LOCUS AF098865 2199 bp mRNA linear HUM 16-FEB-2000
DEFINITION Homo sapiens squalene epoxidase (ERG1) mRNA, complete cds.
ACCESSION AF098865
VERSION AF098865.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2199)
AUTHORS Tang,Y. and Porter,T.D.
TITLE Cloning of Human Squalene Epoxidase
JOURNAL Flavins Flavoproteins 12, 97-100 (1997)
REFERENCE 2 (bases 1 to 2199)
AUTHORS Laden,B.P., Tang,Y. and Porter,T.D.
TITLE Cloning, heterologous expression, and enzymological
characterization of human squalene monooxygenase
JOURNAL Arch. Biochem. Biophys. 374 (2), 381-388 (2000)
PUBMED 10666321
REFERENCE 3 (bases 1 to 2199)
AUTHORS Porter,T.D. and Tang,Y.
TITLE Direct Submission
JOURNAL Submitted (14-OCT-1998) College of Pharmacy, University of
Kentucky, Rose St., Lexington, KY 40536-0082, USA
FEATURES Location/Qualifiers
source 1..2199
/db_xref="H-InvDB:HIT000068562"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/sex="male"
/tissue_type="liver; microsomal endoplasmic reticulum"
gene 1..2199
/gene="ERG1"
CDS 156..1880
/gene="ERG1"
/EC_number="1.14.99.7"
/note="flavoprotein monooxygenase; squalene monooxygenase"
/codon_start=1
/product="squalene epoxidase"
/protein_id="AAD10823.1"
/translation="MWTFLGIATFTYFYKKFGDFITLANREVLLCVLVFLSLGLVLSY
RCRHRNGGLLGRQQSGSQFALFSDILSGLPFIGFFWAKSPPESENKEQLEARRRRKGT
NISETSLIGTAACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPD
RIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQV
QSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKEL
HAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSPVLI
YQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDNSHLRSMPASF
LPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEA
KKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGL
LSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIFPLIY
SEMKYMVH"
BASE COUNT 602 a 447 c 492 g 658 t
ORIGIN
1 ctggtctgat cggacttctc gtcctgggac acagtttact ggagtctggc cggctctccg
61 tgctcctctt ggtacctcat tttggggaga accttaaacc cactcgagca gataatctcc
121 gccttgaccg gtgccaccaa agaagccttg gaaccatgtg gacttttctg ggcattgcca
181 ctttcaccta tttttataag aagttcgggg acttcatcac tttggccaac agggaggtcc
241 tgttgtgcgt gctggtgttc ctctcgctgg gcctggtgct ctcctaccgc tgtcgccacc
301 gaaacggggg tctcctcggg cgccagcaga gcggctccca gttcgccctc ttctcggata
361 ttctctcagg cctgcctttc attggcttct tctgggccaa atccccccct gaatcagaaa
421 ataaggagca gctcgaggcc aggaggcgca gaaaaggaac caatatttca gaaacaagct
481 taataggaac agctgcctgt acatcaacat cttctcagaa tgacccagaa gttatcatcg
541 tgggagctgg cgtgcttggc tctgctttgg cagctgtgct ttccagagat ggaagaaagg
601 tgacagtcat tgagagagac ttaaaagagc ctgacagaat agttggagaa ttcctgcagc
661 cgggtggtta tcatgttctc aaagaccttg gtcttggaga tacagtggaa ggtcttgatg
721 cccaggttgt aaatggttac atgattcatg atcaggaaag caaatcagag gttcagattc
781 cttaccctct gtcagaaaac aatcaagtgc agagtggaag agctttccat cacggaagat
841 tcatcatgag tctccggaaa gcagctatgg cagagcccaa tgcaaagttt attgaaggtg
901 ttgtgttaca gttattagag gaagatgatg ttgtgatggg agttcagtac aaggataaag
961 agactggaga tatcaaggaa ctccatgctc cactgactgt tgttgcagat gggcttttct
1021 ccaagttcag gaaaagcctg gtctccaata aagtttctgt atcatctcat tttgttggct
1081 ttcttatgaa gaatgcacca cagtttaaag caaatcatgc tgaacttatt ttagctaacc
1141 cgagtccagt tctcatctac cagatttcat ccagtgaaac tcgagtactt gttgacatta
1201 gaggagaaat gccaaggaat ttaagagaat acatggttga aaaaatttac ccacaaatac
1261 ctgatcacct gaaagaacca ttcttagaag ccactgacaa ttctcatctg aggtccatgc
1321 cagcaagctt ccttcctcct tcatcagtga agaaacgagg tgttcttctt ttgggagacg
1381 catataatat gaggcatcca cttactggtg gaggaatgac tgttgctttt aaagatataa
1441 aactatggag aaaactgcta aagggtatcc ctgaccttta tgatgatgca gctattttcg
1501 aggccaaaaa atcattttac tgggcaagaa aaacatctca ttcctttgtc gtgaatatcc
1561 ttgctcaggc tctttatgaa ttattttctg ccacagatga ttccctgcat caactaagaa
1621 aagcctgttt tctttatttc aaacttggtg gcgaatgtgt tgcgggtcct gttgggctgc
1681 tttctgtatt gtctcctaac cctctagttt taattggaca cttctttgct gttgcaatct
1741 atgccgtgta tttttgcttt aagtcagaac cttggattac aaaacctcga gcccttctca
1801 gtagtggtgc tgtattgtac aaagcgtgtt ctgtaatatt tcctctaatt tactcagaaa
1861 tgaagtatat ggttcattaa gcttaaaggg gaaccatttg tgaatgaata tttggaactt
1921 accaagtcct aagagacttt tggaagagga tatatatagc atagtaccat accacttata
1981 aagtggaaac tcttggacca agattaggat taatttgttt ttgaagtttt ttgtatataa
2041 atatgtaaat acatgcttta atttgcaatt taaaatgaag gggttaaata agttagacat
2101 ttaaaagaaa tgattgttac cataaattag tgctaatgct gaggagaact acagtttttc
2161 ttttgaattt agtatttgag atgagttgtt gggacatgc
//