LOCUS AF099082 2970 bp mRNA linear HUM 24-JAN-2012
DEFINITION Homo sapiens xenotropic and polytropic murine retrovirus receptor
(XPR1) mRNA, complete cds.
ACCESSION AF099082
VERSION AF099082.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2970)
AUTHORS Battini,J.L., Rasko,J.E. and Miller,A.D.
TITLE A human cell-surface receptor for xenotropic and polytropic murine
leukemia viruses: possible role in G protein-coupled signal
transduction
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (4), 1385-1390 (1999)
PUBMED 9990033
REFERENCE 2 (bases 1 to 2970)
AUTHORS Van Hoeven,N.S. and Miller,A.D.
TITLE Use of different but overlapping determinants in a retrovirus
receptor accounts for non-reciprocal interference between
xenotropic and polytropic murine leukemia viruses
JOURNAL Retrovirology 2, 76 (2005)
PUBMED 16354307
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2970)
AUTHORS Vaughan,A.E., Mendoza,R., Aranda,R., Battini,J.L. and Miller,A.D.
TITLE Xpr1 is an atypical G-protein-coupled receptor that mediates
xenotropic and polytropic murine retrovirus neurotoxicity
JOURNAL J. Virol. 86 (3), 1661-1669 (2012)
PUBMED 22090134
REFERENCE 4 (bases 1 to 2970)
AUTHORS Battini,J.-L., Rasko,J.E.J. and Miller,A.D.
TITLE Direct Submission
JOURNAL Submitted (16-OCT-1998) Molecular Medicine, Fred Hutchinson Cancer
Research Center, 1100 Fairview Ave. N., Seattle, WA 98109-1024, USA
FEATURES Location/Qualifiers
source 1..2970
/db_xref="H-InvDB:HIT000068574"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q25.1"
/cell_line="HeLa"
gene 1..2970
/gene="XPR1"
CDS 170..2260
/gene="XPR1"
/note="related to yeast G-protein-coupled protein SYG1"
/codon_start=1
/product="xenotropic and polytropic murine retrovirus
receptor"
/protein_id="AAD08928.1"
/translation="MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDE
DTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNELQSSLDAQKEST
GVTTLRQRRKPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKIL
KKHDKILETSRGADWRVAHVEVAPFYTCKKINQLISETEAVVTNELEDGDRQKAMKRL
RVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVLAAVFKLETDRSIWPLIRIYRGGF
LLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSHQHLFEIAGFLGILWCLSLLAC
FFAPISVIPTYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFA
DFWLADQLNSLSVILMDLEYMICFYSLELKWDESKGLLPNNSEESGICHKYTYGVRAI
VQCIPAWLRFIQCLRRYRDTKRAFPHLVNAGKYSTTFFMVAFAALYSTHKERGHSDTM
VFFYLWIVFYIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCAIIED
VILRFAWTIQISITSTTLLPHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFR
AVRDISVAPLNADDQTLLEQMMDQDDGVRNRQKNRSWKYNQSISLRRPRLASQSKARD
TKVLIEDTDDEANT"
BASE COUNT 788 a 665 c 677 g 840 t
ORIGIN
1 actagagatg gcgggcgggc tgctctgaag agacctcggc ggcggcggag gaggagagaa
61 gcgcagcgcc gcgccgcgcc ggggcccatg tggggaggag tcggagtcgc tgttgccgcc
121 gccgcctgta gctgctggac ccgagtggga gtgaggggga aacggcagga tgaagttcgc
181 cgagcacctc tccgcgcaca tcactcccga gtggaggaag caatacatcc agtatgaggc
241 tttcaaggat atgctgtatt cagctcagga ccaggcacct tctgtggaag ttacagatga
301 ggacacagta aagaggtatt ttgccaagtt tgaagagaag tttttccaaa cctgtgaaaa
361 agaacttgcc aaaatcaaca cattttattc agagaagctc gcagaggctc agcgcaggtt
421 tgctacactt cagaatgagc ttcagtcatc actggatgca cagaaagaaa gcactggtgt
481 tactacgctg cgacaacgca gaaagccagt cttccacttg tcccatgagg aacgtgtcca
541 acatagaaat attaaagacc ttaaactggc cttcagtgag ttctacctca gtctaatcct
601 gctgcagaac tatcagaatc tgaattttac agggtttcga aaaatcctga aaaagcatga
661 caagatcctg gaaacatctc gtggagcaga ttggcgagtg gctcacgtag aggtggcccc
721 attttataca tgcaagaaaa tcaaccagct tatctctgaa actgaggctg tagtgaccaa
781 tgaacttgaa gatggtgaca gacaaaaggc tatgaagcgt ttacgtgtcc cccctttggg
841 agctgctcag cctgcaccag catggactac ttttagagtt ggcctatttt gtggaatatt
901 cattgtactg aatattaccc ttgtgcttgc cgctgtattt aaacttgaaa cagatagaag
961 tatatggccc ttgataagaa tctatcgggg tggctttctt ctgattgaat tcctttttct
1021 actgggcatc aacacgtatg gttggagaca ggctggagta aaccatgtac tcatctttga
1081 acttaatccg agaagcaatt tgtctcatca acatctcttt gagattgctg gattcctcgg
1141 gatattgtgg tgcctgagcc ttctggcatg cttctttgct ccaattagtg tcatccccac
1201 atatgtgtat ccacttgccc tttatggatt tatggttttc ttccttatca accccaccaa
1261 aactttctac tataaatccc ggttttggct gcttaaactg ctgtttcgag tatttacagc
1321 ccccttccat aaggtaggct ttgctgattt ctggctggcg gatcagctga acagcctgtc
1381 agtgatactg atggacctgg aatatatgat ctgcttctac agtttggagc tcaaatggga
1441 tgaaagtaag ggcctgttgc caaataattc agaagaatca ggaatttgcc acaaatatac
1501 atatggtgtg cgggccattg ttcagtgcat tcctgcttgg cttcgcttca tccagtgcct
1561 gcgccgatat cgagacacaa aaagggcctt tcctcattta gttaatgctg gcaagtactc
1621 cacaactttc ttcatggtgg cgtttgcagc cctttacagc actcacaaag aacgaggtca
1681 ctcggacact atggtgttct tttacctgtg gattgtcttt tatatcatca gttcctgcta
1741 taccctcatc tgggatctca agatggactg gggtctcttc gataagaatg ctggagagaa
1801 cactttcctc cgggaagaga ttgtataccc ccaaaaagcc tactactact gtgccataat
1861 agaggatgtg attctgcgct ttgcttggac tatccaaatc tcgattacct ctacaacttt
1921 gttgcctcat tctggggaca tcattgctac tgtctttgcc ccacttgagg ttttccggcg
1981 atttgtgtgg aacttcttcc gcctggagaa tgaacatctg aataactgtg gtgaattccg
2041 tgctgtgcgg gacatctctg tggcccccct gaacgcagat gatcagactc tcctagaaca
2101 gatgatggac caggatgatg gggtacgaaa ccgccagaag aatcggtcat ggaagtacaa
2161 ccagagcata tccctgcgcc ggcctcgcct cgcttctcaa tccaaggctc gtgacactaa
2221 ggtattgata gaagacacag atgatgaagc taacacttga attttctgaa gtctagctta
2281 acatctttgg ttttcctact ctacaatcct ttcctcgacc aacgcaacct ctagtacctt
2341 tccagccgaa aacaggagaa aacacataac acattttccg agctcttccg gatcggatcc
2401 tatggactcc aaacaagctc actgtgtttc ttttcttttc ttctggttta attttaattt
2461 tctattttca aaacaagtat ttacttcatt tgccaatcag aggatgtttt aagaaacaaa
2521 acatagtatc ttatggattg tttacaatca caaggacata gatacctatc aggatgaaga
2581 acaggcattg caaggaccct ctgatgggac ggtactgaga tatctcggct tccgctcagc
2641 ccggttttga atggttgaaa ccggacattg gtttttaaat tttttgtcag tttatgtgga
2701 gaattttttt ctttccttca tacccagcgc aaaggcactg gccgcacttg caggaaaagt
2761 gcaacttaaa gcagtacctt cattcatgaa gctacttttt aatttgatgt aacttttctt
2821 attttgggaa gggttgctgg gtgggtggga aatatgatgt atttgttaca catagttttc
2881 tcattattta tgaaacttaa ccatacagaa tgatataact cctgtgcaat gaaggtgata
2941 acagtaaaag aaggcaggag aaaaaaaaaa
//