LOCUS AF098642 2076 bp mRNA linear HUM 15-AUG-2000
DEFINITION Homo sapiens phospholipid scramblase 1 mRNA, complete cds.
ACCESSION AF098642 AF008445
VERSION AF098642.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2076)
AUTHORS Zhou,Q., Zhao,J., Stout,J.G., Luhm,R.A., Wiedmer,T. and Sims,P.J.
TITLE Molecular cloning of human plasma membrane phospholipid scramblase.
A protein mediating transbilayer movement of plasma membrane
phospholipids
JOURNAL J. Biol. Chem. 272 (29), 18240-18244 (1997)
PUBMED 9218461
REFERENCE 2 (bases 1 to 2076)
AUTHORS Zhou,Q., Wiedmer,T. and Sims,P.J.
TITLE Molecular cloning and genomic structure of human phospholipid
scramblase gene
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 2076)
AUTHORS Zhou,Q., Wiedmer,T. and Sims,P.J.
TITLE Direct Submission
JOURNAL Submitted (13-OCT-1998) Blood Research Institute, 8727 Watertown
Plank Road, Milwaukee, WI 53226, USA
COMMENT On Jan 1, 1999 this sequence version replaced gi:2282600.
FEATURES Location/Qualifiers
source 1..2076
/db_xref="H-InvDB:HIT000068554"
/organism="Homo sapiens"
/mol_type="mRNA"
/strain="K-562"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q23"
CDS 256..1212
/note="expressed in platelets, erythrocytes, leukocytes, T
& B lymphocytes, vascular endothelial cells, fibroblasts,
spleen, thymus, prostate, testis, uterus, intestine,
colon; also expressed in the following cell lines: HL-60,
HeLa, K-562, MOLT-4, Raji, SW480, A549, G361, U937; plasma
membrane phospholipid scramblase"
/codon_start=1
/product="phospholipid scramblase 1"
/protein_id="AAC99413.1"
/translation="MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQV
SYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYL
SQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPF
TLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFT
IQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADN
FGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW"
BASE COUNT 642 a 397 c 391 g 646 t
ORIGIN
1 cgagcgccag cgcgggaacc gggaaaagga aaccgtgttg tgtacgtaag attcaggaaa
61 cgaaaccagg agccgcgggt gttggcgcaa aggttactcc cagacccttt tccggctgac
121 ttctgagaag gttgcgcagc agctgtgccc gacagtctag aggcgcagaa gaggaagcca
181 tcgcctggcc ccggctctct ggaccttgtc tcgctcggga gcggaaacag cggcagccag
241 agaactgttt taatcatgga caaacaaaac tcacagatga atgcttctca cccggaaaca
301 aacttgccag ttgggtatcc tcctcagtat ccaccgacag cattccaagg acctccagga
361 tatagtggct accctgggcc ccaggtcagc tacccacccc caccagccgg ccattcaggt
421 cctggcccag ctggctttcc tgtcccaaat cagccagtgt ataatcagcc agtatataat
481 cagccagttg gagctgcagg ggtaccatgg atgccagcgc cacagcctcc attaaactgt
541 ccacctggat tagaatattt aagtcagata gatcagatac tgattcatca gcaaattgaa
601 cttctggaag ttttaacagg ttttgaaact aataacaaat atgaaattaa gaacagcttt
661 ggacagaggg tttactttgc agcggaagat actgattgct gtacccgaaa ttgctgtggg
721 ccatctagac cttttacctt gaggattatt gataatatgg gtcaagaagt cataactctg
781 gagagaccac taagatgtag cagctgttgt tgtccctgct gccttcagga gatagaaatc
841 caagctcctc ctggtgtacc aataggttat gttattcaga cttggcaccc atgtctacca
901 aagtttacaa ttcaaaatga gaaaagagag gatgtactaa aaataagtgg tccatgtgtt
961 gtgtgcagct gttgtggaga tgttgatttt gagattaaat ctcttgatga acagtgtgtg
1021 gttggcaaaa tttccaagca ctggactgga attttgagag aggcatttac agacgctgat
1081 aactttggaa tccagttccc tttagacctt gatgttaaaa tgaaagctgt aatgattggt
1141 gcctgtttcc tcattgactt catgtttttt gaaagcactg gcagccagga acaaaaatca
1201 ggagtgtggt agtggattag tgaaagtctc ctcaggaaat ctgaagtctg tatattgatt
1261 gagactatct aaactcatac ctgtatgaat taagctgtaa ggcctgtagc tctggttgta
1321 tacttttgct tttcaaatta tagtttatct tctgtataac tgatttataa aggtttttgt
1381 acatttttta atactcattg tcaatttgag aaaaaggaca tatgagtttt tgcatttatt
1441 aatgaaactt cctttgaaaa actgctttga attatgatct ctgattcatt gtccatttta
1501 ctaccaaata ttaactaagg ccttattaat ttttatataa attatatctt gtcctattaa
1561 atctagttac aatttatttc atgcataaga gctaatgtta ttttgcaaat gccatatatt
1621 caaaaaagct caaagataat tttctttact attatgttca aataatattc aatatgcata
1681 ttatctttaa aaagttaaat gtttttttaa tcttcaagaa atcatgctac acttaacttc
1741 tcctagaagc taatctatac cataatattt tcatattcac aagatattaa attaccaatt
1801 ttcaaattat tgttagtaaa gaacaaaatg attctctccc aaagaaagac acattttaaa
1861 tactccttca ctctaaaact ctggtattat aacttttgaa agttaatatt tctacatgaa
1921 atgtttagct cttacactct atccttccta gaaaatggta attgagatta ctcagatatt
1981 aattaaatac aatatcatat atatattcac agagtataaa cctaaataat gatctattag
2041 attcaaatat ttgaaataaa aacttgattt ttttgt
//