LOCUS       AF095844                3380 bp    mRNA    linear   HUM 23-JAN-2002
DEFINITION  Homo sapiens melanoma differentiation associated protein-5 (MDA5)
            mRNA, complete cds.
ACCESSION   AF095844
VERSION     AF095844.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3380)
  AUTHORS   Kang,D.C., Gopalkrishnan,R.V., Wu,Q., Jankowsky,E., Pyle,A.M. and
            Fisher,P.B.
  TITLE     mda-5: An interferon-inducible putative RNA helicase with
            double-stranded RNA-dependent ATPase activity and melanoma
            growth-suppressive properties
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (2), 637-642 (2002)
   PUBMED   11805321
REFERENCE   2  (bases 1 to 3380)
  AUTHORS   Kang,D.-C. and Fisher,P.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-1998) Urology, Columbia University, P&S, 630
            W168th, New York, NY 10032, USA
FEATURES             Location/Qualifiers
     source          1..3380
                     /db_xref="H-InvDB:HIT000068449"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_line="HO-1"
                     /tissue_type="melanoma"
     gene            1..3380
                     /gene="MDA5"
     CDS             169..3246
                     /gene="MDA5"
                     /codon_start=1
                     /product="melanoma differentiation associated protein-5"
                     /protein_id="AAG34368.1"
                     /translation="MSNGYSTDENFRYLISCFRARVKMYIQVEPVLDYLTFLPAEVKE
                     QIQRTVATSGNMQAVELLLSTLEKGVWHLGWTREFVEALRRTGSPLAARYMNPELTDL
                     PSPSFENAHDEYLQLLNLLQPTLVDKLLVRDVLDKCMEEELLTIEDRNRIAAAENNGN
                     ESGVRELLKRIVQKENWFSAFLNVLRQTGNNELVQELTGSDCSESNAEIENLSQVDGP
                     QVEEQLLSTTVQPNLEKEVWGMENNSSESSFADSSVVSESDTSLAEGSVSCLDESLGH
                     NSNMGSDSGTMGSDSDEENVAARASPEPELQLRPYQMEVAQPALEGKNIIICLPTGSG
                     KTRVAVYIAKDHLDKKKKASEPGKVIVLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSG
                     DTQLKISFPEVVKSCDIIISTAQILENSLLNLENGEDAGVQLSDFSLIIIDECHHTNK
                     EAVYNNIMRHYLMQKLKNNRLKKENKPVIPLPQILGLTASPGVGGATKQAKAEEHILK
                     LCANLDAFTIKTVKENLDQLKNQIQEPCKKFAIADATREDPFKEKLLEIMTRIQTYCQ
                     MSPMSDFGTQPYEQWAIQMEKKAAKKGNRKERVCAEHLRKYNEALQINDTIRMIDAYT
                     HLETFYNEEKDKKFAVIEDDSDEGGDDEYCDGDEDEDDLKKPLKLDETDRFLMTLFFE
                     NNKMLKRLAENPEYENEKLTKLRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITE
                     NEKFAEVGVKAHHLIGAGHSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDI
                     KECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAHSGSGVIEHETVNDFREKMMYK
                     AIHCVQNMKPEEYAHKILELQMQSIMEKKMKTKRNIAKHYKNNPSLITFLCKNCSVLA
                     CSGEDIHVIEKMHHVNMTPEFKELYIVRENKALQKKCADYQINGEIICKCGQAWGTMM
                     VHKGLDLPCLKIRNFVVVFKNNSTKKQYKKWVELPITFPNLDYSECCLFSDED"
BASE COUNT         1153 a          644 c          753 g          830 t
ORIGIN      
        1 gcgcgccggc ctgagagccc tgtggacaac ctcgtcattg tcaggcacag agcggtagac
       61 cctgcttctc taagtgggca gcggacagcg gcacgcacat ttcacctgtc ccgcagacaa
      121 cagcaccatc tgcttgggag aaccctctcc cttctctgag aaagaaagat gtcgaatggg
      181 tattccacag acgagaattt ccgctatctc atctcgtgct tcagggccag ggtgaaaatg
      241 tacatccagg tggagcctgt gctggactac ctgacctttc tgcctgcaga ggtgaaggag
      301 cagattcaga ggacagtcgc cacctccggg aacatgcagg cagttgaact gctgctgagc
      361 accttggaga agggagtctg gcaccttggt tggactcggg aattcgtgga ggccctccgg
      421 agaaccggca gccctctggc cgcccgctac atgaaccctg agctcacgga cttgccctct
      481 ccatcgtttg agaacgctca tgatgaatat ctccaactgc tgaacctcct tcagcccact
      541 ctggtggaca agcttctagt tagagacgtc ttggataagt gcatggagga ggaactgttg
      601 acaattgaag acagaaaccg gattgctgct gcagaaaaca atggaaatga atcaggtgta
      661 agagagctac taaaaaggat tgtgcagaaa gaaaactggt tctctgcatt tctgaatgtt
      721 cttcgtcaaa caggaaacaa tgaacttgtc caagagttaa caggctctga ttgctcagaa
      781 agcaatgcag agattgagaa tttatcacaa gttgatggtc ctcaagtgga agagcaactt
      841 ctttcaacca cagttcagcc aaatctggag aaggaggtct ggggcatgga gaataactca
      901 tcagaatcat cttttgcaga ttcttctgta gtttcagaat cagacacaag tttggcagaa
      961 ggaagtgtca gctgcttaga tgaaagtctt ggacataaca gcaacatggg cagtgattca
     1021 ggcaccatgg gaagtgattc agatgaagag aatgtggcag caagagcatc cccggagcca
     1081 gaactccagc tcaggcctta ccaaatggaa gttgcccagc cagccttgga agggaagaat
     1141 atcatcatct gcctccctac agggagtgga aaaaccagag tggctgttta cattgccaag
     1201 gatcacttag acaagaagaa aaaagcatct gagcctggaa aagttatagt tcttgtcaat
     1261 aaggtactgc tagttgaaca gctcttccgc aaggagttcc aaccattttt gaagaaatgg
     1321 tatcgtgtta ttggattaag tggtgatacc caactgaaaa tatcatttcc agaagttgtc
     1381 aagtcctgtg atattattat cagtacagct caaatccttg aaaactccct cttaaacttg
     1441 gaaaatggag aagatgctgg tgttcaattg tcagactttt ccctcattat cattgatgaa
     1501 tgtcatcaca ccaacaaaga agcagtgtat aataacatca tgaggcatta tttgatgcag
     1561 aagttgaaaa acaatagact caagaaagaa aacaaaccag tgattcccct tcctcagata
     1621 ctgggactaa cagcttcacc tggtgttgga ggggccacga agcaagccaa agctgaagaa
     1681 cacattttaa aactatgtgc caatcttgat gcatttacta ttaaaactgt taaagaaaac
     1741 cttgatcaac tgaaaaacca aatacaggag ccatgcaaga agtttgccat tgcagatgca
     1801 accagagaag atccatttaa agagaaactt ctagaaataa tgacaaggat tcaaacttat
     1861 tgtcaaatga gtccaatgtc agattttgga actcaaccct atgaacaatg ggccattcaa
     1921 atggaaaaaa aagctgcaaa aaaaggaaat cgcaaagaac gtgtttgtgc agaacatttg
     1981 aggaagtaca atgaggccct acaaattaat gacacaattc gaatgataga tgcgtatact
     2041 catcttgaaa ctttctataa tgaagagaaa gataagaagt ttgcagtcat agaagatgat
     2101 agtgatgagg gtggtgatga tgagtattgt gatggtgatg aagatgagga tgatttaaag
     2161 aaacctttga aactggatga aacagataga tttctcatga ctttattttt tgaaaacaat
     2221 aaaatgttga aaaggctggc tgaaaaccca gaatatgaaa atgaaaagct gaccaaatta
     2281 agaaatacca taatggagca atatactagg actgaggaat cagcacgagg aataatcttt
     2341 acaaaaacac gacagagtgc atatgcgctt tcccagtgga ttactgaaaa tgaaaaattt
     2401 gctgaagtag gagtcaaagc ccaccatctg attggagctg gacacagcag tgagttcaaa
     2461 cccatgacac agaatgaaca aaaagaagtc attagtaaat ttcgcactgg aaaaatcaat
     2521 ctgcttatcg ctaccacagt ggcagaagaa ggtctggata ttaaagaatg taacattgtt
     2581 atccgttatg gtctcgtcac caatgaaata gccatggtcc aggcccgtgg tcgagccaga
     2641 gctgatgaga gcacctacgt cctggttgct cacagtggtt caggagttat cgaacatgag
     2701 acagttaatg atttccgaga gaagatgatg tataaagcta tacattgtgt tcaaaatatg
     2761 aaaccagagg agtatgctca taagattttg gaattacaga tgcaaagtat aatggaaaag
     2821 aaaatgaaaa ccaagagaaa tattgccaag cattacaaga ataacccatc actaataact
     2881 ttcctttgca aaaactgcag tgtgctagcc tgttctgggg aagatatcca tgtaattgag
     2941 aaaatgcatc acgtcaatat gaccccagaa ttcaaggaac tttacattgt aagagaaaac
     3001 aaagcactgc aaaagaagtg tgccgactat caaataaatg gtgaaatcat ctgcaaatgt
     3061 ggccaggctt ggggaacaat gatggtgcac aaaggcttag atttgccttg tctcaaaata
     3121 aggaattttg tagtggtttt caaaaataat tcaacaaaga aacaatacaa aaagtgggta
     3181 gaattaccta tcacatttcc caatcttgac tattcagaat gctgtttatt tagtgatgag
     3241 gattagcact tgattgaaga ttcttttaaa atactatcag ttaaacattt aatatgatta
     3301 tgattaatgt attcattatg ctacagaact gacataagaa tcaataaaat gattgtttta
     3361 ctctgaaaaa aaaaaaaaaa
//