LOCUS AF097514 5221 bp mRNA linear HUM 19-MAY-1999
DEFINITION Homo sapiens stearoyl-CoA desaturase (SCD) mRNA, complete cds.
ACCESSION AF097514
VERSION AF097514.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5221)
AUTHORS Zhang,L., Ge,L., Parimoo,S., Stenn,K. and Prouty,S.M.
TITLE Human stearoyl-CoA desaturase: alternative transcripts generated
from a single gene by usage of tandem polyadenylation sites
JOURNAL Biochem. J. 340 (Pt 1), 255-264 (1999)
PUBMED 10229681
REFERENCE 2 (bases 1 to 5221)
AUTHORS Zhang,L., Ge,L., Parimoo,S., Stenn,K. and Prouty,S.M.
TITLE Direct Submission
JOURNAL Submitted (05-OCT-1998) Skin Biology TRC, Johnson and Johnson CPWW,
199 Grandview Road, Skillman, NJ 08558, USA
FEATURES Location/Qualifiers
source 1..5221
/db_xref="H-InvDB:HIT000068500"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/tissue_type="liver; brain; adipose; scalp skin; foreskin
keratinocytes"
/dev_stage="adult"
gene 1..5221
/gene="SCD"
CDS 236..1315
/gene="SCD"
/EC_number="1.14.19.1"
/function="catalysis of delta 9 cis-desaturation of
palmitoyl-CoA and stearoyl-CoA"
/codon_start=1
/product="stearoyl-CoA desaturase"
/protein_id="AAD29870.1"
/translation="MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLED
DIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWL
WGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAH
HKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYY
KPGLLLMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPY
DKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAY
DRKKVSKAAILARIKRTGDGNYKSG"
regulatory 3972..3977
/regulatory_class="polyA_signal_sequence"
/gene="SCD"
regulatory 5187..5192
/regulatory_class="polyA_signal_sequence"
/gene="SCD"
BASE COUNT 1344 a 1217 c 1200 g 1460 t
ORIGIN
1 ataaaagggg gctgaggaaa taccggacac ggtcacccgt tgccagctct agcctttaaa
61 ttcccggctc ggggacctcc acgcaccgcg gctagcgccg acaaccagct agcgtgcaag
121 gcgccgcggc tcagcgcgta ccggcgggct tcgaaaccgc agtcctccgg cgaccccgaa
181 ctccgctccg gagcctcagc cccctggaaa gtgatcccgg catccgagag ccaagatgcc
241 ggcccacttg ctgcaggacg atatctctag ctcctatacc accaccacca ccattacagc
301 gcctccctcc agggtcctgc agaatggagg agataagttg gagacgatgc ccctctactt
361 ggaagacgac attcgccctg atataaaaga tgatatatat gaccccacct acaaggataa
421 ggaaggccca agccccaagg ttgaatatgt ctggagaaac atcatcctta tgtctctgct
481 acacttggga gccctgtatg ggatcacttt gattcctacc tgcaagttct acacctggct
541 ttggggggta ttctactatt ttgtcagtgc cctgggcata acagcaggag ctcatcgtct
601 gtggagccac cgctcttaca aagctcggct gcccctacgg ctctttctga tcattgccaa
661 cacaatggca ttccagaatg atgtctatga atgggctcgt gaccaccgtg cccaccacaa
721 gttttcagaa acacatgctg atcctcataa ttcccgacgt ggctttttct tctctcacgt
781 gggttggctg cttgtgcgca aacacccagc tgtcaaagag aaggggagta cgctagactt
841 gtctgaccta gaagctgaga aactggtgat gttccagagg aggtactaca aacctggctt
901 gctgctgatg tgcttcatcc tgcccacgct tgtgccctgg tatttctggg gtgaaacttt
961 tcaaaacagt gtgttcgttg ccactttctt gcgatatgct gtggtgctta atgccacctg
1021 gctggtgaac agtgctgccc acctcttcgg atatcgtcct tatgacaaga acattagccc
1081 ccgggagaat atcctggttt cacttggagc tgtgggtgag ggcttccaca actaccacca
1141 ctcctttccc tatgactact ctgccagtga gtaccgctgg cacatcaact tcaccacatt
1201 cttcattgat tgcatggccg ccctcggtct ggcctatgac cggaagaaag tctccaaggc
1261 cgccatcttg gccaggatta aaagaaccgg agatggaaac tacaagagtg gctgagtttg
1321 gggtccctca ggtttccttt ttcaaaaacc agccaggcag aggttttaat gtctgtttat
1381 taactactga ataatgctac caggatgcta aagatgatga tgttaaccca ttccagtaca
1441 gtattctttt aaaattcaaa agtattgaaa gccaacaact ctgcctttat gatgctaagc
1501 tgatattatt tcttctctta tcctctctct cttctaggcc cattgtcctc cttttcactt
1561 tattgctatc gccctccttt cccttattgc ctcccaggca agcagctggt cagtctttgc
1621 tcagtgtcca gcttccaaag cctagacaac ctttctgtag cctaaaacga atggtctttg
1681 ctccagataa ctctctttcc ttgagctgtt gtgagctttg aagtaggtgg cttgagctag
1741 agataaaaca gaatcttctg ggtagtcccc tgttgattat cttcagccca ggcttttgct
1801 agatggaatg gaaaagcaac ttcatttgac acaaagcttc taaagcaggt aaattgtcgg
1861 gggagagagt tagcatgtat gaatgtaagg atgagggaag cgaagcaaga ggaacctctc
1921 gccatgatca gacatacagc tgcctaccta atgaggactt caagccccac cacatagcat
1981 gcttcctttc tctcctggct cggggtaaaa agtggctgcg gtgtttggca atgctaattc
2041 aatgccgcaa catatagttg aggccgagga taaagaaaag acattttaag tttgtagtaa
2101 aagtggtctc tgctggggaa gggttttctt ttcttttttt ctttaataac aaggagattt
2161 cttagttcat atatcaagaa gtcttgaagt tgggtgtttc cagaattggt aaaaacagca
2221 gctcatggaa ttttgagtat tccatgagct gctcattaca gttctttcct ctttctgctc
2281 tgccatcttc aggatattgg ttcttcccct catagtaata agatggctgt ggcatttcca
2341 aacatccaaa aaaagggaag gatttaagga ggtgaagtcg ggtcaaaaat aaaatatata
2401 tacatatata cattgcttag aacgttaaac tattagagta tttcccttcc aaagagggat
2461 gtttggaaaa aactctgaag gagaggagga attagttggg atgccaattt cctctccact
2521 gctggacatg agatggagag gctgagggac aggatctata ggcagcttct aagagcgaac
2581 ttcacatagg aagggatctg agaacacgtt gccaggggct tgagaaggtt actgagtgag
2641 ttattgggag tcttaataaa ataaactaga tattaggtcc attcattaat tagttccagt
2701 ttctccttga aatgagtaaa aactagaagg cttctctcca cagtgttgtg ccccttcact
2761 catttttttt tgaggagaag ggggtctctg ttaacatcta gcctaaagta tacaactgcc
2821 tggggggcag ggttaggaat ctcttcacta ccctgattct tgattcctgg ctctaccctg
2881 tctgtccctt ttctttgacc agatctttct cttccctgaa cgttttcttc tttccctgga
2941 caggcagcct cctttgtgtg tattcagagg cagtgatgac ttgctgtcca ggcagctccc
3001 tcctgcacac agaatgctca gggtcactga accactgctt ctcttttgaa agtagagcta
3061 gctgccactt tcacgtggcc tccgcagtgt ctccacctac acccctgtgc tcccctgcca
3121 cactgatggc tcaagacaag gctggcaaac cctcccagaa acatctctgg cccagaaagc
3181 ctctctctcc ctccctctct catgaggcac agccaagcca agcgctcatg ttgagccagt
3241 gggccagcca cagagcaaaa gagggtttat tttcagtccc ctctctctgg gtcagaacca
3301 gagggcatgc tgaatgcccc ctgcttactt ggtgagggtg ccccgcctga gtcagtgctc
3361 tcagctggca gtgcaatgct tgtagaagta ggaggaaaca gttctcactg ggaagaagca
3421 agggcaagaa cccaagtgcc tcacctcgaa aggaggccct gttccctgga gtcagggtga
3481 actgcaaagc tttggctgag acctgggatt tgagatacca caaaccctgc tgaacacagt
3541 gtctgttcag caaactaacc agcattccct acagcctagg gcagacaata gtatagaagt
3601 ctggaaaaaa acaaaaacag aatttgagaa ccttggacca ctcctgtccc tgtagctcag
3661 tcatcaaagc agaagtctgg ctttgctcta ttaagattgg aaatgtacac taccaaacac
3721 tcagtccact gttgagcccc agtgctggaa gggaggaagg cctttcttct gtgttaattg
3781 cgtagaggct acaggggtta gcctggacta aaggcatcct tgtcttttga gctattcacc
3841 tcagtagaaa aggatctaag ggaagatcac tgtagtttag ttctgttgac ctgtgcacct
3901 accccttgga aatgtctgct ggtatttcta attccacagg tcatcagatg cctgcttgat
3961 aatatataaa caataaaaac aactttcact tcttcctatt gtaatcgtgt gccatggatc
4021 tgatctgtac catgacccta cataaggctg gatggcacct caggctgagg gccccaatgt
4081 atgtgtggct gtgggtgtgg gtgggagtgt gtctgctgag taaggaacac gattttcaag
4141 attctaaagc tcaattcaag tgacacatta atgataaact cagatctgat caagagtccg
4201 gatttctaac agtccctgct ttggggggtg tgctgacaac ttagctcagg tgccttacat
4261 cttttctaat cacagtgttg catatgagcc tgccctcact ccctctgcag aatccctttg
4321 cacctgagac cctactgaag tggctggtag aaaaaggggc ctgagtggag gattatcagt
4381 atcacgattt gcaggattcc cttctgggct tcattctgga aacttttgtt agggctgctt
4441 ttcttaagtg cccacatttg atggagggtg gaaataattt gaatgtattt gatttataag
4501 tttttttttt tttttgggtt aaaagatggt tgtagcattt aaaatggaaa attttctcct
4561 tggtttgcta gtatcttggg tgtattctct gtaagtgtag ctcaaatagg tcatcatgaa
4621 aggttaaaaa agcgaggtgg ccatgttatg ctggtggtta aggccagggc ctctccaacc
4681 actgtgccac tgacttgctg tgtgaccctg ggcaagtcac ttaactataa ggtgcctcag
4741 ttttccttct gttaaaatgg ggataataat actgacctac ctcaaagggc agttttgagg
4801 catgactaat gctttttaga aagcattttg ggatccttca gcacaggaat tctcaagacc
4861 tgagtatttt ttataatagg aatgtccacc atgaacttga tacgtccgtg tgtcccagat
4921 gctgtcatta gtctatatgg ttctccaaga aactgaatga atccattgga gaagcggtgg
4981 ataactagcc agacaaaatt tgagaataca taaacaacgc attgccacgg aaacatacag
5041 aggatgcctt ttctgtgatt gggtgggatt ttttcccttt ttatgtggga tatagtagtt
5101 acttgtgaca aaaataattt tggaataatt tctattaata tcaactctga agctaattgt
5161 actaatctga gattgtgttt gttcataata aaagtgaagt gaatctaaaa aaaaaaaaaa
5221 a
//