggaat tggcaa
//