LOCUS AF097645 3690 bp mRNA linear HUM 19-OCT-1999 DEFINITION Homo sapiens candidate tumor suppressor protein DICE1 mRNA, complete cds. ACCESSION AF097645 VERSION AF097645.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3690) AUTHORS Wieland,I., Arden,K.C., Michels,D., Klein-Hitpass,L., Bohm,M., Viars,C.S. and Weidle,U.H. TITLE Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas JOURNAL Oncogene 18 (32), 4530-4537 (1999) PUBMED 10467397 REFERENCE 2 (bases 1 to 3690) AUTHORS Wieland,I. and Weidle,U. TITLE Direct Submission JOURNAL Submitted (06-OCT-1998) Institute for Cell Biology (Cancer Research), University of Essen Medical School, Virchowstr. 173, Essen, NRW D-45122 Essen, Germany FEATURES Location/Qualifiers source 1..3690 /db_xref="H-InvDB:HIT000068508" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="13" /map="13q14.12-q14.2" /tissue_type="brain" /dev_stage="fetal" CDS 477..3140 /note="deleted in lung cancer" /codon_start=1 /product="candidate tumor suppressor protein DICE1" /protein_id="AAF03046.1" /translation="MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPA SRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLN RLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKE PFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQ CLESLVQKVQSGVVINFEKAGPDPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKT GVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPL TQFILERKSPQTCWQVYVSNSAKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPL LDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSY SVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAYRKDFQQLLQGI SEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKS TRRFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKK GMMIDEADEFVAGPQNKHKRPGEPNMQGIPKRRRCMSPLLRGRQQNPVVNNHIGGKGP PAPTTQAQPDLIKPLPLHKISETTNDSIIHDVVENHVADQLSSDITPNAMDTEFSASS PASLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDKEQCAEENIPASSLNKGKK LMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEAS RFKKRMLIEQLENFLDEIHRRANQINHINSN" BASE COUNT 1140 a 816 c 790 g 944 t ORIGIN 1 gggccggggt gcggagggag tccctgaaac ttctcccaac agccccaggg ccaatcttcc 61 ctcagcccac tcccctcttc gccagctccc aggtccccac tcctgtaccg ggggtggggt 121 ggggagccag gcccgtctcc cgctgggaca cacacagggg ccggggagcg gggacgggac 181 ccccgaggcg ggggggacga accgacagac agacggctgg gcgcccgccc cagcgggcag 241 gcaggcagga ggaggcggag gcgggggtac gacggggagc actgggtctg gggagtttcc 301 tctcaactat cgggggagaa actccccgca gccggaggaa agacccagac agtgttttcc 361 tcccgggggc cgtgctcccc cgccccgcgt agcggcggtc gccgccaccg gcgcctccac 421 ctctaccatc tcctctttct ccaccacctc gggccccggt gtccccggcc agcactatgc 481 ccatcttact gttcctgata gacacgtctg cctctatgaa ccagcgcagc catctgggca 541 ccacctacct ggacacggcc aaaggcgcgg tagagacctt catgaagctc cgtgcccggg 601 accctgccag cagaggagac aggtatatgc tggtcacttt cgaagagccg ccctatgcta 661 tcaaggctgg atggaaagaa aaccatgcaa cgtttatgaa tgaattgaaa aaccttcagg 721 ctgaaggact tacgactctt ggccaatccc taaggacagc ttttgattta ttaaatttaa 781 atagattagt aactggcata gacaactatg ggcagggaag aaaccctttt ttcttggagc 841 cagcaataat tatcacaatt actgatggga gcaagttgac taccaccagt ggagtccagg 901 atgagcttca tttacctctt aattctcctt tgcctggaag tgaattgacc aaggaacctt 961 ttcgttggga tcagagactc tttgcattag tgttgcggtt gcctggcacc atgtcagtag 1021 aatcagaaca gttgacaggt gtgcctttag atgactctgc aatcacacca atgtgtgaag 1081 tgacaggcgg ccgttcatat tctgtgtgtt ctccaagaat gcttaatcag tgtctggagt 1141 ccttggtgca gaaagtacaa agtggggtgg taataaactt tgaaaaagca ggaccagatc 1201 cttcccctgt agaagatggg cagccagata tatcaaggcc ttttggatct cagccttggc 1261 atagctgtca caaactcata tatgtcagac caaatcctaa aactggggtt cctataggtc 1321 attggcctgt tccagagtct ttttggccag atcaaaattc gccaacacta ccacctcgta 1381 catctcatcc tgtagtgaag ttttcctgta cagactgtga accaatggtt attgataaac 1441 ttccttttga caaatatgag ttggaacctt caccactgac tcaatttatc ctggaaagga 1501 aatctcctca aacatgttgg caggtgtacg tgagcaatag tgcaaaatac agtgaacttg 1561 gtcatccttt tggttacttg aaagccagta cagcactgaa ctgtgtcaac ttatttgtga 1621 tgccttacaa ttatccagtc cttcttcccc tcttagatga cttgtttaaa gtgcataaag 1681 caaaaccaac attgaagtgg agacagtcat ttgaaagtta tttgaagaca atgcctccct 1741 actatcttgg gcccttgaag aaagctgtta ggatgatggg agcacctaac ctaatagcag 1801 acagtatgga atatggactt agttacagtg tcatttcata cctcaaaaaa ctgagtcaac 1861 aggccaaaat agaatctgat cgagtcattg gatctgtagg caaaaaagta gtacaggaga 1921 ctggaataaa agtccggagc cgatcacatg gtttatcaat ggcatatagg aaagattttc 1981 aacaactcct ccagggaatt tcagaggatg tccctcacag actgctagac cttaatatga 2041 aggaatacac tgggttccaa gttgctttgc tgaataagga tttgaagcca cagacattta 2101 gaaatgctta tgacatacca agacgaaatc ttttggatca cttaacaaga atgagatcta 2161 atcttttgaa gagcactcgc agatttctga aaggacagga cgaagatcaa gtgcacagtg 2221 ttcctatagc acaaatgggg aactaccagg aatacctcaa gcaagtacct tctccactaa 2281 gagaacttga tcctgatcag ccacgaaggt tgcatacatt tggcaacccc tttaagctgg 2341 ataagaaggg tatgatgata gatgaagcag atgaatttgt ggctggacct caaaataaac 2401 ataaacgacc cggagaacca aatatgcaag ggatccctaa aagacgtcgg tgtatgtctc 2461 cactactaag aggcagacag cagaatcctg ttgtaaacaa tcatattggg ggaaaaggac 2521 cacctgcacc tacaactcaa gcacagccag atcttattaa acctcttcct cttcataaaa 2581 tttcagaaac cactaatgat tcgataatac atgatgtggt tgaaaatcat gttgcagacc 2641 aactttcatc agacattaca ccaaatgcta tggatacgga attttcagca tcttctccag 2701 ccagtttact ggaacggcca accaatcata tggaggctct tggtcatgac catttaggaa 2761 ccaatgacct cactgttggt ggatttttag aaaatcatga ggagccaaga gataaagaac 2821 aatgtgctga agagaacata ccagcatctt cactcaacaa aggaaagaaa ttgatgcatt 2881 gcagaagcca tgaagaggtc aatactgaac taaaagcaca aataatgaaa gagatccgaa 2941 agccaggaag aaaatatgaa agaatcttca ctttactgaa gcatgtgcaa ggcagtttac 3001 aaacaagact aatattttta caaaatgtca ttaaagaagc atcaaggttt aaaaaacgaa 3061 tgctaataga acaactggag aacttcttgg atgaaattca tcgaagagcc aatcagatca 3121 accatattaa tagcaattaa aagaaaatag aatgtggcca cttatttcac tatcttcttc 3181 aaatacaaag taaataacaa gactgttgtg atcttgcatt cattttctga catgcattgt 3241 tggctatttg aaatactaaa agcaaatcta cagatccttt ttccatcatt ttacagtgac 3301 cttttcttca ttttggttta tttttgtaat gtgaaaagta tcactctaaa aaacattttt 3361 aatttaacaa actaaaaata ttcctccaaa tctcttgctt gtcattgact cttgcgtgtc 3421 aatttccctc aggttctatt ttcttaaacc aacctttaaa attgtcacct ctgttaaggt 3481 tgaactttgc caaaaaaaaa agaagttact ttgtaatttt tggggaaaaa agcacataca 3541 ttaaaactag gtaatgtttt gtatatacag ttattttgga tatattattg taagttgtac 3601 aaatgtattt tgaagaatat ttaagaaaag cacttttgtt attccatcaa taaatgctct 3661 attttaaaaa aaaaaaaaaa aaaaaaaaaa //