LOCUS AF099989 3293 bp mRNA linear HUM 22-NOV-2000
DEFINITION Homo sapiens Ste-20 related kinase SPAK mRNA, complete cds.
ACCESSION AF099989
VERSION AF099989.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3293)
AUTHORS Johnston,A.M., Naselli,G., Gonez,L.J., Martin,R.M., Harrison,L.C.
and DeAizpurua,H.J.
TITLE SPAK, a STE20/SPS1-related kinase that activates the p38 pathway
JOURNAL Oncogene 19 (37), 4290-4297 (2000)
PUBMED 10980603
REFERENCE 2 (bases 1 to 3293)
AUTHORS Johnston,A.M., Naselli,G., Martin,R.M. and DeAizpurua,H.J.
TITLE Direct Submission
JOURNAL Submitted (21-OCT-1998) Autoimmunity and Transplantation Division,
The Walter and Eliza Hall Institute of Medical Research, P.O. Royal
Melbourne Hospital, Parkville, Vic 3050, Australia
FEATURES Location/Qualifiers
source 1..3293
/db_xref="H-InvDB:HIT000068602"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 174..1817
/note="serine-threonine kinase"
/codon_start=1
/product="Ste-20 related kinase SPAK"
/protein_id="AAC72238.1"
/translation="MAEPSGSPVHVQLPQQAAPVTAAAAAAPAAATAAPAPAAPAAPA
PAPAPAPAAQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQ
TSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGE
HKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAF
LATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYH
KYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELL
KCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMD
EKSEEGKAAFSQEKSRRVKEENPEIAVSASTIPEQIQSLSVHDSQGPPNANEDYREAS
SCAVNLVLRLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQK
IVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFAQLSVS"
BASE COUNT 958 a 686 c 755 g 894 t
ORIGIN
1 cgctccctcc cctcctagct ggcttcggcg gggacggcgg cggcggcggc ggcggcggcg
61 gcgggcgggg agggcgtgcg ccggccgaga ggtgtcggcg gcgaggcaaa ggaagtttca
121 agtggaaggt cgtccgtcgg ccggcgcgtc ctcctgctct cctccgcagc atcatggcgg
181 agccgagcgg ctcgcccgtg cacgtccagc ttccccagca ggcggccccg gtgacagcgg
241 cggcggcggc ggccccggcg gccgcgacag cagcgccggc cccggcagct cccgcggccc
301 cggccccggc cccggccccg gccccggcgg cacaggctgt cggctggccc atctgcaggg
361 acgcgtacga gctgcaggag gttatcggca gtggagctac tgctgtggtt caggcagccc
421 tatgcaaacc caggcaagaa cgtgtagcaa taaaacggat caacttggaa aaatgccaga
481 ccagtatgga tgaactatta aaagaaattc aagccatgag tcagtgcagc catcccaacg
541 tagtgaccta ttacacctct tttgtggtca aagatgaact ttggctggtc atgaaattac
601 taagtggagg ttcaatgttg gatatcataa aatacattgt caaccgagga gaacacaaga
661 atggagttct ggaagaggca ataatagcaa caattcttaa agaggttttg gaaggcttag
721 actatctaca cagaaacggt cagattcaca gggatttgaa agctggtaat attcttctgg
781 gtgaggatgg ttcagtacaa atagcagatt ttggggtaag tgcgttccta gcaacagggg
841 gtgatgttac ccgaaataaa gtaagaaaaa cattcgttgg caccccatgt tggatggctc
901 ctgaagtcat ggaacaggtg agaggctatg acttcaaggc tgacatgtgg agttttggaa
961 taactgccat tgaattagca acaggagcag cgccttatca caaatatcct cccatgaaag
1021 tgttaatgtt gactttgcaa aatgatccac ccactttgga aacaggggta gaggataaag
1081 aaatgatgaa aaagtacggc aagtccttta gaaaattact ttcactgtgt cttcagaaag
1141 atccttccaa aaggcccaca gcagcagaac ttttaaaatg caaattcttc cagaaagcca
1201 agaacagaga gtacctgatt gagaagctgc ttacaagaac accagacata gcccaaagag
1261 ccaaaaaggt aagaagagtt cctgggtcaa gtggtcacct tcataaaacc gaagacgggg
1321 actgggagtg gagtgacgac gagatggatg agaagagcga agaagggaaa gcagcttttt
1381 ctcaggaaaa gtcacgaaga gtaaaagaag aaaatccaga gattgcagtg agtgccagca
1441 ccatccccga acaaatacag tccctctctg tgcacgactc tcagggccca cccaatgcta
1501 atgaagacta cagagaagct tcttcttgtg ccgtgaacct cgttttgaga ttaagaaact
1561 ccagaaagga acttaatgac atacgatttg agtttactcc aggaagagat acagcagatg
1621 gtgtatctca ggagctcttc tctgctggct tggtggatgg tcacgatgta gttatagtgg
1681 ctgctaattt acagaagatt gtagatgatc ccaaagcttt aaaaacattg acatttaagt
1741 tggcttctgg ctgtgatggg tcggagattc ctgatgaagt gaagctgatt gggtttgctc
1801 agttgagtgt cagctgatgt atgtcccttg atgtcaccct gatctgtcat gccccaccgc
1861 cacccctact cccttcaacc ctccctcttt ctgcccattt cctcccaccc cctcactccc
1921 atttcctagc aaaatcagaa gattgtgaag aggccggctt caacaaaatg ggataaaaaa
1981 ataatttttt aaaacttaca acactccgag ttctgcttta ttctctagca atccacagta
2041 caagaacaag caaatgccac agctgcacga ctgttgctca tttttccaaa agctatttaa
2101 tattcttagc aatcaatttg gatatccctt aagtgaaaag aatctgaaat acactcaggt
2161 ggtcttattt attggcaaca aaaggaattt tctatccaga agcctatttc tcctttcatt
2221 gttgttattt ctgttataat actttaaatt gtacatctga caatactgcc tcttttatgt
2281 tgtatttaga aattaatata cttataaaat taagatttat tagccaaact tgaattctag
2341 ttttaaaact gactgtgaat tttatttttc atatatttat gcattacaca ccttagctat
2401 aagaaaaaaa gggttttgat tatatgcttc ttgcagttaa tctcgttatt taaacaaaaa
2461 gttttgggtc tgtctttgga gtatttgtaa cttctaaatt ttgaaatgac tgaattagga
2521 atttggatgc ttattctttt agtctgtttg cctaaaaacc aatttacaat ctgactgtct
2581 cttgggagag ggaggtgcct tgcaaacttt cacattaaga atgtgcctga ggctgcttta
2641 ctctggaata gtctcagatc taaaatttcc tctatataag gtggcatatg ttaagttttg
2701 cttcattgga ccgtttagaa tgctatgtaa aatgttgcca ttctgttaga ttgctaacta
2761 tatacccatc tctgatttgg ctctccttaa gtgataggat ttgttattct aaaggtgata
2821 aacttgaaaa tatcagaatc tgagttttac ttgaaatttt gcagaatacc caggtggagt
2881 gaaaattgga agggttttgt gcaatgacta aaaggtaaaa cgctgttaag gttcaagaat
2941 caatactttc aacccaagta gccccctgct tgactgtata ttatggaact agtaaacctt
3001 aggattttga aaattggagt ctaatctttc aaggaggtgg gctcccagga tggtaccatt
3061 gctctttcct agctaaccct agatatggca gctctttaat gtacttcaaa aagcaaatat
3121 atattactaa ggaaaaaaag ttatttataa ttgccttgtc ataattgtta aggtgttcta
3181 gagccatttg catacaattt aatgtaattt cattccattc tattgtttac acaacgatta
3241 ctcgaagatg actgcaaagg taaaaggaaa ataaaagtgt attgcacaat gag
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