LOCUS AF098162 4417 bp mRNA linear HUM 30-NOV-1998
DEFINITION Homo sapiens timeless homolog mRNA, complete cds.
ACCESSION AF098162
VERSION AF098162.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4417)
AUTHORS Sangoram,A.M., Saez,L., Antoch,M.P., Gekakis,N., Staknis,D.,
Whiteley,A., Fruechte,E.M., Vitaterna,M.H., Shimomura,K.,
King,D.P., Young,M.W., Weitz,C.J. and Takahashi,J.S.
TITLE Mammalian circadian autoregulatory loop: a timeless ortholog and
mPer1 interact and negatively regulate CLOCK-BMAL1-induced
transcription
JOURNAL Neuron 21 (5), 1101-1113 (1998)
PUBMED 9856465
REFERENCE 2 (bases 1 to 4417)
AUTHORS Sangoram,A.M., Whiteley,A. and Takahashi,J.S.
TITLE Direct Submission
JOURNAL Submitted (13-OCT-1998) Neurobiology and Physiology, Northwestern
University, 2153 N Campus Dr. 2-160, Evanston, IL 60208, USA
FEATURES Location/Qualifiers
source 1..4417
/db_xref="H-InvDB:HIT000068526"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="closest to WI-7760"
CDS 143..3769
/note="hTIM"
/codon_start=1
/product="timeless homolog"
/protein_id="AAC80011.1"
/translation="MDLHMMNCELLATCSALGYLEGDTYHKEPDCLESVKDLIRYLRH
EDETRDVRQQLGAAQILQSDLLPILTQHHQDKPLFDAVIRLMVNLTQPALLCFGNLPK
EPSFRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEERQEEDNLLIERIL
LLVRNILHVPADLDQEKKIDDDASAHDQLLWAIHLSGLDDLLLFLASSSAEEQWSLHV
LEIVSLMFRDQNPEQLAGVGQGRLAQERSADFAELEVLRQREMAEKKTRALQRGNRHS
RFGGSYIVQGLKSIGERDLIFHKGLHNLRNYSSDLGKQPKKVPKRRQAARELSIQRRS
ALNVRLFLRDFCSEFLENCYNRLMGSVKDHLLREKAQQHDETYYMWALAFFMAFNRAA
SFRPGLVSETLSVRTFHFIEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATV
NEMDLSPDEAVRESSRIIKNNIFYVMEYRELFLALFRKFDERCQPRSFLRDLVETTHL
FLKMLERFCRSRGNLVVQNKQKKRRKKKKKVLDQAIVSGNVPSSPEEVEAVWPALAEQ
LQCCAQNSELSMDSVVPFDAASEVPVEEQRAEAMVRIQDCLLAGQAPQALTLLRSARE
VWPEGDVFGSQDISPEEEIQLLKQILSAPLPRQQGPEERGAEEEEEEEEEEEEELQVV
QVSEKEFNFLDYLKRFACSTVVRAYVLLLRSYQQNSAHTNHCIVKMLHRLAHDLKMEA
LLFQLSVFCLFNRLLSDPAAGAYKELVTFAKYILGKFFALAAVNQKAFVELLFWKNTA
VVREMTEGYGSLDDRSSSRRAPTWSPEEEAHLQELYLANKDVEGQDVVEAILAHLNTV
PRTRKQIIHHLVQMGLADSVKDFQRKGTHIVLWTGDQELELQRLFEEFRDSDDVLGHI
MKNITAKRSRARIVDKLLALGLVAERRELYKKRQKKLASSILPNGAESLKDFCQEDLE
EEENLPEEDSEEEEEGGSEAEQVQGSLVLSNENLGQSLHQEGFSIPLLWLQNCLIRAA
DDREEDGCSQAVPLVPLTEENEEAMENEQFQQLLRKLGVRPPASGQETFWRIPAKLSP
TQLRRAAASLSQPEEEQKLQPELQPKVPGEQGSDEEHCKEHRAQALRALLLAHKKKAG
LASPEEEDAVGKEPLKAAPKKRQLLDSDEEQEEDEGRNRAPELGAPGIQKKKRYQIED
DEDD"
BASE COUNT 1142 a 1056 c 1229 g 990 t
ORIGIN
1 ggcacgagtg gcggaaaggc tgcggccccg cgccagaggg ccggtggctc ctccgggctt
61 ctgaggaccc gcagggagcg ggcctcatca tttctgtctc ctgtttctcc acttccttct
121 ctattggttg gtccactgat gtatggactt gcacatgatg aactgtgaac ttctagccac
181 atgtagtgcc cttgggtact tggagggaga cacttaccat aaggaaccag attgcttaga
241 gagcgtgaag gatctgatcc gctatttgag gcatgaggat gagacacgag atgtgcggca
301 gcagctgggg gcagcccaga tcctacagag cgaccttctg cccatcctca cccagcacca
361 ccaggacaag cctctctttg atgctgttat cagactgatg gtgaacttga cacaaccagc
421 cttgctctgt tttggcaatc tgcctaagga gcccagcttt cggcaccatt ttttgcaggt
481 gctaacttat ttgcaggcct acaaagaggc ctttgccagt gagaaggctt ttggagtcct
541 cagtgaaacc ttgtatgagc tgctgcagct gggctgggag gaacggcagg aggaagacaa
601 cttgctgatt gaacggatcc tactgctggt cagaaatatt ctccatgtcc cagctgacct
661 tgatcaggag aagaagattg atgatgacgc cagtgcccat gaccagctcc tctgggcgat
721 tcacctcagc ggcctggatg acctgctcct ctttctggcc agctcgtctg ctgaggagca
781 atggagccta catgtgctag agattgtctc ccttatgttt cgtgaccaga accccgagca
841 gctggcggga gtagggcagg gacgcttagc tcaggagcgg agtgcagatt ttgcagaact
901 ggaggtattg cgccagcgag agatggcaga aaagaagact cgagccctcc agcgaggcaa
961 caggcattct cgatttgggg gctcctatat tgtccagggg ttgaaatcca ttggggagag
1021 ggacctcatc tttcacaaag gccttcacaa cctacgaaac tacagttcag atttgggaaa
1081 gcagccgaaa aaggtgccta aacgtcgcca ggccgcccga gagctgtcca ttcagcgccg
1141 ttctgccctc aatgtgaggc tcttcctcag agacttctgc tctgagttcc tggagaactg
1201 ttacaaccgg ctcatgggat cagtaaagga tcacctgctt cgggagaaag ctcagcagca
1261 tgatgagacc tattatatgt gggccttggc tttcttcatg gccttcaacc gagctgcctc
1321 cttccggcca ggcctggttt ctgagaccct cagtgtccgt accttccact tcattgagca
1381 gaacctcacc aactactatg agatgatgct gactgaccgc aaggaagctg cctcctgggc
1441 acgccggatg cacttggctc tgaaggccta tcaggagctg ctggcaacag tgaatgagat
1501 ggacttatct ccagatgagg ctgtgaggga gagcagccgc atcatcaaga acaatatttt
1561 ctatgtgatg gagtaccgag aactattcct ggcacttttt cgaaagtttg atgagagatg
1621 ccagccccgc tctttccttc gtgacctggt ggagaccacc cacctcttcc tcaaaatgtt
1681 ggagcgattc tgtcggagcc gtgggaacct ggtggtgcag aacaaacaaa agaagagaag
1741 gaagaagaag aagaaggtcc tagaccaggc cattgtttct ggtaatgtcc catctagccc
1801 agaagaagtg gaggctgtgt ggccagccct ggctgagcag ctacagtgct gtgcccagaa
1861 ttctgagctc agcatggact ccgtggttcc ctttgatgcg gcctcagagg tgccagtgga
1921 ggagcagcgg gcagaagcta tggtacggat ccaagactgt ctcctggctg gccaggcccc
1981 acaggccctg actctcctga ggtctgctcg ggaggtgtgg cctgaaggag atgtgtttgg
2041 ctctcaagac atttctccag aggaagagat ccagttgctg aaacaaatcc tctctgctcc
2101 acttccccgg cagcagggcc cagaggaacg tggggcagag gaagaagaag aggaggagga
2161 ggaggaagag gaggagttgc aagtggtcca ggtgtcggag aaagaattta attttctgga
2221 ctacctgaaa cgctttgcat gttcaactgt cgttcgagcc tatgtgctgc tactaaggag
2281 ctaccagcag aatagtgccc acactaacca ttgcattgtg aagatgctgc accggctggc
2341 ccatgacctc aaaatggaag ccctactttt tcagctgtca gtcttctgcc tcttcaatcg
2401 tctgcttagt gaccctgctg ctggagccta caaagagcta gtgacttttg ccaaatacat
2461 cctgggcaaa ttttttgcac tggctgcagt caaccaaaaa gcctttgtgg agctgttgtt
2521 ctggaagaac acagctgtgg ttcgagagat gactgagggc tatggctccc tggatgacag
2581 gtcttccagt cgcagagcac ctacatggag ccccgaagaa gaggctcatc ttcaggagct
2641 gtacctcgcc aataaggacg tggaagggca ggatgtggtg gaagccatct tggcccacct
2701 gaatactgtt cctcgaacac gcaagcagat catccaccat ctggtacaga tgggactggc
2761 tgacagtgtc aaggacttcc aaaggaaagg aacccatatt gtactgtgga cgggggatca
2821 ggagttggag ctgcagcggc tttttgagga attccgggac tcagatgatg tcctgggtca
2881 tatcatgaag aatatcacag ccaaacgctc acgggcccga atagtggata aactcttggc
2941 tctggggctg gtggctgagc ggcgggagct gtacaagaaa cggcagaaaa agttggcatc
3001 ctccatcttg ccaaatggag cggagtccct gaaagatttt tgccaggaag atctggaaga
3061 agaggaaaac ctgcctgagg aagacagcga agaggaagaa gaagggggct cagaagcaga
3121 acaagtccag ggtagcttag tcctttcaaa tgaaaacctt ggtcaaagcc tgcatcagga
3181 aggcttttct atcccgctcc tatggctcca gaactgcctg atccgagcag ctgatgatcg
3241 ggaagaggat ggctgctccc aggccgttcc attggtgcca ctcacagagg aaaatgagga
3301 agccatggaa aacgaacagt ttcagcagct gttgcgcaag ctaggggttc ggccccctgc
3361 ctctgggcag gaaaccttct ggcgaattcc agccaagctg agtcctaccc agctccggag
3421 ggcagcagct tctttgagtc aaccagagga ggaacagaag ctgcagccag agctgcagcc
3481 taaagtccct ggagagcaag gctctgatga ggagcactgt aaagagcacc gagcacaagc
3541 cctgagggcc ctcttgctag cccacaagaa gaaagcgggc ctggcatccc cagaggagga
3601 agacgctgtt ggtaaagagc cgctgaaggc agcacccaag aaacgacaat tgctggacag
3661 cgacgaggaa caggaagaag atgagggcag gaacagagca ccagagttgg gagctccagg
3721 aatccaaaag aagaaacgat accagattga ggatgatgag gatgactgaa gagctaagaa
3781 gcctaggggt agagatagac acgtttttag atggtgcatt caagtcagag ttggaagggt
3841 catacaggac ccagaagctc ctcttactgg acagagcagt agaatcccag gctctttcac
3901 ggatttaggc tgagaaactt cagcagcagt attggacttc tctgctgtca gtctttgttt
3961 ctcccagttt ttatcggtat gccccagcag ctctctggag atttagttct cttcttctag
4021 gaaccatttc ttttggttat tggagctcct tagcaaataa gaggagtgag tgaaatagag
4081 aaagcacccc ggaccccttt tattggtctg ttcctttggc tttctcttgg aggtgggtcg
4141 cagcaccaga tggggagctt tatgacatga caggcgggag ttttgtacca cttttagaag
4201 ataccagatg cctctgtcct cattttgttt cctatgatca tcctctagat accagataga
4261 ggcccattcc tgcatttgag atagggttgg aatatagtac tctagatgat gaatgtgttt
4321 gctttgtgtt tggtattaaa catgtaagat tagaagttct caaaaaaaaa aaaaaaaaaa
4381 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//