LOCUS       AF097645                3690 bp    mRNA    linear   HUM 19-OCT-1999
DEFINITION  Homo sapiens candidate tumor suppressor protein DICE1 mRNA,
            complete cds.
ACCESSION   AF097645
VERSION     AF097645.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3690)
  AUTHORS   Wieland,I., Arden,K.C., Michels,D., Klein-Hitpass,L., Bohm,M.,
            Viars,C.S. and Weidle,U.H.
  TITLE     Isolation of DICE1: a gene frequently affected by LOH and
            downregulated in lung carcinomas
  JOURNAL   Oncogene 18 (32), 4530-4537 (1999)
   PUBMED   10467397
REFERENCE   2  (bases 1 to 3690)
  AUTHORS   Wieland,I. and Weidle,U.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-OCT-1998) Institute for Cell Biology (Cancer
            Research), University of Essen Medical School, Virchowstr. 173,
            Essen, NRW D-45122 Essen, Germany
FEATURES             Location/Qualifiers
     source          1..3690
                     /db_xref="H-InvDB:HIT000068508"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.12-q14.2"
                     /tissue_type="brain"
                     /dev_stage="fetal"
     CDS             477..3140
                     /note="deleted in lung cancer"
                     /codon_start=1
                     /product="candidate tumor suppressor protein DICE1"
                     /protein_id="AAF03046.1"
                     /translation="MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPA
                     SRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLN
                     RLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKE
                     PFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQ
                     CLESLVQKVQSGVVINFEKAGPDPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKT
                     GVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPL
                     TQFILERKSPQTCWQVYVSNSAKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPL
                     LDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSY
                     SVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAYRKDFQQLLQGI
                     SEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKS
                     TRRFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKK
                     GMMIDEADEFVAGPQNKHKRPGEPNMQGIPKRRRCMSPLLRGRQQNPVVNNHIGGKGP
                     PAPTTQAQPDLIKPLPLHKISETTNDSIIHDVVENHVADQLSSDITPNAMDTEFSASS
                     PASLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDKEQCAEENIPASSLNKGKK
                     LMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEAS
                     RFKKRMLIEQLENFLDEIHRRANQINHINSN"
BASE COUNT         1140 a          816 c          790 g          944 t
ORIGIN      
        1 gggccggggt gcggagggag tccctgaaac ttctcccaac agccccaggg ccaatcttcc
       61 ctcagcccac tcccctcttc gccagctccc aggtccccac tcctgtaccg ggggtggggt
      121 ggggagccag gcccgtctcc cgctgggaca cacacagggg ccggggagcg gggacgggac
      181 ccccgaggcg ggggggacga accgacagac agacggctgg gcgcccgccc cagcgggcag
      241 gcaggcagga ggaggcggag gcgggggtac gacggggagc actgggtctg gggagtttcc
      301 tctcaactat cgggggagaa actccccgca gccggaggaa agacccagac agtgttttcc
      361 tcccgggggc cgtgctcccc cgccccgcgt agcggcggtc gccgccaccg gcgcctccac
      421 ctctaccatc tcctctttct ccaccacctc gggccccggt gtccccggcc agcactatgc
      481 ccatcttact gttcctgata gacacgtctg cctctatgaa ccagcgcagc catctgggca
      541 ccacctacct ggacacggcc aaaggcgcgg tagagacctt catgaagctc cgtgcccggg
      601 accctgccag cagaggagac aggtatatgc tggtcacttt cgaagagccg ccctatgcta
      661 tcaaggctgg atggaaagaa aaccatgcaa cgtttatgaa tgaattgaaa aaccttcagg
      721 ctgaaggact tacgactctt ggccaatccc taaggacagc ttttgattta ttaaatttaa
      781 atagattagt aactggcata gacaactatg ggcagggaag aaaccctttt ttcttggagc
      841 cagcaataat tatcacaatt actgatggga gcaagttgac taccaccagt ggagtccagg
      901 atgagcttca tttacctctt aattctcctt tgcctggaag tgaattgacc aaggaacctt
      961 ttcgttggga tcagagactc tttgcattag tgttgcggtt gcctggcacc atgtcagtag
     1021 aatcagaaca gttgacaggt gtgcctttag atgactctgc aatcacacca atgtgtgaag
     1081 tgacaggcgg ccgttcatat tctgtgtgtt ctccaagaat gcttaatcag tgtctggagt
     1141 ccttggtgca gaaagtacaa agtggggtgg taataaactt tgaaaaagca ggaccagatc
     1201 cttcccctgt agaagatggg cagccagata tatcaaggcc ttttggatct cagccttggc
     1261 atagctgtca caaactcata tatgtcagac caaatcctaa aactggggtt cctataggtc
     1321 attggcctgt tccagagtct ttttggccag atcaaaattc gccaacacta ccacctcgta
     1381 catctcatcc tgtagtgaag ttttcctgta cagactgtga accaatggtt attgataaac
     1441 ttccttttga caaatatgag ttggaacctt caccactgac tcaatttatc ctggaaagga
     1501 aatctcctca aacatgttgg caggtgtacg tgagcaatag tgcaaaatac agtgaacttg
     1561 gtcatccttt tggttacttg aaagccagta cagcactgaa ctgtgtcaac ttatttgtga
     1621 tgccttacaa ttatccagtc cttcttcccc tcttagatga cttgtttaaa gtgcataaag
     1681 caaaaccaac attgaagtgg agacagtcat ttgaaagtta tttgaagaca atgcctccct
     1741 actatcttgg gcccttgaag aaagctgtta ggatgatggg agcacctaac ctaatagcag
     1801 acagtatgga atatggactt agttacagtg tcatttcata cctcaaaaaa ctgagtcaac
     1861 aggccaaaat agaatctgat cgagtcattg gatctgtagg caaaaaagta gtacaggaga
     1921 ctggaataaa agtccggagc cgatcacatg gtttatcaat ggcatatagg aaagattttc
     1981 aacaactcct ccagggaatt tcagaggatg tccctcacag actgctagac cttaatatga
     2041 aggaatacac tgggttccaa gttgctttgc tgaataagga tttgaagcca cagacattta
     2101 gaaatgctta tgacatacca agacgaaatc ttttggatca cttaacaaga atgagatcta
     2161 atcttttgaa gagcactcgc agatttctga aaggacagga cgaagatcaa gtgcacagtg
     2221 ttcctatagc acaaatgggg aactaccagg aatacctcaa gcaagtacct tctccactaa
     2281 gagaacttga tcctgatcag ccacgaaggt tgcatacatt tggcaacccc tttaagctgg
     2341 ataagaaggg tatgatgata gatgaagcag atgaatttgt ggctggacct caaaataaac
     2401 ataaacgacc cggagaacca aatatgcaag ggatccctaa aagacgtcgg tgtatgtctc
     2461 cactactaag aggcagacag cagaatcctg ttgtaaacaa tcatattggg ggaaaaggac
     2521 cacctgcacc tacaactcaa gcacagccag atcttattaa acctcttcct cttcataaaa
     2581 tttcagaaac cactaatgat tcgataatac atgatgtggt tgaaaatcat gttgcagacc
     2641 aactttcatc agacattaca ccaaatgcta tggatacgga attttcagca tcttctccag
     2701 ccagtttact ggaacggcca accaatcata tggaggctct tggtcatgac catttaggaa
     2761 ccaatgacct cactgttggt ggatttttag aaaatcatga ggagccaaga gataaagaac
     2821 aatgtgctga agagaacata ccagcatctt cactcaacaa aggaaagaaa ttgatgcatt
     2881 gcagaagcca tgaagaggtc aatactgaac taaaagcaca aataatgaaa gagatccgaa
     2941 agccaggaag aaaatatgaa agaatcttca ctttactgaa gcatgtgcaa ggcagtttac
     3001 aaacaagact aatattttta caaaatgtca ttaaagaagc atcaaggttt aaaaaacgaa
     3061 tgctaataga acaactggag aacttcttgg atgaaattca tcgaagagcc aatcagatca
     3121 accatattaa tagcaattaa aagaaaatag aatgtggcca cttatttcac tatcttcttc
     3181 aaatacaaag taaataacaa gactgttgtg atcttgcatt cattttctga catgcattgt
     3241 tggctatttg aaatactaaa agcaaatcta cagatccttt ttccatcatt ttacagtgac
     3301 cttttcttca ttttggttta tttttgtaat gtgaaaagta tcactctaaa aaacattttt
     3361 aatttaacaa actaaaaata ttcctccaaa tctcttgctt gtcattgact cttgcgtgtc
     3421 aatttccctc aggttctatt ttcttaaacc aacctttaaa attgtcacct ctgttaaggt
     3481 tgaactttgc caaaaaaaaa agaagttact ttgtaatttt tggggaaaaa agcacataca
     3541 ttaaaactag gtaatgtttt gtatatacag ttattttgga tatattattg taagttgtac
     3601 aaatgtattt tgaagaatat ttaagaaaag cacttttgtt attccatcaa taaatgctct
     3661 attttaaaaa aaaaaaaaaa aaaaaaaaaa
//